The emerging relationship between mucosal-associated invariant T cell populations and the onset and progression of type 1 diabetes by Devin R. Fraser, Andrew W. Stadnyk, Andrew W. Stadnyk, Andrew W. Stadnyk

“…MAIT cells appear to have dual protective and pathogenic roles impacted by microbiome interactions. …”
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Probiotic Bacillus pumilus LV149 enhances gut repair, modulates microbiota, and alters transcriptome in DSS-induced colitis mice by Xinyu Sun, Long Yun, Keming Xie, Renhui Liu, Xinyue Ren, Bokun Zeng, Xudong Cao, Zhi Li, Guihao Zhou, Bang Liu, Luo Peng, Lihong Yuan

“…LV149 further modulated the gut microbiota, increasing beneficial bacteria and reducing pathogenic populations. Transcriptomic analysis indicated that LV149-L may exert gut repair effects via the IL-17 signaling pathway, whereas LV149-H appears to act through the JAK-STAT signaling pathway.ConclusionThis study demonstrated that LV149, particularly at a higher dose, effectively mitigated DSS-induced colonic injury by modulating gut microbiota, enhancing gut barrier integrity, and reducing inflammation. …”
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Hyodeoxycholic acid modulates gut microbiota and bile acid metabolism to enhance intestinal barrier function in piglets by Jie Chong, Jie Chong, Yongming Zhou, Zhi Li, Xiaokai Li, Jinwei Zhang, Jinwei Zhang, Haoran Cao, Jideng Ma, Liangpeng Ge, Liangpeng Ge, Hang Zhong, Hang Zhong, Jing Sun, Jing Sun

“…Concurrently, HDCA enhanced intestinal barrier integrity by upregulating tight junction proteins (ZO-1, Claudin, Occludin) and suppressing pro-inflammatory cytokines (TNF-α, IL-1β). …”
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Acute myeloneuropathy due to Glutaric aciduria-1: Expanding the phenotypic spectrum by Dipti Baskar, Rita Christopher, Gautham Arunachal, Davuluri Durga Srinivas Anudeep, Ambati Mounika, TA Sangeeth, Kiran Polavarapu, BS Shalini, Tarachand Joshi, Sai Bhargava Sanka, Saraswati Nashi, Pritam Raja, Ravindranadh Mundlamuri Chowdary, Ravi Yadav, Atchayaram Nalini, Seena Vengalil

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Living with rare genetic disease during the COVID-19 pandemic: A qualitative study of adolescents and young adults with Li-Fraumeni syndrome by Allison Werner-Lin, Payal P. Khincha, Ashley S. Thompson, Camella Rising, Alix Sleight, Catherine Wilsnack, Patrick Boyd, Alexandra Feldman, Rowan Forbes Shepherd, Sharon A. Savage

“…Thirty adolescents and young adults (22 female, 8 male, median age 31 years, range 18–41) with a confirmed pathogenic TP53 variant completed a semi-structured qualitative interview. …”
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SBML Level 3: an extensible format for the exchange and reuse of biological models by Sarah M Keating, Dagmar Waltemath, Matthias König, Fengkai Zhang, Andreas Dräger, Claudine Chaouiya, Frank T Bergmann, Andrew Finney, Colin S Gillespie, Tomáš Helikar, Stefan Hoops, Rahuman S Malik‐Sheriff, Stuart L Moodie, Ion I Moraru, Chris J Myers, Aurélien Naldi, Brett G Olivier, Sven Sahle, James C Schaff, Lucian P Smith, Maciej J Swat, Denis Thieffry, Leandro Watanabe, Darren J Wilkinson, Michael L Blinov, Kimberly Begley, James R Faeder, Harold F Gómez, Thomas M Hamm, Yuichiro Inagaki, Wolfram Liebermeister, Allyson L Lister, Daniel Lucio, Eric Mjolsness, Carole J Proctor, Karthik Raman, Nicolas Rodriguez, Clifford A Shaffer, Bruce E Shapiro, Joerg Stelling, Neil Swainston, Naoki Tanimura, John Wagner, Martin Meier‐Schellersheim, Herbert M Sauro, Bernhard Palsson, Hamid Bolouri, Hiroaki Kitano, Akira Funahashi, Henning Hermjakob, John C Doyle, Michael Hucka, SBML Level 3 Community members, Richard R Adams, Nicholas A Allen, Bastian R Angermann, Marco Antoniotti, Gary D Bader, Jan Červený, Mélanie Courtot, Chris D Cox, Piero Dalle Pezze, Emek Demir, William S Denney, Harish Dharuri, Julien Dorier, Dirk Drasdo, Ali Ebrahim, Johannes Eichner, Johan Elf, Lukas Endler, Chris T Evelo, Christoph Flamm, Ronan MT Fleming, Martina Fröhlich, Mihai Glont, Emanuel Gonçalves, Martin Golebiewski, Hovakim Grabski, Alex Gutteridge, Damon Hachmeister, Leonard A Harris, Benjamin D Heavner, Ron Henkel, William S Hlavacek, Bin Hu, Daniel R Hyduke, Hidde de Jong, Nick Juty, Peter D Karp, Jonathan R Karr, Douglas B Kell, Roland Keller, Ilya Kiselev, Steffen Klamt, Edda Klipp, Christian Knüpfer, Fedor Kolpakov, Falko Krause, Martina Kutmon, Camille Laibe, Conor Lawless, Lu Li, Leslie M Loew, Rainer Machne, Yukiko Matsuoka, Pedro Mendes, Huaiyu Mi, Florian Mittag, Pedro T Monteiro, Kedar Nath Natarajan, Poul MF Nielsen, Tramy Nguyen, Alida Palmisano, Jean‐Baptiste Pettit, Thomas Pfau, Robert D Phair, Tomas Radivoyevitch, Johann M Rohwer, Oliver A Ruebenacker, Julio Saez‐Rodriguez, Martin Scharm, Henning Schmidt, Falk Schreiber, Michael Schubert, Roman Schulte, Stuart C Sealfon, Kieran Smallbone, Sylvain Soliman, Melanie I Stefan, Devin P Sullivan, Koichi Takahashi, Bas Teusink, David Tolnay, Ibrahim Vazirabad, Axel von Kamp, Ulrike Wittig, Clemens Wrzodek, Finja Wrzodek, Ioannis Xenarios, Anna Zhukova, Jeremy Zucker

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Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in Trypanosoma cruzi by Mayara S. Bertolini, Sabrina E. Cline, Miguel A. Chiurillo, Brian S. Mantilla, Aharon Eidex, Logan P. Crowe, Danye Qiu, Henning J. Jessen, Adolfo Saiardi, Roberto Docampo

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RNF213 Acts as a Molecular Switch for Cav-1 Ubiquitination and Phosphorylation in Human Cells by Jungmi Choi, Ryoichi Inoue, Yuki Masuo, Yukiko Shimizu, Kazuhiro Sonomura, Minsoo Kim, Hatasu Kobayashi, Kouji H. Harada, Yohei Mineharu, Akio Koizumi, Tohru Tezuka, Shohab Youssefian

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Quaking–cZFP609 Axis Remedies Aberrant Plasticity of Vascular Smooth Muscle Cells via Mediating Platelet‐Derived Growth Factor Receptor β Degradation by Yong‐Qing Dou, Xiao‐Yun Zhang, Rui‐Juan Guo, Xiao‐Fu Huang, Yu Song, Xin‐Long Liu, Jie Shi, Fan‐Qin Li, Dan‐Dan Zhang, Peng Kong, Lei Nie, Han Li, Fan Zhang, Mei Han

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Gut Barrier Dysfunction and Microbiota Variations in Cryptosporidiosis: A Comprehensive Review by Munwar Ali, Chang Xu, Mingyue Wang, Qazal Hina, Yaru Ji, Subiha Anwar, Sijia Lu, Qing He, Yawei Qiu, Kun Li

“…<i>Cryptosporidium</i>-induced dysbiosis is characterized by reduced microbial diversity and richness, a shift from commensal to pathogenic bacteria, as evidenced by increased pro-inflammatory taxa like Proteobacteria, and reduced proportions of beneficial SCFAs producing bacteria, e.g., Firmicutes. …”
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Copper and Zinc Sulfates Suppress <i>Streptomyces</i> spp. and Enhance Potato Resistance via Thaxtomin A Inhibition and Defense Gene Regulation by Nianzhou Chen, Shuning Zhou, Shuo Yan, Xin Yuan, Weiqi Jiao, Xinbo Wang, Jie Liu, Xuanzhe Zhang

“…., significantly reducing the production of the pathogenic toxin Thaxtomin A by 57.02% and 41.29%, respectively. …”
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An umbrella review of systematic reviews/meta-analyses evaluating the antimicrobial activity of various nanoparticles on orthodontic materials &amp; components by Vaibhav Kumar, Ruchira Shreevats, Aysha Syed, Mansi Jaiswal, Meghna Vandekar

“…Traditional preventive measures include fluoride treatments and meticulous oral hygiene, but integrating antimicrobial nanoparticles into orthodontic materials offers a promising alternative. …”
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Fungi and cancer: unveiling the complex role of fungal infections in tumor biology and therapeutic resistance by Wanli Zhang, He Zhang, Yiru Gao, Jianjun Lei, Chenhao Suo

“…Fungi, which are omnipresent microorganisms, have traditionally been considered opportunistic pathogens. However, recent research highlights their broader impact on host immunity and their potential contributions to cancer pathogenesis. …”
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MCM9 deficiency impairs DNA damage repair during spermatogenesis, leading to Sertoli cell-only syndrome in humans by Xuan Sha, Xin Zhang, Hao Geng, Yuqian Li, Xun Xia, Guotong Li, Rong Hua, Kuokuo Li, Yang Gao, Qunshan Shen, Rui Guo, Yuping Xu, Xiaojin He, Yunxia Cao, Mingxi Liu, Huan Wu

“…The absence of testicular MCM9 confirmed the pathogenicity of these LoF mutations. Furthermore, diminished HR-mediated DNA repair capacity observed in HEK293T cells, either lacking MCM9 or overexpressing mutant MCM9 plasmids, highlighted the deleterious impact of these LoF mutations on HR repair. …”
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Staphylococcus aureus nt5 gene mutation through CRISPR RNA-guided base editing weakens bacterial virulence and immune evasion by Xinpeng Liu, Lan Huang, Yang Ye, Haiyi Wang, Min Tang, Fuqiang He, Zijing Xia, Shi Deng, Peng Zhang, Ruiwu Dai, Shufang Liang

“…It is essential to explore key pathogenicity-driven genes/proteins in bacterial infection and antibiotics resistance, which contributes to develop novel therapeutic strategies against S. aureus infections. …”
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Comorbidity of hypertension and lung cancer: interplay of genetics and environment by Jingtong Zeng, Difang Shi, Daqian He, Wenxun Dong, Zhenghong Yang, Ying Chen

“…The relationship between hypertension and lung cancer is complex, with shared risk factors and common pathogenic mechanisms, including inflammation, oxidative stress, and metabolic dysregulation. …”
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Response of Pedunculate Oak (<i>Quercus robur</i> L.) to Adverse Environmental Conditions in Genetic and Dendrochronological Studies by Konstantin V. Krutovsky, Anna A. Popova, Igor A. Yakovlev, Yulai A. Yanbaev, Sergey M. Matveev

“…Investigating its responses to stressors such as drought, extreme temperatures, pests, and pathogens provides valuable insights into its capacity to adapt to climate change. …”
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Spatial dynamics of Culex quinquefasciatus abundance: geostatistical insights from Harris County, Texas by Morgan Jibowu, Melissa S. Nolan, Ryan Ramphul, Heather T. Essigmann, Abiodun O. Oluyomi, Eric L. Brown, Maximea Vigilant, Sarah M. Gunter

“…Culex quinquefasciatus is the primary vector for several mosquito-borne pathogens, including West Nile virus. Using spatial analysis and modeling techniques, we investigated the geospatial distribution of Culex quinquefasciatus abundance in the large metropolis of Harris County, Texas, from 2020 to 2022. …”
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Host–Microbiota–Parasite Interactions in Grass Carp: Insights from <i>Ichthyophthirius multifiliis</i> Infection by Fangxiang Li, Dongdong Jiang, Qing Wang, Ouqin Chang, Jiyuan Yin, Meiling Yu, Houjun Pan

“…At the genus level, opportunistic pathogens <i>Aeromonas</i> and <i>Vibrio</i> proliferated in the intestine, whereas <i>Flavobacterium</i> and <i>Candidatus</i> Megaira increased in the skin and gills. …”
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CATS: a bioinformatic tool for automated Cas9 nucleases activity comparison in clinically relevant contexts by Ettore Rocchi, Ettore Rocchi, Federico Magnani, Federico Magnani, Gastone Castellani, Gastone Castellani, Antonio Carusillo, Martina Tarozzi, Martina Tarozzi

“…CATS automates the detection of overlapping PAM sequences across different Cas9 nucleases and identifies allele-specific targets, particularly those arising from pathogenic mutations. One of the key parameters in CATS is the proximity of PAM sites, which helps minimize sequence composition bias. …”
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