A Senomorphlytic Three‐Drug Combination Discovered in Salsola collina for Delaying Aging Phenotypes and Extending Healthspan by Jiqun Wang, Wenwen Liu, Yunyuan Huang, Guangwei Wang, Xiaobo Guo, Donglei Shi, Tianyue Sun, Chaojiang Xiao, Chao Zhang, Bei Jiang, Yuan Guo, Jian Li

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Epidemiology and risk factors of healthcare-associated urinary tract infections: a prospective study in a Tunisian tertiary hospital by Hela Ghali, Omar Khalil Ben Saad, Sana Bhiri, Salma Balhi, Farah Azouzi, Amani Maatouk, Sameh Boughattas, Saoussen Layouni, Jihed Anoun, Sofien Benzarti, Emna Trabelsi, Zeineb Mrizak, Maha Brahim, Arwa Nafetti, Aroua Kamel, Fatima E. Khouya, Sofien Aidani, Yosr Boussoukaya, Mohamed Ben Rejeb, AbdelHalim Trabelsi, Houyem S. Latiri, Asma Ben Cheikh

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Unveiling the therapeutic potential of natural products in Alzheimer’s disease: insights from in vitro, in vivo, and clinical studies by Nahida Aktary, Yerim Jeong, Seungji Oh, Yeju Shin, Yoonsoo Sung, Muntajin Rahman, Livia Ramos Santiago, Jinwon Choi, Han Gyeul Song, Fahrul Nurkolis, Rosy Iara Maciel Azambuja Ribeiro, Moon Nyeo Park, Bonglee Kim

“…Emerging evidence highlights the therapeutic potential of natural products, particularly herbal medicines, as versatile modulators of key pathogenic processes in AD. These compounds exert neuroprotective effects by mitigating oxidative stress, suppressing neuroinflammation, inhibiting tau hyperphosphorylation, and reducing amyloid-beta aggregation. …”
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A phase separation-related gene signature for prognosis prediction and immunotherapy response evaluation in gastric cancer with targeted natural compound discovery by Yanjuan Jia, Yuanyuan Ma, Zhenhao Li, Wenze Zhang, Rukun Lu, Wanxia Wang, Chaojun Wei, Chunyan Wei, Yonghong Li, Xiaoling Gao, Tao Qu

“…Abstract Background Aberrant phase separation (PS) has emerged as a pivotal pathogenic mechanism in cancer development. However, its prognostic significance and influence on the tumor immune microenvironment in gastric cancer (GC) remain largely unexplored. …”
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Investigation of food safety perceptions, practices, and workplace policies among employees of pet and animal feed stores that sell and do not sell raw meat-based diets by Jennifer Lord, Marie Cozzarelli, Sara Lyon, Sara Lyon, Sheri Pugh, Sheri Pugh, Sharon R. Thompson, Sharon R. Thompson

“…BackgroundPet and animal feed store employees face numerous occupational health hazards, including exposure to pathogens from handling contaminated animal food products. …”
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Bacterial extracellular biomolecules-derived multimodal manganese nanoparticles control watermelon Fusarium wilt by dysregulating fusaric acid biosynthesis pathway and precise tuni... by Muhammad Noman, Temoor Ahmed, Mohammad Shafiqul Islam, Jing Wang, Yingying Cai, Shuang Liang, Zhongna Hao, Hayssam M. Ali, Haiping Qiu, Zhen Zhang, Rongyao Chai, Yanli Wang, Bin Li, Jiaoyu Wang

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Bioinformatics analysis of the tomato (Solanum lycopersicum) methylesterase gene family by Jing Shang, Fujun Li, Xiangrong Kong, Yue Ji, Yanan Li, Sarfaraz Hussain, Xiaoan Li, Ling Li, Xinhua Zhang, Zienab F. R. Ahmed

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Sustainable enhancement of basil quality and resilience through biopriming with Pseudomonas JP0825 by Ahmed M. Mahmoud, Maha H. Khalaf, Ahmed M. Reyad, Shereen Magdy Korany, Emad A. Alsherif, Hiba Shaghaleh, Yousef Alhaj Hamoud, Mohamed S. Sheteiwy, Ali El-Keblawy, Zaid Ulhassan

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Identification of novel ABCB4 variants and genotype-phenotype correlation in progressive familial intrahepatic cholestasis type 3 by Senyan Wang, Qi Liu, Xiaoyan Sun, Wenjuan Wei, Leilei Ding, Xiaofang Zhao

“…Elucidating the genotype-phenotype correlations and expanding the mutational spectrum of the ABCB4 gene are crucial for enhancing diagnostic accuracy and therapeutic strategies.Clinical and genetic data from 2 original PFIC3 patients from our institution, along with 118 additional cases identified through a comprehensive literature review, were integrated for a comprehensive analysis. The study included statistical analysis of clinical information, genetic analysis, multi-species sequence alignment, protein structure modeling, and pathogenicity assessment. …”
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Preparation, Physicochemical Properties, Biological Activity of a Multifunctional Composite Film Based on Zein/Citric Acid Loaded with Grape Seed Extract and Its Application in Sol... by Ning Wang, Jiaxin Wei, Cuntang Wang, Jian Ren

“…Antimicrobial assays demonstrated selective bacteriostatic effects against Gram-negative pathogens. Notably, the composite film containing 6 wt% GSEE had a remarkable restraining effect on the oxidation of lard. …”
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Characterization of bacterial cellulose/PVA composite films incorporated with sesame meal protein hydrolysate: Physicochemical, antimicrobial, and antioxidant properties by Parisa Raei, Morteza Khomeiri, Alireza Sadeghi Mahounak, Ali Moayedi, Mahboobeh Kashiri

“…In this study, the effect of integrating the sesame meal protein hydrolysate (SPH) obtained through Bacillus coagulans fermentation was evaluated in a composite film made from bacterial cellulose (BC) and polyvinyl alcohol (PVA). …”
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RNase 7 and Th cytokines synergistically increase the secretion of interleukin-6 from keratinocytes by Shruti Chopra, Janine Siegl, Verena Kopfnagel, Sylvia Dreyer, Franziska Rademacher, Juliane Lokau, Christoph Garbers, Jürgen Harder, Thomas Werfel, Katinka Döhner

“…In conclusion, our data show that R7 enhances the release of IL-6 in undifferentiated primary keratinocytes, which may have consequences for skin inflammation, defense against pathogens, and wound healing.…”
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Acrylamide Impacts on Black Soldier Fly Larvae: Growth, Toxicity, Microbes, and Bioaccumulation Risks for Food/Feed Safety by Jianwei Hao, Jiahui Yang, Yiru Zhang, Shurong Zhao, Shuang Liu, Wenfeng Hu

“…This study investigated the effects of acrylamide on the growth, neurobehavioral responses, gut integrity, microbial composition, and toxicokinetics of black soldier fly larvae (BSFL). …”
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Protein lysine acetylation regulates oral microorganisms by Yuanchao Yang, Yuanchao Yang, Hailun He, Bingshi Liu, Bingshi Liu, Zhuoyue Li, Zhuoyue Li, Jiaman Sun, Jiaman Sun, Zhili Zhao, Yan Yang, Yan Yang

“…Post-translational modifications (PTMs) are integral to the regulation of protein function, stability, and cellular processes. …”
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Development of a controlled-release mosquito RNAi yeast larvicide suitable for the sustained control of large water storage containers by Keshava Mysore, James D. Oxley, Craig Duckham, Clarissa Castilla-Gutierrez, Akilah T. M. Stewart, Nikhella Winter, Rachel Shui Feng, Satish Singh, Lester D. James, Azad Mohammed, David W. Severson, Molly Duman-Scheel

“…Abstract Large household water storage containers are among the most productive habitats for Aedes aegypti (Linnaeus, 1762), the primary mosquito vector for dengue and other arboviral pathogens. Increasing concerns for insecticide resistance and larvicide safety are limiting the successful treatment of large household water storage containers, which are among the most productive habitats for Aedes juveniles. …”
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Quantitative image analysis of the extracellular matrix of esophageal squamous cell carcinoma and high grade dysplasia via two-photon microscopy by Kausalya Neelavara Makkithaya, Wei-Chung Chen, Chun-Chieh Wu, Ming-Chi Chen, Wei-Hsun Wang, Jackson Rodrigues, Ming-Tsang Wu, Nirmal Mazumder, I-Chen Wu, Guan-Yu Zhuo

“…The SHG-based classifiers demonstrated 75%, 84.21%, 95%, and 95.65% for Group 1, Group 2, primary SCC vs. primary HGD, and metachronous HGD (Group 1) vs. metachronous HGD (Group 2), respectively. This integrative approach enabled the characterization of different pathological stages and enhances the understanding of the pathogenic factors involved in the progression of esophageal cancer.…”
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Pattern of antibiotic use over two decades in Iran: a national level assessment based on WHO AWaRe classification from 2000 to 2019 by Maryam Taghizadeh-Ghehi, Mohammad Effatpanah, Mohadeseh Balvardi, Hossein Khalili

“…An Auto-Regressive Integrated Moving Average [ARIMA] model was used to analyze the trends. …”
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Super-enhancers in immune system regulation: mechanisms, pathological reprogramming, and therapeutic opportunities by Xin Lai, Caizhi Li, Xinglinzi Tang, Xinyi Luo, Feiyan Wu, Yuhong Liang, Bihui Huang, Hang Li, Hang Li

“…Emerging therapeutic strategies targeting SE-associated components show promise in dismantling pathogenic enhancer networks through CRISPR-based editing, small-molecule inhibitors, and proteolysis-targeting chimeras(PROTACs). …”
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Microplastics, Antibiotics, and Heavy Metals in Anaerobic Digestion Systems: A Critical Review of Sources, Impacts, and Mitigation Strategies by Hongbo Liu, Xiang Yuan, Yuxuan Yao, Lijin Yao, Junbo Zhang, Claudia Maurer

“…MPs, primarily derived from fragmented plastics and personal care products, accumulate in digestates and act as vectors for adsorbing toxic additives and pathogens. Antibiotics, introduced via livestock manure and wastewater, exert selective pressures that propagate antibiotic resistance genes (ARGs) while disrupting methanogenic consortia. …”
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A machine learning approach to predict phyllosphere resistome abundance across urbanization gradients by Rui-Ao Ma, Yi-Hui Ding, Shifa Zhong, Ting-Ting Jing, Xuechu Chen, Si-Yu Zhang

“…The heightened transmission potential in urban greenspaces may facilitate the spread of antibiotic resistance spread to human pathogens, which poses significant public health threats.…”
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