Limosilactobacillus reuteri SXDT-32-derived shikimic acid protects against colonic inflammation in piglets by inhibiting the PI3K-Akt pathway by Ying Chen, Chengzeng Luo, Zhaohan Zhan, Shuo Liu, Chunran Teng, Ruixiao Mao, Shunfen Zhang, Xunbozan Zhang, Qingshi Meng, Ruqing Zhong, Liang Chen, Hongfu Zhang

“…Results Our tests showed that L. reuteri SXDT-32 alleviated colonic damage induced by pathogenic E. coli SKLAN202302 in weaned pigs by enhancing barrier integrity and inhibiting inflammation. …”
Get full text

The protein kinases family in fungi: adaptability, virulence and conservation between species by Emanoelle La Santrer, Cláudia Barbosa Assunção, Thiago Miguelito Navarro de Camargo, Izabella Rodrigues, Sabrina Sidney Campolina, Edgar Lacerda de Aguiar, Thiago de Souza Rodrigues, Rachel Basques Caligiorne

“…Previous studies have shown that the absence of GCN2 disrupts eIF2α phosphorylation, impairing stress responses and reducing pathogenicity, therefore being an important target for development of new generation antifungals. …”
Get full text

Multiomics comparative analysis of feces AMRGs of Duroc pigs and Tibetan and the effect of fecal microbiota transplantation on AMRGs upon antibiotic exposure by Tao Wang, Yuheng Luo, Xiangfeng Kong, Ling Fang, Liping Zhu, Bing Yu, Ping Zheng, Zhiqing Huang, Xiangbing Mao, Yu Jie, Junqiu Luo, Hui Yan, Jun He

“…Given the escalating antimicrobial resistance crisis, novel therapeutic interventions are imperative to mitigate gut colonization by pathogens and AMRGs. In this regard, we investigated the impact of fecal microbiota from Tibetan and Duroc pig sources on AMRGs excretion in Duroc Landrace Yorkshire (DLY) piglets’ feces following acute antibiotic exposure. …”
Get full text

Efficient Marker-Assisted Pyramiding of <i>Xa21</i> and <i>Xa23</i> Genes into Elite Rice Restorer Lines Confers Broad-Spectrum Resistance to Bacterial Blight by Yao Li, Yulong Fan, Yihang You, Ping Wang, Yuxuan Ling, Han Yin, Yinhua Chen, Hua Zhou, Mingrui Luo, Bing Cao, Zhihui Xia

“…The pyramided lines exhibited enhanced resistance against six virulent <i>Xoo</i> pathogenic races while retaining parental yield performance across key agronomic traits. …”
Get full text

Programming virulent bacteriophages by developing a multiplex genome engineering method by Hailin Zhang, Ru Zhu, Zhaofei Wang, Ruoting He, Yuran Zhang, Ji Luan, Yaxian Yan, Youming Zhang, Hailong Wang

“…ABSTRACT The use of virulent bacteriophages (phages) against pathogenic bacteria has recently attracted considerable interest. …”
Get full text

The prevalence, patterns, and antifungal drug resistance of bloodstream infection-causing fungi in Sichuan Province, China (2019–2023): a retrospective observational study using na... by Jin Deng, Jin Deng, Jin Deng, Ya Liu, Ya Liu, Ya Liu, Ling Shu, Ling Shu, Ling Shu, Dan Zhou, Dan Zhou, Dan Zhou, Yi Xie, Yi Xie, Yi Xie, Ying Ma, Ying Ma, Ying Ma, Mei Kang, Mei Kang, Mei Kang

“…Our objective was to gain insights into regional differences in the distribution and resistance patterns of fungal pathogens.MethodsWe performed a retrospective analysis of fungal bloodstream infections (BSIs) from 31 hospitals (2019–2023). …”
Get full text

Adapting COVID-19 research infrastructure to capture influenza and respiratory syncytial virus alongside SARS-CoV-2 in UK healthcare workers winter 2022/23 and beyond: protocol for... by Victoria Hall, Susan Hopkins, Jonathan Broad, Naomi Platt, Dominic Sparkes, Sarah Foulkes, Anna Howells, Michelle Cole, Jameel Khawam, Conall Watson, Nick Andrews

“…Introduction During the COVID-19 pandemic, extensive research was conducted on SARS-CoV-2; however, important questions about other respiratory pathogens remain unanswered. A severe influenza season in 2022–2023 with simultaneous circulation of SARS-CoV2 and respiratory syncytial virus is anticipated. …”
Get full text

Myocardial dysfunction caused by MyBPC3 P459fs mutation in hypertrophic cardiomyopathy: evidence from multi-omics approaches and super-resolution imaging by Yupeng Wu, Yupeng Wu, Yuzhu Zhang, Yuzhu Zhang, Qirui Zheng, Qirui Zheng, Qiyuan Wang, Qiyuan Wang, Xingyu Fang, Xingyu Fang, Zaihan Zhu, Zaihan Zhu, Jing Lu, Dandan Sun, Dandan Sun

“…IntroductionMutations in the sarcomere protein, particularly in cardiac myosin binding protein C gene (MyBPC3), were the most frequent genetic cause of hypertrophic cardiomyopathy (HCM). The pathogenic MyBPC3 P459fs mutation has been reported in HCM patients. …”
Get full text

Exploration of mycovirus composition in a hypovirulent strain of Sclerotinia sclerotiorum potentially uncovers mycovirus cross-taxa transmission by Lixia Gao, Weimeng Li, Jichun Jia, Jiasen Cheng, Yanping Fu, Xueqiong Xiao, Qing Cai, Yang Lin, Tao Chen, Bo Li, Xiao Yu, Tom Hsiang, Daohong Jiang, Jiatao Xie

Get full text

Clinical, electromyographic, and biophysical characterization of the rare Nav1.4 channel mutation SCN4A L1436P by François Charles Wang, François Charles Wang, Olivier Bouquiaux, Olivier Bouquiaux, Isabelle Lievens, Bernard Lakaye, Laura Vandries, Margaux Poleur, Samira Abdou Ide, Nurcan Inci, Vincent Seutin

“…IntroductionOur aims were to provide an integrated clinical and biophysical characterization of the rare variant NM_000334.4(SCN4A) c.4307T&gt;C (p.Leu1436Pro; L1436P), affecting the skeletal muscle sodium channel Nav1.4, and to compare its functional consequences with both wild-type (WT) channels and the well-established pathogenic variant p.Arg1448His (R1448H).MethodsWe retrospectively analyzed nine unrelated patients carrying the heterozygous L1436P variant. …”
Get full text

Effect of newborn genomic screening for lysosomal storage disorders: a cohort study in China by Xin Wang, Yun Sun, Xian-Wei Guan, Yan-Yun Wang, Dong-Yang Hong, Zhi-Lei Zhang, Ya-Hong Li, Pei-Ying Yang, Tao jiang, Zheng-feng Xu

“…Of these, 4 were excluded, 15 were diagnosed as LSD-presymptomatic individuals based on enzyme deficiency and pathogenic variants conforming to inheritance patterns, and 11 remain under follow-up. …”
Get full text

Molecular Detection of Antibiotic Resistance Genes Using Respiratory Sample from Pneumonia Patients by Eman Abdullah Alsuof, Ahmad R. Alsayed, Manar Saleh Zraikat, Heba A. Khader, Luai Z. Hasoun, Mamoon Zihlif, Osama Abu Ata, Malek A. Zihlif, Mahmoud Abu-Samak, Mohammed Al Maqbali

“…In this study, we evaluated 14 antibiotic resistance genes in pneumonia pathogens, highlighting their diverse resistance mechanisms. …”
Get full text

MVA-based SARS-CoV-2 vaccine candidates encoding different spike protein conformations induce distinct early transcriptional responses which may impact subsequent adaptive immunity by Ilka Grewe, Ilka Grewe, Ilka Grewe, Ilka Grewe, Monika Friedrich, Monika Friedrich, Monika Friedrich, Marie-Louise Dieck, Marie-Louise Dieck, Marie-Louise Dieck, Michael Spohn, Michael Spohn, Michael Spohn, My Linh Ly, My Linh Ly, My Linh Ly, Verena Krähling, Verena Krähling, Leonie Mayer, Leonie Mayer, Leonie Mayer, Sibylle C. Mellinghoff, Sibylle C. Mellinghoff, Sibylle C. Mellinghoff, Monika Rottstegge, Monika Rottstegge, Monika Rottstegge, Rebekka Kraemer, Asisa Volz, Asisa Volz, Stephan Becker, Stephan Becker, Anahita Fathi, Anahita Fathi, Anahita Fathi, Anahita Fathi, Christine Dahlke, Christine Dahlke, Christine Dahlke, Leonie M. Weskamm, Leonie M. Weskamm, Leonie M. Weskamm, Marylyn M. Addo, Marylyn M. Addo, Marylyn M. Addo

“…IntroductionVaccine platforms such as viral vectors and mRNA can accelerate vaccine development in response to newly emerging pathogens, as demonstrated during the COVID-19 pandemic. …”
Get full text

<i>Lactobacillus</i> Re-Engineers Gut Microbiota to Overcome <i>E. coli</i> Colonization Resistance in Mice by Jianlei Jia, Pengjia Bao, Qinran Yu, Ning Li, Hao Ren, Qian Chen, Ping Yan

“…The intestinal health and functionality of animals play pivotal roles in nutrient digestion and absorption, as well as in maintaining defense against pathogenic invasions. These biological processes are modulated by various determinants, including husbandry conditions, dietary composition, and gut microbial ecology. …”
Get full text

Transcriptomic insights into the interplay between polyketide biosynthesis and other secondary metabolite biosynthetic clusters and biological pathways in entomopathogen Beauveria... by Wachiraporn Toopaang, Wachiraporn Toopaang, Wachiraporn Toopaang, Wachiraporn Toopaang, Thippawan Yoocha, Thippawan Yoocha, Chaiwat Naktang, Chaiwat Naktang, Nuchnudda Wichienchote, Phornsiri Pechsrichuang, Sithichoke Tangphatsornruang, Sithichoke Tangphatsornruang, Morakot Tanticharoen, Yu-Liang Yang, Yu-Liang Yang, Alongkorn Amnuaykanjanasin

“…Our findings indicate that pks15 plays an important role in fungal development and pathogenicity. Within the pks15 cluster, the UDP-glucosyl transferase gene Bbugt1 was consistently upregulated 3-fold in the WT in vivo compared to the WT in vitro armyworm group 48–96 h post-inoculation. …”
Get full text

Application of Cold Atmospheric Pressure Plasma Jet Results in Achievement of Universal Antibacterial Properties on Various Plant Seeds by Jakub Orlowski, Agata Motyka-Pomagruk, Anna Dzimitrowicz, Pawel Pohl, Dominik Terefinko, Ewa Lojkowska, Piotr Jamroz, Wojciech Sledz

“…The data presented herein may contribute to future development of the plasma agriculture field and provide alternatives to pesticides or the prevention-based control methods towards plant pathogenic bacteria.…”
Get full text

SToP (See, Treat, Prevent) skin sores and scabies trial: study protocol for a cluster randomised, stepped-wedge trial for skin disease control in remote Western Australia by Marianne J Mullane, Timothy C Barnett, Jeffrey W Cannon, Jonathan R Carapetis, Ray Christophers, Juli Coffin, Frieda Mc Loughlin, Vicki O'Donnell, Rebecca Pavlos, Bec Smith, Andrew C Steer, Steven Y C Tong, Roz Walker, Asha C Bowen

“…Secondary outcome measures include scabies diagnosis, other child health indicators, resistance to cotrimoxazole in circulating pathogenic bacteria, determining the economic burden of skin disease and evaluating the cost effectiveness of SToP activities.Ethics and dissemination This study protocol was approved by the health ethics review committees at the Child and Adolescent Health Service (Approval number RGS0000000584), the Western Australian Aboriginal Health Ethics Committee (Reference number: 819) and the University of Western Australia (Reference RA/4/20/4123). …”
Get full text

Assessment of antibiotic utilization patterns in an Indian Level-1 Trauma Center: a pilot study exploring days of antibiotic spectrum coverage and defined daily doses using WHO AWa... by M Nizam Ahmed, Arpan Kumar Thakur, Smriti Srivastava, Aparna Ningombam, Madhavi Kirti, Sushma Sagar, Keshav Goyal, Subodh Kumar, Ashish Bindra, Gyaninder Pal Singh, Navdeep Sokhal, Richa Aggarwal, Vijay Sharma, Samarth Mittal, Kamran Farooque, Purva Mathur

“…We measured days of therapy (DOT), DDD, and DASC for 46 antibiotics across 12 pathogens [e.g., methicillin-susceptible Staphylococcus aureus (MSSA), carbapenem-resistant Enterobacteriaceae]. …”
Get full text

Long noncoding RNA LINC00339 promotes osteoporosis development via modulating of regulator CDC42 by binding PARP1 by Dong-Li Zhu, Yan Zhang, Xiao-Yu Zhang, Zi-Han Qiu, Ke Li, Xiao-Rong Zhou, Zhen-Zhen He, Xiao-Feng Chen, Shan-Shan Dong, Wen Tian, Ya-Kang Wang, Tie-Lin Yang, Bo Yang, Yan Guo

“…Further investigation established that the LINC00339-PARP1 axis cooperatively modulates transcriptional programs critical to bone homeostasis, potentially driving pathogenic mechanisms underlying osteoporosis progression. …”
Get full text

Development of a host-signature-based machine learning model to diagnose bacterial and viral infections in febrile children by Fang Bai, Zelong Gong, Dong Cui, Xiaomei Zhang, Wenteng Hong, Yi Gao, Kai Lin, Weijie Chen, Lu Li, Juan Huang, Biying Zheng, Junfa Xu, Na Xiao

“…For the generalized RF model, 1,042 patients were included with various aetiological infections, such as Staphylococcus aureus, pathogenic Escherichia coli, Salmonella, Shigella, adenovirus, HHV6, enterovirus, rhinovirus, human rotavirus, human norovirus, and influenza A pneumonia. …”
Get full text