Targeting Streptococcus pyogenes atpF protein for multi-epitope vaccine development: a genomics-driven immunoinformatics strategy by Manisha Agarwal, Sanjeeb Handique, Sanchaita Rajkhowa, Abhichandan Das, Debashis Panda, Sami A. Al-Hussain, Magdi E.A. Zaki

“…Streptococcus pyogenes, a medium-priority pathogen on the WHO’s 2024 Bacterial Pathogen Priority List, is a major cause of infectious disease-related mortality. …”
Get full text

Temperature and pH dynamics during carcass decomposition and implications for disease management by Janine Rietz, Burkhard Beudert, Nicolas Ferry, Lukas Böcker, Franz J. Conraths, Carolina Probst, Andreas Zedrosser, Helmut Küchenhoff, Martin Hais, Jens Schlüter, Tomas Lackner, Christian von Hoermann, Jörg Müller, Marco Heurich

Get full text

Patient-centric analysis of Orientia tsutsugamushi spatial diversity patterns across Hainan Island, China. by Chuanning Tang, Yi Huang, Gaoyu Wang, Liying Xue, Xiaoyuan Hu, Ruoyan Peng, Jiang Du, Jinyan Yang, Yi Niu, Wanxin Deng, Yibo Jia, Yijia Guo, Siqi Chen, Nan Ge, Liyuan Zhang, Fahui Wang, Yongguo Du, Yueping Wang, Long Sun, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Biao Wu, Feifei Yin

“…Without accounting for potential confounding factors or dataset limitations, the Karp_B_2 sub-genotype showed a significant increasing trend in pathogen density with prolonged fever duration, while Gilliam sub-genotypes exhibited a slower or even declining trend.…”
Get full text

Balancing Human Mobility and Health Care Coverage in Sentinel Surveillance of Brazilian Indigenous Areas: Mathematical Optimization Approach by Juliane Fonseca Oliveira, Adriano O Vasconcelos, Andrêza L Alencar, Maria Célia S L Cunha, Izabel Marcilio, Manoel Barral-Netto, Pablo Ivan P Ramos

“… Abstract BackgroundOptimizing sentinel surveillance site allocation for early pathogen detection remains a challenge, particularly in ensuring coverage of vulnerable and underserved populations. …”
Get full text

Climate change as a wildlife health threat: a scoping review by Sabrina S. Greening, Lucie R. Pascarosa, Avery L. Munster, Roderick B. Gagne, Julie C. Ellis

“…Practitioners are working to integrate concepts such as vulnerability, adaptation, and resilience into wildlife health research, surveillance, and management actions. …”
Get full text

Transcriptomic analysis of two Chinese wheat landraces with contrasting Fusarium head blight resistance reveals miRNA-mediated defense mechanisms by Lijuan Wu, Lijuan Wu, Junqiang Wang, Shian Shen, Zaijun Yang, Xinkun Hu

“…The GO and KEGG pathway enrichment analyses further revealed that WY enriched for plant-pathogen interaction and secondary metabolite biosynthesis pathways, which are crucial for pathogen resistance. …”
Get full text

Navigating the outbreak: a comprehensive analysis of pediatric Mycoplasma pneumoniae pneumonia via targeted next-generation sequencing in Wuhan, 2022–2023 by Changzhen Li, Jingjing Rao, Xiaomei Wang, Lifang Feng, Yun Xiang, Feng Tang

“…Pediatric patients admitted to Wuhan Children’s Hospital with pneumonia from 1 October 2022 to 31 October 2023 were included. tNGS was used for comprehensive pathogen detection, including MP and other respiratory pathogens, with additional sequencing of the 23S rRNA gene V region to identify macrolide resistance mutations. …”
Get full text

Trehalose and α-glucan mediate distinct abiotic stress responses in Pseudomonas aeruginosa. by Stuart D Woodcock, Karl Syson, Richard H Little, Danny Ward, Despoina Sifouna, James K M Brown, Stephen Bornemann, Jacob G Malone

“…An important prelude to bacterial infection is the ability of a pathogen to survive independently of the host and to withstand environmental stress. …”
Get full text

Combining polyesters of citric and azelaic acids to obtain potential topical application biomaterials with antimicrobial activity by Aleksandra Bandzerewicz, Anna Herman, Ewa Dutkowska, Klara Niebuda, Paweł Ruśkowski, Agnieszka Gadomska-Gajadhur

“…The biocidal effect of polycitrate film against P. aeruginosa is the most important and promising result, especially given the resistance of the pathogen to commonly used antibiotics.…”
Get full text

Colonization and endophytic establishment of diazotrophic Lysinibacillus sphaericus in Oryza sativa and its efficacy in plant growth promotion by Shabanamol Subaida Beevi, Meenu Thampi, Jisha Manakulam Shaikh Moideen, Shafeeq Rahman

Get full text

Insights into the burden of bacterial antimicrobial resistance (AMR) in the WHO Eastern Mediterranean Region: a crucial step towards evidence-informed and targeted public health in... by Dr. Tomislav Mestrovic, Dr Gisela Robles Aguilar, Mr Lucien R Swetschinski, Mrs Nicole Davis Weaver, Mrs Eve E Wool, Mrs Authia P Gray, Prof Kevin S Ikuta, Mr Chieh Han, Mrs Anna Gershberg Hayoon, Prof Erin Chung, Prof Simon I Hay, Prof Christiane Dolecek, Prof Benn Sartorius, Prof Christopher J L Murray, Prof Mohsen Naghavi

“…A predictive statistical modeling approach - which included five components (the role of infection in deaths, the attribution of infectious deaths to specific syndromes, the proportion of infectious syndrome deaths attributable to specific pathogens, the percentage of pathogen resistant to antibiotics, and the excess risk of mortality associated with this resistance) - was used to integrate this data. …”
Get full text

The Unique Immune System of Bats: An Evolutionary Analysis and Bibliometric Study by Rui Li, Wenliang Zhao, Apeng Chen, Zhiqiang Wu, Gejing De

Get full text

Streptolysin O accelerates the conversion of plasminogen to plasmin by Di Tang, Hamed Khakzad, Elisabeth Hjortswang, Lars Malmström, Simon Ekström, Lotta Happonen, Johan Malmström

“…Abstract Group A Streptococcus (GAS) is a human-specific bacterial pathogen that can exploit the plasminogen-plasmin fibrinolysis system to dismantle blood clots and facilitate its spread and survival within the human host. …”
Get full text

Exosomes: Potential Therapies for Disease via Regulating TLRs by Hong-Yan Guo, An-Chun Cheng, Ming-Shu Wang, Zhong-Qiong Yin, Ren-Yong Jia

“…Innate immunity is an important process that protects the organism through activating pattern recognition receptors (PRRs), which then can induce inflammatory factors to resist pathogen invasion. Toll-like receptor (TLR) is one member of PRRs and is important in pathogen clearance and nervous disease development. …”
Get full text

Meningitis caused by Aspergillus fumigatus: a case report by Yifei Zhang, Yu Ma, Rushuang Yue, Yuan Meng, Yue Jin, Chengwei Yin, Qianmei Zhou, Rong Shi

Get full text

Competing microorganisms with exclusion effects against multidrug-resistant Salmonella Infantis in chicken litter supplemented with growth-promoting antimicrobials by María Alejandra Ospina Barrero, Maryeimy Varón-López, Lina M. Peñuela-Sierra

“…These findings support the development of integrated litter management strategies to mitigate zoonotic and resistant pathogen dissemination, particularly in AGP-using systems. …”
Get full text

Rigorous methodological approaches to address knowledge gaps in exercise, nutrition, immunity, and infection risk research by G. Davison, C. Chidley, A. W. Jones

“…For future research, we recommend prioritizing clinically relevant endpoints (validated URTI logs; pathogen screening); using in vivo markers representing the integrated immune response; large sample size; and implementing stringent study controls. …”
Get full text

Microbial biotechnology alchemy: Transforming bacterial cellulose into sensing disease- A review by Ali Jawad Akki, Pratheek Jain, Ravindra Kulkarni, Raghavendra Rao Badkillaya, Raghavendra V. Kulkarni, Farhan Zameer, V Raghu Anjanapura, Tejraj M. Aminabhavi

“…The invention of a phage-immobilized BC biosensor for S. aureus detection is a significant contribution to the field, highlighting the biosafety and efficiency of BC in pathogen identification and demonstrating BC's versatility across multiple sensing platforms. …”
Get full text

Environmental RNA‐Based Surveillance of Viral Hemorrhagic Septicemia Virus (VHSV) in Olive Flounder (Paralichthys olivaceus) Aquaculture: Detection Dynamics and Risk Assessment by Hyo‐Young Kang, Yoonhang Lee, Jiyeon Park, Ju‐Yeop Lee, Young‐Ung Heo, Nameun Kim, Jae‐Ok Kim, Mun‐Gyeong Kwon, Chan‐Il Park, Do‐Hyung Kim

“…ABSTRACT Viral hemorrhagic septicemia virus (VHSV) is a major pathogen in aquaculture worldwide, causing significant outbreaks through waterborne transmission. …”
Get full text

Evolution of copper resistance in Xanthomonas euvesicatoria pv. perforans population by Amandeep Kaur, Gerald V. Minsavage, Neha Potnis, Jeffrey B. Jones, Erica M. Goss

“…ABSTRACT The widespread use of antimicrobials that target bacterial pathogens has driven evolution of resistance, compromising the efficacy of these bactericides. …”
Get full text