DNA Damage Response Regulation Alleviates Neuroinflammation in a Mouse Model of α-Synucleinopathy by Sazzad Khan, Himanshi Singh, Jianfeng Xiao, Mohammad Moshahid Khan

“…Although the molecular mechanisms driving PD progression remain incompletely understood, emerging evidence suggests that the buildup of nuclear DNA damage, especially DNA double-strand breaks (DDSBs), plays a key role in contributing neurodegeneration, promoting senescence and neuroinflammation. Despite the pathogenic role for DDSB in neurodegenerative disease, targeting DNA repair mechanisms in PD is largely unexplored as a therapeutic approach. …”
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Liver failure diagnosis: key diagnostic biomarkers discovery and bioinformatic validation by Quan Ye, Kai Wang, Hong Ye

“…This study investigates GPX3’s diagnostic potential and mechanistic contributions to LF pathogenesis.MethodsWe integrated two high-quality liver tissue datasets (GSE38941 and GSE14668) from the Gene Expression Omnibus (GEO) database. …”
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Analysis of PERV-C superinfection resistance using HA-tagged viruses by Merle Flecks, Nicole Fischer, Jacomina Krijnse Locker, Ralf R. Tönjes, Antonia W. Godehardt

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Intracranial intermediate-grade meningeal melanocytoma: A 5-month-old child case report by Wangbin Deng, Guofu Li, Yonkang Zhang

“…Molecular profiling of the tumor failed to identify known pathogenic mutations. Postoperative recovery was uneventful, and the patient remained seizure-free on sodium valproate throughout a 12-month follow-up period. …”
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Identification of key ferroptosis genes in hepatocellular carcinoma and type 2 diabetes mellitus through bioinformatics analysis by Jinjin Zhou, Yage Shi, Yulun Jian, Yuhan Li, Wenya Yu, Wei Mu, Yang Ge

“…In conclusion, this study is the first to integrate bioinformatics tools to investigate the potential mechanistic links between iron metabolism and the comorbidity of T2DM and HCC, uncovering a novel pathogenic pathway. …”
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Essential role of hepcidin in host resistance to disseminated candidiasis by Tanmay Arekar, Divya Katikaneni, Sadat Kasem, Dhruv Desai, Thrisha Acharya, Augustina Cole, Nazli Khodayari, Sophie Vaulont, Bernhard Hube, Elizabeta Nemeth, Alexander Drakesmith, Michail S. Lionakis, Borna Mehrad, Yogesh Scindia

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Virulence Gene Profiling and Molecular Typing of Clinical Isolates of Listeria monocytogenes from Wenzhou, Eastern China by Chen A, Chen X, Zheng Z, Wang H, Hu M

“…Additionally, epidemiological survey data were integrated to explore the relationship between the absence of key virulence genes and the serotypes of Listeria monocytogenes.Results: All strains exhibited sensitivity to penicillin, erythromycin, meropenem, and co-trimoxazole. …”
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The in vitro potential of non-thermal atmospheric pressure plasma against Nosema ceranae infection in honeybees (Apis mellifera) by Thummanoon Boonmee, Chainarong Sinpoo, Kasidet Laokulsiri, Gaokaew Piyaphonsakon, Kamonporn Panngom, Terd Disayathanoowat, Jeffery S. Pettis, Veeranan Chaimanee

“…However, the development of plasma devices and PAW, as well as their safety for honeybees should be further investigated for effective control of N. ceranae and other pathogens in honeybees.…”
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An expanded polyglutamine in ATAXIN1 results in a loss-of-function that exacerbates severity of Multiple Sclerosis in an EAE mouse model by Gourango Talukdar, Lisa Duvick, Praseuth Yang, Brennon O’Callaghan, Gavin J. Fuchs, Marija Cvetanovic, Harry T. Orr

“…Methods Hemizygous Atxn1 (Atxn1 2Q/− ) mice or f-ATXN1 146Q/2Q , heterozygous mice that have one copy of the endogenous mouse gene replaced with a polyQ expanded pathogenic human ATXN1 gene, were injected with myelin oligodendrocytes glycoprotein (MOG35 − 55) peptide to induce EAE. …”
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Association of pro-inflammatory and anti-inflammatory cytokine polymorphisms with COVID-19 severity in unvaccinated patients by Laura E. Martínez-Gómez, Carla I. Oropeza-Vélez, Maylin Almonte-Becerril, Leslie Chavez-Galan, Carlos Martinez-Armenta, Rosa P. Vidal-Vázquez, Juan P. Ramírez-Hinojosa, Paola Vázquez-Cárdenas, Diana Gómez-Martín, Gilberto Vargas-Alarcón, José M. Rodríguez-Pérez, Lucero A. Ramón-Luing, Julio Flores-Gonzalez, José G. Carrasco, Ivette Cruz-Bautista, Mónica M. Mata-Miranda, Gustavo J. Vázquez-Zapién, Adriana Martínez-Cuazitl, Nancy M. Parra-Torres, Felipe de J. Martínez-Ruiz, Dulce M. Zayago-Angeles, Ma. Luisa Ordoñez-Sánchez, Yayoi Segura-Kato, Carlos Suarez-Ahedo, Jessel Olea-Torres, Brígida Herrera-López, Carlos Pineda, Gabriela A. Martínez-Nava, Alberto G. López-Reyes

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Dataset on physico-chemical characteristics of Exogenous Organic Matters (EOMs) gathered from various European countriesZenodo by Aurélia Marcelline Michaud, Hélène Van Der Smissen, Lucille Caradec, Elina Tampio, Johanna Laakso, Florent Levavasseur, Karolina Barcauskaite, Donata Drapanauskaite, Maria Valentina Lasorella, Irene Criscuoli, Paulien Van Asperen, Janjo De Haan, Julie Jimenez, Sabine Houot

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Cloning and Functional Analysis of Skin Host Defense Peptides from Yakushima Tago’s Brown Frog (<i>Rana tagoi yakushimensis</i>) and Development of Serum Endotoxin Detection System... by Taichi Aono, Saki Tamura, Yua Suzuki, Taichi Imanara, Ryosei Niwa, Yoshie Yamane, Tetsuya Kobayashi, Sakae Kikuyama, Itaru Hasunuma, Shawichi Iwamuro

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Evaluation of the retinal morphological and functional findings in optic neuritis related to multiple sclerosis by Katanić-Pasovski Katarina, Rančić Nemanja, Pasovski Viktor, Sajić Marija, Resan Mirko, Dinčić Evica

“…Using OCT, significant differences in the structural integrity and thickness of retinal layers between the eye in which RBN had been detected and the contralateral, nonaffected eye were found (83.73 ± 18.36 vs. 98.67 ± 11.84; p = 0.013). …”
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Impact of propensity to COVID-19 vaccination/vaccine on influenza vaccination from willingness to behavior among older adults in rural China by Shan-Shan Zhang, Wanna Shi, Juan Du, Wan-Xue Zhang, Mengjun Yuan, Yiguo Zhou, Lili Wang, Tianshuo Zhao, Qin-Yi Ma, Sihui Zhang, Han Yang, Xiyu Zhang, Mingting Wang, Ninghua Huang, Jing Zeng, Yaqiong Liu, Yuanshan Zhang, Fuqiang Cui, Qing-Bin Lu

“…There was a positive impact of COVID-19 vaccine/vaccination on influenza vaccination from willingness to behavior among the older adults in rural China after COVID-19 pandemic, suggesting that integrating health education of related pathogens and vaccines might promote influenza vaccination.…”
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Goondicones A–H: Spiro-Isoindolinone Heartworm Anthelmintics from an Australian Pasture-Soil-Derived <i>Streptomyces</i> sp. by Jianying Han, David F. Bruhn, Cynthia T. Childs, Yovany Moreno, Angela A. Salim, Taizong Wu, Robert J. Capon

“…Conclusions: While goondicones <b>1</b>–<b>8</b> exhibit little to no in vitro inhibitory activity against Gram-positive, Gram-negative, and/or fungal pathogens, human carcinoma cells, or the livestock gastrointestinal parasite <i>Haemonchus contortus</i> L1–L3 larvae, <b>5</b> and <b>6</b> (and, to a lesser extent, <b>1</b>) inhibit the motility of heartworm <i>Dirofilaria immitis</i> microfilaria (IC₅₀ 10–11 μM). …”
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Molecular epidemiology and antimicrobial resistance of Salmonella at the human–macaque–environment interface in Thailand: A One Health surveillance study by Suchawan Pornsukarom, Daraka Tongthainan, Phairot Phromwat, Suwarak Wannaratana, Kulchai Nakbubpa, Sarut Muangsri

“…The findings advocate for public awareness initiatives, environmental hygiene improvements, and integrative One Health strategies to mitigate AMR dissemination at the human–animal–ecosystem interface.…”
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Proteomic analysis of laser captured tubular tissues reveals complement activation and mitochondrial dysfunction in autoimmune related kidney diseases by Mengyun Xiao, Xianggeng Chi, Xiaohui Zhu, Zigan Xu, Yaoshuang Zou, Yue Peng, Shaodong Luan, Jingjing Dong, Yong Dai, Lianghong Yin

“…Clinical parameters and histopathological assessments were integrated with proteomic findings to comprehensively investigate underlying pathogenic processes. …”
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Osteogenic and Antibacterial Response of Levofloxacin-Loaded Mesoporous Nanoparticles Functionalized with <i>N</i>-Acetylcysteine by Alberto Polo-Montalvo, Natividad Gómez-Cerezo, Mónica Cicuéndez, Blanca González, Isabel Izquierdo-Barba, Daniel Arcos

“…This pathology is mostly due to bacterial pathogens, among which <i>S. aureus</i> stands out. …”
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Pecan-medicinal crops intercropping improved soil fertility and promoted interactions between soil microorganisms and metabolites by Ruyuan Wang, Chenyang Liu, Xuesong Bie, Yan Dai, Xu Feng, Ren Wang, Ming Wang, Shu Xu, Yu Chen

“…Intercropping also significantly altered the structures of both bacterial and fungal communities in bulk soil, stabilised the enrichment of nitrogen-cyclic bacteria, for instance, Bacillus, and decreased the relative abundances of plant–pathogenic fungi, for instance, Fusarium. In addition, the result of metabolomic analysis showed that intercropping promoted the synthesis of functional compounds, such as trehalose and ethanolamine, which enhanced plant disease resistance in bulk soils. …”
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Prevalence of dengue and leptospirosis coinfection and associated mortality rates: a systematic review and meta-analysis by Suraj Tiwari, Mahalaqua Nazli Khatib, Rekha MM, Mandeep Kaur, Girish Chandra Sharma, Puneet Sudan, K. Satyam Naidu, Rajesh Singh, Teena Vishwakarma, Sonam Puri, Muhammed Shabil, Anuradha Yadav, Takveer Singh, Sahil Khurana, Rachana Mehta, Prakasini Satapathy, Renu Sah, Abhay M Gaidhane, Ganesh Bushi

“…Co-infection of these pathogens places additional strain on healthcare resources in endemic areas. …”
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