Stress Responses and Mechanisms of Phytopathogens Infecting Humans: Threats, Drivers, and Recommendations by Md. Motaher Hossain, Farjana Sultana, Mahabuba Mostafa, Humayra Ferdus, Mrinmoy Kundu, Shanta Adhikary, Nabela Akter, Ankita Saha, Md. Abdullah Al Sabbir

“…To address the complex threats posed by cross-kingdom phytopathogens, a comprehensive One Health approach that bridges plant, animal, and human health strategies is advocated. Integrating molecular surveillance, pathogen genomics, AI-powered predictive modeling, and global biosecurity initiatives is essential to detect, monitor, and mitigate cross-kingdom infections. …”
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Diosgenin producing Bacillus sp. strain IRMC27M2 as a genome-mined weapon against multidrug-resistant Candidozyma (Candida) auris by Rahaf Alquwaie, Noor B. Almandil, Reem AlJindan, Nehal Mahmoud, Sarah Almofty, Dana Almohazey, Hoor Hashim Alqudihi, Sarah Hunachagi, Tharmathass Stalin Dhas, P. Sowmiya, Sayed AbdulAzeez, J. Francis Borgio

“…Candidozyma auris (Candida auris) is an emerging multidrug-resistant (MDR) fungal pathogen prioritised by the World Health Organisation that poses a significant global health threat due to high mortality. …”
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Integrated analyses of the transmission history of SARS-CoV-2 and its association with molecular evolution of the virus underlining the pandemic outbreaks in Italy, 2019-2023 by Eleonora Cella, Vagner Fonseca, Francesco Branda, Stephane Tosta, Keldenn Moreno, Gabriel Schuab, Sobur Ali, Svetoslav Nanev Slavov, Fabio Scarpa, Luciane Amorim Santos, Simone Kashima, Eduan Wilkinson, Houriiyah Tegally, Carla Mavian, Alessandra Borsetti, Francesca Caccuri, Marco Salemi, Tulio de Oliveira, Taj Azarian, Ana Maria Bispo de Filippis, Luiz Carlos Junior Alcantara, Giancarlo Ceccarelli, Arnaldo Caruso, Vittorio Colizzi, Alessandro Marcello, José Lourenço, Massimo Ciccozzi, Marta Giovanetti

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Lyophyllum decastes-derived polysaccharides alleviate DSS-induced colitis in mice by suppressing inflammation, enhancing intestinal barrier integrity, and restoring gut microbiota... by Eslam Ghaleb, Yamina Alioui, Jamalat Yazeed, Natheer Wahan, Ahmed Bashah, Ali AL-waqeerah, Aamna Atta, Yuxin Sun, Yi Xin, Liang Wang, Bin Feng, Weifeng Mao

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Performance of dispatcher-assisted cardiopulmonary resuscitation integrating with mouth-and-nose covering instructions during the COVID-19 pandemic: a population-based retrospectiv... by Hideki Asai, Hidetada Fukushima, Yasuyuki Kawai, Keita Miyazaki, Kouji Yamamoto, Arisa Kinoshita, Hirozumi Okuda

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A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1). by Rohina Rubicz, Robert Yolken, Eugene Drigalenko, Melanie A Carless, Thomas D Dyer, Lara Bauman, Phillip E Melton, Jack W Kent, John B Harley, Joanne E Curran, Matthew P Johnson, Shelley A Cole, Laura Almasy, Eric K Moses, Nikhil V Dhurandhar, Ellen Kraig, John Blangero, Charles T Leach, Harald H H Göring

“…Although EBV has been the focus of extensive research, much still remains unknown concerning what makes some individuals more sensitive to infection and to adverse outcomes as a result of infection. Here we use an integrative genomics approach in order to localize genetic factors influencing levels of Epstein Barr virus (EBV) nuclear antigen-1 (EBNA-1) IgG antibodies, as a measure of history of infection with this pathogen, in large Mexican American families. …”
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Chikungunya virus drives gut microbiota shifts and IFN-Mediated intestinal repair: insights into microbiota-immune interplay by Hongyu Chen, Kaiyun Ding, Cong Tang, Jingwen Xu, Fengyuan Zhang, Yao Yan, Bai Li, Yanan Zhou, Yun Yang, Hao Yang, Qing Huang, Wenhai Yu, Haixuan Wang, Daoju Wu, Shuaiyao Lu, Hongqi Liu

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Revealing the Immune Response of <i>Sitona callosus</i> Gyllenhal to Entomopathogenic Fungi <i>Beauveria bassiana</i> Infection Through Integrative Analyses of Transcriptomics and... by Nan Li, Xin Gu, Ming Xin, Xinpu Wang

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Integrated analysis of transcriptomics and metabolomics and high-throughput amplicon sequencing reveals the synergistic effects of secondary metabolites and rhizosphere microbiota... by Li Yingtao, Li Qiaofeng, Wang Lijuan, Qi Shuyun, Jiang Zhou, Zhang Wenping, Zhang Aili

“…Therefore, we conclude that these secondary metabolites may could resist pathogen invasion directly or serve as an “intermediate medium” to recruit growth-promoting microorganisms to resistant the root rot. …”
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Metabolome integrated with transcriptome, and genome analysis revealed higher accumulations of phytoalexins enhance resistance against Magnaporthe oryzae in new Zhefang rice variet... by Owais Iqbal, Xingrun Yang, Ruoping Wang, Chun Wang, Dandan Li, Jiancheng Wen, Jiasheng Ding, Sauban Musa Jibril, Chengyun Li, Yi Wang

“…Abstract Background Magnaporthe oryzae is one of the most devastating pathogens of rice, causing significant economic losses worldwide. …”
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Traditional Chinese medicine as a promising choice for future control of PEDV by Conghao Ji, Shuxuan Li, Cunhai Hu, Tongtong Liu, Qingqing Huang, Mengyuan Yang, Mengxin Yang, Qianqian Wang, Aifang Li, Dandan Guo, Yu Huang, Sugai Yin, Shuying Feng

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Sow reproductive disorders: a key issue affecting the pig industry by Yihan Wang, Youshun Jin, Yanyan Wang, Yunhui Li, Yunhui Li, Xiaoxue Wang, Xiaoxue Wang, Zhaocai Li, Jizhang Zhou

“…We also outline preventive and control strategies, alongside integrated management approaches, by analyzing the underlying causes and pathogenic mechanisms of pregnancy disorders. …”
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Bacterial extracellular vesicles for gut microbiome–host communication and drug development by Dingfei Qian, Peijun Xu, Xinwei Wang, Chong Du, Xiao Zhao, Jiaqi Xu

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ERA-CRISPR/Cas12a-based, fast and specific diagnostic detection for Chlamydia pneumoniae by Yanxia Zhou, Zijun Yan, Shi Zhou, Weiwei Li, Hongyu Yang, Hongliang Chen, Zhongliang Deng, Qilin Zeng, Peiyuan Sun, Yimou Wu

“…Chlamydia pneumoniae (C. pneumoniae) is a specialized intracellular parasitic pathogen capable of causing pneumonia, sinusitis, bronchitis, and other respiratory diseases, which pose significant public health challenges. …”
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An integrated machine learning model of transcriptomic genes in multi-center chronic obstructive pulmonary disease reveals the causal role of TIMP4 in airway epithelial cell by Erkang Yi, Haiqing Li, Yu Liu, Qingyang Li, Chengshu Xie, Ruining Sun, Fan Wu, Zhishan Deng, Kunning Zhou, Hairong Wang, Xinru Ran, Yumin Zhou, Pixin Ran

“…Identifying a core set of genes consistently involved in COPD pathogenesis, independent of patient variability, is essential. Methods We integrated lung tissue sequencing data from patients with COPD across two centers. …”
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Integrative analysis identifies IL-6/JUN/MMP-9 pathway destroyed blood-brain-barrier in autism mice via machine learning and bioinformatic analysis by Cong Hu, Heli Li, Jinru Cui, Yunjie Li, Feiyan Zhang, Hao Li, Xiaoping Luo, Yan Hao

“…Growing evidence implicates neuroinflammation-induced blood-brain barrier (BBB) dysfunction as a key pathogenic mechanism in ASD, although the underlying molecular pathways remain poorly understood. …”
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Use of integrated genomic surveillance by local public health authorities: Recommendations based on a mixed-methods study of current adoption, applications and success factors, Ger... by Simone Scheithauer

“…Background Integrated genomic surveillance (IGS), i.e. the integrated analysis of pathogen whole genome sequencing and classical epidemiological data, can contribute substantially to the disease surveillance and infection prevention activities of local public health authorities (LPHAs). …”
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The Arabidopsis leucine-rich repeat receptor kinase MIK2/LRR-KISS connects cell wall integrity sensing, root growth and response to abiotic and biotic stresses. by Dieuwertje Van der Does, Freddy Boutrot, Timo Engelsdorf, Jack Rhodes, Joseph F McKenna, Samantha Vernhettes, Iko Koevoets, Nico Tintor, Manikandan Veerabagu, Eva Miedes, Cécile Segonzac, Milena Roux, Alice S Breda, Christian S Hardtke, Antonio Molina, Martijn Rep, Christa Testerink, Grégory Mouille, Herman Höfte, Thorsten Hamann, Cyril Zipfel

“…Finally, we found that MIK2 is required for resistance to the fungal root pathogen Fusarium oxysporum. Together, our data identify MIK2 as a novel component in cell wall integrity sensing and suggest that MIK2 is a nexus linking cell wall integrity sensing to growth and environmental cues.…”
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Characterization of the small RNAs carried by outer membrane vesicles produced by hlyF-positive Shiga toxin-producing Escherichia coli by Giorgia Barbieri, Giorgia Barbieri, Alessia Stefano, Agostina Pietrantoni, Federica Fratini, Serena Cavallero, Rosangela Tozzoli, Paola Chiani, Arianna Boni, Stefano Morabito, Valeria Michelacci

“…Shiga toxin (Stx)–producing Escherichia coli (STEC) harboring virulence determinants of Extraintestinal pathogenic E. coli (ExPEC) are currently emerging in Europe as a cause of severe disease. …”
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Function of B8N6S4 in Regulating the Growth and Aflatoxin B1 Biosynthesis of Aspergillus flavus by Xinze ZHANG, Ruisi PU, Jinlu NIU, Wenjie HUANG, Shijuan YAN, Wenyang ZHANG, Shaowen WU

“…Δ B8N6S4 does not directly affect the pathogenicity of A. flavus but significantly enhances its AFB1 production capacity. …”
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