Outbreak reconstruction with a slowly evolving multi-host pathogen: A comparative study of three existing methods on Mycobacterium bovis outbreaks by Hélène Duault, Benoit Durand, Laetitia Canini

“…Mycobacterium bovis is a slowly evolving multi-host pathogen and previous studies on outbreaks involving both cattle and wildlife have identified observation biases. …”
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Extraction of Saponins from Xanthoceras sorbifolium Bunge Leaves Using Deep Eutectic Solvents and Their Inhibitory Activity against Postharvest Pathogenic Fungi by Xue LI, Xinyu CHU, Erzheng SU, Jiahong WANG

“…Additionally, XLs saponin demonstrated effective inhibition of spores of Aspergillus niger, Rhizopus oryzae and Aspergillus flavus of three out of the six typical post-harvest pathogenic fungi of fruits and vegetables. Among the pathogenic fungi studied, the spore germination of Rhizopus oryzae was inhibited with the best effect, the inhibition rate reached 78.76%±2.56%, and XLs saponin inhibited the growth of the fungus by suppressing the antioxidant enzyme activity. …”
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Genetic variants of leptin receptor gene (rs1137101) and obesity risk in prakriti individuals and its pathogenicity prediction using in silico approaches by Manoranjani Murugan, Sourav Musib, Yogesh Vetriselvan, Ilangovan Karthiga, Artchoudane Soccalingam, Melissa Shaelyn Samuel, Irisappan Ganesh, Sambandam Ravikumar

“…The in silico findings indicate that the Q223R variant is pathogenic, as it destabilizes protein structures and impairs leptin receptor activity. …”
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Dual RNA-seq reveals the complement protein C3-mediated host-pathogen interaction in the brain abscess caused by Staphylococcus aureus by Qiyuan Jin, Yaxuan Zhai, Rui Qiang, Xin Ma, Chenhao Zhao, Jinqi Zhong, Jijie Li, Qi Chen, Mingxiao Han, Hong Du, Qifei Cong, Haifang Zhang

“…ABSTRACT This study aimed to elucidate the complement protein C3-mediated host-pathogen interaction in the brain abscess caused by Staphylococcus aureus infection. …”
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Overall in vitro, in vivo, and in silico evaluation of Olea europaea and Ficus carica leaf extracts for antimicrobial activity against multidrug-resistant pathogens by Mahmoud Aloriby, Mahmoud Aloriby, Mohamed Elkawafi, Salem Aldrsy, Mohamed Sweker, Hadeel Elabdeli, Aisha Elbarghathi, Ahmed Benhasouna, Madiha El-Awamie, Nariman Elsharif, Omar Alqabbasi, Salmin Alshalmani, Rabiea Algazal, Farag Bleiblo

“…In this context, the present study evaluates the therapeutic efficacy and safety profiles of Olea europaea and Ficus carica leaf extracts against multidrug-resistant pathogens, integrating in vitro antimicrobial assays, in vivo toxicity assessments, and in silico modeling approaches.MethodsLeaf extracts from O. europaea and F. carica were prepared by solvent-based maceration using methanol, acetone, and distilled water. …”
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An ensemble machine learning-based performance evaluation identifies top In-Silico pathogenicity prediction methods that best classify driver mutations in cancer by Subrata Das, Vatsal Patel, Shouvik Chakravarty, Arnab Ghosh, Anirban Mukhopadhyay, Nidhan K. Biswas

“…Classifiers built using these top 11 PCSAs (DEOGEN2, Integrated_fitCons, MVP, etc.) demonstrated significantly higher performance (p-value < 2.22e-16) compared to those using the remaining 30 PCSAs across all three ML algorithms, in separating pathogenic driver from benign passenger mutations. …”
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Suppression of MT5-MMP Reveals Early Modulation of Alzheimer’s Pathogenic Events in Primary Neuronal Cultures of 5xFAD Mice by Dominika Pilat, Jean-Michel Paumier, Laurence Louis, Christine Manrique, Laura García-González, Delphine Stephan, Anne Bernard, Raphaëlle Pardossi-Piquard, Frédéric Checler, Michel Khrestchatisky, Eric Di Pasquale, Kévin Baranger, Santiago Rivera

“…We now investigate the effect of MT5-MMP on incipient pathogenic pathways that are activated in cortical primary cultures at 21–24 days in vitro (DIV), during which time neurons are organized into a functional mature network. …”
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Fungal Spore Seasons Advanced Across the US Over Two Decades of Climate Change by Ruoyu Wu, Yiluan Song, Jennifer R. Head, Daniel S. W. Katz, Kabir G. Peay, Kerby Shedden, Kai Zhu

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The threat of Alternaria Late Blight of Pistachio and its integrated management by Abdelhak Rhouma, Rabeb Rhouma, Lobna Hajji-Hedfi

“…Moreover, the review covers various management practices to control these diseases, which include biological control with the use of beneficial microbes, limited application of chemical fungicides, efficient methods of irrigation to minimize pathogen-conducive conditions, limitation of pathogen reservoirs by management of weeds, and growing resistant varieties of pistachio. …”
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Impact of Human Body Temperature on Stress Tolerance and Transcriptome of <i>Cronobacter sakazakii</i> by Siqi Li, Yuanyuan Wang, Yahao Yang, Xinlu Yu, Jiajia Liu, Meiling Jiang, Jing Zhang, Ge Yun, Yufei Han, Heng Wang, Qiong Xie, Gukui Chen

“…<i>Cronobacter sakazakii</i> is a food-borne pathogen that can thrive in various environments, including the human body. …”
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Strain of <i>Xanthomonas oryzae</i> pv. <i>oryzae</i> Loses Virulence through Dysregulation of Cardiolipin Synthase by Yiqun Hu, Qingqing Chen, Aifang Zhang, Liyuan Zhang, Hansong Dong

“…Studies on the rice bacterial blight pathogen <i>Xanthomonas oryzae</i> pathovar <i>oryzae</i> strain PXO99^A, previously identified a virulence-associated sRNA, trans3287. …”
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Human Genetic Adaptations to Environmental Pressures: The Role of Migration in Evolutionary Success by Amir Jalali, Majid Komijani, Saja Al-Sailawi

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Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania by Zhi Ming Xu, Michaela Zwyer, Hellen Hiza, Sarah Schmidiger, Mohamed Sasamalo, Miriam Reinhard, Anna Doetsch, Sonia Borrell, Olivier Naret, Sina Rüeger, Dylan Lawless, Simon Tang, Faima Isihaka, Hosiana Temba, Thomas Maroa, Rastard Naftari, Christian Beisel, Jerry Hella, Klaus Reither, Daniela Brites, Damien Portevin, Sebastien Gagneux, Jacques Fellay

“…While previous genomic studies have largely examined human and bacterial genomes separately, we adopted an integrated approach to uncover host–pathogen interactions. …”
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Assessment of Filifactor alocis and Porphyromonas gingivalis Levels in Subgingival Plaque of Patients with Type 2 Diabetes Mellitus with and without Periodontitis: A Case-Control S... by Rajalakshmi Ashok Kumar, Ram Sabarish, Reshma Achu Joseph, Balaji Subbusamy Kanakasabapathy, Mohanapriya Chinambedu Dandapani

“…Conclusion: These findings underscore the synergistic role of these pathogens in periodontal inflammation and their potential impact on glycaemic control, highlighting the importance of integrated oral and systemic care.…”
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Digoxin reveals a functional connection between HIV-1 integration preference and T-cell activation. by Alexander Zhyvoloup, Anat Melamed, Ian Anderson, Delphine Planas, Chen-Hsuin Lee, Janos Kriston-Vizi, Robin Ketteler, Andy Merritt, Jean-Pierre Routy, Petronela Ancuta, Charles R M Bangham, Ariberto Fassati

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Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration. by Lihong Zhou, Elena Sokolskaja, Clare Jolly, William James, Sally A Cowley, Ariberto Fassati

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Maintaining phagosome integrity during fungal infection: do or die? by Mabel Yang, Glenn F.W. Walpole, Johannes Westman

“…Using C. albicans as a model intracellular pathogen, our recent work reveals a mechanism by which phagosomes respond to intraphagosomal growth of pathogens by expanding their surface area, and as a result, maintain the integrity of the phagosomal membrane. …”
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Impact of viral disease hypophagia on pig jejunal function and integrity. by Emma T Helm, Shelby M Curry, Carson M De Mille, Wesley P Schweer, Eric R Burrough, Nicholas K Gabler

“…Pathogen challenges are often accompanied by reductions in feed intake, making it difficult to differentiate impacts of reduced feed intake from impacts of pathogen on various response parameters. …”
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Risk analysis and governance implications of integrating artificial intelligence and biotechnology by Mian ZU, Lijuan LI, Ting CHEN

“…This paper analyzes the potential risks of integrating AI and biotechnology, focusing on knowledge acquisition, toxin design, and pathogen modification. …”
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Assessing the Impact of Bedaquiline, Clofazimine, and Linezolid on Mycobacterial Genome Integrity by Dániel Molnár, Éva Viola Surányi, Nikoletta Gálik, Judit Tóth, Rita Hirmondó

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