Antimicrobial resistance and beta-lactamase gene distribution among clinical isolates: a two-year cohort study by Yasser Alraey, Mohammed Mushabub Assiry, Irfan Ahmad, Abdulaziz Alqahtani, Nada Basheer, Mohammed A. M. AlAsiri, Saleh A. M. Alshehri, Saeed M. S. Alhamhhum, Sultan Mohammed Alhefdi, Mohd Shahid Khan, Mohd Saleem, Abdulah A. S. Bawazeer

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Genomic characteristics and epidemic trends of NADC30-like PRRSV in China by Siyu Zhang, Hu Xu, Zhenyang Guo, Lirun Xiang, Chao Li, Bangjun Gong, Jinhao Li, Zixuan Feng, Haonan Kang, Qian Wang, Guohui Zhou, Chaoliang Leng, Kuan Zhao, Yan-Dong Tang, Huairan Liu, Tong-Qing An, Xuehui Cai, Jinmei Peng, Zhi-Jun Tian, Hongliang Zhang

“…These sequences were subsequently integrated with 224 whole-genome sequences from China available in the GenBank database. …”
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The diagnostic value of two antigenic domains derived from the Trypanosoma cruzi Tc323 protein in chronic Chagas disease: a study in Brazil by Micaela S. Ossowski, Ângelo Antônio Oliveira Silva, Ângelo Antônio Oliveira Silva, Emily Ferreira Santos, Emily Ferreira Santos, Leonardo Maia Leony, Leonardo Maia Leony, Fred Luciano Neves Santos, Fred Luciano Neves Santos, Fred Luciano Neves Santos, Karina A. Gómez

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Evaluating the feasibility, sensitivity, and specificity of next-generation molecular methods for pleural infection diagnosis by Peter T. Bell, Timothy Baird, John Goddard, Olusola S. Olagoke, Andrew Burke, Shradha Subedi, Tiana R. Davey, James Anderson, Derek S. Sarovich, Erin P. Price

“…These data will help to inform the design of larger prospective clinical trials and identify potential obstacles to be overcome before next-generation sequencing technologies can be integrated into routine clinical practice.…”
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Chondrocyte-specific knockout of Piezo1 and Piezo2 protects against post-traumatic osteoarthritis structural damage and pain in mice by Erica V. Ely, Kristin L. Lenz, Sophie G. Paradi, Seth Ack, Abraham Behrmann, Sarah Dunivan, Lauryn Braxton, Wolfgang Liedtke, Yong Chen, Kelsey H. Collins, Farshid Guilak

“…Results Piezo1 cKO delayed pain onset but ultimately exacerbated cartilage degradation and synovitis, emphasizing its dual role in protective and pathogenic mechanotransduction. While the Piezo2 cKO reduced pain and preserved activity, it failed to protect cartilage. …”
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B cells are not drivers of stromal cell activation during acute CNS infection by Brendan T. Boylan, Mihyun Hwang, Elyse Brozost, Hyunsuk Oh, Alexei V. Tumanov, Antoine Louveau, Cornelia C. Bergmann

“…While chronically activated fibroblast networks can drive pathogenic immune cell aggregates known as tertiary lymphoid structures (TLS), early stromal cell activation during CNS infection can support anti-viral T cells. …”
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Neisseria meningitidis regulates P-glycoprotein transporter activity in brain endothelial cells via sphingosine 1–phosphate receptor 1 by Fatemeh Nosratabadi, Leo M. Endres, Fabian Schumacher, Heike Claus, Burkhard Kleuser, Brandon J. Kim, Alexandra Schubert-Unkmeir

“…Abstract Background The brain endothelial cells (BECs) are essential for protecting the central nervous system (CNS) from xenobiotics and pathogens, including Neisseria meningitidis, while maintaining CNS homeostasis through tight junction (TJ) proteins and specialized transporters. …”
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Antimicrobial Effects of Kelisha Capsule on Escherichia coli Induced Diarrhea in Mice by Shi G, Lu X, Wang G, Qian K, Peng X, Zhu Y, Wu J, Ke H, Chen L, Zheng Y, Yang T, Shi X, Huang P

“…The KLSC significantly inhibit pathogenic bacteria and restore the gut microbiota diversity. …”
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In silico genomic insights into bacteriophages infecting ESBL-producing Escherichia coli from human, animal, and environmental sources by Mabel Kamweli Aworh, Opeyemi U. Lawal, Beverly Egyir, Rene S. Hendriksen

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Rare serovars of non-typhoidal Salmonella enterica isolated from humans, beef cattle and abattoir environments in Nigeria. by Mabel Kamweli Aworh, Pernille Nilsson, Beverly Egyir, Felicia Amoa Owusu, Rene S Hendriksen

“…<h4>Introduction</h4>Salmonella is considered one of the most significant pathogens in public health since it is a bacterium that is frequently linked to food-borne illnesses in humans. …”
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Functional analysis of promoter element 2 within the viral polymerase gene of an emerging paramyxovirus, Sosuga virus by Lipi Akter, Junna Kawasaki, Tofazzal Md. Rakib, Takashi Okura, Fumihiro Kato, Shohei Kojima, Kosuke Oda, Yusuke Matsumoto

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Synergistic Control of Bacterial Fruit Blotch Using <i>Bacillus velezensis</i> ZY1 and Chemical Bactericides by Haoyu Wei, Sheng Han, Maihemuti Mijiti, Tingchang Zhao, Wei Guan, Yuwen Yang

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Antimicrobial Susceptibility Profiles of Commensal <i>Enterococcus</i> spp. Isolates from Turkeys in Hungarian Poultry Farms Between 2022 and 2023 by Ádám Kerek, Ábel Szabó, Franciska Barnácz, Bence Csirmaz, László Kovács, Ákos Jerzsele

“…<i>Enterococcus</i> species are emerging pathogens, particularly in severe nosocomial infections. …”
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Nocardia genomes are a large reservoir of diverse gene content, biosynthetic gene clusters, and species-specific genes by Kiran Kumar Eripogu, Chun-Ping Yu, An-I Tsai, Jinn-Jy Lin, Hsiao-Ching Lin, Wen-Hsiung Li

“…Nocardia, a bacterial genus known for its opportunistic pathogenicity, represents an underexplored group of immense genomic diversity and biosynthetic capabilities. …”
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Target oxidative stress-induced disulfidptosis: novel therapeutic avenues in Parkinson’s disease by Junshi Zhang, Tingting Liu, Haojie Wu, Jianshe Wei, Qiumin Qu

“…Conclusion This study elucidates the pathogenic role of OS-induced disulfidptosis in PD progression. …”
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A NEW METHOD TO ASSESS FUNCTIONAL ACTIVITY OF SERUM COMPLEMENT SYSTEM by E. G. Cheremnykh, P. A. Ivanov, M. I. Faktor, N. S. Karpova, E. F. Vasiljeva, K. V. Gusev, O. S. Brusov

“…Complement system is an important component of innate immunity, providing primary protection against pathogens invading the body. In addition, it was shown that the complement system is associated with many diseases, not only autoimmune and infectious, but also mental disorders. …”
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Evaluation of meningitis surveillance system in rural area, Rwanda by Solange Nyinawabeza, Jean Claude Niyoyita, Emmanuel Nshimiyimana, Jerome Ndayisenga, Angela Umutoni, Caroline Stamatakis

“…Moreover, MoH could enhance the implementation of a national policy requiring mandatory CSF sample testing to confirm pathogens for all suspected cases. Future studies should explore performance-based incentives to improve reporting completeness. …”
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A telomere-associated molecular landscape reveals immunological, microbial, and therapeutic heterogeneity in colorectal cancer by Yinmeng Zhang, Jiawei Fan, Jiahui Zhao, He Zhu, Yan Xia, Hong Xu

“…Although telomere biology has been increasingly implicated in immune modulation and tumor progression, its clinical significance in CRC remains poorly understood.MethodsWe developed a telomere score, termed TELscore, by integrating transcriptomic and intratumoral microbiome profiles from publicly available colorectal cancer (CRC) cohorts. …”
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Exploration of Epigenetic Mechanisms and Biomarkers Among Patients with Very-Late-Onset Schizophrenia-Like Psychosis by Gan Y, Yue W, Sun J, Yang D, Fang C, Zhou Z, Yin J, Zhou H

“…We prioritized key methylation sites through integrated analysis of methylation quantitative trait loci (meQTL), linkage disequilibrium (LD) patterns, and blood-brain methylation correlations. …”
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The commitment of the human cell atlas to humanity by Ido Amit, Kristin Ardlie, Fabiana Arzuaga, Gordon Awandare, Gary Bader, Alexander Bernier, Piero Carninci, Stacey Donnelly, Roland Eils, Alistair R. R. Forrest, Henry T. Greely, Roderic Guigo, Nir Hacohen, Muzlifah Haniffa, Emily Sarah Kirby, Bartha Maria Knoppers, Arnold Kriegstein, Ed S. Lein, Sten Linnarsson, Partha P. Majumder, Miriam Merad, Kerstin Meyer, Musa M. Mhlanga, Garry Nolan, Ntobeko A. B. Ntusi, Dana Pe’er, Shyam Prabhakar, Maili Raven-Adams, Aviv Regev, Orit Rozenblatt-Rosen, Senjuti Saha, Andrea Saltzman, Alex K. Shalek, Jay W. Shin, Henk Stunnenberg, Sarah A. Teichmann, Timothy Tickle, Alexandra-Chloe Villani, Christine Wells, Barbara Wold, Huanming Yang, Xiaowei Zhuang

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