Neem Leaf Extracts and Azadirachtin Trigger a Moderate Early Defense Response in Sunflowers Infected with Downy Mildew Caused by <i>Plasmopara halstedii</i> (Farl.) Berl. et de Ton... by Rita Bán, Pratik Doshi, Arbnora Berisha, Katalin Körösi, József Kiss, György Turóczi, Božena Šerá, András Skornyik, Nisha Nisha

“…These results highlight the potential of neem-derived products, particularly 10% NLE and 0.1% AZA, for the integrated management of sunflower downy mildew through both direct pathogen suppression and enhanced host resistance.…”
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Application of diagnostic network optimization [DNOs] to tackle antimicrobial resistance in Sub-Saharan Africa by Stephen Olaide Aremu, Mariam Loliya Oruye, Egya Idris Adamu, Nankwop Markus Vuetkung, Duku Aondohemba Jonathan, Alpha Gimba Janjaro, Gaius Matthew, Elizabeth Oluwatoyin Adepoju, Pam Jerry Jiji, Phillip Luka Gimba, Godfrey Kwarakwasa, Bitrus Jatau Gonoyah, Donald Ibe Ofili, Oluwanifemi Rhoda Abiola, Akyala Ishaku Adamu

“…It emphasizes the importance of integrating diagnostic tools, such as pathogen identification and antimicrobial susceptibility testing, to optimize patient care and minimize unnecessary antibiotic use. …”
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An NIR‐II Absorbing Injectable Hydrogel for Boosted Photo‐Immunotherapy Toward Human Papillomavirus Associated Cancer by Xinghua Yu, Lingan Zeng, Xinyue Yang, Zuliang Ren, Xuemei Dong, Ge Meng, Guogang Shan, Dingyuan Yan, Dong Wang, Fei Sun

“…ABSTRACT Human papillomavirus (HPV) is a highly prevalent venereal pathogen accounting for genital warts and various cancers like cervical, anal, and oropharyngeal cancers. …”
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Antifungal activity of Bacillus velezensis HY13 against anthracnose disease of Buxus bodinieri caused by Colletotrichum fructicola by Ruiqi Peng, Aiting Zhou, Jianxin Chen, Mingjia Wen, Fang Wang, Jianrong Wu

“…Furthermore, HY13 treatment disrupted the cell membrane integrity of C. fructicola, leading to increased leakage of cellular contents from the fungal mycelium. …”
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Efficacy of Larimichthys crocea TASOR protein-derived peptide FAM286 against Staphylococcus aureus by Ritian Jin, Guanglei Wei, Rong Lin, Wenfeng Lin, Jude Juventus Aweya, Duo Liang, Wuyin Weng, Shen Yang

“…Staphylococcus aureus (S. aureus) is a major foodborne pathogen, could lead cause of intestinal infections in humans. …”
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Antagonistic Effects and Volatile Organic Compound Profiles of Rhizobacteria in the Biocontrol of <i>Phytophthora capsici</i> by José Luis Ávila-Oviedo, Carlos Méndez-Inocencio, María Dolores Rodríguez-Torres, María Valentina Angoa-Pérez, Mauricio Nahuam Chávez-Avilés, Erika Karina Martínez-Mendoza, Ernesto Oregel-Zamudio, Edgar Villar-Luna

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Role of endosomal toll-like receptors in immune sensing of Klebsiella pneumoniae by Giuseppe Valerio De Gaetano, Agata Famà, Germana Lentini, Francesco Coppolino, Mario Venza, Isabella Venza, Pasqualina Laganà, Alessia Berbiglia, Federica Grasso, Luigi Fiore, Giuseppe Teti, Concetta Beninati, Concetta Beninati

“…We investigate here the mechanisms underlying innate immune recognition of this pathogen by focusing on the role of endosomal Toll-like receptors (TLRs), which sense prokaryotic nucleic acids, in comparison with TLR4, which recognizes the cell-wall lipopolysaccharide component. …”
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A Stable and Dependable Visual Technique for On-Site Nipah Virus Nucleic Acids Detection by Wencong Chen, Li Cai, Danni Ye, Jiahao Chen, Xueyan Ai, Xuehua Tang, Anqi Deng, Zihan Gao, Meihua Xiang, Mingen Yu, Kun Zhu, Maopeng Wang

“…Abstract The Nipah Virus (NiV) is a zoonotic pathogen with the mortality rate of up to 75%, recurring in Asia over the past two decades. …”
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Cannabidiol and nano-selenium mediate intestinal barrier function by affecting mucosal microstructures, and gut-associated immunological and oxidative stress response in the gut of... by Dominika Szkopek, Marta Mendel, Misza Kinsner, Katarzyna Ognik, Natalia Szyryńska, Bogdan Lewczuk, Krzysztof Kozłowski, Ivica Kos, Paweł Konieczka, Paweł Konieczka

“…There were also significant correlations between indicators of intestinal barrier function, such as diamine oxidase and lactic acid levels, and histomorphometry and markers of DNA integrity in the blood and intestine of chickens. In addition, it was shown that nano-Se increased hemoglobin concentration, which may be beneficial in the host's response to pathogen stimuli. …”
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Mitochondrial metabolic regulation of macrophage polarization in osteomyelitis and other orthopedic disorders: mechanisms and therapeutic opportunities by Jinglin Li, Lin Zhang, Jiaze Peng, Chuntao Zhao, Wenguang Li, Yang Yu, Xianpeng Huang, Fuyin Yang, Xuan Deng, Xuxu Yang, Tao Zhang, Jiachen Peng, Jiachen Peng

“…Osteomyelitis is a complex infectious bone disease involving pathogen invasion, host immune responses, and dysregulation of the local microenvironment. …”
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Apple Cultivar Responses to Fungal Diseases and Insect Pests Under Variable Orchard Conditions: A Multisite Study by Paula A. Morariu, Adriana F. Sestras, Andreea F. Andrecan, Orsolya Borsai, Claudiu Ioan Bunea, Mădălina Militaru, Catalina Dan, Radu E. Sestras

“…Heritability analysis indicated that genetic factors played a substantial role in shaping cultivar responses to most biotic stressors. The integrated approach to cultivar–location–pathogen and pest interactions offers practical insights for optimizing orchard protection strategies under variable ecological conditions.…”
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An analysis of One Health timeliness metrics across multisectoral public health emergencies in Uganda by Jane K. Fieldhouse, Lydia Nakiire, Joshua Kayiwa, Ali Mirzazadeh, Claire D. Brindis, Ashley Mitchell, Jaime Sepulveda, Issa Makumbi, Alex Riolexus Ario, Elizabeth Fair, Sarah Gallalee, Herbert Isabirye, Musa Sekamatte, Brian H. Bird, Woutrina Smith, Angel Desai, Jonna A. K. Mazet, Mohammed Lamorde

“…Conclusions To complement positive timeliness trends in Uganda, disease-agnostic investments in outbreak preparedness and response efforts will facilitate the ability of health systems to rapidly detect and respond to all outbreaks, irrespective of the pathogen.…”
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Isolation, identification, and characterization of a marine Lactiplantibacillus plantarum strain with antimicrobial activity against Burkholderia contaminans by Yuanshuai Du, Yuanshuai Du, Fan Xin, Ziyi Yang, Jiayi Sui, Shen Yang, Runying Zeng, Zhuhua Chan

“…Burkholderia contaminans, an opportunistic pathogen commonly found in the food and cosmetics industries, has serious potential to cause severe human infections and industrial contamination. …”
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Inflammasomes and Signaling Pathways: Key Mechanisms in the Pathophysiology of Sepsis by Jhan S. Saavedra-Torres, María Virginia Pinzón-Fernández, Martin Ocampo-Posada, H. A. Nati-Castillo, Laura Alejandra Jiménez Hincapie, Eder J. Cadrazo-Gil, Marlon Arias-Intriago, Marlon Rojas-Cadena, Andrea Tello-De-la-Torre, Walter Osejos, Juan S. Izquierdo-Condoy

“…Inflammasomes—cytosolic multiprotein complexes of the innate immune system—serve as critical platforms for sensing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs). …”
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Galectin-3: a novel antimicrobial host factor identified in goat nasal mucus by Yichao Ma, Xinming Qin, Jiachen Liu, Shiqi Liu, Ruoyang Lin, Baoyan Meng, Xiaojing Cui, Qian Yang

“…Abstract Respiratory infections caused by pathogenic bacteria pose a rapidly growing public health threat. …”
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Identification of RC3H1 as antiviral host factor binding to the non-structural protein 1 of Influenza A virus via a 3-stage computational pipeline and cell-based analysis by Swee Teng Teo, Shamima Rashid, Kong Yen Liew, Kah Man Lai, Teng Ann Ng, Jifeng Jiao, Chee Keong Kwoh, Yee-Joo Tan

“…Abstract To complete its life-cycle in the infected host, Influenza A virus (IAV) hijacks host machineries by expressing multiple viral proteins to bind to specific host proteins. In the era of integrative genomics, there is an opportunity to develop computational techniques to accurately and quickly predict host-pathogen protein-protein interactions (HP-PPI). …”
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Autophagy in inflammatory bowel disease: immunization, etiology, and therapeutic potential by Zhong-Xing Miao, Huan Meng, Jie Wang, Xiao-Ting Hou, Wen-Wen Cheng, Bao-Hong Liu, Qing-Gao Zhang, Qing-Gao Zhang, Shuo Yuan, Shuo Yuan

“…Autophagy, an evolutionarily conserved cellular homeostasis mechanism, plays a dual role in IBD pathogenesis by maintaining cellular integrity and modulating immune responses. This process contributes to IBD immunopathology through multiple mechanisms, including pathogen clearance, immune cell regulation, inflammatory signaling modulation, and inflammasome suppression. …”
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Development of a deep learning-based MRI diagnostic model for human Brucella spondylitis by Binyang Wang, Jinquan Wei, Zhijun Wang, Pengying Niu, Lvlin Yang, Yanmei Hu, Dan Shao, Wei Zhao

“…Rapid and accurate differentiation between these two conditions is crucial for effective clinical management; however, current imaging and pathogen-based diagnostic methods fall short of fully meeting clinical requirements. …”
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Dynamics of Physiological Changes of Shiga Toxin-Producing <i>Escherichia coli</i> O157:H7 on Romaine Lettuce During Pre-Processing Cold Storage, and Subsequent Effects on Virulenc... by Dimple Sharma, Joshua O. Owade, Corrine J. Kamphuis, Avery Evans, E. Shaney Rump, Cleary Catur, Jade Mitchell, Teresa M. Bergholz

“…Prolonged cold storage during transportation may impact pathogen physiology, affecting subsequent stress survival and virulence. …”
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Ferroptosis: a key driver and therapeutic target in the pathogenesis of acute respiratory distress syndrome by Mingjun Yao, Jinfeng Liao, Zheng Liu, Wei Zhao, Siyuan Song, Xiaobo Huang, Yi Wang, Yi Wang

“…Immune cells like macrophages and neutrophils, while essential for pathogen clearance, can also contribute to lung injury when overactivated, highlighting the need for therapeutic strategies to modulate ferroptosis. …”
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