Reverse transcription progression and genome length regulate HIV-1 core elasticity and disassembly. by Akshay Deshpande, Jiong Shi, Noa Rotem-Dai, Christopher Aiken, Itay Rousso

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Molecular identification of a malaria merozoite surface sheddase. by Philippa K Harris, Sharon Yeoh, Anton R Dluzewski, Rebecca A O'Donnell, Chrislaine Withers-Martinez, Fiona Hackett, Lawrence H Bannister, Graham H Mitchell, Michael J Blackman

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Inadequate clearance of translocated bacterial products in HIV-infected humanized mice. by Ursula Hofer, Erika Schlaepfer, Stefan Baenziger, Marc Nischang, Stephan Regenass, Reto Schwendener, Werner Kempf, David Nadal, Roberto F Speck

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A GDP-mannose-1-phosphate guanylyltransferase as a potential HIGS target against Sclerotinia sclerotiorum. by Cheng Zhang, Yan Xu, Lin Li, Mingsong Wu, Zheyi Fang, Jinyi Tan, Jeffrey A Rollins, Honghui Lin, Xinyi Huang, Shawn D Mansfield, Xin Li, Yuelin Zhang

“…Host-induced gene silencing (HIGS) has shown promise in disease control against insects and fungal pathogens, but effective HIGS target genes against S. sclerotiorum remain limited. …”
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Mobilizable antibiotic resistance genes are present in dust microbial communities. by Sarah Ben Maamar, Adam J Glawe, Taylor K Brown, Nancy Hellgeth, Jinglin Hu, Ji-Ping Wang, Curtis Huttenhower, Erica M Hartmann

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Blood vessel occlusion by Cryptococcus neoformans is a mechanism for haemorrhagic dissemination of infection. by Josie F Gibson, Aleksandra Bojarczuk, Robert J Evans, Alfred Alinafe Kamuyango, Richard Hotham, Anne K Lagendijk, Benjamin M Hogan, Philip W Ingham, Stephen A Renshaw, Simon A Johnston

“…Meningitis caused by infectious pathogens is associated with vessel damage and infarct formation, however the physiological cause is often unknown. …”
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The two-domain LysX protein of Mycobacterium tuberculosis is required for production of lysinylated phosphatidylglycerol and resistance to cationic antimicrobial peptides. by Erin Maloney, Dorota Stankowska, Jian Zhang, Marek Fol, Qi-Jian Cheng, Shichun Lun, William R Bishai, Malini Rajagopalan, Delphi Chatterjee, Murty V Madiraju

“…Together, our results suggest that LysX-mediated production of L-PG is necessary for the maintenance of optimal membrane integrity and for survival of the pathogen upon infection.…”
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Effectiveness of Pseudomonas aeruginosa type VI secretion system relies on toxin potency and type IV pili-dependent interaction. by Marta Rudzite, Sujatha Subramoni, Robert G Endres, Alain Filloux

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Epigenomic modifications predict active promoters and gene structure in Toxoplasma gondii. by Mathieu Gissot, Krystyna A Kelly, James W Ajioka, John M Greally, Kami Kim

“…Mechanisms of gene regulation are poorly understood in Apicomplexa, a phylum that encompasses deadly human pathogens like Plasmodium and Toxoplasma. Initial studies suggest that epigenetic phenomena, including histone modifications and chromatin remodeling, have a profound effect upon gene expression and expression of virulence traits. …”
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Compromised base excision repair pathway in Mycobacterium tuberculosis imparts superior adaptability in the host. by Saba Naz, Shruti Dabral, Sathya Narayanan Nagarajan, Divya Arora, Lakshya Veer Singh, Pradeep Kumar, Yogendra Singh, Dhiraj Kumar, Umesh Varshney, Vinay Kumar Nandicoori

“…UDGs encoded by ung and udgB initiate the repair; hence we investigated the biological impact of deleting UDGs in the adaptation of pathogen. We generated gene replacement mutants of uracil DNA glycosylases, individually (RvΔung, RvΔudgB) or together (RvΔdKO). …”
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Single-cell analysis reveals lasting immunological consequences of influenza infection and respiratory immunization in the pig lung. by Andrew Muir, Basudev Paudyal, Selma Schmidt, Ehsan Sedaghat-Rostami, Soumendu Chakravarti, Sonia Villanueva-Hernández, Katy Moffat, Noemi Polo, Nicos Angelopoulos, Anna Schmidt, Matthias Tenbusch, Graham Freimanis, Wilhelm Gerner, Arianne C Richard, Elma Tchilian

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Red-light is an environmental effector for mutualism between begomovirus and its vector whitefly. by Pingzhi Zhao, Xuan Zhang, Yuqing Gong, Duan Wang, Dongqing Xu, Ning Wang, Yanwei Sun, Lianbo Gao, Shu-Sheng Liu, Xing Wang Deng, Daniel J Kliebenstein, Xueping Zhou, Rong-Xiang Fang, Jian Ye

“…However, whether and how light affects the host defense which further affects insect preference and performance, remains unclear, nor has been demonstrated how pathogens co-adapt light condition to facilitate vector transmission. …”
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PHD3-VHL axis controls HIV-2 infection through oxygen-dependent hydroxylation and degradation of Vpx. by Kei Miyakawa, Kiho Tanaka, Yoko Ino, Yayoi Kimura, Taichi Kameya, Fuminori Mizukoshi, Mayuko Nishi, Masaru Yokoyama, Jun Nakabayashi, Masako Nomaguchi, Hironori Sato, Hirokazu Kimura, Hirofumi Akari, Tomoyuki Miura, Akinori Takaoka, Hideki Hasegawa, Tetsuro Matano, Yoji Andrew Minamishima, Akihide Ryo

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Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans. by Barbara Holzer, Pramila Rijal, Adam McNee, Basudev Paudyal, Veronica Martini, Becky Clark, Tanuja Manjegowda, Francisco J Salguero, Emily Bessell, John C Schwartz, Katy Moffat, Miriam Pedrera, Simon P Graham, Alistair Noble, Marie Bonnet-Di Placido, Roberto M La Ragione, William Mwangi, Peter Beverley, John W McCauley, Rodney S Daniels, John A Hammond, Alain R Townsend, Elma Tchilian

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Chronic immune activation and gut barrier dysfunction is associated with neuroinflammation in ART-suppressed SIV+ rhesus macaques. by Sarah J Byrnes, Kathleen Busman-Sahay, Thomas A Angelovich, Skyler Younger, Sol Taylor-Brill, Michael Nekorchuk, Stephen Bondoc, Rachel Dannay, Margaret Terry, Catherine R Cochrane, Trisha A Jenkins, Michael Roche, Claire Deleage, Steven E Bosinger, Mirko Paiardini, Bruce J Brew, Jacob D Estes, Melissa J Churchill

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Chitosan Mediates Germling Adhesion in Magnaporthe oryzae and Is Required for Surface Sensing and Germling Morphogenesis. by Ivey A Geoghegan, Sarah J Gurr

“…The fungal cell wall not only plays a critical role in maintaining cellular integrity, but also forms the interface between fungi and their environment. …”
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Lytic coelomocyte death is tuned by cleavage but not phosphorylation of MLKL in echinoderms. by Kaiyu Chen, Sikou Shen, Zhimeng Lv, Ming Guo, Yina Shao, Chenghua Li

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Regulators of Trypanosoma brucei cell cycle progression and differentiation identified using a kinome-wide RNAi screen. by Nathaniel G Jones, Elizabeth B Thomas, Elaine Brown, Nicholas J Dickens, Tansy C Hammarton, Jeremy C Mottram

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An RIG-I-Like RNA helicase mediates antiviral RNAi downstream of viral siRNA biogenesis in Caenorhabditis elegans. by Rui Lu, Erbay Yigit, Wan-Xiang Li, Shou-Wei Ding

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Engineering, decoding and systems-level characterization of chimpanzee cytomegalovirus. by Quang Vinh Phan, Boris Bogdanow, Emanuel Wyler, Markus Landthaler, Fan Liu, Christian Hagemeier, Lüder Wiebusch

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