Chaihuang Qingyi Huoxue granule ameliorates severe acute pancreatitis by modulating gut microbiota and repairing the intestinal mucosal barrier by Xiaobin Zhang, Xusen Zeng, Wen Guo, Xin Zhou, Xin Zhou, Yi Zhang, Mingyun Tang, Juan Fu, Yuqing Deng, Xin Liang, Long Zhao, Zhi Li, Zhi Li, Zhi Li, Tiangang Wang, Li Li, Guohui Xiao

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Evaluation of molecular mouse sepsis panel: new portable and rapid tests for microorganism detection in suspected blood stream infection by Claudia Colosimo, Claudia Colosimo, Maria Sofia Montanari, Maria Sofia Montanari, Anna Marzucco, Anna Marzucco, Giulia Gatti, Giulia Gatti, Lucrezia Puccini, Laura Grumiro, Laura Grumiro, Laura Dionisi, Laura Dionisi, Martina Brandolini, Martina Brandolini, Ludovica Ingletto, Ludovica Ingletto, Massimiliano Guerra, Giorgio Dirani, Silvia Zannoli, Alessandra Scagliarini, Alessandra Mistral De Pascali, Alessandra Mistral De Pascali, Vittorio Sambri, Vittorio Sambri, Monica Cricca, Monica Cricca

“…IntroductionBloodstream infections (BSIs) represent a significant public health concern, characterized by the presence of pathogens in the bloodstream, leading to serious conditions. …”
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De novo KCNK4 variant caused epilepsy with febrile seizures plus, neurodevelopmental abnormalities, and hypertrichosis by Hong-Jun Yan, Wen-Hui Liu, Min-Xing Xu, Peng-Yu Wang, Yu-Jie Gu, Hua Li, Jing Guo, Sheng Luo

“…Analysis of other eight cases with KCNK4 variants outlined the phenotypic spectrums of KCNK4, ranging from mild benign epilepsy, EFS+ with neurodevelopmental abnormalities, to syndromic neurodevelopmental disorders and revealed neurodevelopmental abnormalities and epilepsy as its core phenotypes. Integrated analysis suggested that minor allele frequency and in silico meta-predictors effectively distinguish pathogenic variants.ConclusionThis study suggested the KCNK4 gene as a novel candidate causative gene of EFS+, which would be helpful for the genetic diagnosis and clinical management of patients.…”
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Depletion-restitution therapy for autoimmune rheumatic diseases. Part 1. Fundamental prerequisites and efficacy of modern treatment technologies: anti-B-cell drugs and CAR-T therap... by A. M. Lila, A. L. Maslyanskiy, D. A. Dibrov, A. V. Torgashina, E. G. Zotkin, M. Yu. Samsonov

“…This approach is characterized by methods based on massive, shortterm cytotoxic impact, leading to profound reduction of pathogenic autoreactive cellular clones, followed by repopulation with "naive" cellular elements. …”
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Non-antibiotic therapies for multidrug-resistant gastrointestinal infections: an overview of the use of probiotics, natural compounds, and bacteriophages by Manuela Oliveira, Manuela Oliveira, Áurea Madureira-Carvalho, Áurea Madureira-Carvalho, Ricardo Jorge Dinis-Oliveira, Ricardo Jorge Dinis-Oliveira, Ricardo Jorge Dinis-Oliveira, Ricardo Jorge Dinis-Oliveira, Diana Dias da Silva, Diana Dias da Silva, Diana Dias da Silva, Diana Dias da Silva

“…One of these alternatives is probiotics, harmless bacteria that compete with pathogenic species, which have been considered beneficial due to their therapeutic potential since they strengthen the mucosal barrier and modulate the host immune response. …”
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Rapid and accurate detection of Fusarium oxysporum f. sp. Lycopersici using one-pot, one-step LAMP-CRISPR/Cas12b method by Shijie Dai, Yangsheng Wu, Na Zhu, Yujin Zhao, Mingjiang Mao, Zheming Li, Bo Zhu, Weichun Zhao, Xiaofeng Yuan, Xiaofeng Yuan

“…Lycopersici (Fol) is one of the most devastating plant pathogenic fungi, the causal agent of root rot for Atractylides macrocephala Koidz (AMK). …”
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<i>Trichoderma harzianum</i> in Biocontrol of Maize Fungal Diseases and Relevant Mycotoxins: From the Laboratory to the Field by Ivana Mitrović, Petar Čanak, Sonja Tančić Živanov, Hunor Farkaš, Marko Vasiljević, Svetlana Ćujić, Miroslav Zorić, Bojan Mitrović

“…<b>Methods:</b> This study evaluated the biocontrol potential of <i>Trichoderma harzianum</i> K179 as an eco-friendly alternative to synthetic fungicides for protecting maize from two major pathogens, <i>Fusarium graminearum</i> and <i>Aspergillus flavus</i>. …”
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Advancements in Antibacterial Therapy: Feature Papers by Giancarlo Angeles Flores, Gaia Cusumano, Roberto Venanzoni, Paola Angelini

“…The emergence of multidrug-resistant (MDR) pathogens, exacerbated by the misuse of antibiotics in healthcare and agriculture, underscores the urgent need for innovative solutions. (1) Background: AMR arises from complex interactions between human, animal, and environmental health, further aggravated by the overuse and inadequate regulation of antibiotics. …”
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Nature’s Arsenal: Uncovering Antibacterial Agents Against Antimicrobial Resistance by Ina Gajic, Dusan Kekic, Marko Jankovic, Nina Tomic, Mila Skoric, Milos Petrovic, Dragana Mitic Culafic, Natasa Opavski, Petar Ristivojevic, Maja Krstic Ristivojevic, Bojana Lukovic

“…The World Health Organization has established a priority list highlighting critical multidrug-resistant (MDR) pathogens that demand urgent research on antimicrobial treatments. …”
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Impact of essential oil and probiotics supplementation on growth performance, serum biomarkers, antioxidants status, bioenergetics and histomorphometry of intestine of Nile tilapia... by Walaa S. Raslan, Ahmed Shehab, Aya F. Matter, Hadeer A. Youssuf, Omar Ahmed Farid, Ahmed Sabek, Yasmeen Magdy, Amgad Kadah

“…Results The results revealed that using probiotics and or essential oils in Nile tilapia diets improved growth performance, reduced oxidative stress, enhanced immunity, maintained intestinal integrity, and enhanced resistance to pathogenic infection (P ≤ 0.05). …”
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A Randomized Clinical Study of a Curcumin and Melatonin Toothpaste Against Periodontal Bacteria by Riccardo Pulcini, Antonio Maria Chiarelli, Bruna Sinjari, Jessica Elisabetta Esposito, Francesco Avolio, Riccardo Martinotti, Vittorio Pignatelli, Luca Pignatelli, Laura Berlincioni, Stefano Martinotti, Elena Toniato

“…In addition, a modulation of pathogenic bacteria and saprophytic bacteria was shown. …”
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Phytosanitary problems in elephant garlic (Allium ampeloprasum var. holmense) in the “Val di Chiana” area (Central Italy), and evaluation of potential control strategies by Francesco TINI, Giovanni BECCARI, Niccolò TERZAROLI, Enrica BERNA, Lorenzo COVARELLI, Mara QUAGLIA

“…Fungi often also developed from asymptomatic components, but a correlation was found between isolated pathogens and disease symptoms. Pathogenicity and virulence towards elephant garlic cloves were verified for a representative isolate of each identified species, and Penicillium allii was the most virulent. …”
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Potential of Cameroonian isolates of Beauveria bassiana and Metarhizium anisopliae for the biocontrol of the banana aphid, Pentalonia nigronervosa, vector of banana bunchy top viru... by Aime Cheoh Enoh, Jane-Francis Akoachere, Tatsinkou Bertrand Fossi, Gertrude Membang, Sergine Ngatat, Apollin Fotso Kuate, Rachid Hanna, P Lava Kumar, Komi K Mokpokpo Fiaboe

“…Four isolates (BIITAC6.2.2, BIITAC10.3.3, BIITAC8.1.5, and MIITAC6.2.2) were highly pathogenic, causing greater than 75% aphid mortality in all populations. …”
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Antimycobacterial and Antifungal Activities of Leaf Extracts From Trichilia emetica by Lydia Chenesai Mugayi, Stanley Mukanganyama

“…Antimicrobial drug resistance is a rapidly growing problem with potentially devastating consequences. Various pathogens can cause skin infections, such as bacteria, fungi, and parasites. …”
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Health System-Led Early Consent and Direct Contact of At-Risk Relatives: Pilot Study Results by Nora B. Henrikson, Aaron Scrol, Jamilyn M. Zepp, Melissa L. Anderson, Paula R. Blasi, John J. Ewing, Jane Grafton, James D. Ralston, Stephanie M. Fullerton, Kathleen A. Leppig

“…All relatives reached (n = 43) received their proband’s test results, including 6 pathogenic/likely pathogenic findings. Conclusion: A direct contact program was acceptable, reached at-risk relatives, and communicated proband test results. …”
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Mechanism by Which Laser Irradiation Combined with Spirulina platensis Enhances FeSO4-Induced Ferroptosis in Salmonella Typhimurium and Listeria monocytogenes by SUN Jinyue, PAN Jianeng, CHEN Yiying, LIU Rencheng, ZHOU Wenwen

“…In conclusion, the Fe + SP + L treatment could effectively reduce the counts of ST and LM in both planktonic and biological states, indicating its good potential for controlling foodborne pathogens on the surface of lettuce and other foods.…”
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Climate change unveils hidden microbial dangers by Haoxuan Yu

“…These changes facilitate the proliferation of pathogenic microorganisms such as Vibrio cholerae and harmful algae like cyanobacteria, which thrive in warmer, nutrient-enriched environments. …”
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The signal peptide-like segment of hpaXm is required for its association to the cell wall in transgenic tobacco plants. by Le Li, Weiguo Miao, Wenbo Liu, Shujian Zhang

“…Harpins, encoded by hrp (hypersensitive response and pathogenicity) genes of Gram-negative plant pathogens, are elicitors of hypersensitive response (HR). …”
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Pathophysiological features of the visual cycle, cascade and metabolic pathways in retinitis pigmentosa by M. E. Weener, D. S. Atarshchikov, V. V. Kadyshev, I. V. Zolnikova, A. M. Demchinsky, D. Barh, L. M. Balashova, J. M. Salmasi

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Unveiling the influence of lipidomes on inflammatory bowel disease: a bidirectional mendelian randomization study by Hang Lei, Yuhong Jiang, Zhe Chen, Jiaqi Yao, Wenjun Ma, Yiqi Huang, Pengcheng Zhang, Zhijun Xie, Lv Zhu, Wenfu Tang

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