Single-cell RNA sequencing reveals the heterogeneity and regulatory modules of cell-specific RNA-binding proteins in patients with systemic lupus erythematosus by Sheng-Yan Lin, Yikai Yu, Daan Nie, Lili Yang, Yuxue Chen, Yu Chen, Cheng Wen, Zhipeng Zeng

“…These molecular hubs, embedded within immune regulatory networks, may drive pathogenic rewiring of T cell responses in SLE.…”
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Structural convergence and membrane interactions of Aβ1-42 along the primary nucleation process studied by solid state NMR by Maurine K. Kengwerere, June M. Kenyaga, Peng Xiao, Shubha S. Gunaga, Faith J. Scott, Xyomara Wutoh-Hughes, James Wang, Brian Lum, Yan Sun, Frederic Mentink-Vigier, Tuo Wang, Wei Qiang

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Emergence of invasive Streptococcus dysgalactiae subsp. equisimilis in Spain (2012-2022): genomic insights and clinical correlations by Guillem López de Egea, Aida González-Díaz, Randall J Olsen, Gérard Guédon, Dàmaris Berbel, Immaculada Grau, Jordi Càmara, Lucía Saiz-Escobedo, Sara Calvo-Silveria, Irene Cadenas-Jiménez, José María Marimón, Emilia Cercenado, Antonio Casabella, Sara Martí, M. Ángeles Domínguez, Nathalie Leblond-Bourget, James M Musser, Carmen Ardanuy

“…These findings underscore the need for ongoing surveillance of this emerging pathogen.…”
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Anti-cariogenic potential and pharmacokinetics of Licorice and Xylitol infused chewing gum by Jencia Amaly, Ramya Ramadoss, K. Nitya, Sundar Sandhya, Suganya Panneer Selvam, K. Hema Shree, G. Radha

“…Results: FTIR and XRD confirmed the successful integration of bioactive components and an amorphous matrix structure, promoting controlled release and stability. …”
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Nanobiosensors for revolutionizing parasitic infections diagnosis: a critical review to improve global health with an update on future challenges prospect by Soheil Sadr, Ashkan Hajjafari, Alireza Sazmand, Cinzia Santucciu, Giovanna Masala, Mahdi Soroushianfar, Shakiba Nazemian, Abbas Rahdar, Sadanand Pandey, Moez Guettari, Hassan Borji

“…Development of multiplex nanobiosensors using polymer nanofibers or hybrid nanoparticles for simultaneous detection of multiple pathogens, along with integration of lab-on-a-chip technology for point-of-care (PoC) platforms, is an important future prospect that needs to be worked on. …”
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SNP rs615552 and lncRNA CDKN2B-AS1 influence brain cancer pathogenesis through multi-omic mechanisms by Zheng Ye, Jiaqi Yuan, Qianbei Yi, Peng Xu, Wenbin Liu

“…The SNP rs615552_AL359922.1 represents a significant pathogenic SNP for brain cancer. The identification of shared genetic mechanisms, particularly involving TERT, with other diseases points to new opportunities for developing therapeutic targets and diagnostic tools. …”
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Mapping the AMR Infection Landscape in Bihar: Implications for Strengthening Policy and Clinical Practice by Vinay Modgil, Sundeep Sahay, Neelam Taneja, Burhanuddin Qayyumi, Ravikant Singh, Arunima Mukherjee, Bibekananda Bhoi, Gitika Arora

“…<b>Methods:</b> This study aimed to characterize the AMR infection landscape across five public tertiary care hospitals in Bihar over three years (2022–2024) and to assess the feasibility of integrating digital workflows for real-time microbiological reporting. …”
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Prophages divert Staphylococcus aureus defenses against host lipids by Biyang Zhou, Amit Pathania, Deepak Pant, David Halpern, Philippe Gaudu, Patrick Trieu-Cuot, Andressa Dias-Leao, Charlotte Pagot, Audrey Solgadi, Alexandra Gruss, Karine Gloux

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Engineered albumin hydrogel with in-situ silver oxide nanoparticles for biomedical applications by Smrity Sonbhadra, Rushikesh Fopase, Anurag Mishra, Nandini Dhakaan, Lalit M Pandey

“…Antibacterial tests confirmed the broad-spectrum activity against pathogenic gram-positive and gram-negative bacteria in a dose-dependent manner. …”
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Composition analysis and mechanism of Guizhi Fuling capsule in anti-cisplatin-resistant ovarian cancer by Lei Dou, Yan Yan, Enting Lu, Fangmei Li, Dongli Tian, Lei Deng, Xue Zhang, Rongjin Zhang, Yin Li, Yi Zhang, Ye Sun

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A rare deleterious missense mutation in the AXIN2 gene in Chinese women with polycystic ovary syndrome by Ying Zhang, Yu Chen, Fa-Ying Liu, Jing-Wen Fu, Xian-Xian Liu, Jun Tan, Ou-Ping Huang, Yang Zou

“…Previous genome-wide association study (GWAS) showed that Wing-less-related integration site (Wnt) signaling is the most affected pathway among PCOS-related risk genes, and genetic mutations in the Wnt/β-catenin signaling may lead to abnormal development of PCOS.Objective To explore the possibility of axis inhibitor-2 (AXIN2) variants in Chinese women with PCOS and assess their pathogenicities.Methods A total of 365 Chinese women with PCOS and 905 women without PCOS as control were recruited from Jiangxi Provincial Maternal and Child Health Hospital, All of the 11 exons and flanking regions of the AXIN2 gene were amplified by polymerase chain reaction (PCR), the potential variants were analyzed by Sanger sequencing. …”
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Genome-wide association analysis study and genomic prediction for resistance to soybean mosaic virus in soybean population by Tiantian Zhao, Fengmin Wang, Jin Qi, Qiang Chen, Lijuan Zhu, Luping Liu, Long Yan, Yuling Chen, Chunyan Yang, Jun Qin

“…The latter is linked to Glyma.04G086700, a gene encoding a leucine-rich repeat protein kinase integral to pathogen recognition and resistance, showing three distinct haplotypes correlated with varying resistance levels, governed by specific allelic variations at certain SNP sites. …”
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Case Report: Clinical, molecular, and functional characterization of autoimmune lymphoproliferative syndrome—a family study with a multimodal diagnosis by Bruna Cândido Guido, Ricardo Camargo, Caroliny Victoria dos Santos Silva, Anna Carolina Silva Dias, Robéria Mendonça de Pontes, Agenor de Castro Moreira dos Santos Júnior, Raquel Alves Toscano, Fabíola Scancetti Tavares, Alexandre de Albuquerque Antunes, Karina Mescouto de Melo, Karina Mescouto de Melo, Karina Mescouto de Melo

“…Autoimmune Lymphoproliferative Syndrome (ALPS) is a rare immunological disorder caused by defective apoptosis, commonly due to pathogenic variants in the FAS gene. We report a comprehensive clinical, immunophenotypic, molecular, and functional evaluation of nine members of a consanguineous Brazilian family harboring the pathogenic FAS (NM_000043.6:c.748C &gt; T) variant. …”
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Long-Read Sequencing and Structural Variant Detection: Unlocking the Hidden Genome in Rare Genetic Disorders by Efthalia Moustakli, Panagiotis Christopoulos, Anastasios Potiris, Athanasios Zikopoulos, Despoina Mavrogianni, Grigorios Karampas, Nikolaos Kathopoulis, Ismini Anagnostaki, Ekaterini Domali, Alexandros T. Tzallas, Peter Drakakis, Sofoklis Stavros

“…Case studies illustrate how this technique has revealed new pathogenic pathways and solved cases that were previously undetected. …”
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Invasive mould infection in immunocompromised children: Pulmonary computed tomography findings from two multicentre paediatric cohorts by Daniel K Yeoh, Derek J Roebuck, Madusha Chandratilleke, Julia E Clark, Adrienne Lam, Rishi S Kotecha, Monica A Slavin, Gabrielle M Haeusler, Christopher C Blyth, Karin A Thursky

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Comprehensive Analysis of Differences in N6-Methyladenosine RNA Methylation Groups in CVB3-Induced Viral Myocarditis and Identification of the Anti-Apoptotic Role of RBM15B by Hu Y, Lin J, Yi L, Cheng S, You G, Chang H, Liu H, Yang Z, Chen S

“…RNA-seq detected 1,597 upregulated and 2,942 downregulated mRNAs. Integrated analysis of MeRIP-seq and RNA-seq identified 38 hypermethylated-upregulated, 23 hypermethylated-downregulated, 65 hypomethylated-downregulated, and 13 hypomethylated-upregulated genes. …”
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Clonal expansion of chromosome-borne CTX-M-55 extended-spectrum β-lactamase-producing Salmonella enterica serovar Agona, Taiwan by Ying-Shu Liao, Yu-Ping Hong, Bo-Han Chen, You-Wun Wang, Ru-Hsiou Teng, Yung-Chen Chien, Shiu-Yun Liang, Hsiao Lun Wei, Jui-Hsien Chang, Ming-Hao Yang, Chi-Sen Tsao, Chien-Shun Chiou

“…These findings underscore the urgent need for enhanced surveillance, targeted interventions, and global antimicrobial stewardship to curb the spread of MDR pathogens and safeguard public health.…”
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Cohort profile: the Oxford Parkinson’s Disease Centre Discovery Cohort MRI substudy (OPDC-MRI) by Ricarda A L Menke, Michael Lawton, Thomas R Barber, Johannes C Klein, Clare Mackay, Konrad Szewczyk-Krolikowski, Michele T Hu, Michal Rolinski, Ludovica Griffanti, Samuel G Evetts, Faye Begeti, Marie Crabbe, Jane Rumbold, Richard Wade-Martins

“…Baseline MRI data are currently available for 290 participants: 119 patients with early idiopathic Parkinson’s, 15 Parkinson’s patients with pathogenic mutations of the leucine-rich repeat kinase 2 or glucocerebrosidase (GBA) genes, 68 healthy controls and 87 individuals at risk of Parkinson’s (asymptomatic carriers of GBA mutation and patients with idiopathic rapid eye movement sleep behaviour disorder-RBD).Findings to date Differences in brain structure in early Parkinson’s were found to be subtle, with small changes in the shape of the globus pallidus and evidence of alterations in microstructural integrity in the prefrontal cortex that correlated with performance on executive function tests. …”
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Hydrolyzable tannins in local Thai plants: Potential applications as poultry feed supplements: A systematic review by Tanakamol Mahawan, Pornchai Pornpanom, Surya Nur Rahmatullah, Tuempong Wongtawan, Thotsapol Thomrongsuwannakij

“…HT-rich extracts demonstrated strong antimicrobial effects against 19 pathogenic bacterial species and enhanced the growth of beneficial gut microbiota, including Lactobacillus spp. and Faecalibacterium prausnitzii. …”
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Genetic variants and molecular profiling of 46,XY gonadal dysgenesis using whole-exome sequencing by Ning Zhang, Ning Zhang, Ning Zhang, Shuoming You, Shuoming You, Jingjing Guo, Jingjing Guo, Xingyu Chang, Xingyu Chang, Junjun Qiu, Junjun Qiu, Keqin Hua, Keqin Hua

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