Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques. by Rachele M Bochart, Kathleen Busman-Sahay, Stephen Bondoc, David W Morrow, Alexandra M Ortiz, Christine M Fennessey, Miranda B Fischer, Oriene Shiel, Tonya Swanson, Christine M Shriver-Munsch, Hugh B Crank, Kimberly M Armantrout, Aaron M Barber-Axthelm, Charlotte Langner, Cassandra R Moats, Caralyn S Labriola, Rhonda MacAllister, Michael K Axthelm, Jason M Brenchley, Brandon F Keele, Jacob D Estes, Scott G Hansen, Jeremy V Smedley

“…Here, we assessed the efficacy of a short-course multimodal therapy (enrofloxacin, azithromycin, fenbendazole, and paromomycin) to eliminate common macaque endemic pathogens (EPs) and evaluated its impact on gastrointestinal (GI) microbiota, mucosal integrity, and local and systemic inflammation in sixteen clinically healthy macaques. …”
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Advances in Wastewater-Based Epidemiology for Pandemic Surveillance: Methodological Frameworks and Future Perspectives by Weihe Zhu, Daxi Wang, Pengsong Li, Haohao Deng, Ziqing Deng

“…This review critically examines the methodological framework of WBE systems through the following three core components: (1) sampling strategies that address spatial–temporal variability in wastewater systems, (2) comparative performance of different platforms in pathogen detection, and (3) predictive modeling integrating machine learning approaches. …”
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HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency. by Torsten Schaller, Karen E Ocwieja, Jane Rasaiyaah, Amanda J Price, Troy L Brady, Shoshannah L Roth, Stéphane Hué, Adam J Fletcher, KyeongEun Lee, Vineet N KewalRamani, Mahdad Noursadeghi, Richard G Jenner, Leo C James, Frederic D Bushman, Greg J Towers

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Broad-spectrum antimicrobial activities of a food fermentate of Aspergillus oryzae by Dasol Choi, Ahmad F. Alshannaq, Yohan Bok, Jae-Hyuk Yu

“…Mechanistically, NP disrupts the structural integrity of bacterial and fungal cell membranes, increasing membrane permeability and leading to cell death. …”
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Innovative fast and low-cost method for the detection of living bacteria based on trajectory by Paul Perronno, Julie Claudinon, Carmen Senin, Serap Elçin-Guinot, Lena Wolter, Olga N. Makshakova, Norbert Dumas, Dimitri Klockenbring, Joseph Lam-Weil, Vincent Noblet, Siegfried Steltenkamp, Winfried Römer, Morgan Madec

“…Most conventional detection methods require skilled staff and specific laboratory equipment for sample collection and analysis or are specific to a given pathogen. Thus, they cannot be easily integrated into a portable device. …”
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Brucella infection induces chromatin restructuring in host cells to activate immune responses by Dejian Xie, Heling Xu, Changwei Su, Jingjing Lu, Wenlong Shen, Ping Li, Bingyu Ye, Jiabao Hou, Junwei Deng, Yan Zhang, Shanhu Li, Zhihu Zhao

“…While their molecular mechanisms are well-characterized, how Brucella induces chromatin restructuring in host cells remains poorly understood, representing a critical gap in host-pathogen interaction research.MethodsUsing an established in vitro infection model of Brucella-infected RAW264.7 murine macrophages, we integrated Hi-C, ATAC-seq, and RNA-seq to generate multi-omics datasets. …”
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Prebiotic Oligosaccharides in Skin Health: Benefits, Mechanisms, and Cosmetic Applications by Meijun Zeng, Yang Li, Jie Cheng, Jingyu Wang, Qiyu Liu

“…Then, we discuss in vitro studies demonstrating their efficacy in promoting skin commensals, inhibiting pathogens, and conferring protective effects, such as antioxidant, anti-inflammatory, anti-melanogenic, and wound-healing properties. …”
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Transforming Microbiological Diagnostics in Nosocomial Lower Respiratory Tract Infections: Innovations Shaping the Future by Ingrid G. Bustos, Lina F. Martinez-Lemus, Luis Felipe Reyes, Ignacio Martin-Loeches

“…Advanced molecular tools, such as real-time PCR and multiplex PCR, allow rapid pathogen identification but are constrained by predefined panels. …”
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Development and use of a Chinook salmon spleen stromal-like cell line to study the cellular immune response to Vibrio anguillarum by Shawna L. Semple, Daniel D. Heath, Brian Dixon

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Development and validation of a droplet digital PCR assay for sensitive detection and quantification of Phytophthora nicotianae by Yuanyuan Liu, Yuanyuan Liu, Jiali Li, Jiali Li, Zining Guo, Zining Guo, Chao Feng, Yunhua Gao, Danmei Liu, Di Wang

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Drosophila melanogaster as a model system for studying the effects of porcine rotavirus on intestinal immunity by Xiao Chun Wang, Xiao Chun Wang, Shuang Deng, Liyun Yu, Rongan Cao, Rongan Cao, Liangyu Li

“…Given that flies primarily consume decaying organic matter, harmful microorganisms present in their food can enter the intestine, leading to frequent infections by exogenous pathogens. When these pathogens are introduced into the intestinal environment, a cascade of immune responses is triggered within the intestinal tissue, aimed at preserving the integrity of the intestinal barrier and ensuring the proper physiological functions of the gut. …”
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Genetic and wind field analysis of wheat leaf rust (Puccinia triticina) dispersal: from winter sources in Gansu and Shaanxi to summer epidemics in China by Hongfu Li, Hongfu Li, Na Zhao, Na Zhao, Qinqin Zhang, Qinqin Zhang, Liang Huang, Liang Huang, Hao Zhang, Hao Zhang, Li Gao, Li Gao, Wanquan Chen, Taiguo Liu, Taiguo Liu, Taiguo Liu

“…In the 2021 epidemic season, two pathways of pathogen dispersal were proposed: (1) from the Guanzhong basin to Henan province; (2) through the Hanshui River Valley to Hubei province. …”
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An integrated approach to the diagnosis of bacterial and fungal bloodstream infections in cancer patients by O. Yu. Kutsevalova, Yu. Yu. Kozel, V. V. Dmitrieva, O. V. Kozuk, I. B. Lysenko

“…An integrated approach to the diagnosis of bloodstream infections improved and, just as importantly, significantly accelerated the pathogen verification. …”
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Integrated pest management programme for cereal blast fungus Magnaporthe oryzae by Hai-feng ZHANG, Tofazzal ISLAM, Wen-de LIU

“…The Oryza pathotype (MoO) of M. oryzae is the most devastating pathogen of rice, causing 10–30% yield loss in the world. …”
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Revealing the CRISPR array in bacteria living in our organism by Matei-Ștefan DOBRESCU, Dumitrana IORDACHE, Anca BUTIUC-KEUL

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Genome-Wide Prediction of Vaccine Candidates for Leishmania major: An Integrated Approach by Satarudra Prakash Singh, Kriti Roopendra, Bhartendu Nath Mishra

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Isolation and identification of strawberry anthracnose and fungicide screening in Henan province by SUN Wenbin, ZHANG Jingjing, SONG Yanhong, ZHAO Xia, LI Gang, ZHOU Houcheng, LIU Lifeng

“…Inoculation experiments were conducted to determine the pathogenicity of isolated strains, which involved inoculating detached leaves, petioles, and fruits of strawberries as well as applying spore suspensions onto living strawberry leaf surfaces and integrating spore suspensions into substrates. …”
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Integrating microbial communities into algal biotechnology: a pathway to enhanced commercialization by Hari Koneru, Safiatou Bamba, Aksel Bell, Adrian A. Estrada-Graf, Zackary I. Johnson, Zackary I. Johnson

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The Role of Vitamins in Pediatric Urinary Tract Infection: Mechanisms and Integrative Strategies by Joanna Wróblewska, Hanna Złocińska, Marcin Wróblewski, Jarosław Nuszkiewicz, Alina Woźniak

“…Vitamin A supports mucosal barrier integrity and immune modulation, reducing pathogen adhesion and colonization. …”
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Resilience in Resistance: The Role of Cell Wall Integrity in Multidrug-Resistant Candida by Iván A. Banda-Flores, David Torres-Tirado, Héctor M. Mora-Montes, Gabriela Pérez-Flores, Luis A. Pérez-García

“…MAPK signaling pathways, like the cell wall integrity pathway and the high-osmolarity glycerol pathway, play a crucial role in responding to cell wall stressors. …”
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