The Impact of Ozone on Periodontal Cell Line Viability and Function by Nada Tawfig Hashim, Rasha Babiker, Shahistha Parveen Dasnadi, Md Sofiqul Islam, Nallan CSK Chaitanya, Riham Mohammed, Nancy Soliman Farghal, Bakri Gobara, Muhammed Mustahsen Rahman

“…This review of the use of ozone therapy in periodontal disease breaks down the multifaceted mechanism of ozone therapy, which includes the selective antimicrobial action against biofilm-associated pathogens, immunomodulatory effects on host cells, and stimulation of tissue repair. …”
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A trans-acting sRNA SaaS targeting hilD, cheA and csgA to inhibit biofilm formation of S. Enteritidis by Chongyang Lyu, Haijing Hu, Linlin Cai, Shuwen He, Xinglian Xu, Guanghong Zhou, Huhu Wang

“…The sRNA SaaS has been identified previously, that promotes pathogenicity by regulating invasion and virulence factors. …”
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Blockade of de novo dNTP biosynthesis pathway delays HIV-1 early life cycle kinetics and dynamics by Mohammad Anwar Siddique, Michael D. McRaven, Muhammad Shoaib Arif, Edward J. Allen, Charia McKee, Shravya Honne, Tahmina Sultana, Baek Kim, Ann M. Carias, João I. Mamede, Thomas J. Hope

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Modulation of colonic DNA methyltransferase by mild moxibustion and electroacupuncture in ulcerative colitis TET2 knockout mice by Gege Feng, Yue Zhang, Huangan Wu, Lu Zhu, Hongxiao Xu, Zhe Ma, Yan Huang

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Microbiome and fragmentation pattern of blood cell-free DNA and fecal metagenome enhance colorectal cancer micro-dysbiosis and diagnosis analysis: a proof-of-concept study by Zhongkun Zhou, Yunhao Ma, Dekui Zhang, Rui Ji, Yiqing Wang, Jianfang Zhao, Chi Ma, Hongmei Zhu, Haofei Shen, Xinrong Jiang, Yuqing Niu, Juan Lu, Baizhuo Zhang, Lixue Tu, Hua Zhang, Xin Ma, Peng Chen

“…Furthermore, compared to the blood microbiome, the fecal microbiome shows a different community composition, whereas their changes in KEGG pathways are similar. Pathogenic bacteria Fusobacterium nucleatum (F. nucleatum) in feces increased gradually from the healthy group to the adenoma and CRC groups. …”
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Characterizing circulating biomarkers for childhood dementia disorders: A scoping review of clinical trials by Arlene D'Silva, James Barnes, Jason Djafar, Kaustuv Bhattacharya, Jingya Yan, Shekeeb Mohammad, Sushil Bandodkar, Alexandra Johnson, Michel Tchan, Christina Miteff, Kristina L. Elvidge, Russell C. Dale, Michelle Farrar

“…Disease-related biomarkers were associated with 1) the primary pathophysiology 2) downstream pathogenic events 3) drug-related pharmacokinetics, safety and/or tolerability. …”
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Renal-clearable and mitochondria-targeted metal-engineered carbon dot nanozymes for regulating mitochondrial oxidative stress in acute kidney injury by Jiangpeng Pan, Juntao Wang, Wei Wang, Ziyang Liu, Shuai Huo, Lei Yan, Wei Jiang, Fengmin Shao, Yue Gu

“…Mitochondrial dysfunction-induced oxidative stress is a key pathogenic factor in acute kidney injury (AKI). Despite this, current mitochondrial-targeted antioxidant therapies have shown limited efficacy in clinical settings. …”
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The gut dysbiosis and plasma lipid metabolisms signatures in children with active tuberculosis by Baixu Sun, Xiaoran Yu, Hui Qi, Fang Xu, Weiwei Jiao, Min Fang, Li Duan, Xi Zeng, Xuemei Yang, Xingyun Wang, Yu Zhu, Kaixia Mi, Adong Shen, Lin Sun

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Multidrug Resistance, Biofilm-Forming Ability, and Molecular Characterization of <i>Vibrio</i> Species Isolated from Foods in Thailand by Watcharapong Mitsuwan, Ratchadaporn Boripun, Phirabhat Saengsawang, Sutsiree Intongead, Sumaree Boonplu, Rawiwan Chanpakdee, Yukio Morita, Sumalee Boonmar, Napapat Rojanakun, Natnicha Suksriroj, Chollathip Ruekaewma, Titima Tenitsara

“…Background: <i>Vibrio</i> species are common foodborne pathogens that cause gastrointestinal tract inflammation. …”
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Multiomic analysis of monocyte-derived alveolar macrophages in idiopathic pulmonary fibrosis by Miaomiao Zhang, Jinghao Zhang, Haisheng Hu, Yuan Zhou, ZhiWei Lin, Hui Jing, Baoqing Sun

“…Abstract Background Monocyte-derived alveolar macrophages (Mo_AMs) are increasingly recognised as potential pathogenic factors for idiopathic pulmonary fibrosis (IPF). …”
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Zhongfeng Xingnao Liquid Ameliorated the Early Impairment of Intracerebral Hemorrhage by Inhibiting NF-&amp;kappa;B/NLRP3 Axis in Rats by Yang H, Luo B, Du Y, Guo J, Zhang S, Wang P, Dai Y, Lu Y, Xu S

“…Heyu Yang,1– 3,&amp;ast; Bingqian Luo,1– 3,&amp;ast; Yifan Du,3,4,&amp;ast; Jiafu Guo,1– 3 Shiqi Zhang,1– 3 Ping Wang,1– 3 Yuan Dai,3,4 Yun Lu,3,5 Shijun Xu1– 3 1State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, People’s Republic of China; 2School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, People’s Republic of China; 3Institute of Material Medica Integration and Transformation for Brain Disorders, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, People’s Republic of China; 4School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, People’s Republic of China; 5Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610072, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Yun Lu, Email luyun999@126.com Shijun Xu, Email xushijun@cdutcm.edu.cnBackground: Perihematomal neuroinflammation serves as a pivotal pathogenic driver of secondary brain injury during the acute stage of intracerebral hemorrhage (ICH). …”
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Regulating periodontal disease with smart stimuli-responsive systems: Antimicrobial activity, immunomodulation, periodontium regeneration by Guang-Liang Su, Yu-Jun Peng, Hong-Ze Ruan, Juan Cheng, Tian Deng, Yu-Feng Zhang

“…Coordinated integration of functional mechanisms is crucial to achieving periodontal disease recovery. …”
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Evaluating the effectiveness of field-based probiotic treatments for stony coral tissue loss disease in southeast Florida, USA by Kelly A. Pitts, Mackenzie Scheuermann, Jonathan S. Lefcheck, Blake Ushijima, Blake Ushijima, Natalie Danek, E. Murphy McDonald, Aaron R. Milanese, Monica D. Schul, Julie L. Meyer, Kathryn A. Toth, Zachary Ferris, Yesmarie T. De La Flor, Thomas DeMarco, Hunter K. G. Noren, Brian K. Walker, Valerie J. Paul

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Untargeted proteomics enables ultra-rapid variant prioritisation in mitochondrial and other rare diseases by Daniella H. Hock, Nikeisha J. Caruana, Liana N. Semcesen, Nicole J. Lake, Luke E. Formosa, Sumudu S. C. Amarasekera, Tegan Stait, Simone Tregoning, Leah E. Frajman, Adam M. Bournazos, David R. L. Robinson, Megan Ball, Boris Reljic, Bryony Ryder, Mathew J. Wallis, Anand Vasudevan, Cara Beck, Heidi Peters, Joy Lee, Natalie B. Tan, Mary-Louise Freckmann, MitoMDT Diagnostic Network for Genomics and Omics, Vasiliki Karlaftis, Chantal Attard, Paul Monagle, Amanda Samarasinghe, Rosie Brown, Weimin Bi, Monkol Lek, Robert McFarland, Robert W. Taylor, Michael T. Ryan, Sandra T. Cooper, Zornitza Stark, John Christodoulou, Alison G. Compton, David R. Thorburn, David A. Stroud

“…A major barrier is the lack of disease agnostic functional tests suitable for implementation in routine diagnostics that can provide evidence supporting pathogenicity of novel variants, especially those refractory to RNA sequencing. …”
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Network and systems biology approaches help investigate gene regulatory interactions between Salmonella disease and host in chickens: Model‐based in silico evidence combined with g... by Reza Tohidi, Hoda Javaheri Bargourooshi, Arash Javanmard

“…The host's genetic immune system determines the pathogenicity of a particular bacterium. To shed light on this topic, it was necessary to understand the key candidate genes essential for regulating susceptibility and resistance to the target disease. …”
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Protease-responsive protein hydrogel enabling spatiotemporal ClO2 release for precision treatment of intracellular infections and periodontitis by Xianxian Huang, Yingjuan Zhang, Yonghui Huang, Qiurui Hu, Zhisong Mai, Yuan Qin, Cui Huang, Yanhua Wei, Fengyuan Zhou, Yicai Luo, Yinge Wei, Xinglu Jiang, Hongbing Liao

“…Antibiotics exhibit limited efficacy against intracellular pathogens and biofilms in periodontitis, thus often leading to drug resistance and compromised the long-term therapeutic outcomes. …”
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Mapping Antimicrobial Resistance in <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> from Complicated Urinary Tract Infections in Oman: Phenotypic and Genotypic Insights by Nawal AL Shizawi, Zaaima AL Jabri, Fatima Khan, Hiba Sami, Turkiya AL Siyabi, Zakariya AL Muharrmi, Srinivasa Rao Sirasanagandla, Meher Rizvi

“…<b>Background:</b> Mapping the local etiology and susceptibility of common pathogens causing complicated urinary tract infection (cUTI) is important for promoting evidence-based antimicrobial prescribing. …”
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Human T-Lymphotropic Virus (HTLV): Epidemiology, Genetic, Pathogenesis, and Future Challenges by Francesco Branda, Chiara Romano, Grazia Pavia, Viola Bilotta, Chiara Locci, Ilenia Azzena, Ilaria Deplano, Noemi Pascale, Maria Perra, Marta Giovanetti, Alessandra Ciccozzi, Andrea De Vito, Angela Quirino, Nadia Marascio, Giovanni Matera, Giordano Madeddu, Marco Casu, Daria Sanna, Giancarlo Ceccarelli, Massimo Ciccozzi, Fabio Scarpa

“…HTLV-1 is associated with severe diseases such as adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), while HTLV-2 shows a lower pathogenic potential, with occasional links to neurological disorders. …”
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Preparedness and response to the international poliovirus and diphtheria reintroduction alert: public health interventions and strategy review in the Veneto Region, Italy by Marco Milani, Marco Milani, Michele Nicoletti, Michele Nicoletti, Michele Tonon, Davide Gentili, Stefan-Alexandru Panaite, Stefan-Alexandru Panaite, Filippo Da Re, Andrea Basso, Gloria Pagin, Marco Zampini, Debora Ballarin, Francesca Zanella, Vanessa Groppi, Silvia Cocchio, Francesca Russo, Vincenzo Baldo

“…Strengthening data integration and adopting innovative surveillance methods will be crucial to sustaining high vaccination coverage and ensuring public health security.…”
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Antimicrobial Activity and the Synergy Potential of <i>Cinnamomum aromaticum</i> Nees and <i>Syzygium aromaticum</i> (L.) Merr. et Perry Essential Oils with Antimicrobial Drugs by Soraia El Baz, Bouchra Soulaimani, Imane Abbad, Zineb Azgaou, El Mostapha Lotfi, Mustapha Malha, Noureddine Mezrioui

“…Importantly, the observed synergistic effects of these EOs with conventional antibiotics support their integration into medical treatments as a strategy to address microbial resistance. …”
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