Genomic analysis of IMP-8-producing Enterobacter hormaechei with a novel plasmid pK432-IMP by Jiao Feng, Zhiwei Song, Piaopiao Dai, Huimin Chen, Dakang Hu, Lianhua Yu, Jin Zhang, Xinhua Luo

“…ABSTRACT: Background: Carbapenem-resistant Enterobacter cloacae (CR-ECC) complex has posed significant challenges to the clinical treatment of infections, and Enterobacter hormaechei (E. hormaechei) is the most commonly identified nosocomial pathogen of CR-ECC. Methods: Carbapenemases were detected by the immunocolloidal gold technique. …”
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The role of machine learning in infectious disease early detection and prediction in the MENA region: A systematic review by Radwan Qasrawi, Ghada Issa, Suliman Thwib, Razan AbuGhoush, Malak Amro, Raghad Ayyad, Stephanny Vicuna, Eman Badran, Yousef Khader, Raeda Al Qutob, Faris Al Bakri, Hana Trigui, Elie Sokhn, Emmanuel Musa, Jude Dzevela Kong

“…The findings reveal a predominance of deep learning approaches, particularly Convolutional Neural Networks (CNNs), achieving mean accuracy rates of 96.3 % in pathogen detection from medical imaging. Random Forest algorithms demonstrated superior performance in disease outbreak prediction, with mean ACC scores of 0.85. …”
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An overview of rapid non-culture-based techniques in various clinical specimens for the laboratory diagnosis of Talaromyces marneffei by Huamei Wei, Huamei Wei, Patcharin Thammasit, Artid Amsri, Artid Amsri, Kritsada Pruksaphon, Fenglian Deng, Joshua D. Nosanchuk, Sirida Youngchim

“…They enable faster and more convenient pathogen identification, improving diagnostic efficiency and facilitating earlier initiation of treatment. …”
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CHML regulates migration and invasion in hepatocellular carcinoma via transcriptional and metabolic reprogramming by Huanqian Cao, Siyu Wang, Li Zhang, Li Zhang, Heying Xie, Yiqiong Liu, Ruijiao Kong, Yin Jia, Ling Lu, Junfeng Jiang, Junfeng Jiang, Shanrong Liu

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Structural remodeling activates bacterial anti-phage immunity: insights from HerA-DUF4297 by Xiaoyan Wang, Xiaoyan Wang, Leiliang Zhang, Leiliang Zhang

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Clinical implement of Probe‐Capture Metagenomics in sepsis patients: A multicentre and prospective study by Qin Sun, Ran Teng, Qiankun Shi, Yun Liu, Xing Cai, Bin Yang, Quan Cao, Chang Shu, Xu Mei, Weiqi Zeng, Bingxue Hu, Junyi Zhang, Haibo Qiu, Ling Liu

“…Abstract Background Accurate pathogen identification is critical for managing sepsis. …”
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Remote sensing-based detection of brown spot needle blight: a comprehensive review, and future directions by Swati Singh, Lana L. Narine, Janna R. Willoughby, Lori G. Eckhardt

“…Due to its severity, L. acicola is designated as a quarantine pathogen in several countries, requiring effective early detection and control of its spread. …”
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Vaxtherapy, a Multiphase Therapeutic Protocol Approach for Longvax, the COVID-19 Vaccine-Induced Disease: Spike Persistence as the Core Culprit and Its Downstream Effects by Jose Crespo-Barrios

“…Persistent vaccine derived spike protein appears to trigger microvascular fibrin amyloid microclots, immune dysfunction, pathogen reactivation and multisystem injury. This article proposes an integrative approach, Vaxtherapy, to tackle these mechanisms. …”
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Mechanisms of host-bacterial interactions during Escherichia coli or Staphylococcus aureus infection of mammary epithelial cells by Zhengge Zhao, Zhiming Hou, Jianmin Chai, Chunfang Li, Tingyu Liu, Jianming Li, Shuyi Zhang, Lei Zhang, Yabin Ma

“…Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) are the two most predominant pathogens. However, the specific molecular mechanisms underlying the interactions between these pathogens and bovine mammary epithelial cells, especially for two pathogenic co-infections, remain poorly understood.MethodsHere, this study employed high-throughput RNA sequencing to comprehensively analyze the gene expression changes in bovine mammary epithelial cells upon individual and co-infection with E. coli and S. aureus.ResultsTranscriptomic analysis identified 282 differentially expressed genes (DEGs) in the E. coli-infected group (E group), with 246 upregulated and 36 downregulated genes. …”
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Construction of biological control strain of Trichoderma viride and study of their ability to induce plant disease resistance by LIU Shi-wang, GUO Ze-jian

“…Control its difficult because pathogens mutate frequently, and this leads in frequent breaking of disease resistance in commercial cultivars. …”
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Microbial responses to antibiotics cryptically shift the direction of disease outcomes by Isabela Velasquez, Kyra Ricci, Eve Milusich, Bryon F. Tuthill, Karin Sauer, Obed Hernández-Gómez, Jessica Hua

“…These findings underscore the hidden consequences of interactions between microbial responses to environmental changes and pathogens on infectious disease dynamics and highlight the need to integrate environmental change and eco-evolutionary perspectives into disease research.…”
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Avocado genotypes resistant to Phytophthora cinnamomi in Colombia by Yeison David López-Galé, Mauricio Fernando Martínez, Liliana Rios-Rojas, Mario Augusto García-Dávila

“…Management of this disease has been based on epidemiological studies and integrated crop management, where resistant rootstocks are considered one of the main options. …”
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The intensity of the transcriptional response varies across infection with distinct viral strains in an insect host by Allyson M. Ray, Anja Tehel, Jason L. Rasgon, Robert J. Paxton, Christina M. Grozinger

“…Overall, this study provides the first evidence for strain-specific immune responses to DWV infection, and integrates these findings into the broader domain of insect immunity and host-pathogen dynamics.…”
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Signaling pathways governing the pathobiological features and antifungal drug resistance of Candida auris by Hyunjin Cha, Doyeon Won, Yong-Sun Bahn

“…This review provides a comprehensive analysis of known signaling pathways associated with C. auris pathogenicity and antifungal drug resistance, integrating insights from other fungal pathogens. …”
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Natural and experimental infection of Caenorhabditis nematodes by novel viruses related to nodaviruses. by Marie-Anne Félix, Alyson Ashe, Joséphine Piffaretti, Guang Wu, Isabelle Nuez, Tony Bélicard, Yanfang Jiang, Guoyan Zhao, Carl J Franz, Leonard D Goldstein, Mabel Sanroman, Eric A Miska, David Wang

“…An ideal model system to study antiviral immunity and host-pathogen co-evolution would combine a genetically tractable small animal with a virus capable of naturally infecting the host organism. …”
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A functional portrait of Med7 and the mediator complex in Candida albicans. by Faiza Tebbji, Yaolin Chen, Julien Richard Albert, Kearney T W Gunsalus, Carol A Kumamoto, André Nantel, Adnane Sellam, Malcolm Whiteway

“…Mediator is a multi-subunit protein complex that regulates gene expression in eukaryotes by integrating physiological and developmental signals and transmitting them to the general RNA polymerase II machinery. …”
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Occurrence and diversity of Campylobacter species in diarrheic children and their exposure environments in Ethiopia. by Dinaol Belina, Tesfaye Gobena, Ameha Kebede, Meseret Chimdessa, Bahar Mummed, Cecilie Amalie Neijendam Thystrup, Tine Hald

“…The majority of isolates shared MLST profiles and clustered together, demonstrating the involvement of multiple vectors in the transmission of the pathogen. Genome-based integrated studies supported by an attribution model are recommended to determine the relative contribution of each source.…”
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The cyclic di-GMP receptor YcgR links the second messenger with the putrescine quorum sensing system in modulation of Dickeya oryzae motility by Weihan Gu, Yufan Chen, Congcong Xie, Zhongqiao Chen, Huagui Gao, Yaping Zhu, Lian-hui Zhang, Lisheng Liao

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Identification of a Highly Virulent <i>Verticillium nonalfalfae</i> Strain Vn011 and Expression Analysis of Its Orphan Genes During Potato Inoculation by Mengyuan Wan, Xinlong Chen, Xiaoxi Yi, Yi Fu, Yuanliang Jin, Dianqiu Lyu

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Rapid diagnostic testing combined with an immediate infectious disease consultation increases the rate of septic intensive care unit patients on targeted antibiotic therapy by Evelyn Kramme, Nadja Käding, Nadja Käding, Tobias Graf, Karolin Schmoll, Heidi Linnen, Katharina Nagel, Esther Grote-Levi, Susanne Hauswaldt, Dennis Nurjadi, Dennis Nurjadi, Jan Rupp, Jan Rupp, Jan Rupp

“…Phenotypic resistance testing with the Accelerate PhenoTest® took too long to be successfully integrated into the intervention. Adaptation of empirical antibiotic therapy was recommended for 72.7% of the patients. …”
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