Antiprotozoal agents – Integration of drug discovery, medicinal chemistry, and advanced computational approaches: An in-depth review by Aviral Kaushik, Naureenbanu Makarani, Krupanshi Bharadava, Jeetaram Gehlot, Bhukya Vishnu Naik, Ankita Singh, Sumit Govil, Radhey Shyam Kaushal

“…Challenges include limited healthcare access in endemic areas, inadequate NTD funding, adaptive pathogen evolution and an underdeveloped antiprotozoal drug pipeline. …”
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Mycobiota and Antifungal Antibodies as Emerging Targets for the Diagnosis and Prognosis of Human Diseases by Eguzkiñe Diez-Martin, Leidi Hernandez-Suarez, Egoitz Astigarraga, Andoni Ramirez-Garcia, Gabriel Barreda-Gómez

“…However, fungi, collectively known as “the mycobiota,” are increasingly recognized as integral components of the microbiota, inhabiting nearly all mucosal surfaces. …”
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Structural and functional insights of sortases and their interactions with antivirulence compounds by Sowmiya Sri Sivaramalingam, Deepsikha Jothivel, Deenadayalan Karaiyagowder Govindarajan, Lohita Kadirvelu, Muthusaravanan Sivaramakrishnan, Dhivia Dharshika Chithiraiselvan, Kumaravel Kandaswamy

“…Both sortases and their substrate proteins are major virulence factors in numerous Gram-positive pathogens, making them attractive targets for antimicrobial intervention. …”
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Hyperuricemia as a Systemic Risk Factor for Periodontal Disease: A Review of Clinical and Microbial Evidence by Anca Silvia Dumitriu, Stana Paunica, Irina Bodnar, Dragos Nicolae Ciongaru, Brindusa Florina Mocanu, Marina Cristina Giurgiu, George Alexandru Denis Popescu, Dana Bodnar

“…In addition, gout, a condition linked to chronic hyperuricemia, is associated with a higher prevalence of periodontal disease. (2) Objective: This study aims to investigate the association between hyperuricemia and periodontal disease, focusing on their inflammatory and microbial pathways. By integrating the literature data, the research attempts to better understand the potential role of gout as a risk factor for periodontal disease. (3) Methods: A systematic review was conducted following the PICOS framework, including studies that evaluated the association between gout and periodontal disease. (4) Results: The review highlighted a consistent association between gout and increased periodontal inflammation, which was likely driven by shared inflammatory mediators. (5) Conclusions: The effective management of periodontal disease in patients with gout requires supportive oral hygiene practices, lifestyle changes/control of uric acid levels through diet, as well as specific therapy to reduce inflammation and microbial pathogens to reduce disease severity.…”
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Evaluation of oral hygiene and gingival parameters in pediatric nephrotic syndrome within an interdisciplinary care model by Paula Piekoszewska-Ziętek, Małgorzata Pańczyk-Tomaszewska, Dorota Olczak-Kowalczyk

“…Dental calculus was also less frequently observed in these patients.Despite being a medically vulnerable population, children with nephrotic syndrome under interdisciplinary care demonstrated favorable oral hygiene and reduced colonization by key periodontal pathogens. These findings suggest that systematic dental follow-up integrated with nephrology care may have a protective effect on oral health and help prevent inflammation-associated complications.Implementing regular dental screening within pediatric nephrology care can enhance early intervention, reduce oral disease burden, and support systemic health in children with nephrotic syndrome.…”
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Evaluation of different in silico tools for the assessment of deleterious variants in acute myeloid leukemia by Wardah Qureshi, Muhammad Irfan, Ishtiaq Ahmad Khan, Muhammad Shakeel

“…However, deciphering the genomic variations and determining their pathogenicity can be intricate. The widely accepted practice of using in silico pathogenicity predictions as evidence when interpreting genetic variants is an integral part of standard variant classification guidelines. …”
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Validation of a Rapid, High-Throughput Isothermal Recombinase Polymerase Amplification Screening Assay for Phytophthora ramorum by Kerri A. Neugebauer, Bryant Davenport, Carrie Harmon, Jan M. Byrne, Laura Miles, Karen Snover-Clift, Suzanne Rooney-Latham, Frank N. Martin, Douglas G. Luster, Timothy D. Miles

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Integrative analysis of crotonylation-associated genes reveals prognostic and therapeutic targets in gliomas by Bowen Yin, Bowen Yin, Zhuoyang Fan, Panpan Yu, Panpan Yu, Jin Li, Jin Li, Yilin Wang, Yilin Wang, Minfeng Shu, Minfeng Shu

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Integrated Nematode Management Strategies: Optimization of Combined Nematicidal and Multi-Functional Inputs by Mahfouz M. M. Abd-Elgawad

“…Hence, further explorations of novel integrated pest management plans that boost synergy and coverage to control multiple pathogens/pests on a single crop are required. …”
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Exploring pesticide risk in autism via integrative machine learning and network toxicology by Ling Qi, Jingran Yang, Qiao Niu, Jianan Li

“…This study aims to investigate the pathogenic mechanisms of ASD and identify potential causative pesticides by integrating bioinformatics, machine learning, network toxicology, and molecular docking approaches. …”
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Genomic integration of HHV-6 mimicking viral reactivation after autologous stem cell transplantation by rossana mineri, Jacopo Mariotti, Barbara Sarina, Lucio Morabito, roberto crocchiolo, stefania bramanti, tiziana sarno, federica tordato, carmelo carlo-stella, armando santoro, Luca Castagna

“…This case might be helpful for discriminate HHV-6 reactivation from viral integration, thus avoiding unnecessary and potentially toxic antiviral therapy once the genomic integration is confirmed.…”
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Unique immune and other responses of human nasal epithelial cells infected with H5N1 avian influenza virus compared to seasonal human influenza A and B viruses by Kai Sen Tan, Jing Liu, Anand Kumar Andiappan, Zhe Zhang Ryan Lew, Ting Ting He, Hsiao Hui Ong, Douglas Jie Wen Tay, Zhen Qin Aw, Bowen Yi, Arfah Mohd Fauzi, Thinesshwary Yogarajah, Lee Ching Pei Carmen, Justin Jang Hann Chu, Vincent T. Chow, Mookkan Prabakaran, De-Yun Wang

“…Highly pathogenic avian influenza (HPAI) virus (e.g. H5N1) infects the lower airway to cause severe infections, and constitute a prime candidate for the emergence of disease X. …”
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Alteration of reactive oxygen species master transcription factor Nrf2 in keratinocytes exposed to monoclonal pathogenic antibody AK23 against desmoglein-3 in pemphigus vulgaris by Faris Mohsin Ali Alabeedi

“…This study investigates changes in Nrf2 expression in keratinocytes following pathogenic anti-Dsg3 antibody AK23 exposure, using dose- and time-dependent studies employing immunofluorescence analysis. …”
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Inactivation of Salmonella and avian pathogens on hatchery eggs using gas phase hydroxyl-radical process vs formaldehyde fumigation: Efficacy, hatching performance and grow-out of... by Harleen Kaur Dhillon, Mahdiyeh Hasani, Brenda Zai, Kathryn Yip, Lara Jane Warriner, Ivy Mutai, Belinda Wang, Michael Clark, Sudhakar Bhandare, Keith Warriner

“…Consequently, there is a need for effective egg disinfection methods that can reduce the pathogen burden while preserving the egg integrity and embryo. …”
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Histological Dissection of Fusarium-Banana Interaction Using a GFP-Tagged Subtropical Race 4 Strain of <i>Fusarium oxysporum</i> f. sp. <i>cubense</i> on Banana Cultivars with Diff... by Andrew Chen, Ting-Yan Chou, Yi Chen, Sumayyah M. A. Fallatah, Jay Anderson, Jiaman Sun, Harry Cosgrove, Siyuan Gao, Brett J. Ferguson, Amelie Soper, Donald M. Gardiner, Elizabeth A. B. Aitken

“…The use of the fluorescently tagged <i>Foc</i> strain provides valuable insight into the infection process, and supports efforts in the integrated management of Fusarium wilt of banana.…”
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Platelet Transfusions: Current Practices and Emerging Alternatives in the United States by Mark Friedman, Victoria Costa, Behnam Rafiee, Timothy Hilbert, Mansab Jafri, Ding Wen Wu

“…Using a holistic approach, this manuscript addresses not only conventional practices (such as dosing standards and storage methods), but also cutting-edge alternatives like cold-stored and freeze-dried platelets, pathogen reduction technologies, and synthetic platelet substitutes. …”
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Autophagy in aquatic animals: mechanisms, implications, and future directions by Md. Abu Kawsar, Md. Abu Kawsar, Md. Abu Kawsar, Md. Abu Kawsar, Diponkor Adikari, Yang Zhang, Yang Zhang

“…This review synthesizes current knowledge on the regulation and function of autophagy in aquatic species, emphasizing key molecular pathways, environmental triggers such as temperature, salinity, hypoxia, and pollutants, and host responses to pathogenic infections. We explore model systems, particularly zebrafish, that have advanced our mechanistic understanding of autophagy, while also identifying gaps in research concerning economically important aquaculture species. …”
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Self-Inhibition Effects of Litter-Mediated Plant-Phyllosphere Feedback on Seedling Growth in Invasive and Native Congeneric Species by Kaili Cao, Peili Shi, Xingliang Xu, Jingsheng Wang

“…Future research should integrate spatiotemporal metagenomic and metabolomic approaches to decipher the dynamic pathogen/microbe networks and their phytochemical interactions.…”
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The Molecular Dialogue Between Zymoseptoria tritici and Wheat by Lukas Meile, Cristian Carrasco-López, Cécile Lorrain, Gert H. J. Kema, Cyrille Saintenac, Andrea Sánchez-Vallet

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Dynamic proteomic changes and ultrastructural insights into Pochonia chlamydosporia’s parasitism of Parascaris equorum eggs by Luyao Hao, Luyao Hao, Fengmiao Zhao, Hongyou Liu, Hongyou Liu, Chengyu Ma, Chengyu Ma, Xiaoqing Jia, Xiaoqing Jia, Lili Jiang, Zhaobin Fan, Rui Wang, Rui Wang

“…Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis identified key pathways including signal transduction, cell wall biosynthesis, energy metabolism, and host-pathogen interactions. qPCR validation further supported the molecular basis of parasitic behavior. …”
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