The Replicative Consequences of Papillomavirus E2 Protein Binding to the Origin Replication Factor ORC2. by Marsha DeSmet, Sriramana Kanginakudru, Anne Rietz, Wai-Hong Wu, Richard Roden, Elliot J Androphy

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Characterisation of guided entry of tail-anchored proteins in Magnaporthe oryzae. by Felix Abah, Qiaojia Zheng, Xinru Chen, Linwan Huang, Xiaomin Chen, Jules Biregeya, Osakina Aron, Zonghua Wang, Wei Tang

“…In summary, this finding provides valuable insight into the biological functions of the GET components in plant fungal pathogens.…”
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HIV infects astrocytes in vivo and egresses from the brain to the periphery. by Victoria Lutgen, Srinivas D Narasipura, Hannah J Barbian, Maureen Richards, Jennillee Wallace, Roshanak Razmpour, Tetyana Buzhdygan, Servio H Ramirez, Lisa Prevedel, Eliseo A Eugenin, Lena Al-Harthi

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Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development. by Gunnar R Mair, Edwin Lasonder, Lindsey S Garver, Blandine M D Franke-Fayard, Céline K Carret, Joop C A G Wiegant, Roeland W Dirks, George Dimopoulos, Chris J Janse, Andrew P Waters

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The dual functions of the GTPase BipA in ribosome assembly and surface structure biogenesis in Salmonella enterica serovar Typhimurium. by Eunsil Choi, Eunwoo Ryu, Donghwee Kim, Ji-Won Byun, Kahyun Kim, Minho Lee, Jihwan Hwang

“…In this study, we aimed to elucidate the role of BipA in the pathogenicity of Salmonella enterica serovar Typhimurium. …”
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Neuroimmunological blood brain barrier opening in experimental cerebral malaria. by Adela Nacer, Alexandru Movila, Kerstin Baer, Sebastian A Mikolajczak, Stefan H I Kappe, Ute Frevert

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EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment. by Chao-Jiang Gu, Alejandra Borjabad, Eran Hadas, Jennifer Kelschenbach, Boe-Hyun Kim, Wei Chao, Ottavio Arancio, Jin Suh, Bruce Polsky, JoEllyn McMillan, Benson Edagwa, Howard E Gendelman, Mary Jane Potash, David J Volsky

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CAGE-seq analysis of Epstein-Barr virus lytic gene transcription: 3 kinetic classes from 2 mechanisms. by Reza Djavadian, Mitchell Hayes, Eric Johannsen

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SARS-CoV-2 infection of salivary glands compromises the production of a secreted antifungal peptide with potential implications for development of oral candidiasis. by Areej A Alfaifi, Tristan W Wang, Paola Perez, Ahmed S Sultan, Timothy F Meiller, Peter Rock, David E Kleiner, Daniel S Chertow, Stephen M Hewitt, Billel Gasmi, Sydney Stein, Sabrina Ramelli, Daniel Martin, Blake M Warner, Mary Ann Jabra-Rizk

“…Saliva contains antimicrobial peptides considered integral components of host innate immunity, and crucial for protection against colonizing microbial species. …”
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An intact S-layer is advantageous to Clostridioides difficile within the host. by Michael J Ormsby, Filipa Vaz, Joseph A Kirk, Anna Barwinska-Sendra, Jennifer C Hallam, Paola Lanzoni-Mangutchi, John Cole, Roy R Chaudhuri, Paula S Salgado, Robert P Fagan, Gillian R Douce

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Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium. by Talita B Gagliardi, Monty E Goldstein, Daniel Song, Kelsey M Gray, Jae W Jung, Maxinne A Ignacio, Kimberly M Stroka, Gregg A Duncan, Margaret A Scull

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Role of the CTCF binding site in Human T-Cell Leukemia Virus-1 pathogenesis. by Ancy Joseph, Xiaogang Cheng, John Harding, Jacob Al-Saleem, Patrick Green, Malachi Griffith, Deborah Veis, Daniel A Rauch, Lee Ratner

“…Overall, these findings indicate that the vCTCF-BS regulates Tax expression, proviral load, and HTLV pathogenicity in vivo.…”
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A systematic analysis of host factors reveals a Med23-interferon-λ regulatory axis against herpes simplex virus type 1 replication. by Samantha J Griffiths, Manfred Koegl, Chris Boutell, Helen L Zenner, Colin M Crump, Francesca Pica, Orland Gonzalez, Caroline C Friedel, Gerald Barry, Kim Martin, Marie H Craigon, Rui Chen, Lakshmi N Kaza, Even Fossum, John K Fazakerley, Stacey Efstathiou, Antonio Volpi, Ralf Zimmer, Peter Ghazal, Jürgen Haas

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HIV evolution in early infection: selection pressures, patterns of insertion and deletion, and the impact of APOBEC. by Natasha Wood, Tanmoy Bhattacharya, Brandon F Keele, Elena Giorgi, Michael Liu, Brian Gaschen, Marcus Daniels, Guido Ferrari, Barton F Haynes, Andrew McMichael, George M Shaw, Beatrice H Hahn, Bette Korber, Cathal Seoighe

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Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration. by Irini Sereti, Jacob D Estes, William L Thompson, David R Morcock, Margaret A Fischl, Thérèse Croughs, Stéphanie Beq, Sylvie Lafaye de Micheaux, Michael D Yao, Alexander Ober, Eleanor M P Wilson, Ven Natarajan, Hiromi Imamichi, Mohamed R Boulassel, Michael M Lederman, Jean-Pierre Routy

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The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis. by Margherita Bertuzzi, Markus Schrettl, Laura Alcazar-Fuoli, Timothy C Cairns, Alberto Muñoz, Louise A Walker, Susanne Herbst, Maryam Safari, Angela M Cheverton, Dan Chen, Hong Liu, Shinobu Saijo, Natalie D Fedorova, Darius Armstrong-James, Carol A Munro, Nick D Read, Scott G Filler, Eduardo A Espeso, William C Nierman, Hubertus Haas, Elaine M Bignell

“…ΔpacC mutants are defective in both contact-mediated epithelial entry and protease expression, and significantly attenuated for pathogenicity in leukopenic mice. We combined murine infection modelling, in vivo transcriptomics, and in vitro infections of human alveolar epithelia, to delineate two major, and sequentially acting, PacC-dependent processes impacting epithelial integrity in vitro and tissue invasion in the whole animal. …”
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Salivary shield: Rhodnius prolixus salivary glandular extract reduces intestinal immunopathology and protects against Toxoplasma gondii infection by Roberto Augusto Pereira Sousa, Jean Henrique Nunes de Paula, Rafaela José Silva, Samuel Cota Teixeira, Flávia Batista Ferreira França, Amanda Helena Leão Gonçalves, Túlio Rodrigues Oliveira Silva, Maria Julia Granero-Rosa, Murilo Vieira Silva, Marcos de Lucca Moreira Gomes, Marcos Vinícius Silva, Virmondes Rodrigues Junior, José Roberto Mineo, Bellisa Freitas Barbosa, Eloisa Amália Vieira Ferro, Carlo José Freire Oliveira, Angelica Oliveira Gomes

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Coupling culturomics and metagenomics sequencing to characterize the gut microbiome of patients with cancer treated with immune checkpoint inhibitors by Khoudia Diop, Babacar Mbaye, Somayeh Nili, Alysé Filin, Myriam Benlaifaoui, Julie Malo, Anne Sophie Renaud, Wiam Belkaid, Sebastian Hunter, Meriem Messaoudene, Karla A. Lee, Arielle Elkrief, Bertrand Routy

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Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. by Wesley C Van Voorhis, John H Adams, Roberto Adelfio, Vida Ahyong, Myles H Akabas, Pietro Alano, Aintzane Alday, Yesmalie Alemán Resto, Aishah Alsibaee, Ainhoa Alzualde, Katherine T Andrews, Simon V Avery, Vicky M Avery, Lawrence Ayong, Mark Baker, Stephen Baker, Choukri Ben Mamoun, Sangeeta Bhatia, Quentin Bickle, Lotfi Bounaadja, Tana Bowling, Jürgen Bosch, Lauren E Boucher, Fabrice F Boyom, Jose Brea, Marian Brennan, Audrey Burton, Conor R Caffrey, Grazia Camarda, Manuela Carrasquilla, Dee Carter, Maria Belen Cassera, Ken Chih-Chien Cheng, Worathad Chindaudomsate, Anthony Chubb, Beatrice L Colon, Daisy D Colón-López, Yolanda Corbett, Gregory J Crowther, Noemi Cowan, Sarah D'Alessandro, Na Le Dang, Michael Delves, Joseph L DeRisi, Alan Y Du, Sandra Duffy, Shimaa Abd El-Salam El-Sayed, Michael T Ferdig, José A Fernández Robledo, David A Fidock, Isabelle Florent, Patrick V T Fokou, Ani Galstian, Francisco Javier Gamo, Suzanne Gokool, Ben Gold, Todd Golub, Gregory M Goldgof, Rajarshi Guha, W Armand Guiguemde, Nil Gural, R Kiplin Guy, Michael A E Hansen, Kirsten K Hanson, Andrew Hemphill, Rob Hooft van Huijsduijnen, Takaaki Horii, Paul Horrocks, Tyler B Hughes, Christopher Huston, Ikuo Igarashi, Katrin Ingram-Sieber, Maurice A Itoe, Ajit Jadhav, Amornrat Naranuntarat Jensen, Laran T Jensen, Laran T Jensen, Rays H Y Jiang, Annette Kaiser, Jennifer Keiser, Thomas Ketas, Sebastien Kicka, Sunyoung Kim, Kiaran Kirk, Vidya P Kumar, Dennis E Kyle, Maria Jose Lafuente, Scott Landfear, Nathan Lee, Sukjun Lee, Adele M Lehane, Fengwu Li, David Little, Liqiong Liu, Manuel Llinás, Maria I Loza, Aristea Lubar, Leonardo Lucantoni, Isabelle Lucet, Louis Maes, Dalu Mancama, Nuha R Mansour, Sandra March, Sheena McGowan, Iset Medina Vera, Stephan Meister, Luke Mercer, Jordi Mestres, Alvine N Mfopa, Raj N Misra, Seunghyun Moon, John P Moore, Francielly Morais Rodrigues da Costa, Joachim Müller, Arantza Muriana, Stephen Nakazawa Hewitt, Bakela Nare, Carl Nathan, Nathalie Narraidoo, Sujeevi Nawaratna, Kayode K Ojo, Diana Ortiz, Gordana Panic, George Papadatos, Silvia Parapini, Kailash Patra, Ngoc Pham, Sarah Prats, David M Plouffe, Sally-Ann Poulsen, Anupam Pradhan, Celia Quevedo, Ronald J Quinn, Christopher A Rice, Mohamed Abdo Rizk, Andrea Ruecker, Robert St Onge, Rafaela Salgado Ferreira, Jasmeet Samra, Natalie G Robinett, Ulrich Schlecht, Marjorie Schmitt, Filipe Silva Villela, Francesco Silvestrini, Robert Sinden, Dennis A Smith, Thierry Soldati, Andreas Spitzmüller, Serge Maximilian Stamm, David J Sullivan, William Sullivan, Sundari Suresh, Brian M Suzuki, Yo Suzuki, S Joshua Swamidass, Donatella Taramelli, Lauve R Y Tchokouaha, Anjo Theron, David Thomas, Kathryn F Tonissen, Simon Townson, Abhai K Tripathi, Valentin Trofimov, Kenneth O Udenze, Imran Ullah, Cindy Vallieres, Edgar Vigil, Joseph M Vinetz, Phat Voong Vinh, Hoan Vu, Nao-Aki Watanabe, Kate Weatherby, Pamela M White, Andrew F Wilks, Elizabeth A Winzeler, Edward Wojcik, Melanie Wree, Wesley Wu, Naoaki Yokoyama, Paul H A Zollo, Nada Abla, Benjamin Blasco, Jeremy Burrows, Benoît Laleu, Didier Leroy, Thomas Spangenberg, Timothy Wells, Paul A Willis

“…In addition, many compounds demonstrated activity against other pathogens, showing hits in assays with 16 protozoa, 7 helminths, 9 bacterial and mycobacterial species, the dengue fever mosquito vector, and the NCI60 human cancer cell line panel of 60 human tumor cell lines. …”
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Bactericera cockerelli (Sulc), a potential threat to China's potato industry by Oluwashola OLANIYAN, Neus RODRÍGUEZ-GASOL, Nathalie CAYLA, Eleonor MICHAUD, Steve D. WRATTEN

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