p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils. by Asako Itakura, Joseph E Aslan, Branden T Kusanto, Kevin G Phillips, Juliana E Porter, Paul K Newton, Xiaolin Nan, Robert H Insall, Jonathan Chernoff, Owen J T McCarty

“…Neutrophils serve as a first line of defense in innate immunity owing in part to their ability to rapidly migrate towards chemotactic factors derived from invading pathogens. As a migratory function, neutrophil chemotaxis is regulated by the Rho family of small GTPases. …”
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Signatures of omicron-like adaptation in early SARS-CoV-2 variants and chronic infection by Mark Tsz Kin Cheng, Mazharul Altaf, Jesu Castin, Ann-Kathrin Reuschl, Benjamin L. Sievers, Kimia Kamelian, Dejan Mesner, Rebecca B. Morse, Adam Abdullahi, Bo Meng, Kata Csiba, Steven A. Kemp, Darren P. Martin, Clare Jolly, Christopher Ruis, Lipi Thukral, Ravindra K. Gupta

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Comprehensive Analysis of Congenital Aniridia and Differential Diagnoses: Genetic Insights and Clinical Manifestations by Jonathan Hall, Marta Corton, Fabian Norbert Fries, Jessica Obst, Clara Grünauer-Kloevekorn, Berthold Seitz, Maria della Volpe Waizel, Eszter Jávorszky, Kálmán Tory, Erika Maka, Maryam Amini, Shweta Suiwal, Tanja Stachon, Nóra Szentmáry

“…We included all studies describing the clinical characteristics, pathogenic variants, and associated syndromes of congenital aniridia. …”
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Focal Segmental Glomerulosclerosis Patient Baseline Characteristics in the Sparsentan Phase 3 DUPLEX Study by Howard Trachtman, Jai Radhakrishnan, Michelle N. Rheault, Charles E. Alpers, Jonathan Barratt, Hiddo J.L. Heerspink, Irene L. Noronha, Vlado Perkovic, Brad Rovin, Hernán Trimarchi, Muh Geot Wong, Alex Mercer, Jula Inrig, William Rote, Ed Murphy, Patricia W. Bedard, Sandra Roth, Stewart Bieler, Radko Komers

“…Thirty-three patients (9.4% of 352 evaluable samples) had pathogenic or likely pathogenic (P/LP) variants of genes essential to podocyte structural integrity and function, 27 (7.7%) had P/LP collagen gene (COL4A3/4/5) variants, and 14 (4.0%) had high-risk APOL1 genotypes. …”
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Global changes in gene expression of mRNA and miRNA in liver tissues of Micropterus salmoides after infection with Aeromonas hydrophila by Zhi Lei Yao, Ming Yu, Xiao Wang, Hong Ju Chen, Xiang Shan Ji, Yan Zhao

“…Aeromonas hydrophila is a common pathogenic bacterium in cultivated Largemouth bass (Micropterus salmoides), but its pathogenicity to Largemouth bass and the molecular mechanism of host anti-A. hydrophila infection remains uncertain. …”
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Modeling and optimization of essential oils and extracts for meat quality evaluation during storage, with high-performance liquid chromatography analysis of aflatoxin levels by Sarah Alharthi, Sarah Alharthi, Rokayya Sami, Hilary Uguru, Ruqaiah I. Bedaiwi, Awatif M. Almehmadi, Suzan A. Abushal, Roqayah H. Kadi, Buthaina M. Aljehany, Eman A. Abduljawad, Abeer A. Aljehani, Sarah S. Aggad, Sarah A. Alasmari, Dalal A. Alkhudhayri, Fayez Alsulaimani, Fayez Alsulaimani, Ahmed M. Basri, Ahmed M. Basri

“…This study’s results have highlighted the effectiveness of using oils and extracts derived from discarded onion and plantain peels, in improving meat quality, integrity and inhibiting pathogens survival.…”
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Comprehensive approach to coastal lagoon ecological health evaluation: Example of Petrel Lagoon, Central Chile by Morgane Derrien, Céline Lavergne, Polette Aguilar-Muñoz, Yoelvis Sulbaran, María Soledad Pavlov, Macarena Pérez, Carolina Reyes, Gabriel Arriagada, Etienne Bresciani, Ismael Maldonado, Tania Villaseñor, Verónica Molina, Claudia Rojas

“…In this study, we present an innovative and interdisciplinary approach that integrates the analysis of the physicochemical properties, metal concentrations, and microbial communities in the San Antonio River and Petrel Lagoon, located in Central Chile, to evaluate the ecological health of this coastal ecosystem. …”
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Exploring Genetic Factors Associated with <i>Moniezia</i> spp. Tapeworm Resistance in Central Anatolian Merino Sheep via GWAS Approach by Yunus Arzik, Mehmet Kizilaslan, Sedat Behrem, Lindsay M. W. Piel, Stephen N. White, Mehmet Ulaş Çınar

“…Additionally, it regulates macrophage function in bacterial infections, showcasing its versatility in mediating immune responses against diverse pathogens. From a practical perspective, the findings of the current research underscore the potential of integrating genomic information into breeding programs to bolster disease resilience in livestock populations for sustainable production purposes. …”
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Mesalazine: a novel therapeutic agent for periodontitis via regulation of periodontal microbiota and inhibiting Porphyromonas gingivalis by Yuqi Wang, Yuqi Wang, Jun Ma, Haoyu Wang, Haoyu Wang, Jingzheng Yi, Yuxin Bai, Yuxin Bai, Min Hu, Min Hu, Jiaqing Yan, Jiaqing Yan

“…The data also suggested that mesalazine could disrupt the integrity of the P. gingivalis cell membrane and inhibit the expression of virulence factors. …”
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Airway microbiota associated D-phenylalanine promotes non-small cell lung cancer metastasis through epithelial mesenchymal transition by Lin Gao, Hua Liao, Yuehua Chen, Cuiping Ye, Liping Huang, Mingming Xu, Jiangzhou Du, Jinming Zhang, Danhui Huang, Shaoxi Cai, Hangming Dong

“…Methods Bronchoalveolar lavage fluid (BALF) samples were collected from 30 non-small cell lung cancer (NSCLC) patients, including 11 patients without metastasis (M0) and 19 patients with metastasis (M1). Integrated pathogenic metagenomic and Liquid chromatography-mass spectrometry (LC‒MS) analyses were employed to explore differences between two groups. …”
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Enteromorpha prolifera soluble dietary fiber alleviates ulcerative colitis through restoration of mucosal barrier and gut microbiota homeostasis by Yuan-Yuan Ding, Yuan-Yuan Ding, Xin-Yi Tang, Yu Tian, Feng-Long Zhang, Xiang Ding, Meng-Chun Qi, Wei Dong, Chen-Guang Liu

“…Additionally, EDFM promoted the proliferation of beneficial probiotics (Alloprevotella, Lachnospiraceae_NK4A136_group, and Ruminococcaceae_UCG-014), while inhibiting pathogenic bacteria (Escherichia-Shigella, Parabacteroides, Rikenellaceae_RC9_gut_group, Odoribacter, and [Ruminococcus]_torques_group).ConclusionEDFM supplementation significantly ameliorates UC through dual modulation of gut microbiota and intestinal barrier integrity, indicating its potential as a functional food ingredient for UC prevention and treatment.…”
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Development and validation of a deep learning-based pathomics signature for prognosis and chemotherapy benefits in colorectal cancer: a retrospective multicenter cohort study by Shenghan Lou, Yanming Huang, Fenqi Du, Jingmin Xue, Genshen Mo, Hao Li, Zhanjiang Yu, Yuanchun Li, Hang Wang, Yuze Huang, Haonan Xie, Wenjie Song, Xinyue Zhang, Huiying Li, Chun Lou, Peng Han, Peng Han, Peng Han

“…The PSCRC offers a promising aid for clinical decision-making by shedding light on key pathogenic processes. Nevertheless, further validation through prospective studies remains essential.…”
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Restored Collagen VI Microfilaments Network in the Extracellular Matrix of CRISPR-Edited Ullrich Congenital Muscular Dystrophy Fibroblasts by Daniela Benati, Eleonora Cattin, Federico Corradi, Tommaso Ferrari, Eleonora Pedrazzoli, Clarissa Patrizi, Matteo Marchionni, Roberto Bertorelli, Veronica De Sanctis, Luciano Merlini, Alessandra Ferlini, Patrizia Sabatelli, Francesca Gualandi, Alessandra Recchia

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The pivotal regulatory role of the FEV-SLC7A11 axis in ferroptosis elucidates the anti-aging mechanism of β-sitosterol in a cross-species study by Zhihan Fang, Zhihan Fang, Liyao Xie, Jing Wang, Junyi Li, Yirui Pan, Lei Chen, Shuyi Cao, Qi Zhou, Shaobin Li, Chao Zhang, Li Li

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Duplication of the autism-related gene Chd8 leads to behavioral hyperactivity and neurodevelopmental defects in mice by Atsuki Kawamura, Kazuki Fujii, Kota Tamada, Yoshifumi Abe, Kenta Nitahara, Tomoya Iwasaki, Sho Yagishita, Kenji F. Tanaka, Toru Takumi, Keizo Takao, Masaaki Nishiyama

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Progress of cGAS-STING signaling pathway-based modulation of immune response by traditional Chinese medicine in clinical diseases by Hui Zhi, Hui Fu, Yunxin Zhang, Ni Fan, Chengcheng Zhao, Yunfei Li, Yujiao Sun, Yingpeng Li

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Identification of therapeutic targets for Alzheimer’s Disease Treatment using bioinformatics and machine learning by ZhanQiang Xie, YongLi Situ, Li Deng, Meng Liang, Hang Ding, Zhen Guo, QinYing Xu, Zhu Liang, Zheng Shao

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Possible Clinical Effects of Ketoconazole on Sorafenib-induced Hand–Foot Skin Reaction and Cytoprotection Mechanisms of Antifungal Agents against Multikinase Inhibitor-induced Kera... by Rui Kato, Yayoi Kamata, Mitsutoshi Tominaga, Ryoma Kishi, Takahide Kaneko, Akira Tsujimura, Yasushi Suga, Kenji Takamori

“…As the pathogenic mechanisms of these skin disorders are unknown, no effective treatments have been established. …”
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Ox-LDL induces a non-inflammatory response enriched for coronary artery disease risk in human endothelial cells by Jiahao Jiang, Thomas K. Hiron, Anil Chalisey, Yashaswat Malhotra, Thomas Agbaedeng, Chris A. O’Callaghan

“…Our results reveal that the exposure of HAECs to ox-LDL leads to pathogenic changes in metabolism, transcriptome and epigenome, but in the absence of a typical inflammatory endothelial phenotype. …”
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Combining long-read DNA and RNA sequencing to enhance molecular understanding of structural variations leading to copy gains by Jade Fauqueux, Jean-Pascal Meneboo, Roseline Caumes, Luc Thomès, Emilie Ait Yahya, Caroline Thuillier, Elise Boudry, Celine Villenet, Martin Figeac, Jamal Ghoumid, Thomas Smol

“…Due to their complexity, these SVs were not fully resolved by standard methods. By integrating LRS with transcriptomic and chromosomal conformation analyses, we provided a comprehensive understanding of SV formation and its pathogenic impact. …”
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