Fighting Fungal Threats: Verification of an antifungal susceptibility assay to improve antifungal stewardship in the management of Candida infections by Miss Ashleigh Hale, Miss Disha Lawrence, Mr Adam Pattinson

“…Various specimens received in the Microbiology laboratory between August and October 2023, were sent to the reference laboratory for antifungal susceptibility testing and tested in parallel on the MICRONAUT-AM assay. Each sample required one 96-well microtitre plate, which included nine different antifungals in serial dilutions. …”
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Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling by Asra Asgharzadeh, Mubarak Patel, Martin Connock, Sara Damery, Iman Ghosh, Mary Jordan, Karoline Freeman, Anna Brown, Rachel Court, Sharin Baldwin, Fatai Ogunlayi, Chris Stinton, Ewen Cummins, Lena Al-Khudairy

“…The system includes a combination of real-time continuous glucose monitoring from a continuous glucose monitoring device and a control algorithm to direct insulin delivery through an insulin pump. …”
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Aquatic Environment and Nitrogen and Phosphorus Balance in Micropterus salmoides Culture Under Biofloc Model by Yuqin JIN, Shunlong MENG, Huimin XU, Chao SONG, Limin FAN, Liping QIU, Dandan LI

“…Each group had three parallel setups, with a stocking density of 20 tails per tank. …”
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Six months of hybrid closed-loop therapy improves diabetes-specific positive well-being, and reduces diabetes distress and fear of hypoglycemia: secondary analysis of a randomized... by Anthony C Keech, Vijaya Sundararajan, Bruce R King, Sara Vogrin, Richard J MacIsaac, Leon A Bach, Jane Speight, Alicia J Jenkins, Christel Hendrieckx, David O’Neal, Sybil A McAuley, Geoff R Ambler, Fergus J Cameron, Jan M Fairchild, Elizabeth A Davis, Timothy W Jones, Morton G Burt, Philip M Clarke, Neale D Cohen, Peter G Colman, Joey Kaye, Kavita Kumareswaran, Melissa H Lee, Roland W Mccallum, Barbora Paldus, Stephen N Stranks, Steven Trawley, Glenn M Ward, David N O’Neal, Sienna Russell-Green, Deborah Jane Holmes-Walker, Benjamin Lam, Jennifer A Halliday, Glenn Ward, Catriona M Sims, D Jane Holmes-Walker, Andrzej Januszewski, Hanafi Mohammed Husin, Martin I de Bock, Mary B Abraham

“…Introduction This analysis aimed to investigate diabetes-specific psychological outcomes among adults with type 1 diabetes (T1D) using hybrid closed-loop (HCL) versus standard therapy.Research design and methods In this multicenter, open-label, randomized, controlled, parallel-group clinical trial, adults with T1D were allocated to 26 weeks of HCL (MiniMed™ 670G) or standard therapy (insulin pump or multiple daily injections without real-time continuous glucose monitoring). …”
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Chronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised tr... by Jihoon A Kim, Anjali Sankar, Rebecca Marks, Erin Carrubba, Bernadette Lecza, Susan Quatrano, Linda Spencer, R. Todd Constable, Brian Pittman, Eli R Lebowitz, Wendy K Silverman, Holly A Swartz, Hilary P Blumberg

“…Background Mood episodes and high suicide risk of bipolar disorder (BD) are thought to derive from amygdala–ventral prefrontal cortex emotion regulation brain circuitry dysfunction and resulting emotion dysregulation, making these potential intervention targets.Objective To assess feasibility, acceptability, and preliminary efficacy in engaging the emotion regulation targets of two Brain Emotion Circuitry-targeted Self-Monitoring and Regulation Therapy (BE-SMART) variations in adolescents and young adults with BD (BDAYA): BE-SMART-ER, which directly targets emotion regulation, and BE-SMART-DR, a social rhythm therapy (SRT)-based chronotherapeutic intervention designed to reduce daily rhythm (DR) irregularities.Methods In a single-blind, parallel, pilot-randomised trial, 60 BDAYA (aged 16–29 years) were randomised to 12 weekly sessions (9 telehealth) of BE-SMART-DR or BE-SMART-ER. …”
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4D label-free proteomics reveals that lignin and gossypol biosynthesis are enhanced in the roots of cotton (Gossypium hirsutum L. cv. TM-1) seedlings after a fifteen-days exposure... by Yuanhao Ding, Ping Li, Wenjie Lai, Yalan Li, Sihui Huang, Qiuping Zhong, Long Lu, Liyan Yin, Wei Gao, Haiyan Hu

“…Furthermore, roots from a glandless cotton mutant (CCRI12gl, lacking gossypol) were significant shorter than those of its wide-type counterpart (CCRI12, glandular, containing gossypol) after AgNPs treatment, suggesting that gossypol enhances cotton tolerance to AgNPs. Additionally, parallel reaction monitoring (PRM) technology validated that the expression levels of proteins involved in lignin and gossypol biosynthesis were consistent with the findings of the 4D label-free proteomics analysis. …”
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Longitudinal multimodal MRI analysis of lecanemab treatment in mild cognitive impairment: a pilot study of structural, perfusion, and microstructural changes by Toshiya Takahashi, Dinh Ha Duy Thuy, Shingo Takenaka, Sayaka Ono, Maya Fukui, Yasushi Okada, Tomohiko Asada, Kan Niimi, Kaku Kimura, Akio Ikeda, Ryosuke Takahashi, Riki Matsumoto, Hidenao Fukuyama

“…Multimodal MRI may contribute to monitoring treatment response in patients with MCI receiving lecanemab.…”
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Research On Calculation of Longitudinal Deformation of The Underlying Shield Tunnel Caused By Excavation of The Foundation Pit Considering Consolidation Effects by LYU Linhai, DONG Cheng, ZHAO Zhe, JIANG Mingjie, JI Yongkai, QIU Shizheng, ZHANG Zhendong, MEI Guoxiong

“…The proposed theoretical methodology was employed to calculate the tunnel uplift displacement, with its predictive accuracy rigorously validated against field monitoring data. In this case study, the rebound modulus of each soil layer was determined as four times its compression modulus, following established engineering practice for cohesive soils. …”
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Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT by Cherry-Ann Waldron, Philip Pallmann, Simon Schoenbuchner, Debbie Harris, Lucy Brookes-Howell, Céu Mateus, Jolanta Bernatoniene, Katrina Cathie, Saul N Faust, Josie Henley, Lucy Hinds, Kerry Hood, Chao Huang, Sarah Jones, Sarah Kotecha, Sarah Milosevic, Helen Nabwera, Sanjay Patel, Stéphane Paulus, Colin VE Powell, Jenny Preston, Huasheng Xiang, Emma Thomas-Jones, Enitan D Carrol

“…Design A pragmatic, multicentre, open-label, parallel two-arm, individually randomised controlled trial with internal pilot phase, qualitative study and health economic evaluations. …”
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Dynamic Tensile Properties of Ultra–High–Performance Concrete Under Impact Splitting Tensile Load Based on Digital Image Correlation Technology by Xudong CHEN, Xuyang WANG, Tao JI, Jixuan LIU, Yingjie NING

“…Simultaneously, some secondary cracks develop near and parallel to the main crack as the main crack expands, demonstrating the bridging effect of steel fibers in the damage process of UHPC under impact load. …”
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Continuous sensing of water status in the root zone of wheat plants reveals features of circadian-dependent water uptake under mild water deficit by Ismael Gutiérrez-Fernández, Ouardia Bendou, Emilio L. Marcos-Barbero, Nara Bueno-Ramos, Ana I. González-Hernández, Rosa Morcuende, Juan B. Arellano

“…At maturity, grain yield and plant biomass showed parallel reductions in ca. 40 %, reflecting the difference in water use between water treatments. …”
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Innovation Ecosystem of Iran's Tourism Industry with Emphasis on Supply Chain by Azizolah Jafari, mahdi alaei kerahrudi

“…Although parallel institutions pose a problem, creating a mechanism to consolidate opinions, share resources, and achieve synergies can transform this challenge into an opportunity. …”
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Co-designing and testing the learn together guidance to support patient and family involvement in patient safety investigations: a mixed-methods study by Jane O’Hara, Lauren Ramsey, Siobhan McHugh, Joseph Langley, Justin Waring, Ruth Simms-Ellis, Gemma Louch, Jenni Murray, Carl Macrae, John Baker, Rebecca Lawton, Daisy Halligan, Olivia Rogerson, Penny Phillips, Debra Hazeldine, Sarah Seddon, Joanne Hughes, Rebecca Partridge, Katherine Ludwin, Laura Sheard

“…A synthesis phase ran parallel with the first two, bringing them together through a series of analytical workshops. …”
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The use of 18F-Fluoro-deoxy-glucose positron emission tomography (18F-FDG PET) as a non-invasive pharmacodynamic biomarker to determine the minimally pharmacologically active dose... by Juliana Maynard, Sally-Ann Emmas, Francois-Xavier Ble, Herve Barjat, Emily Lawrie, Urs Hancox, Urszula M Polanska, Alison Pritchard, Kevin Hudson

“…This data supports and parallels observations obtained with this class of compounds in patients.…”
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Intersecting factors of disadvantage and discrimination and their effect on daily life during the coronavirus pandemic: the CICADA-ME mixed-methods study by Carol Rivas, Amanda P Moore, Alison Thomson, Kusha Anand, Zainab Zuzer Lal, Alison Fang-Wei Wu, Ozan Aksoy

“…Methods We used a transformative, convergent parallel mixed-methods design integrating three strands – quantitative, qualitative and a secondary data strand – across three phases over 18 months, to answer the study objectives. …”
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