Study on the Effect of Phillyrin on <i>Streptococcus suis</i> In Vivo and In Vitro by Fangyan Yuan, Lihan Zheng, Mengzhe Wang, Wei Liu, Xiaoyue Li, Ting Gao, Rui Guo, Zewen Liu, Keli Yang, Chang Li, Qiong Wu, Jiajia Zhu, Yongxiang Tian, Danna Zhou

“…As a zoonotic pathogen, <i>S. suis</i> serotype 2 (SS2) can cause severe diseases in both pigs and humans, and develop resistance to antibiotics. …”
Get full text

Unraveling the complex genetic landscape of OTOF-related hearing loss: a deep dive into cryptic variants and haplotype phasing by Pei-Hsuan Lin, Cheng-Yu Tsai, Yu-Ting Chiang, Chang-Han Ho, Yue-Sheng Lu, Jacob Shu-Jui Hsu, Yen-Fu Cheng, Shih-Feng Tsai, Chuan-Jen Hsu, Pei-Lung Chen, Chen-Chi Wu

“…Abstract Background Pathogenic variants in OTOF are a major cause of auditory synaptopathy. …”
Get full text

Genomic and phylogeographical analysis revealed CTX-M-55 producing Escherichia coli ST10 and ST2325 clones of One Health concern from dairy farm waste in Gansu, China by Muhammad Shoaib, Muhammad Muddassir Ali, Minjia Tang, Wang Weiwei, Xuejing Zhang, Zhuolin He, Zhongyong Wu, Shengyi Wang, Baocheng Hao, Ruichao Li, Wanxia Pu

“…Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli resists broad-spectrum cephalosporins, considered as a critical priority pathogen, and its presence in animals, humans, and the environment highlights its significance as a One Health issue. …”
Get full text

Multi-Omics Technologies Applied to Improve Tick Research by Arlex Rodríguez-Durán, Vinícius Andrade-Silva, Muhammad Numan, Jéssica Waldman, Abid Ali, Carlos Logullo, Itabajara da Silva Vaz Junior, Luís Fernando Parizi

“…Future directions point to the integration of spatial omics and artificial intelligence to further unravel tick biology and improve control strategies.…”
Get full text

A versatile platform based on matrix metalloproteinase-sensitive peptides for novel diagnostic and therapeutic strategies in arthritis by Mingyang Li, Tao Deng, Quan Chen, Shenghu Jiang, Hang Li, Jiayi Li, Shenglan You, Hui-qi Xie, Bin Shen

“…Matrix metalloproteinases (MMPs), coupled with other proteinases and glycanases, can degrade proteoglycans, collagens, and other extracellular matrix (ECM) components in inflammatory and non-inflammatory arthritis, making them important pathogenic molecules and ideal disease indicators and pharmaceutical intervention triggers. …”
Get full text

The Influence of Substrate Composition on Nutritional Content and Biological Activity of Some <i>Pleurotus</i> Mushrooms Extracts by Ionuț-Cristian Rusu, Oana-Elena Pascariu, Aglaia Popa (Burlacu), Camelia-Filofteia Diguță, Livia Apostol, Mihai-Bogdan Nicolcioiu, Alexandru Valentin Zăgrean, Florentina Israel-Roming

“…Among the strains, only <i>P. ostreatus</i> and <i>P. columbinus</i> exerted antimicrobial activity against two pathogens: <i>Staphylococcus aureus</i> and <i>Streptococcus pyogenes</i>. …”
Get full text

Discovery and molecular identification of a new orthophasmavirus in the Asian citrus psyllid (Diaphorina citri) by Song Zhang, Song Zhang, Jing Chen, Jing Chen, Luqin Liu, Luqin Liu, Zhipeng Xie, Zhipeng Xie, Jiamei Liang, Jiamei Liang, Fulin Yan, Fulin Yan, Yaqin Song, Xuefeng Wang, Xuefeng Wang, Changyong Zhou, Changyong Zhou, Mengji Cao, Mengji Cao, Jinxiang Liu, Jinxiang Liu

Get full text

Laboratory Testing to Inform Antimicrobial Use for Bovine Respiratory Disease: Perceptions of Canadian Feedlot Veterinarians by Olufunto O. Adewusi, Candace I. J. Nykiforuk, Cheryl L. Waldner, Nathan E. N. Erickson, Sheryl P. Gow, Simon J. G. Otto

“…Thematic analysis revealed four themes: (1) lived experience of feedlot veterinarians with laboratory testing for BRD pathogens and antimicrobial resistance (AMR), (2) evidence-informed BRD management that integrates multiple data sources and their components, (3) organizational factors that affect the uptake and use of laboratory tests, and (4) the role of laboratory testing to support AMS in BRD management. …”
Get full text

Progresses in genetic testing in congenital heart disease by Han Gao, Ying Liu, Wei Sheng, Weinian Shou, Guoying Huang

“…With the advancement of cohort studies, genomic data on these variations can be robustly collected and classified according to their pathogenicity, thereby enhancing our understanding of CHD genetics. …”
Get full text

Single-cell multiomic analysis unveils the immune landscape dynamics of graves’ ophthalmopathy by Shurui Ke, Zhong Liu, Ming Zhou, Bing Xiao, Qiuling Hu, Jinshan Lin, Huijing Ye, Lixia Luo, Xianchai Lin

“…Our study reveals the epigenetic and transcriptomic landscape in the peripheral blood of GO patients, enhancing the understanding of the pathogenic molecular mechanisms and offering potential directions for prevention and treatment.…”
Get full text

One-step and two-step qPCR assays for CAPRV2023: development and application in full-cycle epidemiological surveillance of golden pompano by Heng Sun, Heng Sun, Bissih Fred, Bissih Fred, Haoyu Wang, Haoyu Wang, Jie Huang, Jie Huang, Zihao Wu, Zihao Wu, Dandan Wu, Dandan Wu, Yishan Lu, Yishan Lu, Jichang Jian, Jichang Jian, Yucong Huang, Yucong Huang

“…Carpione rhabdovirus strain 2023 (CAPRV2023) has recently emerged as a significant pathogen responsible for substantial mortality in farmed golden pompano (Trachinotus ovatus) across China, threatening the sustainability of the aquaculture industry. …”
Get full text

Genomic approach to evaluate the intrinsic antibacterial activity of novel diazabicyclooctanes (zidebactam and nacubactam) against clinical Escherichia coli isolates from diverse c... by Farah Al-Marzooq, Akela Ghazawi, Maitha Alshamsi, Abdulrahman Alzaabi, Omar Aleissaee, Hamad Almansoori, Abdullah Alsaadi, Rauda Aldhaheri, Hafsa Ahli, Lana Daoud, Amna Ahmad, Timothy Collyns, Seema Oommen

“…While the inclusion of DBO therapies in the antibiotic arsenal could significantly impact MDR pathogen treatment, realizing their full potential requires further research, clinical evaluation, and vigilant monitoring of resistance mechanisms through integrated genomic approaches.…”
Get full text

Longitudinal transcriptome analysis reveals distinct gene expression patterns in traditional Chinese medicine syndromes of upper respiratory tract infections by Hao Zou, Hao Zou, Changrui Huang, Changrui Huang, Qinqi Feng, Qinqi Feng, Bang Yu, Bang Yu, Jian Liu, Xinyang Shu, Xiaolu Nie, Hongchun Zhang, Xiaohui Zou

Get full text

Selective protection of cereals using artificial neural networks by Wiesław Golka, Magdalena Szechyńska-Hebda, Jolanta Kowalska, Adrian Golka, Robert Grolik, Magdalena Jakubowska, Mateusz Góra, Aleksander Bomberski

“…Global agricultural losses due to pests and pathogens are substantial, particularly for wheat, maize, and potatoes. …”
Get full text

The clinical application and challenges of preimplantation genetic testing by Fan Zhou, Fan Zhou, Xinlian Chen, Xinlian Chen, Shanling Liu, Shanling Liu, Xiaodong Wang, Xiaodong Wang

“…Preimplantation genetic testing (PGT) has rapidly advanced due to the significant development of genetic testing technologies. As an integration of genetic testing and assisted reproductive technology (ART), PGT plays a pivotal role in the primary prevention of birth defects, mainly chromosomal abnormalities and monogenic disease with known pathogenic variants. …”
Get full text

High prevalence of constitutional BRCA1 epimutation in patients with early-onset triple-negative breast cancer by Mathias Schwartz, Sabrina Ibadioune, Hélène Delhomelle, Solenn Barraud, Sandrine M. Caputo, Olfa Trabelsi-Grati, Marie-Charlotte Villy, Anthony Laugé, Roseline Tang, Etienne Rouleau, Emmanuelle Mouret-Fourme, Dominique Stoppa-Lyonnet, Éric Pasmant, Lisa Golmard, Chrystelle Colas, Ivan Bièche

“…Our results highlight the role of constitutional BRCA1 epimutations in early-onset TNBC risk and call for their integration into multifactorial models used to compute personalized breast cancer risk.…”
Get full text

Structure, conservation and health implications of urban wild meat value chains: A case study of Lagos, Nigeria by Samuel N. Akpan, Pim van Hooft, Anise N. Happi, Ralph Buij, Frank van Langevelde, Elizabeth A.J. Cook, James M. Hassell, Dawn M. Zimmerman, Sherrill P. Masudi, Christian T. Happi, Lian F. Thomas

“…Formal governance should be integrated into the value chain to aid effective monitoring and regulation. …”
Get full text

Seeking Solutions for Inclusively Economic, Rapid, and Safe Molecular Detection of Respiratory Infectious Diseases: Comprehensive Review from Polymerase Chain Reaction Techniques t... by Yaping Xie, Zisheng Zong, Qin Jiang, Xingxing Ke, Zhigang Wu

“…Frequent outbreaks of respiratory infectious diseases, driven by diverse pathogens, have long posed significant threats to public health, economic productivity, and societal stability. …”
Get full text

Clinicopathological profile of eosinophilic fasciitis: a retrospective cohort study from a neuromuscular disorder center in China by Xiaoyuan Wang, Lining Zhang, Ying Hou, Tingjun Dai, Xiaotian Ma, Kai Shao, Chuanzhu Yan, Bing Zhao

Get full text

Exploring the additive antibacterial potential of Cinnamomum cassia volatile oil and imipenem against Acinetobacter baumannii: a multi-omics investigation by Youyuan Lu, Youyuan Lu, Wanlin Xu, Jiahui Xue, Mingxia Xie, Haotian Liu, Ruilin Wang, Gang Li, Hanqing Wang, Hanqing Wang

“…IntroductionAcinetobacter baumannii has been identified as a critical pathogen, and new antibiotics are urgently needed. …”
Get full text