Inference of antimicrobial resistance (AMR) from a whole genome database outperforming AMR gene detection by Pornsawan Cholsaktrakool, Kornthara Kawang, Nicha Sangpiromapichai, Pannaporn Thongsuk, Songtham Anuntakarun, Pattapon Kunadirek, Natthaya Chuaypen, Sumanee Nilgate, Naris Kueakulpattana, Ubolrat Rirerm, Tanittha Chatsuwan, Elita Jauneikaite, Frances Davies, Ploy N. Pratanwanich, Sira Sriswasdi, Voraphoj Nilaratanakul

“…This study supports the integration of pathogen-specific genome databases into clinical workflows to enable rapid and accurate antimicrobial susceptibility prediction. …”
Get full text

Real world effectiveness of early ensitrelvir treatment in patients with SARS-CoV-2, a retrospective case series by Shuichi Abe, Dhammika Leshan Wannigama, Yu Suzuki, Daisuke Akaneya, Junko Igarashi, Mayu Suto, Kazunori Moriya, Daisuke Ishizawa, Yoshikazu Okuma, Parichart Hongsing, Cameron Hurst, Thammakorn Saethang, Paul G. Higgins, Stephen M. Stick, Anthony Kicic

Get full text

Cerebrospinal fluid proteomics reveals the innate immunity and blood-brain barrier dysregulation in a patient with multidrug-resistant Acinetobacter baumannii ventriculitis treated... by Mengyao Li, Dongyu Liu, Phillip J. Bergen, Silin Liang, Juan Chen, Zhi Ying Kho, Jing Lu, Huiying Sun, Weiqing Hong, Xiaofen Liu, Chengying Hong, Youlian Chen, Wei Li, Hongxia You, Shunyao Xu, Yu Wang, Huaiji Gao, Chun Hin Lam, Jian Li, Xiaoyin Chen, Xueyan Liu

Get full text

Macrophage-augmented intestinal organoids model virus-host interactions in enteric viral diseases and facilitate therapeutic development by Guige Xu, Jiangrong Zhou, Kuan Liu, Yining Wang, Theano Tsikari, Fang Qin, Francijna van den Hil, Patrick P. C. Boor, Ibrahim Ayada, Annemarie C. de Vries, Jiajing Li, Shijin Jiang, Dewy M. Offermans, Denis E. Kainov, Harry L. A. Janssen, Maikel P. Peppelenbosch, Marcel J. C. Bijvelds, Wenshi Wang, Valeria V. Orlova, Qiuwei Pan, Pengfei Li

Get full text

Diversity and Complexity of CTXΦ and Pre-CTXΦ Families in <em>Vibrio cholerae</em> from Seventh Pandemic by Xiaorui Li, Yu Han, Wenxuan Zhao, Yue Xiao, Siyu Huang, Zhenpeng Li, Fenxia Fan, Weili Liang, Biao Kan

“…The toxigenic conversion of environmental <i>V. cholerae</i> strains through CTXΦ lysogenic infection is crucial for the emergence of new pathogenic clones. A special allelic form of CTXΦ, called pre-CTXΦ, is a precursor of CTXΦ and without <i>ctxAB</i>. …”
Get full text

Re-delimiting oversummering regions of Puccinia striiformis f. sp. tritici in China by Jiguang Zhang, Yuxiang Li, Di Liu, Junjie Zhang, Zhibo Zhang, Qiang Yao, Xiangming Xu, Xiaoping Hu

Get full text

A polymicrobial perspective into the ecological role of Enterococcus faecalis in dental root canal infections by Ana Parga, Jade Mattu, Georgios N. Belibasakis, Kimberly A. Kline, Julian G. Leprince, Daniel Manoil

“…Abstract Enterococcus faecalis, a non-oral nosocomial pathogen, intriguingly ranks among the most frequently retrieved species from polymicrobial infections of dental root canals. …”
Get full text

Biofilm Formation, Antibiotic Resistance, and Virulence Analysis of Human and Avian Origin <i>Klebsiella pneumoniae</i> from Jiangsu, China by Yulu Xue, Fangyu Shi, Bangyue Zhou, Yi Shi, Wenqing Luo, Jing Zhu, Yang Yang, Sujuan Chen, Tao Qin, Daxin Peng, Yinyan Yin

“…<i>Klebsiella pneumoniae</i>, a zoonotic pathogen of global concern, poses significant threats to both veterinary and public health. …”
Get full text

Phloretin-induced modulation in gut microbiome, mitigates colonic inflammation and alleviates colitis-associated colorectal cancer in mice by Smita Kapoor, Priyanka Mehta, Vikram Patial, Rajesh Pandey, Yogendra S. Padwad

Get full text

PERITONSILLAR ABSCESS IN CHILDREN. CLINICAL AND MICROBIOLOGICAL METHODS OF INVESTIGATION by N. V. Sirenko, S. I. Alekseyenko, G. P. Tsurikova, M. O. Volkova

“…The choice of antibiotic therapy depends on the pathogen, but at the initial stage of treatment preference should be given to broad-spectrum drugs, including antibacterial drugs of the penicillin group.…”
Get full text

Next-generation diagnostics of bloodstream infections enabled by rapid whole-genome sequencing of bacterial cells purified from blood culturesResearch in context by Vincenzo Di Pilato, Chiara Bonaiuto, Fabio Morecchiato, Alberto Antonelli, Tommaso Giani, Gian Maria Rossolini

Get full text

Gut associated metabolites and their roles in Clostridioides difficile pathogenesis by Andrea Martinez Aguirre, Joseph A. Sorg

“…The nosocomial pathogen Clostridioides difficile is a burden to the healthcare system. …”
Get full text

The relationship between virulence and drug resistance genes in Pseudomonas aeruginosa and antibiotic resistance: a targeted next-generation sequencing approach by Huanhuan Wei, Yuanyong Fu, Weijuan Qin, Zhengyi Liang, Liyan Zhou, Jingwei Gao, Shiyi He, Xiaoning Wu

“…Furthermore, the detection of MDR and CRPA strains appears to lead to an increase in the duration and variety of antibiotic use, as well as prolonged of hospital stay (p&lt;0.05).ConclusionOur study highlights the importance of integrating tNGS results, which provide insights into pathogen identification, resistance, and virulence genes, with phenotypic and clinical data in order to enhance the accuracy of diagnosis and guide treatment strategies.…”
Get full text

Investigating the effects of dietary and management modifications on Salmonella enterica population in harvest-ready beef cattle by Yesica Botero, Kasi Schneid, Kendall L. Samuelson, John T. Richeson, Ty E. Lawrence, Gizem Levent

Get full text

Whole-genome sequencing and metagenomics reveal diversity and prevalence of Listeria spp. from soil in the Nantahala National Forest by Jia Wang, Claire N. Schamp, Lauren K. Hudson, Harleen K. Chaggar, Daniel W. Bryan, Katie N. Garman, Mark Radosevich, Thomas G. Denes

“…Moreover, using a metagenomic approach provides a detailed understanding of the soil microbial ecosystems, leading to more effective monitoring and control of foodborne pathogens. This study also highlights the potential for integrating metagenomics into routine surveillance systems for food safety in the near future.…”
Get full text

Identification of <i>Nigrospora oryzae</i> Causing Leaf Spot Disease in Tomato and Screening of Its Potential Antagonistic Bacteria by Jun Zhang, Fei Yang, Aihong Zhang, Qinggang Guo, Xiangrui Sun, Shangqing Zhang, Dianping Di

Get full text

Research progress on immunometabolism and gut microbiota in cryptococcal meningitis: mechanisms and therapeutic implications by Sha Wen, Sha Wen, Sha Wen, Sha Wen, Mu Liu, Mu Liu, Mu Liu, Chengyu Pan, Chengyu Pan, Chengyu Pan, Linhai Zhang, Linhai Zhang, Linhai Zhang, Rong Yan, Rong Yan, Rong Yan, Zucai Xu, Zucai Xu, Zucai Xu

“…We propose a combined therapeutic strategy of “immunomodulators + metabolic inhibitors + microbiota intervention,” moving beyond traditional single-factor research paradigms to establish a multi-omics integrated framework for the precise treatment of CM—spanning molecular mechanisms to clinical translation—and propelling the field of neuroinfectious diseases towards a host-pathogen-microenvironment systemic regulation paradigm.…”
Get full text

The increasing incidence and mortality of bacteremia in Denmark from 2010 to 2022: a population-based nationwide cohort study by Ram B. Dessau, Ram B. Dessau, Ram B. Dessau, Christian Østergaard Andersen, Christian Østergaard Andersen, John Coia, Svend Ellermann-Eriksen, Sophie Gubbels, Thøger Gorm Jensen, Jenny Dahl Knudsen, Jonas Kähler, Steen Lomborg, Lisbeth Lützen, Marc Trunjer Kusk Nielsen, Bente Scharvik Olesen, Mette Pinholt, Flemming Scheutz, Kirstine Kobberøe Søgaard, Marianne Voldstedlund, Kåre Mølbak, Kåre Mølbak

Get full text

Application of Bait Treated with the Entomopathogenic Fungus Metarhizium anisopliae (Metsch.) Sorokin for the Control of Microcerotermes diversus Silv. by Amir Cheraghi, Behzad Habibpour, Mohammad Saied Mossadegh

“…There was no significant difference between treatments, in the rate of feeding on the bait. The fungal pathogen was not repellent to the target termite over the conidial concentrations used. …”
Get full text

Genomic characterization and multidrug resistance of Pseudomonas aeruginosa isolated from peregrine falcons in Saudi Arabia: A One Health perspective by Ali Wahdan, Mahmoud Mohamed, Mahmoud M. Elhaig, Mohammed Al-Rasheed, Ehab M. Abd-Allah

“…Background and Aim: Pseudomonas aeruginosa is a multidrug-resistant (MDR) zoonotic pathogen increasingly implicated in infections in both humans and animals, including avian species. …”
Get full text