Exome sequencing in Nigerian children with early‐onset epilepsy syndromes by Ibitayo Abigail Ademuwagun, Yagoub Adam, Solomon Oladapo Rotimi, Steffen Syrbe, Maximilian Radtke, Julia Hentschel, Johannes R. Lemke, Ezekiel Adebiyi

“…Computational analysis involved variant calling, curation, and classification using specialized tools and databases. Results Pathogenic variants were identified in 6 out of 22 individuals, equaling a diagnostic yield of 27.3% and comprising variants in BPTF, NAA15, SCN1A, TUBA1A and twice in CACNA1A. …”
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Immunophénotypage et applications envisageables pour l’amélioration génétique des volailles by Fany BLANC

“…L’immunocompétence peut être évaluée en mesurant la résistance ou la tolérance à un pathogène particulier ou en analysant un panel de paramètres immunitaires. …”
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The immunosuppressive role of VSIG4 in colorectal cancer and its interaction with the tumor microenvironment by H. G. Zhang, W. R. Yao, Z. Y. Zhou, L. Liu

“…Methods This study integrated data from the TCGA-COAD dataset with the GEO database, along with single-cell RNA sequencing data, to systematically analyze key genes in colorectal cancer. …”
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Spectrum of γ-Secretase dysfunction as a unifying predictor of ADAD age at onset across PSEN1, PSEN2 and APP causal genes by Sara Gutiérrez Fernández, Cristina Gan Oria, Dieter Petit, Wim Annaert, John M. Ringman, Nick C. Fox, Natalie S. Ryan, Lucía Chávez-Gutiérrez

“…The integration of PSEN1, PSEN2 and APP correlation data shows parallel but shifted lines, suggesting a common pathogenic mechanism with gene-specific shifts in onset. …”
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DENND5B Gene Expression as a Trigger for the Development of Diabetes Mellitus–Peripheral Artery Disease: Insights from a Univariate and Multivariate Mendelian Randomization Study by Qiaoqiao Li, Fuli Cao, Xueping Gao, Yuan Xu, Bo Li, Tianyang Hu

“…Compared to individuals with PAD but no DM, those with concurrent DM and PAD (DM-PAD, diabetes mellitus–peripheral artery disease) face a seven-fold higher risk of critical limb ischemia and a five-fold higher risk of amputation. However, the pathogenic factors and effective therapeutic targets for DM-PAD still remain elusive. …”
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Prognostic impact of donor mitochondrial genomic variants in myelodysplastic neoplasms after stem-cell transplantation by Jing Dong, Shahram Arsang-Jang, Tao Zhang, Zhongyuan Chen, Yung-Tsi Bolon, Stephen Spellman, Raul Urrutia, Paul Auer, Wael Saber

“…In the entire donor cohort, we identified 1,825 mtDNA variants, including 67 potential pathogenic variants. Genetic variants on MT-CYB and MT-ND5 genes were identified as independent predictors of posttransplant outcomes. …”
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Targeting Ocular Biofilms with Plant-Derived Antimicrobials in the Era of Antibiotic Resistance by Monika Dzięgielewska, Michał Tomczyk, Adrian Wiater, Aleksandra Woytoń, Adam Junka

“…These infections are often caused by pathogens, including <i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, and <i>Candida albicans</i>, particularly in patients using contact lenses or intraocular implants—devices that serve as surfaces for biofilm formation. …”
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Recent advances in nano-enhanced biosensors: Innovations in design, applications in healthcare, environmental monitoring, and food safety, and emerging research challenges by Mohamed Hemdan, Khaled Abuelhaded, Abanoub A.S. Shaker, Mohamed M. Ashour, Moustafa M. Abdelaziz, Mohammed I. Dahab, Yara A. Nassar, Amir M.M. Sarguos, Pola S. Zakaria, Haidy A. Fahmy, Sherif S. Abdel Mageed, Mariam O.A. Hamed, Mahmoud F. Mubarak, Mostafa A. Taher, Najla F. Gumaah, Ahmed H. Ragab

“…The integration of nanotechnology into biosensor design has propelled significant advancements, transforming them into essential tools for precise and rapid detection in diverse fields. …”
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Genetics and clinical implications of SPINK1 in the pancreatitis continuum and pancreatic cancer by Qi-Wen Wang, Wen-Bin Zou, Emmanuelle Masson, Claude Férec, Zhuan Liao, Jian-Min Chen

“…We emphasize the integration of a full-length gene splicing assay (FLGSA) with SpliceAI’s predictive capabilities, establishing SPINK1 the first disease gene for which the splicing impact of all possible coding variants was prospectively determined. …”
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Evaluation of antibody serology to determine current helminth and Plasmodium falciparum infections in a co-endemic area in Southern Mozambique. by Rebeca Santano, Rocío Rubio, Berta Grau-Pujol, Valdemiro Escola, Osvaldo Muchisse, Inocência Cuamba, Marta Vidal, Gemma Ruiz-Olalla, Ruth Aguilar, Javier Gandasegui, Maria Demontis, Jose Carlos Jamine, Anélsio Cossa, Charfudin Sacoor, Jorge Cano, Luis Izquierdo, Chetan E Chitnis, Ross L Coppel, Virander Chauhan, David Cavanagh, Sheetij Dutta, Evelina Angov, Lisette van Lieshout, Bin Zhan, José Muñoz, Carlota Dobaño, Gemma Moncunill

“…We also showed the feasibility of measuring antibody serology with a platform that allows the integration of control and elimination programs for different pathogens.…”
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Morphometric and richness analysis of free-living and parasite taxa-invading street wetlands in Port Said, Egypt by Hadeer Abd El-hak Rashed, Layla Omran Elmajdoub, Eman Fayad, Ali Hussein Abu Almaaty

“…Conclusion: The street wetlands in the surveyed area contain various free-living and pathogenic taxa. There is a need to link the presence of these organisms to physicochemical analyses. …”
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An efficient green synthesis of Ag/Fe2O3 nanocomposite using Carica papaya peel extract for enhanced photocatalytic, antioxidant, and antibacterial activities by Tahir Hamza Endres, Ahmed Awol Yimer, Tamene Tadesse Beyene, Guta Gonfa Muleta

“…Based on these results, Ag/Fe2O3-NCs could be used as a useful photocatalyst for water treatment, pathogenic disinfection, and antioxidant tools.…”
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Recurrent Metastatic Basal Cell Carcinomas of the Face in a Patient with Gorlin–Goltz Syndrome by Petko Petrov, Dobromira Shopova, Georgi Goranov, Atanaska Dinkova, Nina Stoyanova, Nikolay Yanev

“…The patient, diagnosed with a pathogenic <i>PTCH1</i> gene mutation, underwent a series of treatment interventions over several years. …”
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Antimicrobial Resistance Profiles of Escherichia coli Isolated from Broiler and Layer Chickens in Arusha and Mwanza, Tanzania by Ruth W. Kiiti, Erick V. Komba, Peter L. Msoffe, Stephen E. Mshana, Mark Rweyemamu, Mecky I. N. Matee

“…The rise in the spread of antibiotic-resistant pathogens such as Escherichia coli is one of the very important dynamics off-putting treatment and prophylaxis possibilities, hence posing a threat to the modern human medicine, veterinary medicine, and food safety. …”
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Rapid visual detection of Monkeypox virus by one-step LAMP-CRISPR/Cas12b assay by Jinlei Guo, Yunfeng Shan, Ge Hu, Xiaojuan Zhu, Kangchen Zhao, Tao Wu, Qiao Qiao, Ying Chi, Lunbiao Cui, Yiyue Ge

“…The limit of detection (LOD) of the assay was demonstrated to be 6.5 copies per reaction and no cross-reactivity with other pathogens such as HSV, EBV, CVA16, EV-A71, and MV was found. …”
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Engineering copper and copper-based materials for a post-antibiotic era by Yingxian Wang, Tongqiang Wen, Fuchao Mao, Fuchao Mao, Fuchao Mao, Fuchao Mao, Shaozhe Yang, Qingwei Zhang, Xiuhong Fu, Chongkai Zhai, Chongkai Zhai, Chongkai Zhai, Chongkai Zhai, Hewei Zhang, Hewei Zhang, Hewei Zhang, Hewei Zhang, Hewei Zhang

“…In recent years, the emergence of multidrug-resistant bacteria and the frequent outbreaks of novel viral pathogens have intensified the demand for novel, efficient, and low-toxicity antimicrobial materials. …”
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Morphofunctional and Biochemical Approaches for Studying Mitochondrial Changes during Myoblasts Differentiation by Elena Barbieri, Michela Battistelli, Lucia Casadei, Luciana Vallorani, Giovanni Piccoli, Michele Guescini, Anna Maria Gioacchini, Emanuela Polidori, Sabrina Zeppa, Paola Ceccaroli, Laura Stocchi, Vilberto Stocchi, Elisabetta Falcieri

“…Other notable proteins, such as superoxide dismutase (MnSOD), a cell protection molecule, and voltage-dependent anion-selective channel protein (VDAC1) involved in the mitochondria-mediated apoptosis, were found to be regulated by the myogenic process. The integration of these approaches represents a helpful tool for studying mitochondrial dynamics, biogenesis, and functionality in comparative surveys on mitochondrial pathogenic or senescent satellite cells.…”
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The role of glucagon-like peptide-1 receptor agonists in the correction of immune and metabolic disorders in women with reproductive dysfunction by N. D. Kozhukhov, A. R. Karpova, A. A. Sadretdinova, D. G. Kodoeva, A. S. Kardanova, A. S. Proshina, A. S. Avbakirova, D. R. Kilichev, I. Sh. Metov, L. M. Magomedov, D. K. Gatsaev, M. E. Balabanova, Kh. B. Mutalieva, Z. M. Alibekova

“…GLP-1RAs target key pathogenic mechanisms underlying these conditions, extending beyond their glucose-lowering effects. …”
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Unveiling pathways to enhance hypertension and diabetes care in rural China: a mixed methods study using the care cascade modelResearch in context by Xuejun Yin, Zhenzhong Wang, Jia Li, Jiawen Ke, Bin Jing, Wenshuai Feng, Qinglan Liu, Jingsong Yang, Alon Rasooly, David Beran, Kunihiro Matsushita, Nizal Sarrafzadegan, Yuxiu Li, Luzhao Feng, Ruitai Shao

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A review of metabolic calorimetric applications in plant stress, waste management, and diagnostics by Michael Bayode, Ifeoluwaposi Ogundana, Oluwatosin Ogundare, Elizabeth Awodire, Patience Abbah, Israel Onifade, Adeola Adeyolanu, Stephen Okunade, Samuel Ogboye, Michael Elabiyi

“…It is advised that these calorimetric studies be used in plant, soil, and waste bodies for ecosystem safety and integrity. IMC not only enhances our understanding of plant responses to stress and pathogens but also aids in achieving Sustainable Development Goal (SDG) 3 by enhancing diagnostic capabilities and disease management. …”
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