Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses. by Sofia Banchenko, Ferdinand Krupp, Christine Gotthold, Jörg Bürger, Andrea Graziadei, Francis J O'Reilly, Ludwig Sinn, Olga Ruda, Juri Rappsilber, Christian M T Spahn, Thorsten Mielke, Ian A Taylor, David Schwefel

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SARS-CoV-2 Omicron variations reveal mechanisms controlling cell entry dynamics and antibody neutralization. by Enya Qing, Julisa Salgado, Alexandria Wilcox, Tom Gallagher

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Selective whole-genome amplification reveals population genetics of Leishmania braziliensis directly from patient skin biopsies. by Olivia A Pilling, João L Reis-Cunha, Cooper A Grace, Alexander S F Berry, Matthew W Mitchell, Jane A Yu, Clara R Malekshahi, Elise Krespan, Christina K Go, Cláudia Lombana, Yun S Song, Camila F Amorim, Alexsandro S Lago, Lucas P Carvalho, Edgar M Carvalho, Dustin Brisson, Phillip Scott, Daniel C Jeffares, Daniel P Beiting

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Mechanisms of resistance against allylamine and azole antifungals in Trichophyton: A renewed call for innovative molecular diagnostics in susceptibility testing. by Aditya K Gupta, Tong Wang, Avantika Mann, Vincent Piguet, Anuradha Chowdhary, Wayne L Bakotic

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Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection. by Haiying Li, Laura E Richert-Spuhler, Tristan I Evans, Jacqueline Gillis, Michelle Connole, Jacob D Estes, Brandon F Keele, Nichole R Klatt, R Keith Reeves

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Secreted LysM proteins are required for niche competition and full virulence in Pseudomonas savastanoi during host plant infection. by Hilario Domínguez-Cerván, Laura Barrientos-Moreno, Luis Díaz-Martínez, Jesús Murillo, Inmaculada Pérez-Dorado, Cayo Ramos, Luis Rodríguez-Moreno

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Fungal virulence and development is regulated by alternative pre-mRNA 3'end processing in Magnaporthe oryzae. by Marina Franceschetti, Emilio Bueno, Richard A Wilson, Sara L Tucker, Concepción Gómez-Mena, Grant Calder, Ane Sesma

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Perivascular Arrest of CD8+ T Cells Is a Signature of Experimental Cerebral Malaria. by Tovah N Shaw, Phillip J Stewart-Hutchinson, Patrick Strangward, Durga B Dandamudi, Jonathan A Coles, Ana Villegas-Mendez, Julio Gallego-Delgado, Nico van Rooijen, Egor Zindy, Ana Rodriguez, James M Brewer, Kevin N Couper, Michael L Dustin

“…However, the mechanisms through which they mediate their pathogenic activity during malaria infection remain poorly understood. …”
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Superior immunogenicity of inactivated whole virus H5N1 influenza vaccine is primarily controlled by Toll-like receptor signalling. by Felix Geeraedts, Nadege Goutagny, Veit Hornung, Martina Severa, Aalzen de Haan, Judith Pool, Jan Wilschut, Katherine A Fitzgerald, Anke Huckriede

“…This TLR dependency largely explains the relative loss of immunogenicity in SV and SU vaccines. The natural pathogen-associated molecular pattern (PAMP) recognized by TLR7 is viral genomic ssRNA. …”
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The transcriptome of HTLV-1-infected primary cells following reactivation reveals changes to host gene expression central to the proviral life cycle. by Aris E N Aristodemou, David S Rueda, Graham P Taylor, Charles R M Bangham

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The allelic rice immune receptor Pikh confers extended resistance to strains of the blast fungus through a single polymorphism in the effector binding interface. by Juan Carlos De la Concepcion, Josephine H R Maidment, Apinya Longya, Gui Xiao, Marina Franceschetti, Mark J Banfield

“…Arms race co-evolution drives rapid adaptive changes in pathogens and in the immune systems of their hosts. …”
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Unique biofilm signature, drug susceptibility and decreased virulence in Drosophila through the Pseudomonas aeruginosa two-component system PprAB. by Sophie de Bentzmann, Caroline Giraud, Christophe S Bernard, Virginie Calderon, Friederike Ewald, Patrick Plésiat, Cathy Nguyen, Didier Grunwald, Ina Attree, Katy Jeannot, Marie-Odile Fauvarque, Christophe Bordi

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Cell type differences in human cytomegalovirus transcription and epigenetic regulation with insights into major immediate-early enhancer-promoter control. by Qiaolin Hu, Ming Li, Mrutyunjaya Parida, Benjamin M Spector, Juan F Santana, Arya Zandvakili, David H Price, Jeffery L Meier

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Antibiotic resistance in Helicobacter pylori: a genetic and physiological perspective by Rania G. Elbaiomy, Xiaoling Luo, Rong Guo, Shiyuan Deng, Meifang Du, Ahmed H. El-Sappah, Mohammed Bakeer, Mahmoud M. Azzam, Ahmed A. Elolimy, Mahmoud Madkour, Zaixin Li, Zhi Zhang

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Unidirectional recruitment between MeCP2 and KSHV-encoded LANA revealed by CRISPR/Cas9 recruitment assay. by Ido Lavi, Supriya Bhattacharya, Ankita Awase, Ola Orgil, Nir Avital, Guy Journo, Vyacheslav Gurevich, Meir Shamay

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The zinc metalloprotein MigC impacts cell wall biogenesis through interactions with an essential Mur ligase in Acinetobacter baumannii. by Jeanette M Critchlow, Joseph S Rocchio, Melanie C McKell, Courtney J Campbell, Juan P Barraza, Evan S Krystofiak, Erin R Green, Tae Akizuki, Walter J Chazin, Michael S VanNieuwenhze, Timothy L Stemmler, David P Giedroc, Eric P Skaar

“…To colonize and survive in the host, bacterial pathogens like Acinetobacter baumannii must acquire zinc (Zn). …”
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Multiple introductions of equine influenza virus into the United Kingdom resulted in widespread outbreaks and lineage replacement. by Laura Mojsiejczuk, Fleur Whitlock, Hanting Chen, Callum Magill, Elihu Aranday-Cortes, Jordan Bone, Lily Tong, Ana Da Silva Filipe, Neil Bryant, J Richard Newton, Thomas M Chambers, Stephanie E Reedy, Manabu Nemoto, Takashi Yamanaka, Joseph Hughes, Pablo R Murcia

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Widespread emergence of OmpK36 loop 3 insertions among multidrug-resistant clones of Klebsiella pneumoniae. by Sophia David, Joshua L C Wong, Julia Sanchez-Garrido, Hok-Sau Kwong, Wen Wen Low, Fabio Morecchiato, Tommaso Giani, Gian Maria Rossolini, Stephen J Brett, Abigail Clements, Konstantinos Beis, David M Aanensen, Gad Frankel

“…Mutations in outer membrane porins act in synergy with carbapenemase enzymes to increase carbapenem resistance in the important nosocomial pathogen, Klebsiella pneumoniae (KP). A key example is a di-amino acid insertion, Glycine-Aspartate (GD), in the extracellular loop 3 (L3) region of OmpK36 which constricts the pore and restricts entry of carbapenems into the bacterial cell. …”
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Vaccinia Virus Immunomodulator A46: A Lipid and Protein-Binding Scaffold for Sequestering Host TIR-Domain Proteins. by Sofiya Fedosyuk, Gustavo Arruda Bezerra, Katharina Radakovics, Terry K Smith, Massimo Sammito, Nina Bobik, Adam Round, Lynn F Ten Eyck, Kristina Djinović-Carugo, Isabel Usón, Tim Skern

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Spatiotemporal profile of an optimal host response to virus infection in the primate central nervous system. by Olga A Maximova, Sarah L Anzick, Daniel E Sturdevant, Richard S Bennett, Lawrence J Faucette, Marisa St Claire, Stephen S Whitehead, Kishore Kanakabandi, Zong-Mei Sheng, Yongli Xiao, John C Kash, Jeffery K Taubenberger, Craig Martens, Jeffrey I Cohen

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