Targeting EGR1-ATF3 signaling mitigates paravertebral muscle degeneration by regulating cell death and inflammaging by Xuke Wang, Qingfeng Wang, Zhe Wang, Yingjie Zhou, Xiaobing Jiang, Yongjin Li

“…Age-related cellular death further accelerates chronic, low-grade inflammation termed “inflammaging” and disrupts the extracellular matrix (ECM), representing a key pathogenic mechanism driving paravertebral muscle degeneration (PMD). …”
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Memory B cell proliferation drives differences in neutralising responses between ChAdOx1 and BNT162b2 SARS-CoV-2 vaccines by David Hodgson, Yi Liu, Yi Liu, Louise Carolan, Siddhartha Mahanty, Kanta Subbarao, Kanta Subbarao, Sheena G. Sullivan, Sheena G. Sullivan, Sheena G. Sullivan, Annette Fox, Annette Fox, Adam Kucharski

“…DiscussionReconstructing in-host kinetics in response to vaccination could help optimise vaccine dosing regimens, improve vaccine efficacy in different population groups, and inform the design of future vaccines for enhanced protection against emerging pathogens.…”
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Monitoring <i>Moringa oleifera</i> Lam. in the Mediterranean Area Using Unmanned Aerial Vehicles (UAVs) and Leaf Powder Production for Food Fortification by Carlo Greco, Raimondo Gaglio, Luca Settanni, Antonio Alfonzo, Santo Orlando, Salvatore Ciulla, Michele Massimo Mammano

“…Plate count analyses confirmed the absence of pathogenic bacterial colonies in the <i>M. oleifera</i> leaf powders, highlighting their potential application as natural and functional additives in food production.…”
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Insects in agricultural greenhouses: a metagenomic analysis of microbes in Trialeurodes vaporariorum infesting tomato and cucumber crops by Abeer Qush, Nada Assaad, Fatima Abdulla Alkhayat, Mohammed Saif Al-Kuwari, Nasser Al-Khalaf, Maya Bassil, Hadi M. Yassine, Hadi M. Yassine, Asad Zeidan, Rozaimi Razali, Rozaimi Razali, Layla Kamareddine, Layla Kamareddine

“…This work provides additional insight into the insect pests paradigm in greenhouses, an upshot that could serve integrated insect pest management strategies in greenhouses for optimal agricultural practices.…”
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Keratin 6A promotes skin inflammation through JAK1-STAT3 activation in keratinocytes by Mengting Chen, Yaling Wang, Mei Wang, San Xu, Zixin Tan, Yisheng Cai, Xin Xiao, Ben Wang, Zhili Deng, Ji Li

“…Abstract Background Skin barrier dysfunction and immune activation are hallmarks of inflammatory skin diseases such as rosacea and psoriasis, suggesting shared pathogenic mechanisms. While barrier disruption may trigger or exacerbate skin inflammation, the precise underlying mechanisms remain unclear. …”
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YOLOv8-RD: High-Robust Pine Wilt Disease Detection Method Based on Residual Fuzzy YOLOv8 by Junchao Yuan, Lina Wang, Tingting Wang, Ali Kashif Bashir, Maryam M. Al Dabel, Jiaxing Wang, Hailin Feng, Kai Fang, Wei Wang

“…Due to the minute size of the pathogens and the concealed symptoms of PWD, early detection through remote sensing image technology is essential. …”
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Antivirus and antibacterial filters for face masks based on silver quantum dots by Jokanović Vukoman, Zdravković Nemanja, Petrović Božana, Živković Marija, Biočanin Vladimir, Aleksić Ema, Milutinović Jovana, Petrović Tamaš

“…Available face masks, used to protect the respiratory system from various types of pathogens, show unsatisfactory efficiency because the size of viruses like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is much smaller than the void spaces in these masks. …”
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Multiple Co-Infecting Caliciviruses in Oral Fluid and Enteric Samples of Swine Detected by a Novel RT-qPCR Assay and a 3′RACE-PCR-NGS Method by Zoltán László, Péter Pankovics, Péter Urbán, Róbert Herczeg, Gyula Balka, Barbara Igriczi, Attila Cságola, Mihály Albert, Fruzsina Tóth, Gábor Reuter, Ákos Boros

“…Caliciviruses including noro- and sapoviruses of family <i>Caliciviridae</i> are important enteric human and swine pathogens, while others, like valoviruses, are less known. …”
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Evaluating the Role of Canada Goose Populations in Transmission Dynamics During Peak HPAI Incidence in Iowa, February 2022–December 2023 by Christopher Jimenez, Sergios-Orestis Kolokotronis, Janet E. Rosenbaum, Lori A. Hoepner

“…Since its emergence in the United States in February 2022, Highly Pathogenic Avian Influenza (HPAI) H5N1 has caused significant losses for poultry operations, particularly in Iowa between February 2022 and December 2023. …”
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Gut mycobiome alterations and network interactions with the bacteriome in patients with atherosclerotic cardiovascular disease by Guangming Su, Ping Huang, Dan Liu, Guorui Xing, Ruochun Guo, Shenghui Li, Shao Fan, Lin Cheng, Qiulong Yan, Wei Yang

“…Predictive models that integrated both bacterial and fungal taxa enhanced prediction accuracy, underscoring the critical role of gut fungi in ACVD. …”
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Duodenal Organoids From Metabolic Dysfunction-Associated Steatohepatitis Patients Exhibit Absorptive and Barrier Alterations by Alia Hadefi, Morgane Leprovots, Gilles Dinsart, Maryam Marefati, Marjorie Vermeersch, Daniel Monteyne, David Pérez-Morga, Anne Lefort, Frédérick Libert, Laurine Verset, Claire Liefferinckx, Christophe Moreno, Jacques Devière, Eric Trépo, Marie-Isabelle Garcia

“…Though MASH is closely tied to metabolic risk factors, the underlying pathogenic mechanisms remain scarcely understood. Recent research has emphasized the importance of the gut-liver axis in its pathogenesis, an aspect less explored in human studies. …”
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Methods for assessing efficacy of cleaning and disinfection in livestock farms: a narrative review by Iryna Makovska, Evelien Biebaut, Pankaj Dhaka, Pankaj Dhaka, Leonid Korniienko, Julia Gabrielle Jerab, Laura Courtens, Ilias Chantziaras, Jeroen Dewulf

“…Cleaning and disinfection (C&amp;D) procedures are essential components of farm biosecurity, aiming to reduce microbial load and eliminate the pathogenic microorganisms in livestock farms facilities. …”
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The interplay between antimicrobial resistance, heavy metal pollution, and the role of microplastics by Igori Balta, Joanne Lemon, Anna Gadaj, Iuliana Cretescu, Ducu Stef, Ioan Pet, Lavinia Stef, David McCleery, Alastair Douglas, Nicolae Corcionivoschi, Nicolae Corcionivoschi

“…This review also emphasizes the urgent need for integrated environmental and public health strategies to mitigate pollutant-driven AMR. …”
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Comprehensive in vitro and whole-genome characterization of probiotic properties in Pediococcus acidilactici P10 isolated from Iranian broiler chicken by Raana Tabashiri, Sahar Mahmoodian, Mohammad Hossein Pakdel, Vahid Shariati, Amir Meimandipour, Javad Zamani

“…Abstract This study presents a comprehensive characterization of Pediococcus acidilactici strain P10, a novel probiotic isolated from native broiler chickens, integrating in vitro analyses with whole-genome sequencing. …”
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Evaluation of the Synergistic Activity of Antimicrobial Peptidomimetics or Colistin Sulphate with Conventional Antifungals Against Yeasts of Medical Importance by Shyam Kumar Mishra, Rajesh Kuppusamy, Christina Nguyen, Jennifer Doeur, Harleen Atwal, Samuel Attard, Kristian Sørensen, Jennifer S. Lin, Edgar H. H. Wong, Alex Hui, Annelise E. Barron, Naresh Kumar, Mark Willcox

“…With rising multidrug-resistant yeast pathogens, conventional antifungals are becoming less effective, urging the need for adjuvants that enhance their activity at lower doses. …”
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A rare germline mutation reverses the suppressive effect of GPC5 thereby promoting lung adenocarcinoma development and tumorigenesis by Zhifa Zheng, Zhifa Zheng, Zhifa Zheng, Zhifa Zheng, Lina Zhao, Lina Zhao, Lina Zhao, Lina Zhao, Sen Zhao, Zhihong Wu, Zhihong Wu, Zhihong Wu, Nan Wu, Nan Wu, Nan Wu

“…Through rigorous rare variant analysis, we prioritized the GPC5 c.776C&gt;T variant, subsequently validating its pathogenicity via integrated computational modeling and immunohistochemical profiling. …”
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Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration by Ting Shen, Jacob W. Vogel, Vivianna M. Van Deerlin, EunRan Suh, Laynie Dratch, Jeffrey S. Phillips, Lauren Massimo, Edward B. Lee, David J. Irwin, Corey T. McMillan

“…Methods We employed an integrative imaging transcriptomics approach to identify both disparate and shared transcriptomic signatures associated with cortical thickness in bvFTD with C9orf72 repeat expansions or pathogenic variants in GRN or MAPT. …”
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Impact of nonsynonymous single nucleotide polymorphisms in PROCR gene on protein stability and thrombotic risk: a molecular dynamic approach by Hytham Ahmed Abuagla, Khalid Mohamed Adam, Mohamed E. Elangeeb, Elsadig Mohamed Ahmed, Elshazali W. Ali, Ali M. Edris, Abubakr Ali Elamin MohamedAhmed, Elmoiz Idris Eltieb, Tarig Babikir Algak Khalid, Bahaeldin K. Elamin, Hiba Mahgoub Ali Osman, Ebtehal Salih Idris

“…This provides mechanistic insight into how PROCR variation may contribute to thrombotic disorders and highlights the utility of in silico approaches for prioritizing potentially pathogenic variants.ConclusionOur study demonstrates that deleterious nsSNPs in the PROCR gene can significantly impair EPCR stability and function, thereby increasing susceptibility to thrombosis. …”
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Analysis and validation of characteristic genes in RNA sequencing datasets from heart failure patients based on multiple algorithms by Yuxuan Li, Ying Bai, Wujiao Wang, Zhaotian Ma, Peng Li, Dong Li, Sinai Li, Jialin Jin, Jialin Jin, Qian Lin

“…This analysis should be conducted in conjunction with transcriptome sequencing data from a large sample of clinical myocardial tissue, in order to identify the core pathogenic mechanisms in heart failure myocardial tissue.MethodTranscriptome data from HF patient myocardial biopsies underwent Robust Rank Aggregation (RRA) to identify differentially expressed genes (DEGs). …”
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Molecular mechanisms and therapeutic targets of acute exacerbations of chronic obstructive pulmonary disease with Pseudomonas aeruginosa infection by Zhiwei Lin, Shuang Liu, Ke Zhang, Tianyu Feng, Yewei Luo, Yu Liu, Baoqing Sun, Luqian Zhou

“…Abstract Background Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of global mortality, with acute exacerbations of COPD (AECOPD) significantly increasing the disease’s morbidity and mortality. Among the pathogens implicated in AECOPD, Pseudomonas aeruginosa (P. aeruginosa) is increasingly recognized as a major co-infecting bacterium. …”
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