Multimodal AI/ML for discovering novel biomarkers and predicting disease using multi-omics profiles of patients with cardiovascular diseases by William DeGroat, Habiba Abdelhalim, Elizabeth Peker, Neev Sheth, Rishabh Narayanan, Saman Zeeshan, Bruce T. Liang, Zeeshan Ahmed

“…In this study, we present a cutting-edge methodology rooted in the integration of traditional bioinformatics, classical statistics, and multimodal machine learning techniques. …”
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Dravet syndrome: novel insights into SCN1A-mediated epileptic neurodevelopmental disorders within the molecular diagnostic-therapeutic framework by Guirui Zhang, Guirui Zhang, Shupeng Huang, Mingzhen Wei, Yongmo Wu, Zhengyi Xie, Jin Wang, Jin Wang, Jin Wang

“…Therapeutic strategies are evolving from empirical seizure control to mechanism-targeted interventions: antisense oligonucleotides (ASOs) restore SCN1A transcript integrity by blocking pathogenic exon inclusion; adeno-associated virus (AAV9)-mediated activation of GABAergic neuron-specific SCN1A promoters and CRISPR/dCas9-driven endogenous Nav1.1 upregulation have both been shown to improve inhibitory synaptic function and elevate seizure thresholds in preclinical models. …”
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Qing-Luo-Yin Eases T Cells-Mediated Angiogenesis in Adjuvant-Induced Arthritis Rats by Activating PPARγ by Song MK, Wang MQ, Ruan YQ, Cui C, Chen WG, Olatunji OJ, Li Y, Zuo J

“…QLY therapy inhibited pathogenic functions of AIA rats’ lymphocytes, shown by changes of cytokines network in the recipients’ joints, where these cells accumulated. …”
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Environmental trafficking of superbug carbapenem-resistant Klebsiella pneumoniae and its silent spread in an urban population: a sewage-based study by Saubhagini Sahoo, Anshuman Sahu, Rajesh Kumar Sahoo, Mahendra Gaur, Debadutta Bhanjadeo, Enketeswara Subudhi

“…Our study advocates for the integration of sewage surveillance as a robust, cost-effective approach to monitor the environmental spread and current trends of pathogens in human populations. …”
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Multi-omics analysis reveals regime shifts in the gastrointestinal ecosystem in chickens following anticoccidial vaccination and Eimeria tenella challenge by Po-Yu Liu, Janie Liaw, Francesca Soutter, José Jaramillo Ortiz, Fiona M. Tomley, Dirk Werling, Ozan Gundogdu, Damer P. Blake, Dong Xia

“…Infection heightened microbiota richness with increases in potentially pathogenic species, while vaccination elevated beneficial Bifidobacterium. …”
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Recombinant Marek’s disease virus expressing VP1 and VP2 proteins provides robust immune protection against chicken infectious anemia virus by Chengfei Ge, Hangqiong Lu, Jinze Han, Guorong Sun, Shihao Li, Xingge Lan, Yongzhen Liu, Mengmeng Yu, Xinyun Hu, Mingxue Hu, Xiaole Qi, Hongyu Cui, Yulu Duan, Suyan Wang, Yuntong Chen, Xiaomei Wang, Xiaomei Wang, Yanping Zhang, Yulong Gao, Changjun Liu

“…In animal studies, vaccination of one-day-old specific-pathogen-free chickens with rMDV induced high levels of CIAV-specific antibodies (1 × 105) and neutralizing antibodies (1:25) and a potent cellular immune response. …”
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Longitudinal profiling of host response and oropharyngeal respiratory microbiome reveals dynamic alterations during recovery from community-acquired pneumonia by Lizhe Hong, Lijun Suo, Kang Chang, Hongyun Cao, Jiahui Luan, Fuxin Zhang, Xiaofeng Yu, Xiaohui Zou, Bo Liu, Bin Cao

“…CAP increased the relative abundance of Streptococcus, Veillonella, and Peptostreptococcus, while decreasing that of Haemophilus, Neisseria, and Porphyromonas. Integrated analysis of host response and oropharyngeal microbiome revealed that the relative abundance of Haemophilus, Neisseria, Porphyromonas, and Stomatobaculum were positively related to mitochondrial structure and function pathways, whereas the relative abundance of Prevotella declined over time in patients and positively correlated with anti-pathogen and interferon signaling pathways. …”
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Similarities between Ixodes ricinus and Ixodes inopinatus genomes and horizontal gene transfer from their endosymbionts by Valérie O. Baede, Oumayma Jlassi, Paulina M. Lesiczka, Hend Younsi, Hans J. Jansen, Khalil Dachraoui, Jane Segobola, Mourad Ben Said, Wouter J. Veneman, Ron P. Dirks, Hein Sprong, Elyes Zhioua

“…Our findings support the existence of different lineages of I. ricinus as well of its symbionts/pathogens from geographically dispersed locations.…”
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The comprehensive transcriptomic atlas of porcine immune tissues and the peripheral blood mononuclear cell (PBMC) immune dynamics reveal core immune genes by Qingyao Zhao, Jiahao Wang, Fuping Ma, Quanzhen Chen, Huatao Liu, Jinyan Yang, Siqian Chen, Yongjie Tang, Siyuan Mi, Lulu Wang, Xini Wang, Guohong Liu, Kai Xing, Ying Yu, Chuduan Wang

“…With the development of genomics technology, the combination of transcriptome, genetic variation, immune response, and QTL mapping data to illustrate the interactions between pathogen and host immune system, will be an effective tool for identification of disease resistance genes in pigs. …”
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Geographic divergence of methicillin-resistant Staphylococcus aureus ST5-SCCmecI in the aftermath of a major earthquake and tsunami: impact of a plasmid harboring heavy metal resis... by Jose R. W. Martínez, Manuel Alcalde-Rico, Estefanía Jara-Videla, Jinnethe Reyes, Lina P. Carvajal, Sandra Rincon, Rafael Ríos, Lorena Diaz, Ana Quesille-Villalobos, Roberto Riquelme-Neira, Lina Rivas, Ahmed M. Moustafa, Blake Hanson, Eduardo A. Undurraga, Jorge Olivares-Pacheco, Patricia García, Rafael Araos, Paul J. Planet, César A. Arias, Jose M. Munita

“…By linking environmental events to pathogen evolution, our study highlights the role of ecological pressures in the spread of MRSA. …”
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Mutational and low-coverage whole genome sequencing identifies actionable DNA repair alterations in prostate cancer plasma DNA by Alessandra Virga, Milena Urbini, Maurizio Polano, Elisabetta Petracci, Gianluca Tedaldi, Giorgia Gurioli, Giorgia Marisi, Davide Angeli, Andrea Ambrosini-Spaltro, Giovanni De Luca, Ilaria Cangini, Valentina Zampiga, Giovanna Cenacchi, Giuseppe Toffoli, Chiara Casadei, Maria Concetta Cursano, Vincenza Conteduca, Ugo De Giorgi, Paola Ulivi

“…Abstract PARP inhibitors (PARPi), recently introduced for treating metastatic castration-resistant prostate cancer (mCRPC), have heightened interest in molecular profiling for pathogenic aberrations in homologous recombination DNA repair (HRR) genes in all mCRPC patients. …”
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Etiological Structure, Clinical and Epidemiological Characteristics of Infections Transmitted by Ixodic Ticks in the Sverdlovsk Region at the Present Stage by N. M. Kolyasnikova, M. G. Toporkova, J. P. Sanchez-Pimentel, A. S. Nazarenko, O. A. Stukolova, I. G. Starodubova, T. A. Chekanova, A. V. Titkov, A. A. Tihomirova, E. A. Kuznetsova, Ya. B. Beikin, Yu. A. Naumov, N. B. Pestov, V. A. Mishchenko, I. V. Vyalykh, A. A. Ishmukhametov, V G. Akimkin

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Multiplexed self-adaptable Janus hydrogels rescue epithelial malfunction to promote complete trachea repair by Yi Chen, Hai Tang, Yan Zhang, Lei Wang, Jun Zhu, Lele Wang, Anqi Li, Xiang Zeng, Binyu Yin, Yu Liang, Xiulin Dong, Qingfeng Bai, Ziyin Pan, Long Wang, Lei Zhang, Minglei Yang, Yunlang She, Weiyan Sun, Kun Zhang, Chang Chen

“…Herein, bacterial infection-induced neutrophilic oxidative stress imbalance and epithelial stemness loss were identified as the pathogenic factors. Targeting pathogenesis, multiplexed hydrogels with adhesive and anti-fouling Janus sides, anti-swelling and anti-bacteria properties are constructed to adapt in mucous and causative agent-rich trachea environments. …”
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Research on chemical control of peach shoot blight and the association between phloem volatile compounds and resistance by HU Zhu, WANG Li, ZHAO Hongyue

“…Key volatile compounds significantly correlated with resistance (identified in the correlation analysis) were quantified in these tissues to observe pathogen-induced changes. [Results] The toxicity test of fungicides showed that prochloraz had the strongest inhibitory effect, with an EC50 value of 0.004 2 mg·L-1. …”
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Advancing Climate-Resilient Sorghum: the Synergistic Role of Plant Biotechnology and Microbial Interactions by Atul Kumar Srivastava, Aamir Riaz, Junmei Jiang, Xiangyang Li, Mohammad Uzair, Pooja Mishra, Aqib Zeb, Jiwei Zhang, Raghvendra Pratap Singh, Lingfeng Luo, Songshu Chen, Sanwei Yang, Yudan Zhao, Xin Xie

“…Biocontrol agents such as Bacillus and Trichoderma contain suppression of pathogens and need less dependence on the use of chemical pesticides. …”
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Evaluation of a Machine Learning Model Based on Laboratory Parameters for the Prediction of Influenza A and B in Chongqing, China: Multicenter Model Development and Validation Stud... by Weiwei Hu, Yulong Liu, Jian Dong, Xuelian Peng, Chunyan Yang, Honglin Wang, Yong Chen, Shan Shi, Jin Li

“… BackgroundInfluenza viruses are major pathogens responsible for acute respiratory infections in humans, which present with symptoms such as fever, cough, sore throat, muscle pain, and fatigue. …”
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SIU-ICUD: Germline Genetic Susceptibility to Prostate Cancer: Utility and Clinical Implementation by James T. Kearns, Annabelle Ashworth, Elena Castro, Rosalind A. Eeles, Liesel M. FitzGerald, Peter J. Hulick, Stacy Loeb, Christian P. Pavlovich, Timothy R. Rebbeck, Susan T. Vadaparampil, Zhuqing Shi, Huy Tran, Jun Wei, Jianfeng Xu, Brian T. Helfand

“…<b>Methods:</b> Comprehensive genetic risk assessment should integrate three components: family history (FH), rare pathogenic mutations (RPMs), and polygenic risk scores (PRS). …”
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Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides by Ka Kiu Lee, Urszula Łapińska, Giulia Tolle, Maureen Micaletto, Bing Zhang, Wanida Phetsang, Anthony D Verderosa, Brandon M Invergo, Joseph Westley, Attila Bebes, Raif Yuecel, Paul A O'Neill, Audrey Farbos, Aaron R Jeffries, Stineke van Houte, Pierluigi Caboni, Mark AT Blaskovich, Benjamin E Housden, Krasimira Tsaneva-Atanasova, Stefano Pagliara

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Harnessing plant–microbe interactions: strategies for enhancing resilience and nutrient acquisition for sustainable agriculture by Abdulhamid Yusuf, Abdulhamid Yusuf, Abdulhamid Yusuf, Min Li, Si-Yu Zhang, Fidelis Odedishemi-Ajibade, Rui-Fang Luo, Ya-Xiao Wu, Ting-Ting Zhang, Adamu Yunusa Ugya, Yunzeng Zhang, Shuo Duan

“…., drought and salinity) and biotic challenges (e.g., pathogens and pests). Integration of these microbiomes with optimized root exudate profiles has been shown to improve nutrient cycling, suppress diseases, and alleviate environmental stresses, thus contributing to more sustainable agricultural practices. …”
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Surveillance of Pediatric Invasive Bacterial Diseases in the Veneto Region: Epidemiological Trends and Outcomes over 17 Years (2007–2023) by Silvia Cocchio, Claudia Cozzolino, Andrea Cozza, Patrizia Furlan, Enrica Frasson, Sara Tarantino, Elisabetta Conte, Lorenzo Chiusaroli, Irene Amoruso, Francesca Zanella, Davide Gentili, Michele Tonon, Francesca Russo, Tatjana Baldovin, Vincenzo Baldo

“…These insights highlight the effectiveness of vaccination programs and the necessity of ongoing monitoring to inform public health policies. Improved data integration and completeness are recommended to enhance surveillance accuracy.…”
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