Current insights on the effects of medicinal plants in the management of obesity and infectious diseases: An update from 2020 by Ezichi Favour Ofoezie, Chinwendu Angela Ogbonna, Ezinne Tiffany George, Chioma Juliet Anunobi, Sandra C. Olisakwe, Simeon Babarinde, Chidera Godson Chukwuemeka, Uzochukwu Eric Ogbonna, Chibuzo Collette Amafili, Justina Onyinyechi Omaba, Henry Nnaemeka Ogbonna

“…Additionally, their antimicrobial properties offer effective solutions against drug-resistant pathogens, presenting a complementary approach to conventional treatments. …”
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Natural small molecules regulating the mitophagy pathway counteract the pathogenesis of diabetes and chronic complications by Du Ye, Junping Zhu, Siya Su, Yunfeng Yu, Jun Zhang, Yuman Yin, Chuanquan Lin, Xuejiao Xie, Qin Xiang, Rong Yu

“…Emerging evidence indicates that dysfunctional mitophagy acts as a key pathogenic driver in the pathogenesis of DM and its associated complications. …”
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Advances in bio-polymer coatings for probiotic microencapsulation: chitosan and beyond for enhanced stability and controlled release by Great Iruoghene Edo, Alice Njolke Mafe, Nawar. F. Razooqi, Ebuka Chukwuma Umelo, Tayser Sumer Gaaz, Endurance Fegor Isoje, Ufuoma Augustina Igbuku, Patrick Othuke Akpoghelie, Rapheal Ajiri Opiti, Arthur Efeoghene Athan Essaghah, Dina S. Ahmed, Huzaifa Umar, Dilber Uzun Ozsahin

“…Detailed mechanistic insights are integrated, illustrating how chitosan influences gut microbiota by promoting beneficial bacteria and suppressing pathogens, thus enhancing its role as a prebiotic or synbiotic. …”
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Nanoparticle-Enhanced Collagen Hydrogels for Chronic Wound Management by Alexandra Cătălina Bîrcă, Mihai Alexandru Minculescu, Adelina-Gabriela Niculescu, Ariana Hudiță, Alina Maria Holban, Adina Alberts, Alexandru Mihai Grumezescu

“…The nanoparticles’ physicochemical properties were characterized using X-ray diffraction (XRD) to confirm crystalline structure, scanning electron microscopy (SEM) for surface morphology, and Fourier-transform infrared spectroscopy (FT-IR) to verify functional groups and successful hydrogel integration. The hydrogels were tested for antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans, which are key pathogens in chronic wounds. …”
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Functional characterization of SOX5 variant causing Lamb–Shaffer syndrome and literature review of variants in the SOX5 gene by Ping Wang, Hanbing Xie, Xiao Xiao, He Wang, Yan Wang, Shanling Liu

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Diagnostics for optimised dengue surveillance: a qualitative focus group study to investigate user experience and requirements in Thailand by Raheelah Ahmad, Alison Holmes, Pantelis Georgiou, Paul Arkell, Sanhapon Ketklao, Adisak Songjaeng, Dumrong Mairiang, Jesus Rodriguez-Manzano, Prida Malasit, Panisadee Avirutnan, Saranath Lawpoolsri

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Immune checkpoint inhibitor-related pneumonitis following discontinuation of pembrolizumab in a patient with advanced lung adenocarcinoma: a case report and literature review by Huan Wang, Yuzhen Jin, Peng Liu, Jie Zhou, Na Fan, Mengjie Li

“…Short-term steroid therapy resulted in significant improvement. Conclusions Integration of clinical presentation, imaging findings, and medication history is crucial for diagnosis. …”
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Unleashing the Power of Multiomics: Unraveling the Molecular Landscape of Peripheral Neuropathy by Julie Choi, Zitian Tang, Wendy Dong, Jenna Ulibarri, Elvisa Mehinovic, Simone Thomas, Ahmet Höke, Sheng Chih Jin

“…Furthermore, we discuss the clinical implications of genomic and multiomic integration, highlighting their potential to enhance diagnostic accuracy, prognostic assessment, and personalized treatment strategies for PN. …”
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Analyzing bacterial networks and interactions in skin and gills of Sparus aurata with microalgae-based additive feeding by I. M. Cerezo, E. A. Herrada, J. Fernández-Gracia, M. I. Sáez-Casado, J. A. Martos-Sitcha, M. A. Moriñigo, S. T. Tapia-Paniagua

“…Polaribacter could demonstrate potential protection against pathogens through negative interactions. These tentative studies open up an additional avenue to consider, such as the interactions among bacterial communities, as well as new proposals to corroborate these findings. …”
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A CFD-informed barn-level swine disease dissemination model and its use for ventilation optimization by Maryam Safari, Christian Fleming, Jason A. Galvis, Aniruddha Deka, Felipe Sanchez, Gustavo Machado, Chi-An Yeh

“…A pen-to-pen contact network is used to construct a transmission matrix according to the transport of airborne respiratory pathogens across pens in the barns, via our Reynolds-averaged Navier–Stokes computational fluid dynamics (CFD) solver. …”
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Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus. by Daniah Trabzuni, Mina Ryten, Warren Emmett, Adaikalavan Ramasamy, Karl J Lackner, Tanja Zeller, Robert Walker, Colin Smith, Patrick A Lewis, Adamantios Mamais, Rohan de Silva, Jana Vandrovcova, International Parkinson Disease Genomics Consortium (IPDGC), Dena Hernandez, Michael A Nalls, Manu Sharma, Sophie Garnier, Suzanne Lesage, Javier Simon-Sanchez, Thomas Gasser, Peter Heutink, Alexis Brice, Andrew Singleton, Huaibin Cai, Eric Schadt, Nicholas W Wood, Rina Bandopadhyay, Michael E Weale, John Hardy, Vincent Plagnol

“…Our results characterize the LRRK2 locus, and highlight the importance and difficulties of fine-mapping and integration of multiple datasets to delineate pathogenic variants and thus develop an understanding of disease mechanisms.…”
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Molecular background of the diverse metabolic profiles in leaves and inflorescences of naked catmint (Nepeta nuda L.) by Luka Petrović, Biljana Filipović, Marijana Skorić, Branislav Šiler, Tijana Banjanac, Dragana Matekalo, Jasmina Nestorović Živković, Slavica Dmitrović, Neda Aničić, Milica Milutinović, Jelena Božunović, Uroš Gašić, Danijela Mišić

“…The results suggest that N. nuda plants most likely invest more in constitutive than inducible biosynthesis of functional metabolites in flowers, since they are of essential importance for both pollination and defense against herbivores and pathogens. Conversely, specialized metabolism of leaves is found to be more susceptible to reprograming in response to differential growth conditions. …”
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Combined Phase 1/2a Initial Clinical Safety Trials and Proof‐of‐Concept Assessment of a Novel Antimicrobial Peptide KSL‐W Anti‐Plaque Chewing Gum by J. Brett Ryan, Brian J. Kirkwood, Kai P. Leung

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The Vaginal Microbiota, Human Papillomavirus, and Cervical Dysplasia—A Review by Justė Kazlauskaitė, Guoda Žukienė, Vilius Rudaitis, Daiva Bartkevičienė

“…<i>Results:</i> Different types of vaginal microbiota communities (CSTs) have different pathogenic or protective potential. Healthy women predominantly exhibited CST I, with <i>Lactobacillus crispatus</i> as the dominant microorganism. …”
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Prevention and Control of Zoonoses in China Under the New Situation: Challenges and Strategies by Qingyun Liu, Peiling Wu, Xiangru Wang, Shengbo Cao, Huanchun Chen

“…A scientific and technological innovation system in zoonotic disease prevention and control is proposed and covers eight research directions: aetiology and epidemiology, structural and functional analysis of pathogens, immunity mechanisms and pathogenesis, diagnostic reagents, new vaccines, new drugs, disease-resistant breeding, and integrated prevention and purification of diseases, aiming to enhance the scientific and technological strength of zoonose prevention and control in China. …”
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Gut microbiome remodeling in chronic kidney disease: implications of kidney replacement therapies and therapeutic interventions by Qianwei Wang, Yucheng Han, Liang Pang, Zhicheng Zhou, Lijuan Dai

“…., Faecalibacterium, Roseburia), and systemic microbial translocation; whereas PD-driven glucose absorption and iron supplementation foster pathogenic proliferation (e.g., Enterobacteriaceae) and impair short-chain fatty acid (SCFA) metabolism. …”
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Feature Selection and Network‐Driven Analyses to Unveil Common RNA Signatures in Colon and Pancreatic KRAS‐Mutant Cancers by Katia Pane, Mario Zanfardino, Anna Maria Grimaldi, Ilaria Leone, Silvia Nuzzo, Marco Salvatore, Monica Franzese

“…Both cancers share common features, such as some KRAS pathogenic variants and common epidemiology. The integration of multidimensional datasets by combining machine learning and bioinformatics approaches could provide deeper insights into the intricate KRAS‐related networks underlying cancer progression and unveil novel biomarkers and potential therapeutic targets. …”
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BioInnovate AI: A Machine Learning Platform for Rapid PCR Assay Design in Emerging Infectious Disease Diagnostics by Hung-Hsin Lin, Hsing-Yi Chung, Tai-Han Lin, Chih-Kai Chang, Cherng-Lih Perng, Kuo-Sheng Hung, Katsunori Yanagihara, Hung-Sheng Shang, Ming-Jr Jian

“…Conventional diagnostic techniques that rely on sequencing and polymerase chain reactions (PCR) frequently lack the speed necessary to efficiently respond to rapidly evolving pathogens. This study describes the development of BioInnovate AI to overcome these limitations using machine learning to expedite PCR assay development. …”
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Improving prenatal diagnosis with combined karyotyping, CNV-seq and QF-PCR: a comprehensive analysis of chromosomal abnormalities in high-risk pregnancies by Jia-pei Liu, Shan-Bing Wang, Li Luo, Ya-mei Guo

“…Notably, neonates carrying pathogenic CNVs inherited from asymptomatic parents demonstrated normal phenotypes.ConclusionThe integration of karyotyping, CNV-seq, and QF-PCR provides superior diagnostic yield compared to individual testing strategies in high-risk pregnancies. …”
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PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2 by Marwah Karim, Manjari Mishra, Chieh-Wen Lo, Sirle Saul, Halise Busra Cagirici, Manon Gourdelier, Luca Ghita, Amrita Ojha, Do Hoang Nhu Tran, Aditi Agrawal, Connor McGraw, Michael P. East, Karen Anbro Gammeltoft, Malaya Kumar Sahoo, Nancie A. Mooney, Gary L. Johnson, Soumita Das, Pieter Leyssen, Johan Neyts, Winston Chiu, Courtney A. Cohen, Jens Bukh, Judith Gottwein, John M. Dye, Norma Neff, Peter K. Jackson, Benjamin A. Pinsky, Tuomo Laitinen, Tatu Pantsar, Antti Poso, Fabio Zanini, Steven De Jonghe, Christopher R. M. Asquith, Shirit Einav

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