Enterovirus-like particles encapsidate RNA and exhibit decreased stability due to lack of maturation. by Louis Kuijpers, Evdokia-Anastasia Giannopoulou, Yuzhen Feng, Wouter van den Braak, Abbas Freydoonian, Ramon Ramlal, Hugo Meiring, Belén Solano, Wouter H Roos, Arjen J Jakobi, Leo A van der Pol, Nynke H Dekker

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Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes. by Martin Zoltner, Ka Fai Leung, Sam Alsford, David Horn, Mark C Field

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A conserved fungal Knr4/Smi1 protein is crucial for maintaining cell wall stress tolerance and host plant pathogenesis. by Erika Kroll, Carlos Bayon, Jason Rudd, Victoria J Armer, Anjana Magaji-Umashankar, Ryan Ames, Martin Urban, Neil A Brown, Kim Hammond-Kosack

“…Encouragingly, the restricted growth and highly reduced virulence phenotypes observed for ΔFgknr4 were replicated upon deletion of the orthologous gene in the wheat fungal pathogen Zymoseptoria tritici. Overall, this study demonstrates the utility of an integrated network-level analytical approach to pinpoint genes of high interest to pathogenesis and disease control.…”
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Lysogeny with Shiga toxin 2-encoding bacteriophages represses type III secretion in enterohemorrhagic Escherichia coli. by Xuefang Xu, Sean P McAteer, Jai J Tree, Darren J Shaw, Eliza B K Wolfson, Scott A Beatson, Andrew J Roe, Lesley J Allison, Margo E Chase-Topping, Arvind Mahajan, Rosangela Tozzoli, Mark E J Woolhouse, Stefano Morabito, David L Gally

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Paratransgenic manipulation of a tsetse microRNA alters the physiological homeostasis of the fly's midgut environment. by Liu Yang, Brian L Weiss, Adeline E Williams, Emre Aksoy, Alessandra de Silva Orfano, Jae Hak Son, Yineng Wu, Aurelien Vigneron, Mehmet Karakus, Serap Aksoy

“…The peritrophic matrix (PM) is a chitinous and proteinaceous barrier that lines the insect midgut and serves as a protective barrier that inhibits infection with pathogens. African trypanosomes must cross tsetse's PM in order to establish an infection in the fly, and PM structural integrity negatively correlates with trypanosome infection outcomes. …”
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Unifying viral genetics and human transportation data to predict the global transmission dynamics of human influenza H3N2. by Philippe Lemey, Andrew Rambaut, Trevor Bedford, Nuno Faria, Filip Bielejec, Guy Baele, Colin A Russell, Derek J Smith, Oliver G Pybus, Dirk Brockmann, Marc A Suchard

“…Yet it remains difficult to test which modes of dispersal drive pathogen spread at various geographic scales using standard epidemiological data alone. …”
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EV71 infection induces neurodegeneration via activating TLR7 signaling and IL-6 production. by Zhen Luo, Rui Su, Wenbiao Wang, Yicong Liang, Xiaofeng Zeng, Muhammad Adnan Shereen, Nadia Bashir, Qi Zhang, Ling Zhao, Kailang Wu, Yingle Liu, Jianguo Wu

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Gut mycobiome alterations and implications for liver diseases. by Suling Zeng, Bernd Schnabl

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Exploring the effects of probiotics on olanzapine-induced metabolic syndrome through the gut microbiota by Syed Mushraf, Kiran Chawla, Shaik Mohammed Abdul Fayaz, Aranjani Jesil Mathew, Gayam Prasanna Kumar Reddy, Mohandas Rao Kappettu Gadahad, Padmaja A. Shenoy, Vasudha Devi, Shalini Adiga, Veena Nayak

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Microbiota-induced peritrophic matrix regulates midgut homeostasis and prevents systemic infection of malaria vector mosquitoes. by Faye H Rodgers, Mathilde Gendrin, Claudia A S Wyer, George K Christophides

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Phylodynamics and human-mediated dispersal of a zoonotic virus. by Chiraz Talbi, Philippe Lemey, Marc A Suchard, Elbia Abdelatif, Mehdi Elharrak, Jalal Nourlil, Abdellah Faouzi, Juan E Echevarría, Sonia Vazquez Morón, Andrew Rambaut, Nicholas Campiz, Andrew J Tatem, Edward C Holmes, Hervé Bourhy

“…These results are strongly supportive of human-mediated dispersal, and demonstrate how an integrated phylogeographic approach will turn viral genetic data into a powerful asset for characterizing, predicting, and potentially controlling the spatial spread of pathogens.…”
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Cholesterol metabolism and intrabacterial potassium homeostasis are intrinsically related in Mycobacterium tuberculosis. by Yue Chen, Berge Hagopian, Shumin Tan

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DHX15 inhibits mouse APOBEC3 deamination. by Wenming Zhao, Ayan Modak, Susan R Ross

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Interplay between porin deficiency, fitness, and virulence in carbapenem-non-susceptible Pseudomonas aeruginosa and Enterobacteriaceae. by Hedi Mammeri, Youssouf Sereme, Eya Toumi, Hélène Faury, David Skurnik

“…In this review, we focus on the specific role of porins in carbapenem-resistance in Enterobacteriaceae and Pseudomonas aeruginosa, which are major human pathogens. Porins are outer membrane proteins, which play a key role in the bacterial permeability to allow nutrients to enter and toxic waste to leave. …”
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Continuous DNA replication is required for late gene transcription and maintenance of replication compartments in gammaherpesviruses. by Dajiang Li, Wenmin Fu, Sankar Swaminathan

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TNF signaling mediates cellular immune function and promotes malaria parasite killing in the mosquito Anopheles gambiae. by George-Rafael Samantsidis, Hyeogsun Kwon, Megan Wendland, Catherine Fonder, Ryan C Smith

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Legionella pneumophila secretes a mitochondrial carrier protein during infection. by Pavel Dolezal, Margareta Aili, Janette Tong, Jhih-Hang Jiang, Carlo M T Marobbio, Sau Fung Lee, Ralf Schuelein, Simon Belluzzo, Eva Binova, Aurelie Mousnier, Gad Frankel, Giulia Giannuzzi, Ferdinando Palmieri, Kipros Gabriel, Thomas Naderer, Elizabeth L Hartland, Trevor Lithgow

“…The Mitochondrial Carrier Family (MCF) is a signature group of integral membrane proteins that transport metabolites across the mitochondrial inner membrane in eukaryotes. …”
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Real-time high resolution 3D imaging of the lyme disease spirochete adhering to and escaping from the vasculature of a living host. by Tara J Moriarty, M Ursula Norman, Pina Colarusso, Troy Bankhead, Paul Kubes, George Chaconas

“…Stationary adhesions and extravasating spirochetes were most commonly observed at endothelial junctions, and translational motility of spirochetes appeared to play an integral role in transendothelial migration. To our knowledge, this is the first report of high resolution 3D and 4D visualization of dissemination of a bacterial pathogen in a living mammalian host, and provides the first direct insight into spirochete dissemination in vivo.…”
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Phosphorylcholine allows for evasion of bactericidal antibody by Haemophilus influenzae. by Sarah E Clark, Julian Snow, Jianjun Li, Tracey A Zola, Jeffrey N Weiser

“…The human pathogen Haemophilus influenzae has the ability to quickly adapt to different host environments through phase variation of multiple structures on its lipooligosaccharide (LPS), including phosphorylcholine (ChoP). …”
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Blood flukes exploit Peyer's Patch lymphoid tissue to facilitate transmission from the mammalian host. by Joseph D Turner, Priyanka Narang, Mark C Coles, Adrian P Mountford

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