An integrative analysis of functional consequences of PKD2 missense variants on RNA and protein structures: a computational approach by Chandra Devi, Prashant Ranjan, Parimal Das

“…It lays the groundwork in identifying high-impact variants in terms of pathogenicity and prioritizing these for further implications in understanding disease heterogeneity and eventually contributing to the development of targeted therapeutic interventions for ADPKD. …”
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The importance of genotyping within the climate-smart plant breeding value chain – integrative tools for genetic enhancement programs by Ana Luísa Garcia-Oliveira, Rodomiro Ortiz, Fatma Sarsu, Søren K. Rasmussen, Paterne Agre, Asrat Asfaw, Moctar Kante, Subhash Chander

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An integrative taxonomic approach reveals two putatively novel species of phlebotomine sand fly (Diptera: Psychodidae) in Thailand by Samiullah Soomro, Siwaporn Tuangpermsub, Thongchai Ngamprasertwong, Morakot Kaewthamasorn

“…Abstract Background The subfamily Phlebotominae comprises 1028 species of sand fly, of which only 90 are recognized as vectors of pathogenic agents such as Trypanosoma, Leishmania, and Bartonella. …”
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An integrated proteomics approach identifies phosphorylation sites on viral and host proteins that regulate West Nile virus infection by Zachary Walter, Minghua Li, Melissa Molho, Lauren Berish, Andrew Isopi, Mary O’Mara, Mark Dittmar, Chike Nwaezeapu, Alicia Richards, Martin McCullagh, Nevan J. Krogan, Sara Cherry, Jeffrey R. Johnson, Holly Ramage

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Integrative multi-omics investigation of sleep apnea: gut microbiome metabolomics, proteomics and phenome-wide association study by Shuxu Wei, Ronghuai Shen, Xiaojia Lu, Xinyi Li, Lingbin He, Youti Zhang, Xianxi Huang, Zhouwu Shu

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Integrated oral-gut microbiota therapy: a novel perspective on preventing bacterial translocation for systemic disease management by Jie Zhu, Ziyi Jiang, Fangli Yu, Linglin Gao, Xiaomei Wang, Qiang Wang

“…It particularly highlights the translational value of integrating oral and gut microbiota research, offering novel insights for the prevention and precision treatment of systemic disorders. …”
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Potassium silicate in the management of anthracnose in post-harvest bananas by Thaylla Caproni Ribeiro, Lucas Campos Dozza, Wesley Felipe Correia, Natália Moreira Mafra, Dalilla Carvalho Rezende

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Integrative single-cell and metagenomic analysis dissects SARS-CoV-2 shedding modes in human respiratory tract by Xiangxing Jin, Lili Ren, Xianwen Ren, Jianwei Wang

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Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model. by Lorenz Loyola, Vasudevan Achuthan, Kathryn Gilroy, Gillian Borland, Anna Kilbey, Nancy Mackay, Margaret Bell, Jodie Hay, Sriram Aiyer, Dylan Fingerman, Rodrigo A Villanueva, Ewan Cameron, Christine A Kozak, Alan N Engelman, James Neil, Monica J Roth

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Integrated Transcriptomic and Metabolomic Analyses Reveal the Importance of the Terpenoid, Fatty Acid, and Flavonoid Pathways in Rice Cell Death and Defense by Pengfei Bai, Yanfang Liu, Laisa Gomes-Dias, Rachel Combs-Giroir, Shaoxing Dai, Naeyeoung Choi, Yun Lin, Matthew Bernier, Emmanuel Hatzakis, Guo-Liang Wang, Joshua J. Blakeslee

“…Lesion mimic mutants provide unique tools to investigate plant–pathogen interactions, often exhibiting hypersensitive responses in the absence of biotic or abiotic stresses. …”
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A New Composite Integrative and Conjugative Element Mediates Multiple Drug Resistance from Streptococcus anginosus to Streptococcus agalactiae by Wang Y, Liu T, Yi S, Zhu Y

“…In addition, its transfer to the major pathogen Streptococcus agalactiae was characterized and proved. …”
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The Clinical Validity and Utility of PCR Compared to Conventional Culture and Sensitivity Testing for the Management of Complicated Urinary Tract Infections in Adults: A Secondary... by Moustafa Kardjadj, Tara W. Chang, Roel Chavez, DeAndre Derrick, Frank L. Spangler, Itoe P. Priestly, Lauren Y. Park, Thomas K. Huard

“…Clinical success in treating complicated urinary tract infections (cUTIs) depends on accurate pathogen detection, given the common occurrence of polymicrobial infections and antimicrobial resistance. …”
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The interdomain linker of AAV-2 Rep68 is an integral part of its oligomerization domain: role of a conserved SF3 helicase residue in oligomerization. by Francisco Zarate-Perez, Martino Bardelli, John W Burgner, Maria Villamil-Jarauta, Kanni Das, Demet Kekilli, Jorge Mansilla-Soto, R Michael Linden, Carlos R Escalante

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Integrative analysis of RNA-Seq data and machine learning approaches to identify Biomarkers for Rhizoctonia solani resistance in sugar beet by Bahman Panahi, Mahdi Hassani, Nahid Hosseinzaeh Gharajeh

“…Rhizoctonia solani is a significant pathogen that causes crown and root rot in sugar beet (Beta vulgaris), leading to considerable yield losses. …”
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Unveiling Ventilator-Associated Pneumonia: S100A8 as a Promising Biomarker Through Integrated RNA-Seq Analysis by Wang Q, Dong J, Jing X, Long Y, Jia H, Li Y, Wang J

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Integrated Transcriptomic and Proteomic Analyses Reveal CsrA-Mediated Regulation of Virulence and Metabolism in <i>Vibrio alginolyticus</i> by Bing Liu, Huizhen Chen, Kai Sheng, Jianxiang Fang, Ying Zhang, Chang Chen

“…<i>Vibrio alginolyticus</i>, a common Gram-negative opportunistic pathogen of marine animals and humans, is known for its rapid growth in organic-matter-rich environments. …”
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Integrative transcriptome and WGCNA analysis reveal key genes mainly in response to Alternaria alternata in Populus simonii × P. nigra by Siyuan Liu, Siyuan Liu, Siyuan Liu, Lijuan Dai, Guanzheng Qu, Xinming Lu, Hong Pan, Xiaoyu Fu, Airong Dong, Airong Dong, Libin Yang

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Identification and validation of diagnostic biomarkers and immune cell abundance characteristics in Staphylococcus aureus bloodstream infection by integrative bioinformatics analys... by Junhong Shi, Li Shen, Yanghua Xiao, Cailing Wan, Bingjie Wang, Peiyao Zhou, Jiao Zhang, Weihua Han, Rongrong Hu, Fangyou Yu, Hongxiu Wang

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Generation of a human induced pluripotent stem cell line (CRICKi021-A) from a patient with Ullrich congenital muscular dystrophy carrying a pathogenic mutation in the COL6A1 gene by Yunsong Jiang, Liani G. Devito, Francesco Muntoni, Lyn Healy, Francesco Saverio Tedesco

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Multi-omics integration and immune profiling identify possible causal networks leading to uterine microbiome dysbiosis in dairy cows that develop metritis by S. Casaro, J. G. Prim, T. D. Gonzalez, F. Cunha, A. C. M. Silva, H. Yu, R. S. Bisinotto, R. C. Chebel, J. E. P. Santos, C. D. Nelson, S. J. Jeon, R. C. Bicalho, J. P. Driver, Klibs N. Galvão

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