Barriers and Facilitators in Diagnostic Pathways That Align Universal Tumor Screening and Mainstream Genetic Testing for Lynch Syndrome in Colorectal Cancer: Protocol for a Scoping... by Linda Battistuzzi, Eva Blondeaux, Alberto Puccini, Luca Boni, Federica Grillo, Lucia Trevisan, Liliana Varesco, Maria Stefania Sciallero

“… BackgroundApproximately 3% of colorectal cancers (CRCs) are due to Lynch syndrome (LS), a hereditary cancer syndrome caused by pathogenic variants (PVs) in the mismatch repair (MMR) genes. …”
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High-throughput sequencing metabarcoding and network analysis elucidate the effects of soil fumigation and biostimulant on potato yield, rhizoctonia canker, and fungal community by Honoré Tekeu, Honoré Tekeu, Honoré Tekeu, Joël D’Astous-Pagé, Thomas Jeanne, Richard Hogue

“…Alternaria spp. and Verticillium nubilum stayed sporadic (<0.5 % reads) but were consistently lowest in fumigated soils. Overall, integrated fumigant–biostimulant management delivered the greatest season−long suppression of pathogenic fungi, the most resilient and functionally connected fungal network, and the highest tuber yield, demonstrating that coupling targeted chemical fumigation with microbial stimulation can reconcile disease control with soil microbiome monitoring in intensive potato systems.…”
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Revisiting antibiotic stewardship: veterinary contributions to combating antimicrobial resistance globally by Muhammad Yasir Alhassan, Muhammad Kabir Kabara, Abdulhamid Abdullahi Ahmad, Jafar Abdulsalam, Habib Ishaq Habib

“…Conclusion Veterinary antibiotic stewardship is integral to combating antimicrobial resistance and achieving Sustainable Development Goals 3 and 12. …”
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Identification of antagonistic bacterium Pseudomonas aeruginosa K5 against watermelon fusarium wilt and its role in disease suppression and plant growth promotion by XIU Junqing, YANG Shibing, ZHAO Shengjie, LI Wenyang, Yushanjiang Maimaiti, LI Meng, KANG Baoshan, LIU Liming, GU Qinsheng, WU Huijie

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Plant-derived nanovesicles: Promising therapeutics and drug delivery nanoplatforms for brain disorders by Ruoning Wang, Yingjie Zhang, Yumiao Guo, Wei Zeng, Jinge Li, Jie Wu, Nengjin Li, Anran Zhu, Jiale Li, Liuqing Di, Peng Cao

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Sensory-spinal neuron co-culture platform enables analysis of sensory-driven spinal activation by Yuki Miyahara, Kenta Shimba, Kiyoshi Kotani, Yasuhiko Jimbo

“…Microstructures were integrated with high-density microelectrode arrays to facilitate electrophysiological recordings during co-culture. …”
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A comprehensive review of deep learning approaches for rice disease detection: Datasets, methodologies, and future directions by Usman Idris Ismail, Hui Na Chua, Rosdiadee Nordin, Muhammed Kabir Ahmed

“…This process has prompted the adoption of automated techniques that integrate deep learning (DL) vision techniques to improve detection accuracy and efficiency. …”
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The role of the interactome in the maintenance of deleterious variability in human populations by Luz Garcia‐Alonso, Jorge Jiménez‐Almazán, Jose Carbonell‐Caballero, Alicia Vela‐Boza, Javier Santoyo‐López, Guillermo Antiñolo, Joaquin Dopazo

“…Most of the deleterious variants observed in healthy individuals are concentrated in peripheral regions of the interactome, in combinations that preserve their connectivity, and have a marginal effect on interactome integrity. On the contrary, likely pathogenic cancer somatic deleterious variants tend to occur in internal regions of the interactome, often with associated structural consequences. …”
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The role of phytochemicals in modulating the gut microbiota: Implications for health and disease by Amandeep Singh, Prabhjot Kaur, Manish Kumar, Sheeba Shafi, Prabhat Kumar Upadhyay, Abhishek Tiwari, Varsha Tiwari, Naresh Kumar Rangra, Vidhya Thirunavukkarasu, Sheeba Kumari, Debajyoti Roy, Maitrayee Ghosh, Nidhi Arora, Nandini Sharma, Yukta Garg

“…These substances affect the chemical composition of microorganisms, decreasing dangerous pathogens and increasing helpful bacteria like Lactobacillus and Bifidobacterium. …”
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SCRV-induced miR-365–3p inhibits viral replication by targeting OTUD7B-mediated autophagy in silver carp (Hypophthalmichthys molitrix) by Kun Gao, Meng Liu, Hanyu Pan, Yiming Wei, Xiaofeng Shan, Guiqin Wang, Xiuyun Jiang, Yunhang Gao

“…Aquatic species, inhabiting ecologically distinct environments, exhibit heightened vulnerability to pathogenic challenges, posing substantial threats to global aquaculture productivity. …”
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Lassa Virus Infection of Primary Human Airway Epithelial Cells by Helena Müller-Kräuter, Sarah Katharina Fehling, Lucie Sauerhering, Birthe Ehlert, Janine Koepke, Juliane Schilling, Mikhail Matrosovich, Andrea Maisner, Thomas Strecker

“…Lassa mammarenavirus (LASV), a member of the family Arenaviridae, is a highly pathogenic virus capable of causing severe systemic infections in humans. …”
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Whole-Exome Sequencing Followed by dPCR-Based Personalized Genetic Approach in Solid Organ Transplantation: A Study Protocol and Preliminary Results by Mirgul Bayanova, Aidos Bolatov, Dias Malik, Aida Zhenissova, Aizhan Abdikadirova, Malika Sapargaliyeva, Lyazzat Nazarova, Gulzhan Myrzakhmetova, Svetlana Novikova, Aida Turganbekova, Yuriy Pya

“…This study aims to report the design and baseline characteristics of an integrated personalized genetic approach in solid organ transplantation, including whole-exome sequencing (WES) and the monitoring of dd-cfDNA by dPCR. …”
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Gastrointestinal changes in paediatric malnutrition that may impact on nutrition choice by Rosan Meyer, Lauren Arpe, Aydan Kansu, Veronica Kelly, Keith Lindley, Mairéad O'Meara, Maria del Carmen Rivero, Suzanne van Zundert, Saioa Vicente-Santamaría, Orjena Žaja, Elena Oliveros, Leanne Olivier, Koen Joosten

“…It can lead to altered gut motility and a deficiency of stomach acid, which can result in intestinal colonization by pathogens, causing diarrhoea and high burdens of intestinal infection. …”
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Genetic and hypoxic alterations of the microRNA‐210‐ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension by Kevin White, Yu Lu, Sofia Annis, Andrew E Hale, B Nelson Chau, James E Dahlman, Craig Hemann, Alexander R Opotowsky, Sara O Vargas, Ivan Rosas, Mark A Perrella, Juan C Osorio, Kathleen J Haley, Brian B Graham, Rahul Kumar, Rajan Saggar, Rajeev Saggar, W Dean Wallace, David J Ross, Omar F Khan, Andrew Bader, Bernadette R Gochuico, Majed Matar, Kevin Polach, Nicolai M Johannessen, Haydn M Prosser, Daniel G Anderson, Robert Langer, Jay L Zweier, Laurence A Bindoff, David Systrom, Aaron B Waxman, Richard C Jin, Stephen Y Chan

“…Thus, driven by acquired (hypoxia) or genetic causes, the miR‐210‐ISCU1/2 regulatory axis is a pathogenic lynchpin causing Fe‐S deficiency and PH. …”
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Surveillance of Antimicrobial Resistance in the Asian Seabass (<i>Lates calcarifer</i>) Supply Chain Using Nanopore Sequencing by Matsapume Detcharoen, Panatda Khrueakaew, Soottawat Benjakul, Chonticha Romyasamit, Watcharapol Suyapoh, Jirakrit Saetang

“…Intensive fish farming worldwide has increased reliance on antibiotics to control bacterial pathogens, raising concerns about antimicrobial resistance (AMR) in aquaculture. …”
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Liquid-liquid phase separation: an emerging perspective on the tumorigenesis, progression, and treatment of tumors by Qin Jian, Qin Jian, Qi Xu, Sirui Xiang, Rongrong Wang, Chuchu Wang, Boxun Zhang, Ruli Li, Junzhi Lin, Chuan Zheng, Chuan Zheng

“…Therefore, we adopt a dual-dimensional analytical framework, where one dimension (the longitude) integrates cellular physiology, tumorigenesis, progression, and therapeutic responses, while the other dimension (the latitude) focuses on the pathogenic characteristics of tumors. …”
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Regulation of cortical neurogenesis by MED13L via transcriptional priming and its implications for MED13L syndrome by Jia Li, Yu-zhu Hao, Jia Cui, Xiao-xiao Cao, Nan Wu, Ji Ma, Shuang-yi Xie, Yi-Hsuan Pan, Xue-lian He, Yu-lan Zhao, Xiao-Bing Yuan

“…Abstract Pathogenic variants in MED13L cause MED13L syndrome, a well-defined neurodevelopmental disorder characterized by motor deficits, intellectual disability, and language delay, yet its underlying developmental and molecular mechanisms remain largely elusive. …”
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Insulin/PHMB-grafted sodium alginate hydrogels improve infected wound healing by antibacterial-prompted macrophage inflammatory regulation by Dan Liu, Tianyi Yu, Shan Ma, Lefeng Su, Shan Zhong, Wenao Wang, Yang Liu, Jia-ao Yu, Min Gao, Yunsheng Chen, He Xu, Yan Liu

“…P-SA/Ins exhibited the favorable physicochemical performance, biocompatibility and antibacterial efficacy against both Gram-negative and Gram-positive pathogens through inhibition of bacterial proliferation and biofilm formation. …”
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Enrichment of Z-DNA-Forming Sequences Within Super-Enhancers: A Computational and Population-Based Study by Yulia V. Makus, German A. Ashniev, Alexey V. Orlov, Petr I. Nikitin, Zoia G. Zaitseva, Natalia N. Orlova

“…Super-enhancers (SEs) orchestrate high-level transcription by integrating multiple regulatory elements and signals. …”
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Current Treatments and Future Directions for Hidradenitis Suppurativa: a Narrative Review of Completed and Ongoing Phase 3 Clinical Trials of Biologic Therapies by Amit Garg, Jennifer Hsiao, Martina L. Porter, Vivian Shi

“…The lack of dedicated therapies targeting pathogenic mechanisms of HS has historically contributed to the unmet needs for disease management. …”
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