Integrated in-silico design and in vivo validation of multi-epitope vaccines for norovirus by Jingxuan Qiu, Yiwen Wei, Jiayi Shu, Wenjing Zheng, Yuxi Zhang, Junting Xie, Dong Zhang, Xiaochuan Luo, Xiulan Sun, Xin Wang, Sijie Wang, Xuanyi Wang, Tianyi Qiu

“…Abstract Background Norovirus (NoVs) is a foodborne pathogen that causes acute gastroenteritis. The diversity of its principal antigenic protein poses a significant challenge to vaccine development and the prevention of large-scale outbreaks globally. …”
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Activity of fungicide cyclobutrifluram against Fusarium fujikuroi and mechanism of the pathogen resistance associated with point mutations in FfSdhB, FfSdhC2 and FfSdhD by Yang Sun, Yu Liu, Li Zhou, Xinyan Liu, Kun Wang, Xing Chen, Chuanqing Zhang, Yu Chen

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An integrated strain-level analytic pipeline utilizing longitudinal metagenomic data by Boyan Zhou, Chan Wang, Gregory Putzel, Jiyuan Hu, Menghan Liu, Fen Wu, Yu Chen, Alejandro Pironti, Huilin Li

“…In this study, we introduce LongStrain, an integrated pipeline for the analysis of large-scale metagenomic data from individuals with longitudinal or repeated samples. …”
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Construction and Virulence of Filamentous Hemagglutinin Protein B1 Mutant of Pasteurella multocida in Chickens by Dong-chun GUO, Yan SUN, Ai-qin ZHANG, Jia-sen LIU, Yan LU, Pei-xin LIU, Dong-wei YUAN, Qian JIANG, Chang-de SI, Lian-dong QU

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Integration of genomic and pharmacokinetic data to predict clinical outcomes in HIV-associated cryptococcal meningitis by Dr Katharine Stott, Mr Jason Mohabir, Miss Kate Bowers, Assistant Professor Jennifer Tenor, Associate Professor Dena Tofaletti, Dr Jennifer Unsworth, Ms Ana Jimenez-Valverde, Mr Ajisa Ahmadu, Dr Melanie Moyo, Mrs Ebbie Gondwe, Mrs Wezi Chimang'anga, Mr Madalitso Chasweka, Dr David Lawrence, Professor Joseph Jarvis, Professor Tom Harrison, Professor William Hope, Professor David Lalloo, Professor Henry Mwandumba, Professor John Perfect, Professor Christina Cuomo

“…The relative contribution of these factors to clinical outcomes is unknown. We integrated pathogen genomic and phenotypic data with pharmacokinetic data to assess the relative contribution of each to clinical outcomes from cryptococcal meningitis. …”
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Exploring the potential association and experimental validation of disrupted circadian rhythms with polycystic ovary syndrome via meta-analysis and bioinformatics: a possible patho... by Wenjia Li, Wenjia Li, Guanmei Zhang, Yue Fang, Siyi Wu, Xiaobo Song, Lushan Zhou, Lei Lei, Chenye Wang, Caifei Ding, Yixuan Wang

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Intelligent integration of AI and IoT for advancing ecological health, medical services, and community prosperity by Abdulrahman Alzahrani, Patty Kostkova, Hamoud Alshammari, Safa Habibullah, Ahmed Alzahrani

“…At the same time, environmental health inequity, causing pathogen-related threats, was reduced by 35 %. The model has an accuracy of 96.8 %. …”
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Efficacy of Commercial Disinfectants Against Black Root Rot (<i>Berkeleyomyces rouxiae</i>) and Verticillium Wilt (<i>Verticillium dahliae</i>) Pathogens of Cotton by Chi P. T. Nguyen, Brenda Vo, Duy P. Le

“…This study provides an additional integrated disease management option aiming to limit the spread of the pathogens.…”
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Metagenomic analysis of human, animal, and environmental samples identifies potential emerging pathogens, profiles antibiotic resistance genes, and reveals horizontal gene transfer... by Rajindra Napit, Anupama Gurung, Ajit Poudel, Ashok Chaudhary, Prajwol Manandhar, Ajay Narayan Sharma, Samita Raut, Saman Man Pradhan, Jyotsna Joshi, Mathilde Poyet, Mathieu Groussin, Rajesh M. Rajbhandari, Dibesh B. Karmacharya

“…Our analysis revealed a complex interplay of pathogenic bacteria, virulence factors (VF), and antimicrobial resistance genes (ARGs) across these different domains. …”
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Proline dehydrogenase, a rate-limiting catabolic enzyme, affecting the growth and pathogenicity of Toxoplasma gondii tachyzoites by regulating the proline metabolism and mitochondr... by Xiao-Ling Geng, Jing-Yu Li, Huan-Yu Xu, Jiang-Ping Wu, De-Liang Tao, Jin-Ming Chen, Ying-Ying Fan, Xin Yang, Jun-Ke Song, Guang-Hui Zhao

“…Abstract Background The pathogenicity of Toxoplasma gondii is closely associated with its intracellular lytic cycle in host cells. …”
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Integrating phage biocontrol in food production: industrial implications and regulatory overview by Harshavardhan Dhulipalla, Nagaraj Basavegowda, Dibyajyoti Haldar, Irshaan Syed, Payel Ghosh, Sandeep Sing Rana, Prathap Somu, Ramesh Naidu, Akhilesh Kumar Yadav, Meng-Jen Lee, Kwang‐Hyun Baek

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COVID-19 vaccination atlas using an integrative systems vaccinology approach by Wasim Aluísio Prates-Syed, Dennyson Leandro Mathias da Fonseca, Shahab Zaki Pour, Aline Lira, Nelson Cortes, Jaqueline Dinis Queiroz Silva, Evelyn Carvalho, Igor Salerno Filgueiras, Tania Geraldine Churascari Vinces, Lena F. Schimke, Lorena C. S. Chaves, Gerhard Wunderlich, Ricardo Durães-Carvalho, Haroldo Dutra Dias, Hans D. Ochs, Niels O. S. Câmara, Helder I. Nakaya, José E. Krieger, Otavio Cabral-Marques, Gustavo Cabral-Miranda

“…Finally, we described the immunological landscape of COVID-19 vaccines and vaccines against other pathogens, at the gene-level and in cell population dynamics.…”
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An integrated structural and biophysical approach to study carbon metabolism in Mycobacterium tuberculosis by Evelyn Y.-W. Huang, Francis Kuang, Haozhe Wu, Chai Xin Yu, Xiaoxu Chen, Glenda Vasku, Le Thao Anh Nguyen, Katherine J. Jeppe, Anna K. Coussens, Brooke X.C. Kwai, Ivanhoe K.H. Leung

“…Such an integrated and interdisciplinary strategy has the potential to uncover novel regulatory mechanisms and identify new therapeutic opportunities for the eradication of tuberculosis. …”
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Systems immunology integrates the complex endotypes of recessive dystrophic epidermolysis bullosa by Nell Hirt, Enzo Manchon, Qian Chen, Clara Delaroque, Aurelien Corneau, Patrice Hemon, Safaa Saker-Delye, Pauline Bataille, Jean-David Bouaziz, Emmanuelle Bourrat, Alain Hovnanian, Helene Le Buanec, Fawzi Aoudjit, Hicham El Costa, Nabila Jabrane-Ferrat, Reem Al-Daccak

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Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO. by Hande Boyaci, Tayyab Shah, Amanda Hurley, Bashkim Kokona, Zhijie Li, Christian Ventocilla, Philip D Jeffrey, Martin F Semmelhack, Robert Fairman, Bonnie L Bassler, Frederick M Hughson

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Analysis of the effect of caffeine on the efficiency of wastewater treatment processes by integrated methods by Angelika Skorupa, Małgorzata Worwąg, Mariusz Kowalczyk

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Trichoderma harzianum in combination with carbendazim for integrated control of rice seedling blight by LI Min, YANG Qian, WANG Shu, DONG Hai, CHEN Yu-ling

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Unraveling heterogeneity and treatment of asthma through integrating multi-omics data by Wei Zhang, Yu Zhang, Lifei Li, Rongchang Chen, Fei Shi, Fei Shi

“…The current application of multi-omics approaches on patient stratification and therapies will be described. Integrating multi-omics and clinical data will provide more insights into the key pathogenic mechanism in asthma heterogeneity and reshape the strategies for asthma management and treatment.…”
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Integrated Functional Analysis of the Nuclear Proteome of Classically and Alternatively Activated Macrophages by John E. Wiktorowicz, Imran H. Chowdhury, Susan Stafford, Subhadip Choudhuri, Nilay Dey, Nisha J. Garg

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Integrating Maternal and Child Health Into Climate Change: A Holistic Approach by Felix Amekpor, Waheed Sakariyau, Nathan Ezie Kengo, Nwodo Amarachukwu Sandra, Joseph Agyapong, Zakariya’u Dauda, Samuel Kwarteng, David Adeoye Adedokun, Gideon Darko

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