An integrated approach to the characterization of immune repertoires using AIMS: An Automated Immune Molecule Separator. by Christopher T Boughter, Martin Meier-Schellersheim

“…The adaptive immune system employs an array of receptors designed to respond with high specificity to pathogens or molecular aberrations faced by the host organism. …”
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The emergence of resistance to the antiparasitic selamectin in Mycobacterium smegmatis is improbable and contingent on cell wall integrity by José Manuel Ezquerra-Aznárez, Henrich Gašparovič, Álvaro Chiner-Oms, Ainhoa Lucía, Jesús Blázquez, Iñaki Comas, Jana Korduláková, José A. Aínsa, Santiago Ramón-García

“…These colonies carried mutations in embB, suggesting that the integrity of the cell envelope is a prerequisite for selamectin resistance. …”
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Optimization of meropenem continuous infusion based on Monte Carlo simulation integrating with degradation study. by Nguyen Tran Nam Tien, Vu Ngan Binh, Pham Thi Thanh Ha, Dang Thi Ngoc Lan, Yong-Soon Cho, Nguyen Phuoc Long, Jae-Gook Shin, Nguyen Hoang Anh, Truong Anh Quan, Do Ngoc Tuan, Nguyen Khac Tiep, Pham The Thach, Nguyen Hoang Anh, Vu Dinh Hoa

“…<h4>Conclusion</h4>Meropenem CI with 8 h of renewal infusion, considering stability even in tropical areas, was feasible to maximize the efficacy to difficult-to-treat pathogens.…”
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Enterotype-stratified gut microbial signatures in MASLD and cirrhosis based on integrated microbiome data by Heng Yuan, Heng Yuan, Junyu Zhou, Junyu Zhou, Xuangao Wu, Shiwei Wang, Sunmin Park, Sunmin Park

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New genetic diagnoses for inherited retinal dystrophies by integrating splicing tools into NGS pipelines by Elena Fernández-Suárez, María González-del Pozo, Cristina Méndez-Vidal, Marta Martín-Sánchez, Marcela Mena, Alejandro García-Nuñez, Nereida Bravo-Gil, María José Morillo-Sánchez, Enrique Rodríguez-de la Rúa, Salud Borrego, Guillermo Antiñolo

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Multidimensional mechanisms of anxiety and depression in Parkinson’s disease: Integrating neuroimaging, neurocircuits, and molecular pathways by Jihu Zhao, Huafang Jia, Pengju Ma, Deyuan Zhu, Yibin Fang

“…Therefore, a comprehensive summary of the pathogenic mechanisms associated with anxiety and depression will aid in better addressing the emergence of these classic psychiatric symptoms in PD. …”
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Decoding Colon Cancer Heterogeneity Through Integrated miRNA–Gene Network Analysis by Qingcai He, Zhilong Mi, Tianyue Liu, Taihang Huang, Mao Li, Binghui Guo, Zhiming Zheng

“…This study establishes a multi-dimensional stratification framework through integrative analysis of miRNA–gene co-expression networks, employing the MRNETB algorithm coupled with Markov flow entropy (MFE) centrality quantification. …”
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TM9SF2 Maintains Golgi Integrity and Regulates Ricin-Induced Cytotoxicity by Yue Meng, Hongzhi Wan, Xinyu Wang, Lina Zhang, Ruozheng Xin, Lingyu Li, Yuhui Wang, Chengwang Xu, Hui Peng, Lu Sun, Bo Wang, Xiaotao Duan

“…TM9SF2 belongs to a family of highly conserved nonaspanin proteins, and has been frequently identified as one of the important host factors for a plethora of lethal pathogens and toxins in previous genome-wide screening studies. …”
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Electronic Cigarettes: Ally or an Enemy in Combating Tobacco-Use-Associated Diseases - An Integrative Review by Hunny Sharma, Manisha Ruikar

“…Methods: This integrative review includes findings from Randomized and non-randomized clinical trials, and laboratory-based Human studies; published in the English language in the last four years. …”
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A targeted vaccination strategy: Integrating vaccines into biosafety, biosecurity, and one health initiatives by Laith N. AL-Eitan, Rabi A. Abu Khiarah, Diana L. Almahdawi

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Integrated Pest Management (IPM) in Agriculture and Its Role in Maintaining Ecological Balance and Biodiversity by Prodipto Bishnu Angon, Sujit Mondal, Israt Jahan, Mitu Datto, Uttam Biswas Antu, Famin Jahan Ayshi, Md. Shafiul Islam

“…Insects, weed pests, and plant pathogens destroy more than 40% of all potential food production every year. …”
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Comprehensive chromosomal abnormality detection: integrating CNV-Seq with traditional karyotyping in prenatal diagnostics by Yan Huang, Shuai Fu, Di Shao, Yanhua Yao, Fangyan Wu, Minrong Yao

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Polystyrene microplastics exposure: Disruption of intestinal barrier integrity and hepatic function in infant mice by Huan Li, Shimin Xu, Feng Zhou, Su Liu, Dong Zhang, Xuanyi Wei

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Muramyl peptide blend ameliorates intestinal inflammation and barrier integrity in cell culture model by D.M. Masiuk, V.S. Nedzvetsky

“…Muramyl peptides (MPs) are small signaling molecules which stimulate intracellular receptors of pathogens and are potent regulators of cell response. …”
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Integrated bioinformatics analysis to develop diagnostic models for malignant transformation of chronic proliferative diseases by Hua Liu, Sheng Lin, Pei-Xuan Chen, Juan Min, Xia-Yang Liu, Ting Guan, Chao-Ying Yang, Xiao-Juan Xiao, De-Hui Xiong, Sheng-Jie Sun, Ling Nie, Han Gong, Xu-Sheng Wu, Xiao-Feng He, Jing Liu

“…The combined analysis of dual diseases can provide new insights into pathogenic mechanisms, identify novel biomarkers, and develop targeted therapeutic strategies. …”
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Unveiling alfalfa root rot resistance genes through an integrative GWAS and transcriptome study by Fei He, Ming Xu, Hao Liu, Yanchao Xu, Ruicai Long, Junmei Kang, Qingchuan Yang, Lin Chen

“….), causing significant yield losses and economic damage. The primary pathogens include Fusarium spp., Rhizoctonia spp., Pythium spp., and Phytophthora spp., with Fusarium being particularly severe. …”
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Releasing the octoPus, an open-source digital tool to promote Integrated Pest Management by Simone Bregaglio, Eugenio Rossi, Lorenzo Ascari, Gabriele Mongiano, Eleonora Del Cavallo, Sofia Bajocco, Luisa Maria Manici, Antonio Gerardo Pepe, Chiara Bassi, Rocchina Tiso, Fabio Pietrangeli, Giovanna Cattaneo, Camilla Nigro, Marco Secondo Gerardi, Simone Bussotti, Angela Sanchioni, Danilo Tognetti, Mariangela Sandra, Irene De Lillo, Paolo Framarin, Sandra Di Ferdinando, Riccardo Bugiani

“…Decision support systems are primary tools to meet EU targets to halve pesticide use, as they advise farmers to use chemical sprays only when weather conditions are conducive to plant pathogens. Although many alternative disease models are available from scientific literature, current decision support systems are often proprietary and based on individual modelling approaches. …”
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Comparative and clinical impact of targeted next-generation sequencing in pediatric pneumonia diagnosis and treatment by Hui Shang, Sini Zou, Zhanying Ma, Qianyu Liang, Ye Zhong, Ling Li, Qishan Chen

“…Conventional microbial tests (CMTs) frequently fail to accurately identify pathogens, especially in cases involving co-infections or less common organisms. …”
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Dual-functional probiotic hydrogel with puerarin integration for microbiota-neuroimmune regulation in antibiotic-free periodontitis therapy by Yi Wang, Yansheng Qu, Xiangmei Liu, Jin Huang, Congyang Mao, Chaofeng Wang, Shengli Zhu, Yufeng Zheng, Zhaoyang Li, Zhenduo Cui, Hui Jiang, Yang Lv, Jie Shen, Shuilin Wu

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A three-way transcriptomic crosstalk interaction in a biocontrol agent (Bacillus velezensis), a fungal pathogen (Colletotrichum gloeosporioides), and a walnut host (Juglans regia L... by Shiwei Wang, Hanmingyue Zhu, Shuying Li, Tianhui Zhu

“…This study addresses knowledge gaps in the biocontrol-pathogen-host interaction and provides a theoretical foundation for developing environmentally sustainable strategies to control walnut anthracnose.…”
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