Dissecting the Cellular Heterogeneity Underlying Liver Diseases Through the Integration of GWASs and Single-Cell RNA Sequencing by Miao Zhou, Meng Liu, Chao Xue

“…Our study provides a refined cellular map of liver disease susceptibility, offering new perspectives for understanding pathogenic mechanisms and informing targeted therapeutic strategies.…”
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Integration of chromosome conformation and gene expression networks reveals regulatory mechanisms in triple negative breast cancer by Helena Reyes-Gopar, Helena Reyes-Gopar, Helena Reyes-Gopar, Keila Adonai Pérez-Fuentes, Matthew L. Bendall, Enrique Hernández-Lemus, Enrique Hernández-Lemus

“…We hypothesized that new insights into pathogenic mechanisms in TNBC can be obtained from studying epigenetic alterations through Hi-C (genome-wide chromosome conformation capture) data analysis.MethodsWe developed a computational strategy that captured key properties of chromatin conformation while incorporating statistical measures of interaction significance. …”
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Integration of multi-omics transcriptome-wide analysis for the identification of novel therapeutic drug targets in diabetic retinopathy by Guoguo Yi, Zhengran Li, Yuxin Sun, Xinyu Ma, Zijin Wang, Jinken Chen, Dong Cai, Ziran Zhang, Zejun Chen, Fanye Wu, Mingzhe Cao, Min Fu

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Ecologically expanding the One Health framework to unify the microbiome sciences by Nichole Ginnan, Sharifa G. Crandall, Madangchanok Imchen, Francisco Dini-Andreote, Tim I. Miyashiro, Vishal Singh, Erika Ganda, Seth R. Bordenstein

“…ABSTRACT The One Health framework, traditionally focused on microbial threats, needs a bold expansion to include the full breadth of microbial diversity—from pathogenic to beneficial—within its ecological and evolutionary context. …”
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Potential antibacterial effects and transcriptomic analysis of a novel reversible photoacid-based crystalline coordination polymer by Chenhua Zheng, Yaying Zheng, Binjie Wu, Yuyan Zheng, Shuye Yu, Rui Qiu, Wanling Chen, Xin Chen, Longze Li, Jianzhen Liao, Fen Hu

“…IntroductionWith the increasing prevalence of antibiotic resistance, the development of novel antibacterial materials is crucial to combat clinically relevant pathogens. This study comprehensively investigated the antibacterial properties and underlying mechanisms of a novel reversible photoacid-based crystalline material.MethodsThe antibacterial efficacy of the material was evaluated against six clinically relevant pathogenic bacteria, including multidrug-resistant strains. …”
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High parasite prevalence driven by the human-animal-environment interface: a One Health study in an urban area in southern of Chile by Daniel Sanhueza Teneo, Omar Cerna, Cédric B. Chesnais, David Cárdenas, Paula Camus

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A One Health approach to the prevention, control, and management of leptospirosis: a scoping review by Khristine L. Sandoval, Kristel Joy S. Cada, Rodel Victor D. Dimasin, Ryan V. Labana

“…It also emphasizes the importance of interdisciplinary collaboration and integrated approaches to effectively address the complex challenges posed by this infectious disease. …”
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Functional characterization of cutinase genes NsCut1-NsCut4 in Neostagonosporella sichuanensis and their effects on fishscale bamboo by Mengyao Lu, Mengyao Lu, Fang Liang, Fang Liang, Lijuan Liu, Lijuan Liu, Yanji Yin, Yanji Yin, Dongxin Xu, Dongxin Xu, Huan Zou, Huan Zou, Yinggao Liu, Yinggao Liu, Chunlin Yang, Chunlin Yang

“…Notably, ΔNsCut1 and ΔNsCut3 resulted in reduced pigmentation, decreased spore production, and increased sensitivity to NaCl, H2O2, and Congo red, along with reduced pathogenicity—indicating that these genes play key roles in metabolic and reproductive processes, oxidative stress responses, and the maintenance of cell wall integrity. …”
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Diversity of Alternaria‐derived toxins and their toxicodynamic and toxicokinetic characteristics in the food chain by Sarfaraz Hussain, Aqleem Abbas, Maratab Ali, Israt Jahan, Muhammad Jabran, Muhammad Afaq Ahmed, Zienab F. R. Ahmed, Xinhua Zhang

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The complete genome sequence of “Candidatus Liberibacter asiaticus” strain 9PA and the characterization of field strains in the Brazilian citriculture by Michele F. S. Dutra, Priscila A. Silva, Jianchi Chen, Nelson A. Wulff

“…The 9PA strain has prophage P-9PA-1, both integrated and circularized, and P-9PA-3, only found in a circularized form. …”
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Tinea capitis in Hainan: a prospective study by Wenai Zheng, Feng Qiao, Xianxu Yang, Xiaozheng Tang, Changyan Lin, Qin Chen, Zhaobing Pan, Rongqiang Chen

“…Data on demographic characteristics, exposure history, and clinical manifestations ​were systematically collated​ using standardized case report forms. Pathogen subtyping ​was performed via​ integrated morphological identification ​supplemented by​ molecular biological analysis of the ITS region.ResultsAmong 76 enrolled patients, minors (≤15 years) ​accounted for​ 80.26% (61/76), with ≤10-year-olds ​representing​ 91.8% (56/61) of pediatric cases. …”
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Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis. by Madushi Wanaguru, David J Barry, Donald J Benton, Nicola J O'Reilly, Kate N Bishop

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Identification of Simultaneous Occurrence of Amphibian Chytrid Fungi and Ranavirus in South Korea by Ji-Eun Lee, Young Jin Park, Mun-Gyeong Kwon, Yun-Kyeong Oh, Min Sun Kim, Yuno Do

“…Continuous monitoring and integrative ecological approaches are essential to mitigate pathogen-induced biodiversity loss and to inform amphibian conservation strategies in East Asia.…”
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Palm-size wireless piezoelectric immune-biosensing system for rapid E. coli O157:H7 detection by Yang Tian, Lisa Kelso, Yiting Xiao, Chaitanya Pallerla, Ramesh Bist, Siavash Mahmoudi, Ziyu Liu, Haizheng Xiong, Jeyam Subbiah, Terry Howell, Dongyi Wang

“…The portable, self-powered system offers a practical solution for rapid, on-site pathogen detection, addressing critical needs in food safety and environmental monitoring. …”
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Mitigating host microRNA interference to enhance mRNA vaccine efficacy in public health interventions by Tielong Xu, Ziqi Lin, Yicheng Yu, Muhammad Irfan, Munir Ahmed, Maya Septriana, Twinky Zebrina Cysta Sumantri, Anindini Winda Amalia, Bin Zheng

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Integrated systems biology analysis of KSHV latent infection reveals viral induction and reliance on peroxisome mediated lipid metabolism. by Zoi E Sychev, Alex Hu, Terri A DiMaio, Anthony Gitter, Nathan D Camp, William S Noble, Alejandro Wolf-Yadlin, Michael Lagunoff

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Campylobacter jejuni motility integrates specialized cell shape, flagellar filament, and motor, to coordinate action of its opposed flagella. by Eli J Cohen, Daisuke Nakane, Yoshiki Kabata, David R Hendrixson, Takayuki Nishizaka, Morgan Beeby

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Characterization of the Antibiotic and Copper Resistance of Emergent Species of Onion-Pathogenic <i>Burkholderia</i> Through Genome Sequence Analysis and High-Throughput Sequencing... by Jonas J. Padilla, Marco A. S. da Gama, Inderjit Barphagha, Jong Hyun Ham

“…In this study, we sequenced and analyzed the genomes of two emergent onion-pathogenic species of <i>Burkholderia</i>, <i>B</i>. …”
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The Toll-like receptor gene family is integrated into human DNA damage and p53 networks. by Daniel Menendez, Maria Shatz, Kathleen Azzam, Stavros Garantziotis, Michael B Fessler, Michael A Resnick

“…The TLR gene family mediates innate immunity to a wide variety of pathogenic threats through recognition of conserved pathogen-associated molecular motifs. …”
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Integrative Taxonomy of <i>Tereancistrum</i> spp. (Monopisthocotyla: Dactylogyridae) Parasites of the Gills of Freshwater Fishes from the Caatinga Domain, Brazil by Priscilla de Oliveira Fadel Yamada, Wallas Benevides Barbosa de Sousa, Mariana Bertholdi Ebert, Maria Fernanda Barros Gouveia Diniz, Marcos Tavares-Dias, Reinaldo José da Silva, Fabio Hideki Yamada

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