Integrated Analysis of Cuproptosis Regulators Reveals Prognostic Significance and Therapeutic Targets in IDH1 Mutant Glioma by Yuxuan Luan, Yong Meng, Chunming Sun, Ruixin Wu, Qimeng Chang, Yilin Wang, Minfeng Shu

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Sustainable management of soil-borne disease: integrating fumigation with Andrographis paniculata residues to rebuild rhizosphere function by Xiangqin Xu, Deqiang Qin, Xiaoping Qin, Xi Gao, Chunhong Li, Xiaowen Liu, Guoxing Wu

“…While single fumigation (W1, M1) transiently suppressed pathogens, it disrupted rhizosphere metabolic homeostasis. …”
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An integrated approach to improve plant protection against olive anthracnose caused by the Colletotrichum acutatum species complex. by Stefanos Kolainis, Anastasia Koletti, Maira Lykogianni, Dimitra Karamanou, Danai Gkizi, Sotirios E Tjamos, Antonios Paraskeuopoulos, Konstantinos A Aliferis

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Exploring the comorbidity mechanisms of ITGB2 in rheumatoid arthritis and membranous nephropathy through integrated bioinformatics analysis by Wenlong Cao, Yuqin Wang, Jing Xiong

“…ITGB2 was finally identified as the shared pathogenic gene of both RA and MN. ITGB2 was predominantly expressed in macrophages, and its expression increased as M0 macrophages differentiated into M1 macrophages. …”
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Genomics and integrative clinical data machine learning scoring model to ascertain likely Lynch syndrome patients by Ramadhani Chambuso, Takudzwa Nyasha Musarurwa, Alessandro Pietro Aldera, Armin Deffur, Hayli Geffen, Douglas Perkins, Raj Ramesar

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Extracellular DNA is essential for maintaining Bordetella biofilm integrity on abiotic surfaces and in the upper respiratory tract of mice. by Matt S Conover, Meenu Mishra, Rajendar Deora

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Mycobacterium tuberculosis PhoP integrates stress response to intracellular survival by regulating cAMP level by Hina Khan, Partha Paul, Harsh Goar, Bhanwar Bamniya, Navin Baid, Dibyendu Sarkar

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Identification of novel drug targets through integrative PWAS of brain and plasma proteins with Ulcerative Colitis GWAS. by Ningning Liu, Yi Hou, Miao Yu, Gaihong Liu, Yingxue Xu, Qiang Jiang, Dongli Wang, Lianzhu Wang, Yujie Zhao

“…Previous genome-wide association studies (GWAS) have identified various risk variants for ulcerative colitis (UC), but there is a lack of evidence showing how these variants contribute to the development of UC. We employed an integrated pipeline to effectively translate genetic associations in order to identify pathogenic genes for UC.By combining GWAS data for UC with proteomic data from the human brain and plasma, we conducted a protein-wide association study (PWAS) and utilized protein-protein interaction (PPI) network analysis to screen for potential key proteins. …”
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Unlocking precision medicine: clinical applications of integrating health records, genetics, and immunology through artificial intelligence by Yi-Ming Chen, Tzu-Hung Hsiao, Ching-Heng Lin, Yang C. Fann

“…Abstract Artificial intelligence (AI) has emerged as a transformative force in precision medicine, revolutionizing the integration and analysis of health records, genetics, and immunology data. …”
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Integrating respiratory microbiome and host immune response through machine learning for respiratory tract infection diagnosis by Hongbin Chen, Tianqi Qi, Siyu Guo, Xiaoyang Zhang, Minghua Zhan, Si Liu, Yuyao Yin, Yifan Guo, Yawei Zhang, Chunjiang Zhao, Xiaojuan Wang, Hui Wang

“…This study suggests that the model integrating LRTM and host transcriptome data can be an effective tool for LRTIs diagnosis.…”
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Post-pandemic surveillance of SARS-CoV-2 in wastewater bodies using integrated molecular analysis by Gayatri Gogoi, Rashmi Rani Boro, Sarangthem Dinamani Singh, Emon Kalyan, Akib Ali, Keshab Nath, Hridoy Jyoti Mahanta, Pankaj Bharali

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Advances in Hydrogel-Integrated SERS Platforms: Innovations, Applications, Challenges, and Future Prospects in Food Safety Detection by Xorlali Nunekpeku, Huanhuan Li, Ayesha Zahid, Chenhui Li, Wei Zhang

“…<i>Background</i>: Food safety remains a global concern due to biological and chemical contaminants, including adulterants, pathogens, antibiotic residues, and pesticides. Traditional detection methods are accurate but limited by time requirements, complex sample preparation, high costs, and poor field applicability. …”
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Meningoencephalitis in a background of inherited chromosomic integration of HHV-6 and CMV infection in an immunocompetent adult, which one is the culprit? by Anne-Laure Lajoye, Doina Ciocanu, Gilles Duverlie, Patrick Berquin

“…The presence of circulating anti-CMV IgM and IgG in a serologic test and the absence of other pathogens argued in favor of a primary CMV infection. …”
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Integrated bioinformatics analysis of biomarkers and pathways to explore the mechanisms and molecular targets related to allergic rhinitis and pyroptosis by Mingai You, Fangrui Liu, Youshijie Cai, Guodong Yu

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Integrative miRNA-mRNA profiling uncovers mechanisms of belimumab action in systemic lupus erythematosus by Maria Royo, Blanca Joseph-Mullol, Sebastian Sandoval, Teresa Moliné, Cristina Solé, Josefina Cortés-Hernández

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Thermoplastic Zinc-Infused Polymer for Chairside Socket Seal Abutments Enhances Antimicrobial and Tissue-Integrative Properties by Wannes Van Holm, Katleen Vandamme, Jill Hadisurya, Ferda Pamuk, Naiera Zayed, Merve Kübra Aktan, Annabel Braem, Andy Temmerman, Wim Teughels

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Integrative Bioinformatics Analysis Unravel the Association between Intracerebral Hemorrhage and Cellular Apoptosis through Immune Infiltration by Pandi Chen, Gengfan Ye, Jia Li, Kuan Feng, Guangyao Zhu, Maosong Chen, Wei Chen

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Digital traceability in horticulture: a systematic review of edge-cloud-blockchain-terminal (ECBT) integration with IoT and AI technologies by Yan Huang, Xin Li, Luyi Xu, Yongqiang Ma

“…Global horticultural supply chains face escalating vulnerabilities from pathogenic outbreaks, climate disruptions, and regulatory demands. …”
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MiRNA-mRNA integration analysis of three continuous embryonic stages of Chinese horseshoe crab Tachypleus tridentatus by Yunfan Huang, Ying Qiao, Shengping Zhong, Xingzhi Zhang, Menghong Hu, Kityue Kwan, Theerakamol Pengsakul, Jiasen Guo, Xuyang Chen, Xiaowan Ma, Qiongzhen Li

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MXene-Based Electrochemical Biosensors: Advancing Detection Strategies for Biosensing (2020–2024) by Joydip Sengupta, Chaudhery Mustansar Hussain

“…These unique properties enable high sensitivity, rapid response, and versatile functionalization, making MXene-based biosensors highly suitable for detecting biomolecules and pathogens in biomedical applications. This review explores recent advancements in MXene-based electrochemical biosensors from 2020 to 2024, focusing on their design principles, fabrication strategies, and integration with microfluidic platforms for enhanced performance. …”
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