Evaluation of Bacillus subtilis ATCC PTA-122264 on the fecal characteristics and microbiota of healthy adult dogs subjected to an abrupt diet change by Patrícia M. Oba, Olivia R. Swanson, Yifei Kang, Julio C. Mioto, John F. Menton, Elena Vinay, Mathieu Millette, Melissa R. Kelly, Kelly S. Swanson, Kelly S. Swanson, Kelly S. Swanson

“…Diet change reduced (p < 0.05) the abundances of short-chain fatty acid (SCFA)-producing bacteria and increased (p < 0.05) the relative abundance of potentially pathogenic bacteria, resulting in an elevated (p < 0.05) dysbiosis index. …”
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Whole-genome analysis and antimicrobial resistance phenotype of Vagococcus fluvialis isolated from wild Niviventer by Jian Zhou, Jian Zhou, Ying Liu, Tao Gu, Jingzhu Zhou, Fengming Chen, Yong Hu, Shijun Li, Shijun Li

“…Its zoonotic potential raises concerns for public health, yet research on its antimicrobial resistance and pathogenicity is still limited. This study aimed to isolate and characterize V. fluvialis from wild Niviventer, analyze its genomic features (including antimicrobial resistance and virulence genes), and evaluate its antibiotic susceptibility profile to assess potential public health risks. …”
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Risk factors associated with urogenital schistosomiasis: a multilevel assessment approach using an Oversampling Schistosomiasis Survey (SOS) community-based, Plateaux region, Togo... by Penelope Vounatsou, Fiona M Fleming, Rachel Pullan, Katherine Gass, Smaila Alidou, Hélène E Kamassa, Fiali Lack, Essoham Ataba, Efoe Sossou, Manani Hemou, Kossi Yakpa, Mawèké Tchalim, Piham Gnossike, Ameyo M Dorkenoo

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COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms by Marek Ostaszewski, Anna Niarakis, Alexander Mazein, Inna Kuperstein, Robert Phair, Aurelio Orta‐Resendiz, Vidisha Singh, Sara Sadat Aghamiri, Marcio Luis Acencio, Enrico Glaab, Andreas Ruepp, Gisela Fobo, Corinna Montrone, Barbara Brauner, Goar Frishman, Luis Cristóbal Monraz Gómez, Julia Somers, Matti Hoch, Shailendra Kumar Gupta, Julia Scheel, Hanna Borlinghaus, Tobias Czauderna, Falk Schreiber, Arnau Montagud, Miguel Ponce de Leon, Akira Funahashi, Yusuke Hiki, Noriko Hiroi, Takahiro G Yamada, Andreas Dräger, Alina Renz, Muhammad Naveez, Zsolt Bocskei, Francesco Messina, Daniela Börnigen, Liam Fergusson, Marta Conti, Marius Rameil, Vanessa Nakonecnij, Jakob Vanhoefer, Leonard Schmiester, Muying Wang, Emily E Ackerman, Jason E Shoemaker, Jeremy Zucker, Kristie Oxford, Jeremy Teuton, Ebru Kocakaya, Gökçe Yağmur Summak, Kristina Hanspers, Martina Kutmon, Susan Coort, Lars Eijssen, Friederike Ehrhart, Devasahayam Arokia Balaya Rex, Denise Slenter, Marvin Martens, Nhung Pham, Robin Haw, Bijay Jassal, Lisa Matthews, Marija Orlic‐Milacic, Andrea Senff-Ribeiro, Karen Rothfels, Veronica Shamovsky, Ralf Stephan, Cristoffer Sevilla, Thawfeek Varusai, Jean‐Marie Ravel, Rupsha Fraser, Vera Ortseifen, Silvia Marchesi, Piotr Gawron, Ewa Smula, Laurent Heirendt, Venkata Satagopam, Guanming Wu, Anders Riutta, Martin Golebiewski, Stuart Owen, Carole Goble, Xiaoming Hu, Rupert W Overall, Dieter Maier, Angela Bauch, Benjamin M Gyori, John A Bachman, Carlos Vega, Valentin Grouès, Miguel Vazquez, Pablo Porras, Luana Licata, Marta Iannuccelli, Francesca Sacco, Anastasia Nesterova, Anton Yuryev, Anita de Waard, Denes Turei, Augustin Luna, Ozgun Babur, Sylvain Soliman, Alberto Valdeolivas, Marina Esteban‐Medina, Maria Peña‐Chilet, Kinza Rian, Tomáš Helikar, Bhanwar Lal Puniya, Dezso Modos, Agatha Treveil, Marton Olbei, Bertrand De Meulder, Stephane Ballereau, Aurélien Dugourd, Aurélien Naldi, Vincent Noël, Laurence Calzone, Chris Sander, Emek Demir, Tamas Korcsmaros, Tom C Freeman, Franck Augé, Jacques S Beckmann, Jan Hasenauer, Olaf Wolkenhauer, Egon L Willighagen, Alexander R Pico, Chris T Evelo, Marc E Gillespie, Lincoln D Stein, Henning Hermjakob, Peter D'Eustachio, Julio Saez‐Rodriguez, Joaquin Dopazo, Alfonso Valencia, Hiroaki Kitano, Emmanuel Barillot, Charles Auffray, Rudi Balling, Reinhard Schneider, the COVID‐19 Disease Map Community

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Molecular Assessment of Traditional Mongolian Medicine Tongola-5 in Lactulose Induced Diarrhea: An in vivo Study by Ma C, Buren Q, Eerde M, Qing M, Bao X, Zhao L, Cao L, Zhang X, Bai Q, Chen M, Hong M, Bao Y, Lian H

“…RNA sequencing analysis showed that TLG5 treatment inhibited the inflammatory pathway. 16S rRNA sequencing demonstrated that TLG5 administration led to an upregulation of beneficial microbial populations and a concomitant downregulation of pathogenic bacteria. The TLG5 treatment group presented a reduction in necrotic areas and inflammatory cell infiltration, as well as preservation of the mucosal structure, with a marked decline in inflammatory lesions. …”
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Viral Mimetic Bacterial Outer Membrane Vesicles for Targeting Angiotensin-Converting Enzyme 2 by Ahn G, Yoon HW, Jeong JH, Kim YH, Shin WR, Song MS, Ahn JY

“…Gna Ahn,1,2,* Hyo-Won Yoon,1,* Ju Hwan Jeong,3,4,* Yang-Hoon Kim,1,* Woo-Ri Shin,1,5,6 Min-Suk Song,3 Ji-Young Ahn1 1Department of Microbiology, Chungbuk National University, Cheongju, Republic of Korea; 2Center for Ecology and Environmental Toxicology, Chungbuk National University, Cheongju, Republic of Korea; 3Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; 4Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Republic of Korea; 5Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; 6Department of Animal Bioscience & Integrated Biotechnology, Gyeongsang National University, Jinju, Republic of Korea*These authors contributed equally to this workCorrespondence: Ji-Young Ahn; Min-Suk Song, Tel +82-43-261-2301 ; +82-43-261-3778, Email jyahn@chungbuk.ac.kr; songminsuk@chungbuk.ac.krPurpose: Outer membrane vesicles (OMVs) derived from Gram-negative bacteria naturally serve as a heterologous nano-engineering platform, functioning as effective multi-use nanovesicles for diagnostics, vaccines, and treatments against pathogens. …”
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Corneal sensory nerve loss induced by repeated subconjunctival and topical bupivacaine disrupts tear secretion and enhances bacterial adhesion via neuropeptide modulation. by Ananya Datta, Grace Kelly Orallo, Nahomy Nelson

“…<h4>Purpose</h4>Corneal sensory innervation plays a crucial role in maintaining ocular surface integrity and immune homeostasis by regulating neuropeptide secretion in tear fluid. …”
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A Closer Look at Periocular Necrotizing Fasciitis: A Systematic Review of Literature by David Oliver-Gutierrez, Elena Ros-Sanchez, Gloria Segura-Duch, Tirso Alonso, Miguel Ángel Arcediano, Alejandra Herranz-Cabarcos, Jessica Matas, Roberto Castro Seco, R. L. P. van der Veen, Anna Boixadera, José García-Arumí, Joan Oliveres

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Investigating the Role and Underlying Mechanisms of 18&amp;beta;-Glycyrrhetinic Acid in the Therapy of Ulcerative Colitis Through Modulation of the PPAR-&amp;gamma;/NF-&amp;kappa;B... by Zhu A, Qiu Q, Xu Z, Zhang Q, Sun F, Liu Y, Chen Z, Zhang Y, Yao J

“…Additionally, 18β-GA promotes a favorable environment that hindered the proliferation of pathogenic bacteria, thereby promoting gut health. Co-culture and scratch assays confirmed that 18β-GA promotes mucosal repair. …”
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Uncovering SPP1+ Macrophage, Neutrophils and Their Related Diagnostic Biomarkers in Intracranial Aneurysm and Subarachnoid Hemorrhage by Jie H, Wang B, Zhang J, Wang X, Song X, Yang F, Fu C, Dong B, Yan F

“…The cell populations were annotated to identify potential pathogenic subpopulations, followed by intercellular communication, pseudotime, and SCENIC analyses. …”
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Clinical characteristics and prognostic factors of COVID-19 in rheumatic patients and their family members: a retrospective study by Yihua Fan, Yihua Fan, Yihua Fan, Yiwen Wang, Yiwen Wang, Juanli Du, Rui Wu, Jianbin Li, Changhong Xiao, Qing Li, Mi Zhou, Ying Liu, Di Zhang, Bei Wang, Songwei Li, Zhina Zhao, Xinliang Lyu, Yuanhao Wu, Yuanhao Wu, Yan Liu, Yan Liu, Xiaomei Ning, Xiaomei Ning, Zhiteng Li, Shujiao Yu, Ensheng Chen, Guangzhao Zhu, Yuxing Zhao, Yuxing Zhao, Juan Liu, Yuquan Liu, Dongyi He, Wei Liu, Wei Liu

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Research advances on reisistance to kiwifruit bacterial canker by ZHANG Min, SUN Leiming, FU Rong, LIN Miaomiao, WANG Ran, QI Xiujuan

“…These toxic effectors can disrupt the immune defense response of plants, allowing patho-gens to quickly adapt to the host environment. The integrative and conjugative elements (ICEs) are large mobile elements, which can confer new phenotypes to Psa and are frequently implicated as the mechanism underlying antimicrobial resistance evolution in bacterial pathogens. …”
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Influence of weather and seasonal factors on whitefly dynamics, associated endosymbiotic microbiomes, and Begomovirus transmission causing tomato leaf curl disease: insights from a... by S. Sujatha, Kopparthi Amrutha Valli Sindhura, Prasanna S. Koti, Shridhar Hiremath, Mantesh Muttappagol, Mantesh Muttappagol, H. D. Vinay Kumar, K. S. Shankarappa, V. Venkataravanappa, K. M. Srinivas Reddy, C. N. Lakshminarayana Reddy

“…These findings underscore the urgent need for integrated management strategies globally to control both whitefly populations and ToLCuD, ensuring the protection of tomato crops and the sustainability of farmer livelihoods.…”
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Culture-Independent Quantitative PCR Detected Mobilized Colistin Resistance Genes (<i>mcr-1</i>, <i>mcr-2</i>, <i>mcr-3</i>, <i>mcr-4</i>, and <i>mcr-5</i>) in Chicken Gut Contents... by Mamun Al Asad, Md Sarower Hossen Shuvo, Shomaia Yasmin Mitu, Sumia, Md Asief Hossain Zihadi, Ayasha Siddique Shanta, Nahidul Islam, Shamsun Nahar, Brian Godman, Salequl Islam

“…Colistin is a ‘Reserve’ antibiotic for human treatment to be conserved for multidrug-resistant pathogens; however, it is being used as an animal growth promoter in many developing countries. …”
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Insights into structure and activity of a UDP-GlcNAc 2-epimerase involved in secondary cell wall polymer biosynthesis in Paenibacillus alvei by Cordula Stefanović, Max S. G. Legg, Nick Mateyko, Jakob J. Ender, Tea Kuvek, Chris Oostenbrink, Christina Schäffer, Stephen V. Evans, Fiona F. Hager-Mair

“…IntroductionS-layer anchoring in Paenibacillus alvei is enabled by a non-covalent interaction between an S-layer homology domain trimer and a secondary cell wall polymer (SCWP), ensuring the structural integrity of the bacterial cell wall. Within the SCWP repeat, pyruvylated ManNAc serves as the ligand and the UDP-GlcNAc-2-epimerase MnaA supplies UDP-ManNAc to SCWP biosynthesis.MethodsTo better understand SCWP biosynthesis and identify strategies for inhibiting pathogens with comparable cell wall architecture, like Bacillus anthracis, MnaA and rational variants were produced in E. coli and their kinetic constants determined. …”
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C/EBPβ–VCAM1 axis in Kupffer cells promotes hepatic inflammation in MASLD by Shuang-Zhe Lin, Yang Xie, Yu-Qing Cheng, Rui Xue, Yin-Shi Su, Mingxi Liu, Yuan-Wen Chen, Jian-Gao Fan

“…Conclusions: Increased C/EBPβ in KCs promotes pathogenic transcriptional activation, leading to increased VCAM1 expression and inflammatory cell infiltration in MASLD. …”
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Disease-Resistance Functional Analysis and Screening of Interacting Proteins of ZmCpn60-3, a Chaperonin 60 Protein from Maize by Bo Su, Lixue Mao, Huiping Wu, Xinru Yu, Chongyu Bian, Shanshan Xie, Temoor Ahmed, Hubiao Jiang, Ting Ding

“…The <i>ZmCpn60-3</i> was highly expressed in the stems and tassels of maize, and could be induced by exogenous plant hormones, mycotoxins, and pathogens; Overexpression of <i>ZmCpn60-3</i> in <i>Arabidopsis</i> improved the resistance to <i>Pst</i> DC3000 by inducing the hypersensitive response and the expression of SA signaling-related genes, and the H₂O₂ and the SA contents of <i>ZmCpn60-3</i>-overexpressing <i>Arabidopsis</i> infected with <i>Pst</i> DC3000 accumulated significantly when compared to the wild-type controls. …”
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Application of the Sponge Model Implants in the Study of Vaccine Memory in Mice Previously Immunized with LBSap by Mariana Ferreira Lanna, Lucilene Aparecida Resende, Paula Mello De Luca, Wanessa Moreira Goes, Maykelin Fuentes Zaldívar, André Tetzl Costa, Walderez Ornelas Dutra, Alexandre Barbosa Reis, Olindo Assis Martins-Filho, Kenneth Jhon Gollob, Sandra Aparecida Lima de Moura, Edelberto Santos Dias, Érika Michalsky Monteiro, Denise Silveira-Lemos, Rodolfo Cordeiro Giunchetti

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Identifying genetic variations in emm89 Streptococcus pyogenes associated with severe invasive infections by Masayuki Ono, Masaya Yamaguchi, Daisuke Motooka, Yujiro Hirose, Kotaro Higashi, Tomoko Sumitomo, Tohru Miyoshi-Akiyama, Rumi Okuno, Takahiro Yamaguchi, Ryuji Kawahara, Hitoshi Otsuka, Noriko Nakanishi, Yu Kazawa, Chikara Nakagawa, Ryo Yamaguchi, Hiroo Sakai, Yuko Matsumoto, Tadayoshi Ikebe, Shigetada Kawabata

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Changes in metabolite profiles in the cerebrospinal fluid and in human neuronal cells upon tick-borne encephalitis virus infection by Satoshi Suyama, Sally Boxall, Benjamin Grace, Andrea Fořtová, Martina Pychova, Lenka Krbkova, Rupasri Mandal, David Wishart, Diane E. Griffin, Daniel Růžek, Niluka Goonawardane

“…Untargeted metabolomics followed by bioinformatics and integrative omics were used to profile the levels of metabolites in the CSF. …”
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