Integrins and pulmonary fibrosis: Pathogenic roles and therapeutic opportunities by Zhangyang Bi, Guodong Zang, Xiaodong Wang, Li Tian, Wei Zhang

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Genomic investigation of emerging zoonotic pathogen Shewanella xiamenensis by Jui-Hsing Wang, Shu-Ying Tseng, Kwong-Chung Tung

“…Objective: Shewanella xiamenensis is an emerging zoonotic pathogen commonly found in aquatic ecosystem. Clustered regularly interspaced short palindromic repeats (CRISPR) and (CRISPR)-associated gene systems act as adaptive immune system of prokaryotes. …”
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Optimising Wastewater Sample Processing for Multiple Pathogen Detection by Miss Shannon Fitz, Debora Akortia, Richard Larbi, Richard Owusu, Gifty Nkrumah, Dr Joyce Akello, Catherine Troman, Dr Jaspreet Mahindroo, Dr Anton Spader, Dr Ben Bellekom, Piya Rajendra, Professor Yaw Adu-Sarkodie, Dr Ellis Owusu-Dabo, Dr Nicholas Grassly, Dr Dilip Abraham, Professor Venkata Raghava Mohan, Dr Michael Owusu, Dr Alex Shaw

“…Expected Outcome: This study aims to provide proof of principle data for cost effective surveillance of multiple pathogens in LMICs with the development of streamlined, integrated protocols. …”
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MAP kinase gene STK1 is required for hyphal, conidial, and appressorial development, toxin biosynthesis, pathogenicity, and hypertonic stress response in the plant pathogenic fungu... by Po LI, Xiao-dong GONG, Hui JIA, Yong-shan FAN, Yun-feng ZHANG, Zhi-yan CAO, Zhi-min HAO, Jian-min HAN, Shou-qin GU, Jin-gao DONG

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Pathogenicity of Klebsiella pneumonia (KpC4) infecting maize and mice by Min HUANG, Li LIN, Yi-xin WU, Ho Honhing, Peng-fei HE, Guo-zhi LI, Peng-bo HE, Guo-ru XIONG, Yuan YUAN, Yue-qiu HE

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Proper pandemic preparedness requires an integrated cross-regional effort, the case of the ECLIPSE consortium in America: a narrative review by Alejandro Bernardin, Tiago Masrour, Brooke Partridge, Alberto J. M. Martin, Alison Kelly, Tomas Perez-Acle

“…This paper focuses on three critical examples: Highly Pathogenic Avian Influenza (HPAI), Dengue Fever (DF), and Antimicrobial Resistance (AMR), emphasizing the importance of the One Health approach, which integrates human, animal, and environmental health strategies. …”
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Cross-feeding between beneficial and pathogenic bacteria to utilize eukaryotic host cell-derived sialic acids and bacteriophages shape the pathogen-host interface milieu by Darab Ghadimi, Regina Fölster-Holst, Sophia Blömer, Michael Ebsen, Christoph Röcken, Jumpei Uchiyama, Shigenobu Matsuzaki, Wilhelm Bockelmann

“…Under an inflamed-intestinal milieu, increased free sialic acids are associated with the overgrowth of some pathogenic bacterial strains. Recently, the protective immunomodulatory activity of gut bacteriophages (phages) has also been highlighted. …”
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Biosensor Technologies for Water Quality: Detection of Emerging Contaminants and Pathogens by Antía Fdez-Sanromán, Nuria Bernárdez-Rodas, Emilio Rosales, Marta Pazos, Elisa González-Romero, Maria Ángeles Sanromán

“…However, the primary focus is on their use in detecting contaminants and pathogens, as well as in environmental monitoring for water quality assessment. …”
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Electrochemical genosensors on-a-chip: Applications in early diagnosis of pathogens by A. Dehghan, M.J. Kiani, A. Gholizadeh, J. Aminizadeh, A. Rahi, I. Zare, E. Pishbin, H. Heli

“…Electrochemical genosensors have emerged as a powerful tool for the early diagnosis of pathogens, offering advantages such as high sensitivity, rapid response times, low cost, and easy adaptability for point-of-care applications. …”
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Advancing food security: The role of machine learning in pathogen detection by Helen Onyeaka, Adenike Akinsemolu, Taghi Miri, Nnabueze Darlington Nnaji, Clinton Emeka, Phemelo Tamasiga, Gu Pang, Zainab Al-sharify

“…Machine Learning (ML) has emerged as an important advancement in pathogen detection, particularly in the field of food safety. …”
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Integrating Nanopore MinION Sequencing into National Animal Health AMR Surveillance Programs: An Indonesian Pilot Study of Chicken Slaughterhouse Effluent and Rivers by Rallya Telussa, Puji Rahayu, Thufeil Yunindika, Curtis J. Kapsak, Kanti Puji Rahayu, Oli Susanti, Imron Suandy, Nuraini Triwijayanti, Aji B. Niasono, Syamsul Ma’arif, Hendra Wibawa, Lestari Lestari, Gunawan B. Utomo, Farida C. Zenal, Luuk Schoonman, Lee E. Voth-Gaeddert

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VdAHA1 positively regulate pathogenicity in Verticillium dahliae by Dongpo Li, Yuan Yuan, Jinglong Zhou, Jinglong Zhou, Zili Feng, Zili Feng, Feng Wei, Feng Wei, Heqin Zhu, Heqin Zhu, Lihong Zhao, Lihong Zhao, Hongjie Feng, Hongjie Feng, Yalin Zhang, Yalin Zhang

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Thermal Adaptation in Worldwide Collections of a Major Fungal Pathogen by Silvia Miñana-Posada, Cécile Lorrain, Bruce A. McDonald, Alice Feurtey

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Preliminary exploration of metagenomic sequencing for pathogenic identification in infectious uveitis by Jinxia Yu, Yane Gao, Hongsheng Bi, Youhua Zhang, Kai Tang, Dadong Guo, Xiaofeng Xie

“…Conclusions MGS holds significant value and promising potential in diagnosing infectious uveitis pathogens. However, it cannot completely replace the traditional diagnostic techniques and still needs to be integrated with conventional methods to enhance the sensitivity and specificity of pathogen detection. …”
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Paper-based analytical devices for smart foodborne pathogen detection by Hadeer M. Bedair, Mohamed Emara, Tamer M. Samir, Mahmoud A.F. Khalil, Shima Mahmoud Ali, Mahmoud Hamed, Fotouh R. Mansour

“…This review explores the advancements in paper-based analytical devices (PADs) as a practical, cost-effective, and portable solution for the detection of foodborne pathogens. Various detection platforms, including nucleic acid-based sensors, aptamer-integrated systems, Immunochromatographic assays, and nanoparticle-enhanced biosensors, are evaluated for their effectiveness in rapid and on-site testing. …”
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Editorial: Opportunistic pathogens: pathogenesis and multi-drug resistance mechanisms by Shicheng Chen, Lisheng Liao, Mingxi Wang

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Advancing vaccine technology through the manipulation of pathogenic and commensal bacteria by Khristine Kaith S. Lloren, Amal Senevirathne, John Hwa Lee

“…These bacteria can modulate immune responses, offering a promising avenue for developing effective and personalized vaccines. Integrating the distinctive characteristics of pathogenic and commensal bacteria with advanced bacterial engineering techniques paves the way for innovative vaccine and therapeutic platforms that could address a wide range of infectious diseases and potentially non-infectious conditions. …”
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A host-pathogen metabolic synchrony that facilitates disease tolerance by Ying-Tsun Chen, Gaurav Kumar Lohia, Samantha Chen, Zihua Liu, Tania Wong Fok Lung, Chu Wang, Sebastián A. Riquelme

“…Here we show, in a Pseudomonas aeruginosa pneumonia mouse model, that disease tolerance depends on the mitochondrial metabolite itaconate, which mediates cooperative host-pathogen interactions. In P. aeruginosa, itaconate modifies key cysteine residues in TCA cycle enzymes critical for succinate metabolism, inducing bioenergetic stress and promoting the formation biofilms that are less immunostimulatory and allow the bacteria to integrate into the local microbiome. …”
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Effects of Ire1 gene on virulence and pathogenicity of Candida albicans by Zhao Huihai, Qin Lixia, Li Mengyan, Jiang Mengyu, Cui Mengge, Wang Hua, Hou Baohua, Wang Fukun, Jia Keran

“…In mouse models, the deletion of Ire1 completely nullified the virulence and pathogenicity of C. albicans in the tail vein infection. …”
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Regulation of Ergosterol Biosynthesis in Pathogenic Fungi: Opportunities for Therapeutic Development by Lingyun Song, Sha Wang, Hang Zou, Xiaokang Yi, Shihan Jia, Rongpeng Li, Jinxing Song

“…Ergosterol plays a dual role in fungal pathogenesis and azole resistance, driving key advancements in the understanding of its biosynthesis regulation. This review integrates the latest research progress on the regulation of fungal ergosterol biosynthesis and its role in drug resistance and pathogenicity. …”
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