Next-Generation Vaccine Platforms: Integrating Synthetic Biology, Nanotechnology, and Systems Immunology for Improved Immunogenicity by Majid Eslami, Bahram Fadaee Dowlat, Shayan Yaghmayee, Anoosha Habibian, Saeedeh Keshavarzi, Valentyn Oksenych, Ramtin Naderian

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Integrated metagenomics and transcriptomics analysis reveals pathways associated with oral periapical lesions formation and progression by Alaa Muayad Altaie, Thenmozhi Venkatachalam, Kiran Patil, Farah Al-Marzooq, Surendra Singh Rawat, Ali Al Qabbani, Mohammed Amjed Alsaegh, Lakshman P. Samaranayake, Sameh S.M. Soliman, Rifat Hamoudi

“…The sequences of the most abundant bacteria were then analyzed to identify secondary metabolites, pathogenic proteins, and their associated metabolic pathways. …”
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Integrated Bioinformatics Analysis Identifies ELAVL1 and APP as Candidate Crucial Genes for Crohn’s Disease by Heli Li, Qianru Li, Shiran Sun, Ping Lei, Xiong Cai, Guanxin Shen

“…Immune imbalance and barrier destruction of intestinal mucosa are the central pathogenic factors of Crohn’s disease (CD). In this study, three independent microarray studies of CD were integrated and 9912 differentially expressed genes (DEGs) were analysed by NetworkAnalyst to screen candidate crucial genes. …”
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Species classification of Tabanus (Diptera: Tabanidae) in Western Thailand: Integrating DNA barcoding and modern morphometrics by Tanasak Changbunjong, Thekhawet Weluwanarak, Sedthapong Laojun, Tanawat Chaiphongpachara

“…The species of Tabanus, commonly known as horse flies, are remarkable ectoparasites capable of transmitting various pathogens to animals and humans. Given their role in disease transmission, accurate identification of horse fly species is critical but traditionally relies on morphological characteristics, requiring significant expertise and posing a high potential for error, especially with damaged specimens. …”
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Integrated serological surveillance for neglected tropical diseases, vaccine-preventable diseases, and arboviruses in Samoa, 2018 by Harriet L. S. Lawford, Helen J. Mayfield, Filipina Amosa-Lei Sam, Satupaitea Viali, Tito Kamu, Robert Thomsen, Colleen L. Lau

“…Using MBA, dried blood spots were assayed for antibodies (Ab) from 10 pathogens: LF, trachoma, yaws, tetanus, diphtheria, rubella, measles, dengue, Zika, and chikungunya. …”
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Integrated prognostic assessment of apoptosis and chemotherapy related gene in bladder cancer: a prognostic signature by Keyuan Zhao, Gang Xu, Jing Jin, Chao Peng, Jiajun Chen, Yulei Li, Weihao Wang, Shouhua Pan

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Integrated multi-omics reveals metabolic determinants of CRAB ST2 airway infection progression by DingYun Feng, JianXia Zhou, Logen Liu, Ying Li, RongHua Zhong, WenBin Wu, WenZheng Zheng, TianTuo Zhang

“…This work advances our understanding of CRAB pathogenicity and offers a novel, metabolism-based strategy to improve diagnostic accuracy, guide targeted therapies, and optimize antimicrobial stewardship in managing CRAB-associated respiratory infections.…”
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Network-based data integration for selecting candidate virulence associated proteins in the cereal infecting fungus Fusarium graminearum. by Artem Lysenko, Martin Urban, Laura Bennett, Sophia Tsoka, Elzbieta Janowska-Sejda, Chris J Rawlings, Kim E Hammond-Kosack, Mansoor Saqi

“…The analysis of already verified virulence genes in phytopathogenic fungi in the context of integrated functional networks can give clues about the underlying mechanisms and pathways directly or indirectly linked to fungal pathogenicity and can suggest new candidates for further experimental investigation, using a 'guilt by association' approach. …”
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Microfluidic Biosensors: Enabling Advanced Disease Detection by Siyue Wang, Xiaotian Guan, Shuqing Sun

“…Microfluidic biosensors integrate microfluidic and biosensing technologies to achieve the miniaturization, integration, and automation of disease diagnosis, and show great potential for application in the fields of cancer liquid biopsy, pathogenic bacteria detection, and POCT. …”
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Coronoidectomy for Alleviating Restricted Mouth Opening in Masticatory Muscle Tendon-Aponeurosis Hyperplasia: Integration With Genetic Mutation Analysis by Hongrong Zhang, Weihong Wang, Liang Wen

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Molecular mechanism of bisphenols induction of breast cancer through PGR revealed by network toxicology and transcriptomics integration analysis by Baowen Yuan, Yu Li, Jinyuan Chang, Chang Guo, Wei Huang, Yan Wang

“…This study offers a theoretical basis for disease prevention and control besides providing a new perspective on the pathogenic mechanism of environmental pollutants. It also promotes the application of the integrated research strategy of network toxicology, bioinformatics, and molecular docking technology in environmental pollutants research.…”
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Improving Lunar Soil Simulant for Plant Cultivation: Earthworm-Mediated Organic Waste Integration and Plant-Microbe Interactions by Zhongfu Wang, Sihan Hou, Boyang Liao, Zhikai Yao, Yuting Zhu, Hong Liu, Jiajie Feng

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Mouse papillomavirus type 1 (MmuPV1) DNA is frequently integrated in benign tumors by microhomology-mediated end-joining. by Lulu Yu, Vladimir Majerciak, Xiang-Yang Xue, Aayushi Uberoi, Aayushi Uberoi, Alexei Lobanov, Xiongfong Chen, Maggie Cam, Stephen H Hughes, Paul F Lambert, Zhi-Ming Zheng

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Temporally integrated single cell RNA sequencing analysis of PBMC from experimental and natural primary human DENV-1 infections. by Adam T Waickman, Heather Friberg, Gregory D Gromowski, Wiriya Rutvisuttinunt, Tao Li, Hayden Siegfried, Kaitlin Victor, Michael K McCracken, Stefan Fernandez, Anon Srikiatkhachorn, Damon Ellison, Richard G Jarman, Stephen J Thomas, Alan L Rothman, Timothy Endy, Jeffrey R Currier

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Integrative Taxonomy of Didymozoids Parasitizing <i>Thunnus obesus</i> (Scombridae) from Southwest Atlantic Ocean: A New Genus and Species by Yuri C. Meneses, Marcia C. N. Justo, Ana Maria Moreira-Silva, Lorrayne S. S. de Brito, Alena M. Iñiguez, Simone C. Cohen

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Goblet cell breakdown: transcriptomics reveals Acinetobacter baumannii early and robust inflammatory response in differentiated human bronchial epithelial cells by Daniela Scribano, Claudia Tito, Astri D. Tagueha, Martina Pasqua, Luciana De Angelis, Francesco Fazi, Dolores Limongi, Marta De Angelis, Lucia Nencioni, Anna Teresa Palamara, Cecilia Ambrosi

“…However, in the last years, pneumonia caused by the opportunistic pathogen Acinetobacter baumannii have become difficult to treat due to the increase of the number of extensively drug resistant strains. …”
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Current condition of immune response types by D. A. Sizov, N. Yu. Rukina

“…The concept of a pathogen of recognizing receptors is disclosed, their interaction and activation is shown for various types of pathogens. …”
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HRP-integrated CRISPR-Cas12a biosensor for rapid point-of-care detection of Langya henipavirus by Xuan Wu, Rong Xiang, Danting Yang, Xiaoyao He, Lu Zhu, Fangfang Sun, Hanqing Li, Ningning Pi, Yi Li

“…Summary: Global pandemic has emphasized the needs for advanced pathogen diagnosis in dealing with newly emerged infectious threats, including the Langya henipavirus (LayV). …”
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Genome sequencing of a novel Verticillium dahliae strain (huangweibingjun) by Vincent Ninkuu, Zhixin Liu, Hao Liu, Chunyang Li, Yaping Zhou, Qianli Zhao, Aizhi Qin, Mengfan Li, Peibo Gao, Lulu Yan, Xiao Song, Luyao Kong, Yajie Xie, Enzhi Guo, Xuwu Sun

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The 16SrXII-P Phytoplasma GOE Is Separated from Other Stolbur Phytoplasmas by Key Genomic Features by Rafael Toth, Bruno Huettel, Mark Varrelmann, Michael Kube

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