Harnessing genomic and bioinformatic data to broaden understanding of leukaemia across continents by Gumelar Gugun, Ulfa Mia Maria, Amukti Danang Prasetyaning, Irham Lalu Muhammad, Yuliani Sapto, Adikusuma Wirawan, Khairi Sabiah, Darmawi Darmawi, Chong Rockie, Ates Ilker, Singh Dilpreet, Chavan Aditya Ashok

“…PATJ maintains brain cell integrity, MINDY1 regulates gene expression, CDKN1B controls the cell cycle and ABCC8 regulates glucose levels. …”
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Comprehensive evaluation and mechanisms of Bacillus velezensis AX22 against rice bacterial blight by Xin Shan, Jiawei Dai, Zhaofeng Xu, Yuting Diao, Ning Yang, Yongjie Fan, Meiqi Ma, Jiahui Zhao, Xiang Li, Shenghan Gao, Ming Xiao, Junmin Pei

“…Antibacterial assays showed that AX22 cell-free supernatant and purified difficidin effectively disrupted Xoo cellular morphology, resulting in nucleic acid and protein leakage and suppressing pathogenic traits such as biofilm formation, EPS production, and extracellular enzyme activity. …”
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Brittle Cornea Syndrome: Molecular Diagnosis and Management by Marco Zeppieri, Mattia Gentile, Antonio Acquaviva, Davide Scollo, Fabiana D’Esposito, Giuseppe Gagliano, Alessandro Avitabile, Caterina Gagliano, Lucia Lapenna

“…Genetic testing identified the homozygous pathogenic variant c.974delG (p.Cys325LeufsX2) in the PRDM5 gene in both cases. …”
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Learning motif features and topological structure of molecules for metabolic pathway prediction by Jianguo Hu, Yiqing Zhang, Jinxin Xie, Zhen Yuan, Zhangxiang Yin, Shanshan Shi, Honglin Li, Shiliang Li

“…Abstract Metabolites serve as crucial biomarkers for assessing disease progression and understanding underlying pathogenic mechanisms. However, when the metabolic pathway category of metabolites is unknown, researchers face challenges in conducting metabolomic analyses. …”
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Comprehensive lung microbial gene and genome catalogs assist the mechanism survey of Mesomycoplasma hyopneumoniae strains causing pig lung lesions by Jingquan Li, Fei Huang, Yunyan Zhou, Tao Huang, Xinkai Tong, Mingpeng Zhang, Jiaqi Chen, Zhou Zhang, Huipeng Du, Zifeng Liu, Meng Zhou, Yiwen Xiahou, Huashui Ai, Congying Chen, Lusheng Huang

“…Based on these data sets and through integrated analysis of the isolation of the related bacterial strains, in vitro infection, and RNA sequencing, we identified and confirmed that Mesomycoplasma hyopneumoniae (M. hyopneumoniae) MAG_47 and its adhesion‐related virulence factors (VFs) were associated with lung lesions in pigs. …”
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Micronutrient deficiency reshapes plant-microbe interaction networks: unraveling microbial community dynamics and functional adaptability in a sterile system by Jie Wu, Sauban Musa Jibril, Rong Liu, Bingjuan Yang, Yuru Xu, Ling Wang, Yi Wang, Chengyun Li

“…Crucially, we propose a bidirectional "plant–microbe" regulatory axis: Cu deficiency directly impairs plant growth by disrupting photosynthetic symbionts and enriching potential pathogens, while Mn/Mo deprivation enriched endophytic taxa linked to potential nutrient metabolism and stress resilience. …”
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The Global Challenge of Antimicrobial Resistance: Mechanisms, Case Studies, and Mitigation Approaches by Abubakar Nazir, Awais Nazir, Varisha Zuhair, Shafaq Aman, Safi Ur Rehman Sadiq, Abdul Haseeb Hasan, Maryam Tariq, Latif Ur Rehman, Mubarak Jolayemi Mustapha, Deusdedith Boniphace Bulimbe

“…., colistin, carbapenems) is rising in pathogens such as Klebsiella pneumoniae and Acinetobacter baumannii, with treatment failure rates exceeding 50% in some regions. …”
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Impact of germline variants on breast and ovarian cancer risk in Japanese women: an original cohort study and meta-analysisResearch in context by Shu Yazaki, Megumi Hori, Hisaki Aiba, Yukihide Momozawa, Masayuki Yoshida, Sho Shiino, Kenichi Harano, Chisako Yamauchi, Takashi Yamanaka, Maiko Miwa, Koichi Matsuda, Yosuke Kawai, Mayumi Kobayashi-Kato, Masakazu Kitagawa, Motonobu Saito, Hiroshi Nakagomi, Kazunoshin Tachibana, Ikuko Sakamoto, Kazuaki Takahashi, Yuka Asami, Kota Katanoda, Aya Kuchiba, Hiroshi Yoshida, Mitsuya Ishikawa, Tastunori Shimoi, Kazuki Sudo, Chikako Shimizu, Akihiko Shimomura, Takeshi Murata, Yuji Yamashita, Takahiro Kogawa, Saori Fujiwara, Haruya Saji, Hisamori Kato, Etsuko Miyagi, Yusuke Iwasaki, Tomomi Aoi, Sadaaki Takata, Aiko Ogasawara, Tohru Ohtake, Keiya Fujimori, Yosuke Hirotsu, Minoru Nagashima, Masaaki Komatsu, Ryuji Hamamoto, Makoto Hirata, Teruhiko Yoshida, Takayuki Honda, Kengo Hiranuma, Maiko Matsuda, Yoko Shimada, Kuniko Sunami, Eisei Noiri, Yosuke Omae, Koji Matsumoto, Aikou Okamoto, Masao Omata, Takafumi Watanabe, Yohei Miyagi, Yoshinori Murakami, Katsushi Tokunaga, Kosei Hasegawa, Tomoyasu Kato, Tatsuya Onishi, Toshinari Yamashita, Yoichi Naito, Akihiko Suto, Kan Yonemori, Takashi Kohno, Kouya Shiraisihi, Yukihide Momozawa, Koichi Matsuda, Yusuke Iwasaki, Tomomi Aoi, Sadaaki Takata, Yoshinori Murakami, Yosuke Kawai, Eisei Noiri, Yosuke Omae, Katsushi Tokunaga

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A rapid and efficient reverse genetics method for generating RNA viruses by Ms Kavitha Sethumadhavan, Ms JyothiLakshmi Sajimon, Dr Pratyajit Mohapatra, Dr Victor Stalin Raj

“…Introduction: Pathogenic RNA viruses pose a significant threat to global health due to their high rates of morbidity, mortality, and substantial economic impact. …”
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Development of a new data management system for the study of the gut microbiome of children who are small for their gestational age by Felix Manske, Magdalena Durda-Masny, Norbert Grundmann, Jan Mazela, Monika Englert-Golon, Marta Szymankiewicz-Bręborowicz, Joanna Ciomborowska-Basheer, Izabela Makałowska, Anita Szwed, Wojciech Makałowski

“…Our system provided more flexibility to conduct study-specific analyses and to integrate specific external resources than existing and necessarily more generic solutions. …”
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Unique trajectory of gene family evolution from genomic analysis of nearly all known species in an ancient yeast lineage by Bo Feng, Yonglin Li, Biyang Xu, Hongyue Liu, Jacob L Steenwyk, Kyle T David, Xiaolin Tian, Carla Gonçalves, Dana A Opulente, Abigail L LaBella, Marie-Claire Harrison, John F Wolters, Shengyuan Shao, Zhaohao Chen, Kaitlin J Fisher, Marizeth Groenewald, Chris Todd Hittinger, Xing-Xing Shen, Shengying Li, Antonis Rokas, Xiaofan Zhou, Yuanning Li

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Optimisation and clinical validation of a metagenomic third-generation sequencing approach for aetiological diagnosis in bronchoalveolar lavage fluid of patients with pneumoniaRese... by Shanshan Zhang, Xi Li, Xia Li, Ying Fu, Long Chen, Wei Wang, Qinqing Lin, Hui Lou, Yake Yao, Wenyu Chen, Cheng Zhong, Jian Ye, Yinan Yao, Huimin Guo, Yunsong Yu, Hua Zhou

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Title: race and ethnicity and the risk of community-acquired third-generation cephalosporin-resistant uropathogens: a systematic review and meta-analysis by Sweta Balaji, Sarah Blackmon, Esther E. Avendano, Samson Alemu Argaw, Rebecca A. Morin, Nanguneri Nirmala, Shira Doron, Maya L. Nadimpalli

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Identification of autoantibodies targeting citrullinated CLEC12A in rheumatoid arthritis patients by Lillian Barra, Sheri Saunders, Mathias Mangion, Guillaume Paré, Halim Maaroufi, Alain Garnier, Ewa Cairns, Maria J. Fernandes

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In vitro and in vivo effectiveness of essential oils against coccidia in Black Livorno chickens by Alessia Zoroaster, Marta Raffaelli, Manuela Diaferia, Fabrizia Veronesi, Margherita Marzoni Fecia di Cossato, Barbara Contiero, Roberto Marani, Antonio Frangipane di Regalbono, Stefania Perrucci

“…Despite the presence of highly pathogenic Eimeria species (E. tenella, E. necatrix), no clinical signs were observed, probably due to the possible low parasitic burden and breed’s inherent resistance. …”
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Type VII secretion system gene mutations driving global mycobacterium tuberculosis transmission revealed by whole genomic sequence by Jian-Jun Yang, Jian-Jun Yang, Yuan-long Hu, Ping-yi Sun, Ling Wang, Xian-Jin Xie, Ting-Ting Wang

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Identification of critical residues at the C-terminal tip of ACKR4 regulating chemokine internalization and βarrestin involvement by Oliver J. Gerken, Nicola Catone, Daniel F. Legler

“…Conclusion This study identifies that the integrity of the C-terminus of ACKR4 is critical for receptor function. …”
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Methicillin-resistant staphylococci biofilms and the possibility of controlling them with chlorhexidine and polyhexanide: prospects for use in real clinical practice by E. M. Gordina, A. D. Shakhmatova, A. R. Kasimova, S. S. Toropov, S. A. Bozhkova

“…Introduction. The leading pathogens of implant-associated infection are S. aureus and S. epidermidis, characterized by the ability to biofilm formation, which pose a serious threat to the life and health of patients. …”
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Decoding Cuproptosis-Sphingolipid-Immune Crosstalk in Atopic Dermatitis: A Multi-Omics Network Analysis by Xiaowen Wen, Shulin Jia, Jing Wu, Suitian Wang, Teng Yu, Haoyou Xu

“…<b>Methods:</b> We integrated two datasets (GSE157194 and GSE193309) from the GEO database and employed weighted gene co-expression network analysis (WGCNA) to identify disease-related modules. …”
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Extracellular vesicles in osteoarthritis synovial fluid contain both transmembrane and intravesical TNF-α by Xin Zhang, Virginia Byers Kraus

“…Conclusions: While intravesical TNF-α may evade TNF-α inhibitors, TNF-α carried by EVs retains pathogenic potential, either by activating pro-inflammatory pathways via TM-TNF-α receptor engagement on target cells, or through the transfer of TNF-α cargo to recipient cells.…”
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