Transforming Meningoencephalitis Diagnosis: A Study of Filmarray ME Panel in a North Indian Tertiary Care Centre by Puneet Bhatt, Vandan Shilimkar, Jyoti Tewatia, Santosh Karade

“…The BioFire FilmArray ME Panel detected pathogens in 14 out of 147 CSF samples, yielding a positivity rate of 9.52%. …”
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Chlamydia trachomatis exploits sphingolipid metabolic pathways during infection of phagocytes by Adriana Moldovan, Fabienne Wagner, Fabian Schumacher, Dominik Wigger, David Komla Kessie, Marcel Rühling, Kathrin Stelzner, Regina Tschertok, Louise Kersting, Julian Fink, Jürgen Seibel, Burkhard Kleuser, Thomas Rudel

“…ABSTRACT Chlamydiae are obligate intracellular pathogens that utilize host cell metabolites for catabolic and anabolic processes. …”
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A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein by Johannes Zeller, Karen S Cheung Tung Shing, Tracy L Nero, James D McFadyen, Guy Krippner, Balázs Bogner, Sheena Kreuzaler, Jurij Kiefer, Verena K Horner, David Braig, Habiba Danish, Sara Baratchi, Mark Fricke, Xiaowei Wang, Michel G Kather, Bernd Kammerer, Kevin J Woollard, Prerna Sharma, Craig J Morton, Geoffrey Pietersz, Michael W Parker, Karlheinz Peter, Steffen U Eisenhardt

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An Update on RNA Virus Discovery: Current Challenges and Future Perspectives by Humberto Debat, Nicolas Bejerman

“…The relentless emergence of RNA viruses poses a perpetual threat to global public health, necessitating continuous efforts in surveillance, discovery, and understanding of these pathogens. This review provides a comprehensive update on recent advancements in RNA virus discovery, highlighting breakthroughs in technology and methodologies that have significantly enhanced our ability to identify novel viruses across diverse host organisms. …”
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The BeeBiome data portal provides easy access to bee microbiome information by Valentine Rech de Laval, Benjamin Dainat, Philippe Engel, Marc Robinson-Rechavi

“…Abstract Bees can be colonized by a large diversity of microbes, including beneficial gut symbionts and detrimental pathogens, with implications for bee health. Over the last few years, researchers around the world have collected a huge amount of genomic and transcriptomic data about the composition, genomic content, and gene expression of bee-associated microbial communities. …”
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Tuberculosis Diagnosis: Current, Ongoing, and Future Approaches by Guilherme Bartolomeu-Gonçalves, Joyce Marinho de Souza, Bruna Terci Fernandes, Laís Fernanda Almeida Spoladori, Guilherme Ferreira Correia, Isabela Madeira de Castro, Paulo Henrique Guilherme Borges, Gislaine Silva-Rodrigues, Eliandro Reis Tavares, Lucy Megumi Yamauchi, Marsileni Pelisson, Marcia Regina Eches Perugini, Sueli Fumie Yamada-Ogatta

“…<i>Mycobacterium tuberculosis</i> causes the formation of granulomas, which will determine, through the host–pathogen relationship, if the infection will remain latent or evolve into active disease. …”
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Food microbiology in the post-COVID-19 era: insights from bibliometric analysis in bioeconomics by Carlos Alberto Zuniga-Gonzalez

“…The study advocates for integrating microbiological insights within bioeconomic frameworks to improve food safety and sustainability. …”
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Transcriptome Insights into Resistance Mechanisms Against Soybean Mosaic Virus Strain SC4 in Soybean by Muhammad Muzzafar Raza, Huiying Jia, Shengyu Gu, Junyi Gai, Kai Li

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RIPK1 kinase drove brain microvascular endothelial cells death and blood-brain barrier disruption in neonatal Escherichia coli meningitis by Xuhang Wang, Yuhan Zhang, Xinru Chen, Kailai Fu, Jiaqi Cui, Jiaoling Wu, Yu Sun, Jianluan Ren, Feng Xue, Jianjun Dai, Fang Tang

“…Inhibition of RIPK1 kinase significantly preserves BBB integrity, and lowers RS218 invasion and neuroinflammation. …”
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Linalool exhibit antimicrobial ability against Elizabethkingia miricola by disrupting cellular and metabolic functions by Mingwang He, Weiming Zhong, Rongsi Dai, Su Long, Ying Zhou, Tongping Zhang, Boyang Zhou, Tao Tang, Linlin Yang, Sifan Jiang, Wenbin Xiao, YanJiao Fu, Jiajing Guo, Zhipeng Gao

“…Elizabethkingia miricola is a gram-negative bacillus, a life-threatening pathogen in humans and animals. Linalool, a naturally occurring monoterpene alcohol found in plant volatile oils, exhibits highly effective antibacterial properties. …”
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The Complexities of Canine Monocytic Ehrlichiosis: Insights into <i>Ehrlichia canis</i> and Its Vector <i>Rhipicephalus sanguineus</i> by Joana Ferrolho, Sandra Antunes, Hugo Vilhena, Sofia Anastácio, Sérgio Ramalho de Sousa, Gonçalo Frouco, Bárbara Ferreira, Ana Domingos

“…Pathogenesis involves complex interactions between the pathogen and host immune responses, influencing disease severity and progression. …”
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Fertility preservation and assisted reproductive strategies in endometrial cancer patients with lynch syndrome by Junhan Liu, Junhan Liu, Ying Zheng, Ying Zheng, Jianhong Liu, Jianhong Liu

“…PGT-M proved valuable in preventing the transmission of pathogenic MMR variants to offspring. Early use of ART and integration of PGT-M are critical for maximizing reproductive success while minimizing oncologic and hereditary risks.…”
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Divergent response associates with the differential amplitudes of immunity against Magnaporthe oryzae by different blast resistance genes by Beenish Hassan, Sadam Hussain Bhutto, Xiao-Xiao Yin, Xiu-Lian Yan, Rong Liao, Mao-Lin Guo, Ya-Ping Tang, Dai-Ming Guo, Si-Jia Yang, Faiza Gulzar, Yan Li, Xian-Yin Zeng, Zhi-Xue Zhao, Wen-Ming Wang

“…The products of most blast resistance (R) genes specifically recognize corresponding a virulence effectors from the pathogen, thereby mediating robust immune responses that are crucial for disease resistance. …”
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Multicenter exploration of microbial communities in hospital toilets reveals: antibiotic exposure in nosocomial settings selects for Enterococcus over commensal taxa by Claudio Neidhöfer, Marcel Neuenhoff, Esther Sib, Anna Rehm, Lúcia Ribeiro Dias, Bernd Neumann, Jörg Steinmann, Manuel Döhla, Yousra Kherabi, Ana Budimir, Crystel Hajjar, Rouba Khatib, Katharina Axtmann, Katjana Schwab, Peter Brossart, Steffen Engelhart, Nico T. Mutters, Gabriele Bierbaum, Stefan Janssen, Marijo Parčina

“…Hence, the issue of hospital acquired infections with MDR pathogens transcends mere pathogen spread, entailing significant changes to both environmental and microbial landscapes over time. …”
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MGV-seq: a sensitive and culture-independent method for detecting microbial genetic variation by Lun Li, Weiyu Kong, Jing Sun, Yongzhong Jiang, Tiantian Li, Zhihui Xia, Junfei Zhou, Zhiwei Fang, Lihong Chen, Shun Feng, Huiyin Song, Huafeng Xiao, Baolong Zhang, Bin Fang, Hai Peng, Hai Peng, Lifen Gao, Lifen Gao

“…BackgroundPrecise detection of microbial genetic variation (MGV) at the strain level is essential for reliable disease diagnosis, pathogen surveillance, and reproducible research. Current methods, however, are constrained by limited sensitivity, specificity, and dependence on culturing. …”
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Synthesis, Antimicrobial Activities, and Model of Action of Indolyl Derivatives Containing Amino-Guanidinium Moieties by Yu-Xi Li, Xiang Geng, Qi Tao, Ruo-Chen Hao, Ya-Jun Yang, Xi-Wang Liu, Jian-Yong Li

“…<i>K. pneumoniae</i> is an important opportunistic pathogen that often threatens the health of immunocompromised people such as the elderly, children, and ICU patients. …”
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Hybrid Antibacterial Surfaces: Combining Laser‐Induced Periodic Surface Structures with Polydopamine‐Chitosan‐Silver Nanoparticle Nanocomposite Coating by Yimeng Wang, Yuhang Dong, Yuhua Quan, Stefan Wackerow, Amin Abdolvand, Svetlana A. Zolotovskaya, Qi Zhao

“…Antibacterial surfaces hold great potential for controlling the survival, growth, and transmission of bacterial pathogens. This study demonstrates the synergetic integration of laser‐assisted topographical surface modification with coating solutions to simultaneously engage both chemical and nano‐/micro‐topography‐sensitive bacterial attachment mechanisms. …”
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Targeting CTP synthetase 1 to restore interferon induction and impede nucleotide synthesis in SARS-CoV-2 infection by Youliang Rao, Chao Qin, Bianca Espinosa, Ting-Yu Wang, Shu Feng, Ali Can Savas, Jill Henley, Lucio Comai, Chao Zhang, Pinghui Feng

“…Our work uncovers an intricate mechanism by which a viral pathogen couples immune evasion to metabolic activation to fuel viral replication. …”
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Implementing a specialized cardiogenomics team for lipid disorders: Insights from a single large health system by Natasha Vartak, Dorota Gruber, Bani Azari, Zahid Ahmad, Xueqi Huang, Joanna Fishbein, Benjamin Hirsh, Julia Frangeskos, Eugenia Gianos

“…Of the 18 patients with pathogenic variants, 50 % had a modification made to therapy and overall experienced greater reductions in LDL-C compared to those with negative results. …”
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Developing Machine-Learning Models to Predict Bacteremia in Febrile Adults Presenting to the Emergency Department: A Retrospective Cohort Study from a Large Center by Chia-Ming Fu, Ike Ngo, Pak Sheung Lau, Yaroslav Ivanchuk, Fan-Ya Chou, Chih-Hung Wang, Chien-Yu Lin, Chu-Lin Tsai, Shey-Ying Chen, Tsung-Chien Lu, Hung-Yu Wei

“…The positive blood culture result of at least one potential pathogen was defined as bacteremia and used as the binary classification label. …”
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