Preeclampsia – A risk factor for dementia in women by Sameen Aftab, Qazi Muhammad Zarlish

“…According to the World Health Organization, at present, more than 55 million people around the world are suffering from dementia, and over 60% of whom live in countries that have middle to low socioeconomic status. Nearly 10 million new cases of dementia present every year. …”
Get full text

The redox function of APE1 is involved in the differentiation process of stem cells toward a neuronal cell fate. by Rossana Domenis, Natascha Bergamin, Giuseppe Gianfranceschi, Carlo Vascotto, Milena Romanello, Silvia Rigo, Giovanna Vagnarelli, Massimo Faggiani, Piercamillo Parodi, Mark R Kelley, Carlo Alberto Beltrami, Daniela Cesselli, Gianluca Tell, Antonio Paolo Beltrami

“…<h4>Unlabelled</h4>Low-to-moderate levels of reactive oxygen species (ROS) govern different steps of neurogenesis via molecular pathways that have been decrypted only partially. …”
Get full text

Rbf/E2F1 control growth and endoreplication via steroid-independent Ecdysone Receptor signalling in Drosophila prostate-like secondary cells. by Aashika Sekar, Aaron Leiblich, S Mark Wainwright, Cláudia C Mendes, Dhruv Sarma, Josephine E E U Hellberg, Carina Gandy, Deborah C I Goberdhan, Freddie C Hamdy, Clive Wilson

“…This physiological change induces genome endoreplication and allows SCs to rapidly replenish their secretory compartments, even when ecdysone levels are low because the male has not previously been exposed to females. …”
Get full text

Hygiene and prevention of the addictions in adolescents: existential-humanistic model by P. N. Moskvitin

“…After training statistically reliable difference of experimental group from control group in each of the parallels of the 8, 9 and 10 classes presented in research is revealed. …”
Get full text

Comprehensive Analysis of a Hybrid Solar Assisted Supercritical CO2 Reheat Recompression Brayton Cycle for Enhanced Performance by Foyez Ahmad, Fardin Mahatab, Sajjad Mahmud, M. Monjurul Ehsan

“…The global energy demand is increasing consistently, paralleled by rising greenhouse gas emissions. The worldwide drive to mitigate CO2 emissions in power generation has prompted countries to prioritize low carbon emission technologies such as renewable energy along with performance improvements. …”
Get full text

Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms: FUTURE, a superiority RCT and economic evaluation by Mohamed Abdel-Fattah, Christopher Chapple, Suzanne Breeman, David Cooper, Helen Bell-Gorrod, Preksha Kuppanda, Karen Guerrero, Simon Dixon, Nikki Cotterill, Karen Ward, Hashim Hashim, Ash Monga, Karen Brown, Marcus Drake, Andrew Gammie, Alyaa Mostafa, Rebecca Bruce, Victoria Bell, Christine Kennedy, Suzanne Evans, Graeme MacLennan, John Norrie

“…Design Female Urgency, Trial of Urodynamics as Routine Evaluations (FUTURE) was a parallel-group, multicentre, superiority, randomised controlled trial. …”
Get full text

Improving older people’s experiences and safety at transitions of care: the PACT mixed-methods study including RCT by Jenni Murray, Ruth Baxter, Jane O’Hara, Laura Sheard, Catherine Hewitt, Natasha Hardicre, Charles Vincent, Eirini Oikonomou, Gerry Richardson, Rosie Shannon, Kalpita Baird, Stephen Brealey, Robbie Foy, Laura Mandefield, Sarah Hampton, Ed Breckin, Lubena Mirza, Alfredo Palacios, Sally Moore, Jayne Marran, Jacqui Elliot, Jane Schofield, Alison Cracknell, Beth Woods, Sarah Cockayne, Thomas Mills, Yvonne Birks, Olivia Joseph, Rebecca Lawton

“…Overall fidelity to the intervention was moderate for majority of wards (n = 11, 68.75%) and low for the remaining five (31.25%). Fidelity to the intervention had no impact on re-admissions at 30 days. …”
Get full text

Digital augmentation of aftercare for patients with anorexia nervosa: the TRIANGLE RCT and economic evaluation by Janet Treasure, Katie Rowlands, Valentina Cardi, Suman Ambwani, David McDaid, Jodie Lord, Danielle Clark Bryan, Pamela Macdonald, Eva Bonin, Ulrike Schmidt, Jon Arcelus, Amy Harrison, Sabine Landau

“…Design Transition Care In Anorexia Nervosa through Guidance Online from Peer and Carer Expertise was a multicentre, parallel-group, superiority randomised controlled trial. …”
Get full text

Infection-Associated Flares in Systemic Lupus Erythematosus by Giuseppe A. Ramirez, Chiara Calabrese, Marta Secci, Luca Moroni, Gabriele D. Gallina, Giovanni Benanti, Enrica P. Bozzolo, Marco Matucci-Cerinic, Lorenzo Dagna

“…Infection-associated flares (IAFs) are common and might rapidly self-resolve, paralleling infection resolution, but their specific clinical phenotype is poorly understood. …”
Get full text

HIV/AIDS infection in critical care: epidemiological profile and risk factors for mortality in a Colombian cohort by Sara Penagos Gaviria, Natalia Zapata, Pablo Villa, Carlos A Agudelo, Francisco J Molina, Marco A González, Laura V Durango, Silvana Zapata, Carlos Galeano, Jonathan Cardona, Sebastián Rivera, Alicia I Hidron

“…However, whether the outcomes have improved in low- and middle-income countries, paralleling those of high-income countries is unknown. …”
Get full text

Climate–carbon-cycle interactions and spatial heterogeneity of the late Triassic Carnian pluvial episode by Xiangdong Zhao, Naihua Xue, Hu Yang, Daran Zheng, Jungang Peng, Joost Frieling, David De Vleeschouwer, Xuewu Fu, Wanglu Jia, Yanan Fang, Sha Li, Meng Wang, Xianye Zhao, Qiang Wang, Haichun Zhang, Jingeng Sha, Hugh C. Jenkyns, Philippe Claeys, Bo Wang

“…The CPE hydrological cycle was typified by increased aridification in continental interiors and multiple precipitation centres at low-latitude eastern regions of Pangea and at the poles. …”
Get full text

Flight-Safe Inference: SVD-Compressed LSTM Acceleration for Real-Time UAV Engine Monitoring Using Custom FPGA Hardware Architecture by Sreevalliputhuru Siri Priya, Penneru Shaswathi Sanjana, Rama Muni Reddy Yanamala, Rayappa David Amar Raj, Archana Pallakonda, Christian Napoli, Cristian Randieri

“…The compressed model is executed on a Xilinx ZCU-104 FPGA and uses a pipelined, AXI-based hardware accelerator with efficient memory mapping and parallelized gate calculations tailored for low-power onboard systems. …”
Get full text

Principles and metrics of extreme learning machines using a highly nonlinear fiber by Hary Mathilde, Brunner Daniel, Leybov Lev, Ryczkowski Piotr, Dudley John M., Genty Goëry

“…Optical computing offers potential for ultra high-speed and low-latency computation by leveraging the intrinsic properties of light, such as parallelism and linear as well as nonlinear ultra-high bandwidth signal transformations. …”
Get full text

Depletion-restitution therapy of autoimmune rheumatic diseases. Part 2. Perspectives on bispecific antibodies by A. L. Maslyanskiy, D. A. Dibrov, A. M. Lila, A. V. Torgashina, E. G. Zotkin, M. Yu. Samsonov, G. A. Togizbayev

“…Recent years have seen attempts to repurpose bsAbs for the treatment of refractory, prognostically unfavorable forms of systemic autoimmune rheumatic diseases (SARDs), supported by theoretical rationale, experimental evidence, and parallels with successful CAR-T cell therapy.Beyond BiTEs, the bsAb platform also enables development of biologics with extended pharmacokinetics, multi-cytokine targeting potential for synergistic suppression of inflammation, and checkpoint-directed modulation of targeted cell functional activity.Advantages such as standardized manufacturing, off-the-shelf availability, predictable pharmacokinetics (with a known and limited half-life), flexible dosing regimens enabling slow escalation of the dose, the possibility of individualizing treatment duration and dosing frequency, the feasibility of repeated treatment cycles, the option to discontinue therapy in case of adverse events, and the significantly lower cost of short low-dose treatment cycles compared to CAR-T cell therapy – all these make bsAb-based strategies a highly attractive priority for next-generation depletion-restitution therapies for SARDs.…”
Get full text

Study protocol for VIdeo assisted thoracoscopic lobectomy versus conventional Open LobEcTomy for lung cancer, a UK multicentre randomised controlled trial with an internal pilot (t... by Tim Batchelor, Babu Naidu, Chris A Rogers, Jane Blazeby, Alan Kirk, Paula Rogers, Stacey Stewart, Syed Qadri, Fiona Strachan, Sarah Wordsworth, Susan J Dutton, Arjun Nair, Amy Kerr, Rajesh Shah, Lisa Jones, Elizabeth A Stokes, Mark Ainsworth, Kathryn Saunders, Daisy Elliott, Rosie Harris, Sangeetha Paramasivan, Tom Treasure, Martyn Cain, Eric Lim, Michael Shackcloth, Joel Dunning, Niall McGonigle, Tim Brush, Lucy Dabner, Holly E Mckeon, Dawn Phillips, Holly Mckeon, Chloe Beard, Alba Realpe Rojas, Elizabeth Stokes, Andrew G Nicholson, Sofina Begum, Simon Jordan, Paulo De Sousa, Monica Tavares Barbosa, Eveline Internullo, Rakesh Krishnadas, Gianluca Casali, Doug West, Karen Bobruk, Catherine O’Donovan, Louise Flintoff, Amelia Lowe, Joanna Nicklin, Emma Heron, Jo Chambers, Becky Houlihan, Laura Beacham, Heather Hudson, Katy Tucker, Toni Farmery, Danielle Davis, Mike Shackcloth, Julius Asante-Siaw, Susannah Love, Sarah Feeney, Lindsey Murphy, Almudena Duran Rosas, Andrea Young, Ian Paul, Hyder Latif, Charlotte Jacobs, Alison Chilvers, Edward Stephenson, Nazalie Iqbal, Vladimir Anikin, Claire Prendergast, Hazem Fallouh, Maninder Kalkat, Richard Steyn, Nicola Oswald, Charlotte Ferris, Jo Webb, Joanne Taylor, Hollie Bancroft, Salma Kadiri, Zara Jalal Senior, Elizabeth Belcher, Dionisios Stavroulias, Francesco Di Chiara, May Havinden-Williams, Mahmoud Loubani, Karen Dobbs, Paul Atkin, Dominic Fellowes, Leanne Cox, Vipin Zamvar, Ruth Langley, Joy Adamson, Ian Hunt, Peter B Licht, Chris Hall, Mike Cowen, Keith Kerr, Nagmi Qureshi

Get full text

Functional Characterization of Cassava A20/AN1 Genes (Metip4, Metip8, and Metip11) in Multiple Abiotic Stresses by Yu‐Lan Chen, Chun‐Wen Huang, Yan‐Liu Wu, Xian‐Wei Fan, You‐Zhi Li

“…As a result, these genes were intron‐free and positively regulated the tolerance of plants to drought, salt, high (32°C) and low (10°C) temperatures, and Mn, but differed in regulating resistance to Cd and Cu, which paralleled changes in plants in contents of proline and relative water, reactive oxygen species, malondialdehyde, endogenous abscisic acid, and/or catalase activity. …”
Get full text

Classification of management tools in small business organizations for developing a sales funnel by E. R. Tolstova, L. V. Silakova

“…This study is aimed at selecting a set of services that can help the development of a small business characterized by low revenue volumes, and, as a result, small budgets for promotion, as well as a small number of staff. …”
Get full text

Experimental and computational analysis of coated milli-structured bioreactor with immobilized nitrilase for continuous production of nicotinic acid by Maïté Michaud, Chalore Teepakorn, Véronique De Berardinis, Anne Zaparucha, Guillaume Nonglaton, Pierre Coste, Zoé Anxionnaz-Minvielle

“…Statement_of_novelty_and_significance: Micro-scale devices with wall-immobilized enzymes intensify mass transfers but the low productivity per unit requires complex parallelization to meet industrial throughput. …”
Get full text

Connectivity guided intermittent theta burst stimulation versus repetitive transcranial magnetic stimulation in moderately severe treatment resistant depression by Richard Morriss, Lucy Webster, Luke Ingram, Mohamed Abdelghani, Adriana Anton, Shaun Barber, Peter Bates, Paul Briley, Clement Boutry, Cassandra Brookes, Edward Cox, Beth Hall, Marilyn James, Matthew Keane, Micheal Kurkar, Sudheer Lankappa, Peter Liddle, Hamish McAllister-Williams, Hyerin Oh, Alexander O’Neill-Kerr, Jehill Parikh, Stefan Pszczolkowski, Ana Suazo Di Paola, Louise Thomson, Yvette Walters, Dorothee Auer

“…Randomisation was stratified by study site and minimised on severity of depression (HDRS-17 score 16–23 moderate or ≥ 24 severe) and degree of treatment resistance [low 2–3.5, medium 4–6, high (≥ 6.5) as assessed at baseline]. …”
Get full text

Cerro del Pueblo Fm (Difunta Group, Upper Cretaceous), Parras Basin, southern Coahuila, Mexico: reference sections, age, and correlation by David A. Eberth, Carlos R. Delgado-de Jesús, John F. Lerbekmo, Donald B. Brinkman, Rubén A. Rodríguez-de la Rosa, Scott D. Sampson

“…Overall, the CdP records deposition in very low gradient lower coastal plain and shallow marine (ramp) settings that were influenced by high-frequency changes in relative sea-level and coastal storm events. …”
Get full text