Gestational diabetes mellitus alters neonatal gut microbiota and increases infection susceptibility by Yifei Hu, Shunjie Zheng, Jing Xu, Yufang Zhao, Jianbao Wang, Zenghui Fang, Lanfang Zhou

“…To establish causality, fecal microbiota transplantation (FMT) was conducted in antibiotic-treated mice using pooled samples from healthy and GDM-exposed neonates, followed by assessment of inflammatory markers and intestinal barrier integrity.Results and discussionGDM significantly reduced the diversity of neonatal gut microbiota and altered its composition, characterized by a depletion of beneficial taxa (Bifidobacterium, Blautia, Faecalibacterium) and an enrichment of potential pathogens (Stenotrophomonas, Chryseobacterium). …”
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Expanding structural insights into DNA packaging apparatus and endolysin LysSA05 function of Epsilon15 bacteriophage by Muhammad Saleem Iqbal Khan, Ju Wu, Shenlin Ji, Demeng Tan, Bingrui Sui, Shanshan Peng, Jinbiao Zhan, Jiajun Yin

“…The rising prevalence of multidrug-resistant (MDR) foodborne pathogens, particularly Salmonella spp., necessitates alternative antimicrobial solutions. …”
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Interference of SARS-CoV-2 with other Respiratory Viral Infections agents during Pandemic by A. A. Sominina, D. M. Danilenko, K. A. Stolyarov, L. S. Karpova, M. I. Bakaev, T. P. Levanyuk, E. I. Burtseva, D. A. Lioznov

“…The incidence growth curves coincided in time with an increase in SARS-CoV-2 activity against the background of a decrease in the detection frequency of other ARVI pathogens, including influenza and RSV viruses, as a result of pronounced interference between pathogens. …”
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Research Updates on Drinking Water Disinfection: From Conventional Chlorine-Based Disinfection to Novel Technologies by Yunqiao ZENG, Tianyang ZHANG, Chao ZENG, Bin XU, Huan HE

“…Through the combination of such mechanisms, these approaches improve disinfection efficiency and mitigate risks such as the formation of harmful DBPs, which are a growing concern with conventional methods. By integrating these technologies, the ability to simultaneously inactivate pathogens and mitigate harmful by-products can be significantly enhanced. …”
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Alcohol accelerates the development of esophageal squamous cell carcinoma through elevated Gram-negative bacteria in peripheral circulation by Zehua Zhang, Le Kang, Yanfen Gu, Zhuyun Leng, Tao Chen, Meidong Xu

“…These findings reveal that alcohol-induced microbial dysbiosis in peripheral circulation and LPS-mediated inflammatory responses form a novel pathogenic mechanism in ESCC. Targeting Gram-negative bacteria and LPS could provide a promising therapeutic strategy for managing alcohol-related ESCC. …”
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Bioinformatics Tools for NGS-Based Identification of Single Nucleotide Variants and Large-Scale Rearrangements in Mitochondrial DNA by Marco Barresi, Giulia Dal Santo, Rossella Izzo, Andrea Zauli, Eleonora Lamantea, Leonardo Caporali, Daniele Ghezzi, Andrea Legati

“…The results indicated that each tool demonstrated high sensitivity and specific accuracy in identifying and quantifying various types of pathogenic variants. The study suggests that the integrated and parallel use of these tools offers a significant advantage over traditional methods in interpreting mtDNA genetic variants, reducing the computational demands, and provides an accurate diagnostic solution.…”
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On the structure of species-function participation in multilayer ecological networks by Sandra Hervías-Parejo, Mar Cuevas-Blanco, Lucas Lacasa, Anna Traveset, Isabel Donoso, Ruben Heleno, Manuel Nogales, Susana Rodríguez-Echeverría, Carlos J. Melián, Victor M. Eguíluz

“…Here we propose a mathematical framework that integrates various types of biotic interactions observed between different species. …”
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The combination of active partitioning and toxin-antitoxin systems is most advantageous for low-copy plasmid fitness by Johannes Effe, Mario Santer, Yiqing Wang, Theresa E. Feenstra, Nils F. Hülter, Tal Dagan

“…Abstract Extrachromosomal and mobile genetic elements, including plasmids, and accessory chromosomes, are prevalent in all life domains. Elements integrated into the host chromosome replicate and segregate via the host life cycle. …”
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Tea Catechins: Potential Plant-Derived Feed Additives for Improving Chicken Intestinal Health and Productivity by Bing Tian, Wenjing Zhuang, Yanle Fan, Yun Hu, Xiaoyan Cui, Tingting Li, Liyang Zhang, Xugang Luo, Shengchen Wang

“…The compounds demonstrate dual biological functions: mitigating oxidative tissue damage and actively remodeling gut microbiota composition by suppressing enteric pathogens (e.g., <i>Clostridium</i>) and enriching beneficial bacteria (e.g., <i>Bifidobacterium</i>). …”
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Phytochemical profile and biological activities of Caesalpinia coriaria extract: a review by Moises Cipriano-Salazar, Mohamed Z. M. Salem, Mona M. M. Y. Elghandour, Shady Selim, Maximilian Lackner, Abdelfattah Z. M. Salem, Abdelfattah Z. M. Salem

“…In livestock production systems, the presence of pathogenic bacteria leads to significant economic losses; in this context, the use of polyphenolic compounds derived from C. coriaria may have a positive effect on animal productivity. …”
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The role of neutrophil extracellular traps in Crohn's disease by Ying Liu, Heng Deng, Jinfeng Yao, Chunrong He, Jun Zhang

“…NETs are intricate structures fashioned from DNA, histones, and granule proteins, and are actively released by neutrophils to entangle and eliminate pathogenic microbes. This review article delves into the intricate role of NETs in the pathogenesis of CD. …”
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In vivo adhesion fault-tolerant coenzyme/queen bee acid nanomicelles self-crosslinked thermoresponsive adhesive hydrogel for efficient oral ulcer treatment by Ying Qi, Jiaxing Shao, Zhen Luo, Qian Zhang, Xu Tian, Rong Yang, Yage Sun, Danyang Chen, Chunyan Cui, Wenguang Liu

“…However, the tissue adhesives reported so far typically fail to integrate an in vivo adhesion fault-tolerant mechanism with autonomous therapeutic activity. …”
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Understanding climate-sensitive tick development and diapause with a structured population model by Kamil Erguler, Anastasios Saratsis, Gerhard Dobler, Lidia Chitimia-Dobler

“…As climate change reshapes the environment, tick populations are expected to expand into previously unsuitable areas, further increasing human exposure to ticks and the pathogens they transmit. Understanding the environmental factors that sustain tick populations is crucial for enhancing prevention and control measures.MethodsThis study presents a multi-process structured population model that simulates nymph activity, development, and diapause in response to temperature and photoperiod. …”
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Construction and validation of an immunity-related prognostic signature for lung squamous cell carcinoma by Qing Yue, Wei Han, Ziling Liu, Zain Abbas, Akmal Zubair, Saba Beigh, Hayaa Mohammad Alhuthali, Hind A. Alzahrani, Rasha Mohammed Saleem, Nahed S. Alharthi

“…Abstract Purpose: The purpose of this paper is to construct and validate the immune-related prognostic signature in lung squamous cell carcinoma through integrated bioinformatics analysis. Methods: We constructed an optimized prognostic risk model consisting of five PIR-lncRNAs (AC107884.1, LCMT1-AS1, AL163051.1, AC005730.3 and LINC02635). …”
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Insects Induced Mango Fruit Rot: Unraveling the Culprits by Sivagami Subramaniam, Noor Aisyah Md Noordin, Noor Azrizal-Wahid, Nur Ain Izzati Mohd Zainudin

“…Mango fruit rot caused by insects and microbes has become a significant threat to mango production in Southeast Asia and worldwide. Insect plant pathogens affect crop yields' profitability, quality, and quantity. …”
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IUPHAR themed review: The gut microbiome in schizophrenia by Srinivas Kamath, Elysia Sokolenko, Kate Collins, Nicole S.L. Chan, Natalie Mills, Scott R. Clark, Francine Z. Marques, Paul Joyce

“…Gut microbial dysbiosis or altered gut microbial consortium, in schizophrenia suggests a pathogenic role through the gut-brain axis, influencing neuroinflammatory and neurotransmitter pathways critical to psychotic, affective, and cognitive symptoms. …”
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INFECTIONS AND FOLLICULAR LYMPHOMA: IS THERE A LINK? by Francesco Zallio, Giulia Limberti, Marco Ladetto

“…A classical model of infection-driven lymphoprolipherative disorder is Helicobacter pylori-induced gastric MALT lymphoma, where antibiotic therapy allows eradication of both the infectious agent and the clonal B-cell expansion;  following the footsteps of these example, several retrospective studies have found a correlation with other pathogens and B-cell Lymphomas, adding new important informations about pathogenesis and laying the groundwork for chemotherapy-free treatments. …”
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Synthesize, antioxidant and antimicrobial properties of a chitosan xerogel film with Nigella Sativa extract by Mohammad Hashem Hashempur, Ali Sabili, Forough Karami, Kamiar Zomorodian, Sara Shenavari, Ahmad Vaez, Kimia Sahraeian, Zahra Zareshahrabadi

“…Abstract The prevalence rates of microbial infections in wounds present a medical challenge, as damaged skin is inherently more susceptible to colonization/infection by pathogens. Deep eutectic solvents are a type of environmentally friendly cost-effective, and efficient solvent used in the extraction of bioactive compounds from plant materials. …”
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Extracellular matrix dysregulation in PCOS: pathogenesis, therapeutic strategies, and innovative technologies by Yunxi Liu, Jialei Zhu, Yingli Yang, Zhengyun Chen, Yong Zhou, Weidong Fei, Xian Zhang, Yongquan Zheng

“…In the second part, we present therapeutic strategies informed by these pathogenic mechanisms, integrating insights from basic and clinical research. …”
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The role of T cells in the treatment of Parkinson’s disease by Zhuomiao Lin, Xihui Yu, Yunming Zhong, Guozhu Tan, Jiahong Zhong

“…The multifactorial etiology of PD continues to challenge researchers, yet substantial evidence implicates α-synuclein as a critical pathogenic mediator. Emerging findings suggest that dysregulated neuroimmune interactions constitute a fundamental mechanism in PD progression, where chronic immune activation appears particularly detrimental to neuronal survival. …”
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