Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy. by John M Coffin, Michael J Bale, Daria Wells, Shuang Guo, Brian Luke, Jennifer M Zerbato, Michele D Sobolewski, Twan Sia, Wei Shao, Xiaolin Wu, Frank Maldarelli, Mary F Kearney, John W Mellors, Stephen H Hughes

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Nano-modified biosensors for detection of pathogenic diseases: The prospect of smart, multiplex and point-of-care testing by Abdullahi Umar Ibrahim, Pwadubashiyi Coston Pwavodi, Mehmet Ozsoz, Basil Birth Duwa, Irkam Irkham, Yeni Wahyuni Hartati

“…Several infectious diseases caused by pathogens such as SARS-CoV-2, Ebola, Zika, Dengue, Marburg viruses, Mycobacterium tuberculosis, etc. have caused a devastating impact on lives and livelihoods around the world. …”
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The small and large subunits of carbamoyl-phosphate synthase exhibit diverse contributions to pathogenicity in Xanthomonas citri subsp. citri by Jing GUO, Xue SONG, Li-fang ZOU, Hua-song ZOU, Gong-you CHEN

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In the coevolution of cotton and pathogenic fungi, resistant cotton varieties lead to an escalation in the virulence of Verticillium dahliae by Yalin Zhang, Lifang Cui, Ruibing Liu, Zili Feng, Hongjie Feng, Jinglong Zhou, Lihong Zhao, Feng Wei, Heqin Zhu

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Microbial landscape of Indian homes: the microbial diversity, pathogens and antimicrobial resistome in urban residential spaces by Saraswati Awasthi, Vikas M Hiremath, Sonam Nain, Shweta Malik, Vanita Srinivasan, Pooja Rose, Ashutosh Choudhury, Ritika Grover, Rakesh Sharma

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PUFA-PLs biosynthesis enzymes contribute to pathogenic development of rice blast fungus Magnaporthe oryzae by Qiao Liu, Ruhui Long, Cailing Zhi, Zhibin Liang, Yi Zhen Deng

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Socioeconomic and Eco-Environmental Drivers Differentially Trigger and Amplify Bacterial and Viral Outbreaks of Zoonotic Pathogens by Payton Phillips, Negin Nazari, Sneha Dharwadkar, Antoine Filion, Benedicta Essuon Akaribo, Patrick Stephens, Mekala Sundaram

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Functional characterization of all CDKN2A missense variants and comparison to in silico models of pathogenicity by Hirokazu Kimura, Kamel Lahouel, Cristian Tomasetti, Nicholas Jason Roberts

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Advancements in Nanotechnology for Enhanced Food Safety and Hygiene: Pathogen Detection, Smart Packaging, and Preservation Applications by Farhang Hameed Awlqadr, Ammar B. Altemimi, Qausar Hamed AlKaisy, Syamand Ahmed Qadir, Aryan Mahmood Faraj, Tablo Azad H.Slih, Rawaa H. Tlay, Tarek Gamal Mohamed Abd El-Maksoud, Franscesco Cacciola

“…This review delves into the advancements in pathogen detection, smart packaging, and food preservation enabled by nanotechnology. …”
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Gut opportunistic pathogens contribute to high-altitude pulmonary edema by elevating lysophosphatidylcholines and inducing inflammation by Xianduo Sun, Gaosheng Hu, Yuting Li, Wenjing Li, Yong Wang, Hui Yan, Guoqing Long, Long Zhao, Anhua Wang, Jingming Jia

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Surface Gene Mutations of Hepatitis B Virus and Related Pathogenic Mechanisms: A Narrative Review by Tingxi Yan, Yusheng Zhang, Huifang Zhou, Ning Jiang, Xiaotong Wang, Wei Yan, Jianhua Yin

“…This review aims to integrate the existing literature, summarize the common mutations in the HBV S gene region, and explore the related pathogenic mechanisms.…”
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Characterization of multispecies microbial communities at beef and pork processing plants and their impact on pathogen stress tolerance by Rong Wang, Sapna Chitlapilly Dass, Vignesh Palanisamy, You Zhou, Tatum Katz, Joseph M. Bosilevac

“…Further, pathogen stress tolerance may vary significantly due to the interactions with the multispecies microbial community at meat plants, which may be affected by processing activity, animal species, and the local selective pressure caused by sanitization practices.MethodsWe characterized natural microorganisms collected from floor drains at various areas at three beef plants and two pork plants and analyzed their impact on pathogen sanitizer tolerance.ResultsThe pathogen strains were able to integrate efficiently into the multispecies community attached on contact surfaces even under low temperatures (7°C and 15°C) commonly seen in processing facilities. …”
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Geocaulosphere soil bacterial community drives potato common scab outcomes beyond pathogen abundance by Wenchong Shi, Minghao Lv, Ruiqi Wang, Muhammad Saleem, Lujun Wang, Mingcong Li, Bing Wang, Rongshan Lin, Bingjie Xu, Chunyu Yang, Tangyuan Ning, Bo Zhou, Zheng Gao

“…Bacterial community structure explained 39.28% (GS) and 15.96% (bulk soil) of PCS variance, outperforming pathogen abundance contributions (14.39% GS, 7.33% BS). …”
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Identifying potential novel widespread determinants of bacterial pathogenicity using phylogenetic-based orthology analysis by Sara Ribeiro, Sara Ribeiro, Karine Alves, Julien Nourikyan, Jean-Pierre Lavergne, Simon de Bernard, Laurent Buffat

“…Both known virulence factors (VFs) and potential novel widespread pathogenicity determinants were uncovered, supported by both statistical testing and complementary protein domain analysis.DiscussionBy integrating curated strain-level pathogenicity annotations from BacSPaD with phylogeny-based OA, we introduce a novel approach and provide a novel resource for bacterial pathogenicity research.…”
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Strongyloides stercoralis combined with concurrent multiple pathogens infections in an immunosuppressed patient: a case report by Jingchun Fang, Jingchun Fang, Huimin Fang, Huimin Fang, Penghao Guo, Yaqin Peng, Peisong Chen

“…Based on the mNGS results and other examination findings, the patient was diagnosed with Strongyloides stercoralis in combination with concurrent multiple pathogens infections. After the combined drug therapy of Meropenem, Vancomycin, and Albendazole, the patient’s condition was gradually brought under control.ConclusionThis case demonstrates the advantage of integrating traditional detection methods with metagenomics next-generation sequencing technology in the etiological diagnosis of immunocompromised individuals. …”
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Caught in the ESKAPE: Wildlife as Key Players in the Ecology of Resistant Pathogens in a One Health Context by Vanessa Silva, Sara Araújo, Manuela Caniça, José Eduardo Pereira, Gilberto Igrejas, Patrícia Poeta

“…Wildlife may act as both sentinels and reservoirs for resistant pathogens, contributing to their persistence and dissemination across ecosystems. …”
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Study on Referential Methodology for Pathogenic Mechanisms of Invigorating Wind/Deficiency Wind in Natural Ventilation Environments by Siwei Xu, Jia Du, Bin Chen

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Targeting epigenetic regulators to overcome drug resistance in the emerging human fungal pathogen Candida auris by Yuping Zhang, Lingbing Zeng, Xinhua Huang, Yuanyuan Wang, Guangsheng Chen, Munika Moses, Yun Zou, Sichu Xiong, Wenwen Xue, Yanmei Dong, Yueru Tian, Ming Guan, Lingfei Hu, Zhe Yin, Dongsheng Zhou, Xiaotian Huang, Changbin Chen

“…These findings highlight the critical role of Gcn5 in the resistance and pathogenicity of C. auris, positioning it as a promising therapeutic target for combating invasive fungal infections.…”
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Metabarcoding Analysis Reveals Microbial Diversity and Potential Soilborne Pathogens Associated with Almond Dieback and Decline by André Albuquerque, Mariana Patanita, Joana Amaro Ribeiro, Maria Doroteia Campos, Filipa Santos, Tomás Monteiro, Margarida Basaloco, Maria do Rosário Félix

“…This study highlights the value of integrating NGS approaches to comprehensively study complex diseases and the need for further research on pathogen interactions and cultivar susceptibility for the future development of new sustainable, targeted management strategies in almond orchards.…”
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Rice Grain Storage Reduces Antibiotic Resistance Risks and Pathogens Through Enrichment of Antimicrobial Metabolites by Fang Wu, Yuanpeng Zhang, Peng Huang, Li Li, Yanguang Zhu, Quanxin Rao, Ruizhang Feng, Jie Tu

“…Multiple correlation analyses confirmed the significant reduction of ARGs and pathogens during storage. Integrated transcriptomic and metabolomic analyses identified genes and metabolites with persistent differential expression over the storage period. …”
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