Analysis of major human and foodborne pathogens and their resistance to antimicrobials in the USA in the past two decades: Implications for surveillance and control of antimicrobia... by PAN Hang, LI Xiaoliang, FANG Weihuan, YUE Min

“…Of the pathogens from human patients in 2016 in China, pathogenic Escherichia coli and Staphylococcus aureus were predominant. …”
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HOST/PATHOGEN INTERACTIONS AND THE ROLE OF THE BARRIERS: ON THE EDGE BETWEEN HEALTH AND MULTIFACTORIAL/COMPLEX DISEASES

“…Future challenges will be the integration of approaches combining immunogenetics, single-cell sequencing, and systems immunology to better define pathogen specific contributions to complex immune-mediated diseases. …”
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Optical and Electrochemical Biosensors for Detection of Pathogens Using Metal Nanoclusters: A Systematic Review by Mahsa Shahrashoob, Mahdiyar Dehshiri, Vahid Yousefi, Mahdi Moassesfar, Hamidreza Saberi, Fatemeh Molaabasi, Yasser Zare, Kyong Yop Rhee

“…The rapid and accurate detection of pathogenic bacteria and viruses is critical for infectious disease control and public health protection. …”
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Enhancing pathogens detection in suspected geriatric bloodstream infections using Nanopore-targeted sequencing by Menghui Zhao, Yan Ouyang, Junchi Mei, Hang Liu

“…NTS demonstrated a pathogen detection rate of 61.1%. The most common bacterial pathogens were Escherichia coli and Staphylococcus aureus (each 7.7%), while Candida albicans was the most prevalent fungal pathogen (30%). …”
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Exploring the role of splicing in TP53 variant pathogenicity through predictions and minigene assays by Cristina Fortuno, Inés Llinares-Burguet, Daffodil M. Canson, Miguel de la Hoya, Elena Bueno-Martínez, Lara Sanoguera-Miralles, Sonsoles Caldes, Paul A. James, Eladio A. Velasco-Sampedro, Amanda B. Spurdle

“…Application of the observed splicing results was used to reclassify 27/59 (46%) test variants as (likely) pathogenic or (likely) benign. Conclusions In conclusion, this study enhances the integration of splicing predictions and provides splicing assay data for exonic variants to support TP53 germline classification. …”
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Application of multi-omics technology in pathogen identification and resistance gene screening of sheep pneumonia by Kai Huang, Lvfeng Yuan, Jia Liu, Xiaolong Li, Dan Xu, Xiaoxue Zhang, Jie Peng, Huibin Tian, Fadi Li, Weimin Wang

“…Conclusions High-throughput sequencing technologies have enabled the rapid and accurate identification of the causative pathogen of sheep pneumonia. By integrating multi-omics data, two genomic loci significantly associated with Mycoplasma pneumonia were screened, as well as an anti-Mycoplasma pneumonia key gene, FOXF1.…”
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Co-detection of respiratory pathogens in children with Mycoplasma pneumoniae pneumonia: a multicenter study by Xiaoyan Dong, Rui Li, Yingxue Zou, Lina Chen, Hailin Zhang, Fangfang Lyu, Wenhao Yang, Yanhua Niu, Haojie Wang, Run Guo, Xu Wang, Li Li, Zihao Lin, Li Luo, Danli Lu, Quan Lu, Hanmin Liu

“…Severe cases were further subdivided into an MP alone group and a multi-pathogen co-detection group. Receiver operating characteristic (ROC) curve analysis was performed to assess the predictive performance of inflammatory biomarkers for multi-pathogen co-detection.ResultsA total of 266 children were enrolled. …”
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Comparative Genomics and Pathogenicity Analysis of Three Fungal Isolates Causing Barnyard Grass Blast by Na Zhang, Xinyang Li, Liangping Ming, Wenda Sun, Xiaofang Xie, Cailing Zhi, Xiaofan Zhou, Yanhua Wen, Zhibin Liang, Yizhen Deng

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Prediction of human pathogenic start loss variants based on self-supervised contrastive learning by Jie Liu, Henghui Fan, Na Cheng, Yansen Su, Junfeng Xia

“…Accurate assessment of the pathogenicity of these variants is crucial for deciphering disease mechanisms and integrating genomics into clinical practice. …”
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Desmoglein-driven dynamic signaling in pemphigus vulgaris: a systematic review of pathogenic pathways by Siavash Rahimi, William V. J. Hariton, Fattaneh Khalaj, Ralf J. Ludwig, Luca Borradori, Eliane J. Müller

“…To better understand the dual function of desmosomal cadherins in structural integrity and cellular signaling, we here performed a systematic, unbiased review on pathogenic signaling effectors identified in models and patients with pemphigus vulgaris (PV). …”
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A Systematic Study of Bovine Viral Diarrhoea Virus Co-Infection with Other Pathogens by Zhiwei Hou, Jiahui Wang, Bin Tan, Shuqin Zhang

“…In this review, by systematically integrating studies on BVDV co-infection, we firstly compared and analysed the characteristics of BVDV co-infection with viruses, bacteria and other pathogens in in vivo/in vitro models in terms of synergism, host immune response and epidemiological transmission. …”
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Editorial: Harnessing marine biodiversity for novel antimicrobial agents against multidrug-resistant pathogens by Guillermin Agüero-Chapin, Dany Domínguez-Pérez, Dany Domínguez-Pérez, Yovani Marrero-Ponce, Yovani Marrero-Ponce

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A new Lactobacillus gasseri strain HMV18 inhibits the growth of pathogenic bacteria by Xiang Gao, Zixuan Wang, Xiang Li, Xiaoling Zhang, Shengqiang Du, Miaomiao Jia, Dailun Hu, Xianxian Jia, Bin Cong, Yan Zhang, Chunling Ma, Song Zhou, Jun Zhang

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Emergence and Prevalence of Puccinia polysora in Korea: A Comparitive Study of Maize Rust Pathogens by Yoo Kyeong Lee, Jae Sung Lee, Seong-Jin Lee, Moonjong Kim, Hyeon-Dong Shin, Young-Joon Choi

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Modelling the regulation of thermal adaptation in Candida albicans, a major fungal pathogen of humans. by Michelle D Leach, Katarzyna M Tyc, Alistair J P Brown, Edda Klipp

“…Adaptation to thermal insults, in particular, is essential for their survival. The major fungal pathogen of humans, Candida albicans, is obligately associated with warm-blooded animals and hence occupies thermally buffered niches. …”
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Fungi-Kcr: a language model for predicting lysine crotonylation in pathogenic fungal proteins by Yong-Zi Chen, Yong-Zi Chen, Xiaofeng Wang, Zhuo-Zhi Wang, Haixin Li, Haixin Li

“…IntroductionLysine crotonylation (Kcr) is an important post-translational modification (PTM) of proteins, playing a key role in regulating various biological processes in pathogenic fungi. However, the experimental identification of Kcr sites remains challenging due to the high cost and time-consuming nature of mass spectrometry-based techniques.MethodsTo address this limitation, we developed Fungi-Kcr, a deep learning-based model designed to predict Kcr modification sites in fungal proteins. …”
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Molecular Insights into Rice Immunity: Unveiling Mechanisms and Innovative Approaches to Combat Major Pathogens by Muhammad Usama Younas, Bisma Rao, Muhammad Qasim, Irshad Ahmad, Guangda Wang, Quanyi Sun, Xiongyi Xuan, Rashid Iqbal, Zhiming Feng, Shimin Zuo, Maximilian Lackner

“…The discussion extends to breakthrough breeding technologies currently revolutionizing rice improvement programs, including DNA marker-assisted selection for accelerating traditional breeding, gene conversion methods for introducing new resistance traits, and precision genome editing tools such as CRISPR/Cas9 for enabling targeted genetic modifications. By integrating advances in molecular biology and genomics, these approaches offer sustainable solutions to safeguard rice yields against evolving pathogens.…”
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Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenic. by Brenda Watt, Danièle Tenza, Mark A Lemmon, Susanne Kerje, Graça Raposo, Leif Andersson, Michael S Marks

“…We propose that the DW and HoSi mutations alter the normally benign amyloid to a pathogenic form that antagonizes melanosome function, and that the secondary mutations found in the Smoky and Dun chickens revert or dampen pathogenicity by functioning as null alleles, thus preventing the formation of aberrant fibrils. …”
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The role of epigenetics in plant pathogens interactions under the changing environments: A systematic review by Wenhao Wu, Guoqiang Fan

“…Epigenetic modifications are emerging as pivotal regulatory mechanisms in plant-pathogen interactions, especially under changing environmental conditions. …”
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Inhibiting heme piracy by pathogenic Escherichia coli using de novo-designed proteins by Daniel R. Fox, Kazem Asadollahi, Imogen Samuels, Bradley A. Spicer, Ashleigh Kropp, Christopher J. Lupton, Kevin Lim, Chunxiao Wang, Hari Venugopal, Marija Dramicanin, Gavin J. Knott, Rhys Grinter

“…To obtain the iron required for growth, many bacterial pathogens encode transporters capable of extracting the iron-containing cofactor heme directly from host proteins. …”
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