Tapping into Metabolomics for Understanding Host and Rotavirus Group A Interactome by Phiona Moloi Mametja, Mmei Cheryl Motshudi, Clarissa Marcelle Naidoo, Kebareng Rakau, Luyanda Mapaseka Seheri, Nqobile Monate Mkolo

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Multifunctional hydrogel with mild photothermal properties enhances diabetic wound repair by targeting MRSA energy metabolism by Qian Gao, Fangfang Hu, Zihan Chai, Caiyun Zheng, Wenhui Zhang, Ke Pu, Ziyi Yang, Yanni Zhang, Seeram Ramrkrishna, Xianglong Wu, Tingli Lu

“…Abstract Background Diabetic wound infections, exacerbated by multidrug-resistant pathogens like MRSA, remain a critical challenge due to biofilm persistence and dysregulated oxidative-inflammatory-metabolic crosstalk. …”
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Whole Genome Analysis of <i>Proteus mirabilis</i> in a Poultry Breeder Farm Reveals the Dissemination of <i>bla</i>_NDM and <i>bla</i>_CTX-M Mediated by Diverse... by Haibin Hu, Ke Wu, Tiejun Zhang, Yuhuan Mou, Luya Liu, Xiaoqin Wang, Wei Xu, Wenping Chen, Xiaojiao Chen, Hongning Wang, Changwei Lei

“…<i>Proteus mirabilis</i> is a significant foodborne opportunistic pathogen associated with various nosocomial infections. …”
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Inflammatory signaling pathways in pancreatic β-cell: New insights into type 2 diabetes pathogenesis by Jie Chen, Shinuan Fei, Lawrence W.C. Chan, Xueting Gan, Bibo Shao, Hong Jiang, Sheng Li, Peng Kuang, Xin Liu, Sijun Yang

“…NF-κB acts as a central hub, integrating metabolic stress signals (e.g., glucolipotoxicity, ER stress) and amplifying inflammatory responses through crosstalk with JAK/STAT and STING pathways. …”
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Reverse vaccinology and immunoinformatics approaches for multi-epitope vaccine design against Klebsiella pneumoniae reveal a novel vaccine target protein by Mayada M. Elfadil, Samah Omer A. Samhoon, Moaaz M. Saadaldin, Sabah A.E. Ibrahim, Ahmed Abdelghyoum M. Mohamed, Omnia H. Suliman, Osama Mohamed, Nadzirah Damiri, Mohd Firdaus-Raih, Sofia B. Mohamed, Qurashi. M. Ali

“…Klebsiella pneumoniae (K. pneumoniae), a Gram-negative pathogen, is a leading cause of hospital-acquired infections in Sudan and worldwide. …”
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Exploration the role of pro-inflammatory fibroblasts and related markers in periodontitis: combing with scRNA-seq and bulk-seq data by Erli Wu, Feihan Gu, Qiangqiang Zhuo, Ziyang Gao, Yu Zhang, Jingjing Li, Xuan Yin, Weimin Bao, Xianqing Zhou, Feng Liang, Shouxiang Yang, Yuanyin Wang, Qingqing Wang, Qingqing Wang, Wei Shao, Wei Shao

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Metal-bearing nanomaterials for oral antibacteria: Mechanisms and applications by Ke Quan, Yuqing Zeng, Sijia Gao, Yanli Lei, Le Yang, Yibo Zhou, Lucky Poh Wah Goh, Zhihe Qing

“…However, conventional treatment strategies for oral pathogens rely on mechanical debridement and antibiotic treatment, which remain unsatisfactory and contribute to the emergence of antimicrobial resistance pathogens. …”
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Enhancing the reverse transcriptase function in Taq polymerase via AI-driven multiparametric rational design by Yulia E. Tomilova, Nikolay E. Russkikh, Igor M. Yi, Elizaveta V. Shaburova, Viktor N. Tomilov, Galina B. Pyrinova, Svetlana O. Brezhneva, Olga S. Tikhonyuk, Nadezhda S. Gololobova, Dmitriy V. Popichenko, Maxim O. Arkhipov, Leonid O. Bryzgalov, Evgeniy V. Brenner, Anastasia A. Artyukh, Dmitry N. Shtokalo, Dmitry N. Shtokalo, Dmitry N. Shtokalo, Denis V. Antonets, Mikhail K. Ivanov, Mikhail K. Ivanov

“…This study illustrates how AI can be effectively integrated with experimental bioengineering to enhance enzyme functionality systematically. …”
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Large-scale genomic analysis reveals significant role of insertion sequences in antimicrobial resistance of Acinetobacter baumannii by Fei Xie, Lifeng Wang, Song Li, Long Hu, Yanhua Wen, Xuming Li, Kun Ye, Zhimei Duan, Qi Wang, Yuanlin Guan, Ye Zhang, Qiqi Shi, Jiyong Yang, Han Xia, Lixin Xie

“…ABSTRACT Acinetobacter baumannii, a prominent nosocomial pathogen renowned for its extensive resistance to antimicrobial agents, poses a significant challenge in the accurate prediction of antimicrobial resistance (AMR) from genomic data. …”
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Mosquito-based detection of retroviruses and arboviruses in Senegal: expanding the scope of xenosurveillance by Marie Henriette Dior Ndione, El Hadji Ndiaye, Madeleine Dieng, Babacar Diouf, Safietou Sankhé, Diawo Diallo, Mouhamed Kane, Ndeye Marie Sene, Maimouna Mbanne, Faty Amadou Sy, Seynabou Mbaye Ba Souna Diop, Serge Freddy Moukaha Doukanda, Amadou Alpha Sall, Ousmane Faye, Ndongo Dia, Scott C. Weaver, Oumar Faye, Mawlouth Diallo, Gamou Fall, Alioune Gaye, Moussa Moise Diagne

“…Xenosurveillance, a method that utilizes blood-feeding arthropods to sample host and pathogen genetic material, has emerged as a valuable tool in viral ecology. …”
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The rules in co-infection of multiple viruses across diverse lineages in a fungal host by Jie Duan, Yuduo Yao, Jialing Xu, Anmeng Zhang, Xiaojing Kong, Yang Lin, Jiatao Xie, Jiasen Cheng, Yanping Fu, Tao Chen, Bo Li, Xiao Yu, Xueliang Lyu, Xueqiong Xiao, Amir Sharon, Naomi Kagan Trushina, Ioly Kotta-Loizou, Daohong Jiang

“…In this study, we surveyed 406 field strains of the plant fungal pathogen Botrytis cinerea and identified 76 mycoviruses. …”
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Development of Enzyme-Mediated Duplex Exponential Amplification Assay for Detection and Identification of <i>Meloidogyne enterolobii</i> in Field by Bingxue Sun, Bo Gao, Rongyan Wang, Shulong Chen, Xiuhua Li, Yonghao Dong, Juan Ma

“…The root-knot nematode <i>Meloidogyne enterolobii</i> has emerged as a devastating pathogen in global agricultural systems. Its geographic distribution is progressively expanding from tropical to temperate zones, leading to difficulties in discerning the symptoms it causes from those of congeners such as <i>M. incognita</i>. …”
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Estimating unreported SARS-CoV-2 infections in Austria using wastewater-based epidemiology by Simon D. Lindner, Herbert Oberacher, Karin Weyermair, Teresa Gisinger, Heribert Insam, Fabiana Nägele, Markus Mayr, Andreas Otto Wagner, Wolfgang Rauch, Rudolf Markt, Ulrich Elling, Fabian Amman, Peter Klimek

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Emergence of mcr-8.1-bearing MDR-hypervirulent Klebsiella pneumoniae ST307 by Jie Sheng, Rory Cave, Mary M. Ter-Stepanyan, Siyu Lu, Yingxiong Wang, Taihang Liu, Hermine V. Mkrtchyan

“…Our study emphasises the importance of genomic surveillance of this emerging MDR-hypervirulent pathogen to provide early interventions.…”
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Helile formula from “Tai ping sheng hui fang”: anti-Helicobacter pylori activity, gut microbiota modulation, and inflammatory response regulation by Ling Ou, Meiyun Chen, Chang Peng, Haobo Chen, Yajie Hao, Qingchang Chen, Zhong Feng, Zhong Feng, Meicun Yao, Meicun Yao, Xianhe Kong, Xianhe Kong, Xianhe Kong

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<i>Bacillus velezensis</i> Isolate X5 Stimulates the Resistance of Resistant and Susceptible Banana Varieties to Foc Through Different Mechanisms by Yunlong Xu, Jun Wang, Guangxiang Tian, Changcong Liang, You Zhou, Lijia Guo, Yang Yang, Laying Yang

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Accessible viral metagenomics for public health and clinical domains with Jovian by Dennis Schmitz, Florian Zwagemaker, Sam Nooij, Thierry K. S. Janssens, Jeroen Cremer, Robert Verhagen, Harry Vennema, Annelies Kroneman, Marion P. G. Koopmans, Jeroen F. J. Laros, Miranda de Graaf

“…Abstract The integration of next-generation sequencing into clinical diagnostics and surveillance initiatives is impeded by the lack of data analysis pipelines that align with privacy legislation and laboratory certification protocols. …”
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Antimicrobial Resistance and Its Impact on Food Safety Determinants Along the Beef Value Chain in Sub-Saharan Africa—A Scoping Review by Godfrey Musuka, Jairus Machakwa, Oscar Mano, Patrick Gad Iradukunda, Pierre Gashema, Enos Moyo, Amon Nsengimana, Shepherd Manhokwe, Tapiwa Dhliwayo, Tafadzwa Dzinamarira

“…Our findings also highlight the role of environmental factors, such as contamination of feed, water, and manure, in the spread of resistant pathogens. Additionally, gaps in AMR surveillance, education, and enforcement limit effective control measures in the region. …”
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Distribution of nontuberculous Mycobacteria among presumptive drug resistance tuberculosis patients from a ministry of health drug resistance surveillance program, in western Kenya by Okumu Albert, Odeny Lazarus, Ochieng John Benjamin, Odhiambo Ben, Sitati Ruth, Tonui Joan, Ogoro Jeremiah, Wandiga Steve, Collins Ouma

“…Introduction: Nontuberculous Mycobacteria (NTM) species are emerging pathogens causing Pulmonary diseases with no definitive treatment. …”
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PCR-Based <i>Legionella</i> Risk Evaluation of Drinking Water Systems—An Empirical Field Evaluation by Markus Petzold, Nicole Zacharias, Sarah Uhle, Laurine Kieper, Nico Tom Mutters, Thomas Kistemann, Christiane Schreiber

“…Pathogens in water systems pose potential health risks. …”
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