<i>Clostridioides difficile</i> in Animal Inflammatory Bowel Disease: A One Health Perspective on Emerging Zoonotic Threats by Felipe Masiero Salvarani, Hanna Gabriela da Silva Oliveira, Francisco Alejandro Uzal

“…Recognized for its pathogenic role in human pseudomembranous colitis, <i>C. difficile</i> is now emerging as a critical agent in veterinary medicine, particularly in livestock (e.g., cattle, pigs), companion animals (dogs, cats), and wildlife. …”
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The interactions between inflammation and insulin resistance: molecular mechanisms in insulin-producing and insulin-dependent tissues by A. D. Yudaeva, I. S. Stafeev, S. S. Michurina, M. Yu. Menshikov, M. V. Shestakova, Y. V. Parfyonova

“…Thus, insulin-producing and insulin-dependent tissues, which are involved in T2DM pathogenesis, through the inflammatory process integrate in pathogenic and self-maintaining cycle, which leads to the suppression of insulin secretion, pancreatic β-cell failure and the development of insulin-dependent tissues insulin resistance.…”
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The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms by Wenli Jiao, Jiayi Lin, Yanfang Deng, Yelin Ji, Chuoyi Liang, Sijia Wei, Xi Jing, Fengxia Yan

“…Unraveling these multifaceted immune-mediated mechanisms provides insights into major depressive disorder’s pathogenic basis and potential biomarkers and targets. …”
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Dengue Virus-Induced Inflammation of the Endothelium and the Potential Roles of Sphingosine Kinase-1 and MicroRNAs by Amanda L. Aloia, Alexander M. Abraham, Claudine S. Bonder, Stuart M. Pitson, Jillian M. Carr

“…One of the main pathogenic effects of severe dengue virus (DENV) infection is a vascular leak syndrome. …”
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Whispers of the polycystic ovary syndrome theater: Directing role of long noncoding RNAs by Xiuying Lin, Xinyu Nie, Ping Deng, Luyao Wang, Cong Hu, Ningyi Jin

“…We examine the dynamic regulatory networks orchestrated by lncRNAs that impact GC function, steroidogenesis, insulin resistance, and inflammatory pathways. By integrating findings from recent studies, we illuminate the potential of lncRNAs as biomarkers for PCOS and highlight their contribution to the disorder, offering a detailed perspective on the lncRNA-mediated modulation of gene expression and pathogenic pathways. …”
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Saccharin disrupts bacterial cell envelope stability and interferes with DNA replication dynamics by Rubén de Dios, Kavita Gadar, Chris R Proctor, Evgenia Maslova, Jie Han, Mohamed A N Soliman, Dominika Krawiel, Emma L Dunbar, Bhupender Singh, Stelinda Peros, Tom Killelea, Anna-Luisa Warnke, Marius M Haugland, Edward L Bolt, Christian S Lentz, Christian J Rudolph, Ronan R McCarthy

“…In addition, we test its potential to disrupt established biofilms (single-species as well as polymicrobial) and its capacity to re-sensitise multidrug-resistant pathogens to last-resort antibiotics. Finally, we present in vitro and ex vivo evidence of the versatility of saccharin as a potential antimicrobial by integrating it into an effective hydrogel wound dressing.…”
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Targeted metabolomics reveals bioactive inflammatory mediators from gut into blood circulation in children with NAFLD by Miyang Luo, Jiayou Luo, Atipatsa C. Kaminga, Jia Wei, Wen Dai, Yan Zhong, Ningan Xu, Xiongwei Li, Haixiang Zhou, Xiongfeng Pan

“…This study identified three novel elevated inflammatory pathogenic metabolites and the relationship between increased inflammation, may be involved in TLR5/MYD88/NFκB pathway. …”
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Unraveling the role of mobile genetic elements in antibiotic resistance transmission and defense strategies in bacteria by Ranjith Kumavath, Puja Gupta, Eswar Rao Tatta, Mahima S. Mohan, Simi Asma Salim, Siddhardha Busi

“…With an emphasis on pathogenic bacteria, this review highlights the salient features of the MGEs that contribute to the development and spread of antibiotic resistance. …”
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Dietary microbes and functional dyspepsia: modulating the gut microecology for therapeutic benefit by Qi Huang, Fei You, Fengxia Liang, Chaoyang Ma

“…Integrating advances in emerging diagnostic technologies, we further discuss feasible approaches and potential targets for personalized FD management. …”
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The Impact of Vegetation Changes in Savanna Ecosystems on Tick Populations in Wildlife: Implications for Ecosystem Management by Tsireledzo Goodwill Makwarela, Nimmi Seoraj-Pillai, Tshifhiwa Constance Nangammbi

“…Addressing these challenges calls for integrated management strategies that include vegetation control, host population monitoring, and sustainable vector control methods. …”
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Quorum Sensing: Not Just a Bridge Between Bacteria by Derun Liu, Yonglin Lu, Ziyun Li, Xin Pang, Xueyan Gao

“…This review highlights innovative approaches to regulating QS, emphasizing the potential of quorum quenching and QS inhibitors to mitigate bacterial pathogenicity. These strategies have shown promise in aquaculture and plant resistance, disrupting QS pathways to combat infections. …”
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The Antimicrobial Resistance Pandemic Is Here: Implementation Challenges and the Need for the One Health Approach by Elena Ponzo, Silvia De Gaetano, Angelina Midiri, Giuseppe Mancuso, Presti Giovanna, Danna Giuliana, Sebastiana Zummo, Carmelo Biondo

“…Consequently, the emergence of antibiotic-resistant pathogens is becoming a recurring concern. This review provides a comprehensive overview of the measures that are necessary to be taken and implemented in order to guarantee global health security.…”
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Mechanisms of Microbial VOC‐Mediated Communication in Plant Ecosystems and Agricultural Applications by Qurban Ali, Abdur Rashid Khan, Waseem Raza, Muhammad Saqib Bilal, Sadia Khalid, Muhammad Ayaz, Atta‐Ur‐Rehman Khan, Sunil Mundra

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Germline mutation analysis and postoperative recurrence risk prediction in breast cancer patients from western China by Zhujun Deng, Xia Xiao, Biqin Mou, Jing Wang, Qiongxia Hu, Juan Jiang, Kang Xie, Wengeng Zhang, Weimin Li, Bojiang Chen

“…Results: In this cohort, 229 germline pathogenic/likely pathogenic (P/LP) mutations were identified in 215 patients (20.1 %). …”
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Incorporating Differential Gene Expression Analysis with Predictive Biomarkers to Identify Novel Therapeutic Drugs for Fuchs Endothelial Corneal Dystrophy by Huaming Wen, Ryan A. Gallo, Xiaosheng Huang, Jiamin Cai, Shaoyi Mei, Ammad Ahmad Farooqi, Jun Zhao, Wensi Tao

“…Based on the differential gene expression analysis for predictive biomarkers with RNA-Sequencing data from Fuchs endothelial corneal dystrophy (FECD) patients, we are aiming to evaluate the efficacy of Library of Integrated Network-based Cellular Signatures (LINCS) perturbagen prediction software to identify novel pharmacotherapeutic targets that can revert the pathogenic gene expression signatures and reverse disease phenotype in FECD. …”
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Enhancing safety with an AI-empowered assessment and monitoring system for BSL-3 facilities by Yi-Ling Fan, Ching-Han Hsu, Ju-Yu Wu, Ying-Ying Tsai, Wei J. Chen, Min-Shi Lee, Fang-Rong Hsu, Lun-De Liao

“…Conclusion: The BSL-3 laboratory monitoring system significantly reduces the risk of exposure to pathogens for personnel during laboratory operations. …”
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Microplastics, invasive species and fungal stressors modulate antioxidative mechanisms, rhizosphere enzymes and microbial dynamics in alfalfa by Muhammad Anas, Muhammad Riaz, Meng-Ting Yan, Yi-Fan Liu, Ying Li, Shan- Shan Qi, Zhi-Cong Dai, Dao-Lin Du

“…Microplastics, invasive species, and fungal pathogens increasingly threaten the sustainability of artificial grasslands. …”
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Regional patterns of genetic variants in expanded carrier screening: a next-generation sequencing pilot study in Fujian Province, China by Danhua Guo, Danhua Guo, Nani Zhou, Qianqian He, Qianqian He, Na Lin, Na Lin, Shuqiong He, Shuqiong He, Deqin He, Deqin He, Yifang Dai, Yifang Dai, Ying Li, Ying Li, Xuemei Chen, Xuemei Chen, Hailong Huang, Hailong Huang, Jia Jia, Hua Cao, Liangpu Xu, Liangpu Xu

“…The mean number of pathogenic or likely pathogenic variants per sample was 1.16. …”
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Analysis of epilepsy‐associated variants in HCN3 – Functional implications and clinical observations by Peiwei Zhao, Hongbo Xiong, Gunagtao Kuang, Chen Sun, Xiankai Zhang, Yufeng Huang, Sukun Luo, Lei Zhang, Jun Jiang, Xuelian He

“…Abstract Objective This case study investigates the role of hyperpolarization‐activated, cyclic nucleotide‐gated (HCN) ion channels, which are integral membrane proteins crucial for regulating neuronal excitability. …”
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Cellular Stress Responses and Gut Microbiota in Inflammatory Bowel Disease by Siyan “Stewart” Cao

“…In recent years, gut microflora has emerged as an essential pathogenic factor and therapeutic target for IBD. Altered compositional and metabolic profiles of gut microbiota, termed dysbiosis, are associated with IBD. …”
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