Carer administration of as-needed subcutaneous medication for breakthrough symptoms in people dying at home: the CARiAD feasibility RCT by Zoë Hoare, Clare Wilkinson, Dyfrig A Hughes, Anthony Byrne, Annmarie Nelson, Julia Hiscock, Bee Wee, Marlise Poolman, Annie Hendry, Stella Wright, Paul Perkins, Anne Parkinson, Emily Holmes, Liz Reymond, Betty Foster, Julie O’Connor, Penney Lewis, Nia Goulden, Rossella Roberts, Sian Roberts

“…Objectives To determine if carer administration of as-needed subcutaneous medication for common breakthrough symptoms in people dying at home is feasible and acceptable in the UK, and if it would be feasible to test this intervention in a future definitive randomised controlled trial.Design We conducted a two-arm, parallel-group, individually randomised, open pilot trial of the intervention versus usual care, with a 1:1 allocation ratio, using convergent mixed methods.Setting Home-based care without 24/7 paid care provision, in three UK sites.Participants Participants were dyads of adult patients and carers: patients in the last weeks of their life who wished to die at home and lay carers who were willing to be trained to give subcutaneous medication. …”
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A holistic approach to promoting early child development: a cluster randomised trial of a group-based, multicomponent intervention in rural Bangladesh by Stephen P Luby, Mahbubur Rahman, Fahmida Tofail, Lia CH Fernald, Esther O Chung, Helen O Pitchik, Fahmida Akter, Jesmin Sultana, Abul Kasham Shoab, Tarique Md. Nurul Huda, Tania Jahir, Md Ruhul Amin, Md Khobair Hossain, Jyoti Bhushan Das, Kendra A Byrd, Farzana Yeasmin, Laura H Kwong, Jenna E Forsyth, Malay K Mridha, Peter J Winch

“…Introduction In low- and middle-income countries, children experience multiple risks for delayed development. …”
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Selective neoadjuvant therapy of rectal cancer patients (SELREC): study protocol for a European randomised controlled, open, multicentre non-inferiority trial by Markus W Büchler, Lukas Baumann, Peter Schirmacher, Christoph W Michalski, Markus K Diener, Dirk Jäger, Pascal Probst, Mohammed Al-Saeedi, Martin Schneider, Alexis Ulrich, Constantin Schwab, Anja Sander, Christina Klose, Christoph Kahlert, Hans-Ulrich Kauczor, Jürgen Debus, Rosa Klotz, Solveig Tenckhoff, Cosima Engerer, Kristin Uzun-Lang, Caroline Wild, Bruno C Köhler

“…The first secondary endpoint is no/minor low anterior resection syndrome (LARS) score at 2 years after surgery, and further secondary endpoints include survival outcomes and quality of life. …”
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Developing SysteMatic: Prevention, precision and equity by design for people living with multiple long-term conditions by Frances S. Mair, Farnaz Nickpour, Barbara Nicholl, Sara MacDonald, Dan W. Joyce, Jonathan Cooper, Nic Dickson, Isobel Leason, Qammer H. Abbasi, Izzettin F. Akin, Fani Deligianni, Elizabeth Camacho, Jennifer Downing, Hilary Garrett, Martina Johnston Gray, David J. Lowe, Muhammad A. Imran, Sandosh Padmanabhan, Colin McCowan, P. John Clarkson, Lauren E. Walker, Iain Buchan

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Effects of ginger supplementation in individuals with mild-to-moderate joint pain II: joint flexibility, markers of health, quality of life, analgesic use, and side effects by Landry Estes, Jacob Broeckel, Megan Leonard, Broderick Dickerson, Drew E. Gonzalez, Martin Purpura, Ralf Jäger, Ryan Sowinski, Christopher J. Rasmussen, Richard B. Kreider

“…Knee and hip range of motion (ROM) was assessed via goniometry, while low back flexibility was assessed via a sit-and-reach test. …”
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The Italian contribution to the Synoptic Arctic Survey programme: the 2021 CASSANDRA cruise (LB21) through the Greenland Sea Gyre along the 75° N transect by M. Bensi, G. Civitarese, D. Borme, C. Caroppo, G. Caruso, F. Cerino, F. Decembrini, A. de Olazabal, T. Diociaiuti, M. Giani, V. Kovacevic, M. Kralj, A. Lo Giudice, G. Maimone, M. Monti, M. Papale, L. Patrolecco, E. Putelli, A. C. Rappazzo, F. Relitti, C. Rizzo, C. Rizzo, F. Spataro, V. Tirelli, C. Turetta, M. Azzaro

“…A stratified upper layer (30–50 m deep) with low surface nutrients, especially nitrate, is observed, while an accumulation of silicate occurs in deep water masses. …”
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Medical‐financial partnerships for improving financial and medical outcomes for lower‐income Americans: A systematic review by Julie Birkenmaier, Brandy R. Maynard, Harly M. Blumhagen, Hannah Shanks

“…Very few studies met inclusion criteria, and those that did were generally low quality, and therefore, we were unable to draw any conclusions regarding the intervention effects. …”
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Poor glycaemic control in type 2 diabetes compromises leukocyte oxygen consumption rate, OXPHOS complex content and neutrophil-endothelial interactions by Julia Cacace, Clara Luna-Marco, Alberto Hermo-Argibay, Catherine Pesantes-Somogyi, Omar A. Hernández-López, María Pelechá-Salvador, Celia Bañuls, Nadezda Apostolova, Luis de Miguel-Rodríguez, Carlos Morillas, Milagros Rocha, Susana Rovira-Llopis, Víctor M. Víctor

“…These alterations occur in parallel to enhanced neutrophil-endothelial interactions and adhesion molecule levels, leaving T2D patients with poor glycaemic control at a higher risk of developing vascular diseases.…”
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Dietary supplementation with Bacillus subtilis PB6 alleviates diarrhea and improves growth performance and immune function in weaned piglets fed a high-protein diet by Yang Liu, Lei Cao, Chenhao Yu, Qiang Zhou, Hua Li, Ruinan Zhang, Jiayong Tang, Zhiming Zhang, Zheng Luo, Xuemei Jiang, Zhengfeng Fang, Yan Lin, Shengyu Xu, Yong Zhuo, Lun Hua, De Wu, Bin Feng, Lianqiang Che

“…A total of 96 weaned piglets were randomly divided into three groups in a randomized complete block design and received a low-protein diet (LP, 18.27% crude protein), a high-protein diet (HP, 20.97% crude protein), or a high-protein diet supplemented with probiotics (HPPRO, B. subtilis PB6 spores 2 × 1011 CFU/ kg) for 21 days. …”
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Six months of hybrid closed-loop therapy improves diabetes-specific positive well-being, and reduces diabetes distress and fear of hypoglycemia: secondary analysis of a randomized... by Anthony C Keech, Vijaya Sundararajan, Bruce R King, Sara Vogrin, Richard J MacIsaac, Leon A Bach, Jane Speight, Alicia J Jenkins, Christel Hendrieckx, David O’Neal, Sybil A McAuley, Geoff R Ambler, Fergus J Cameron, Jan M Fairchild, Elizabeth A Davis, Timothy W Jones, Morton G Burt, Philip M Clarke, Neale D Cohen, Peter G Colman, Joey Kaye, Kavita Kumareswaran, Melissa H Lee, Roland W Mccallum, Barbora Paldus, Stephen N Stranks, Steven Trawley, Glenn M Ward, David N O’Neal, Sienna Russell-Green, Deborah Jane Holmes-Walker, Benjamin Lam, Jennifer A Halliday, Glenn Ward, Catriona M Sims, D Jane Holmes-Walker, Andrzej Januszewski, Hanafi Mohammed Husin, Martin I de Bock, Mary B Abraham

“…HCL did not improve diabetes treatment satisfaction, diabetes-specific QoL, hypoglycemia awareness, or perceived frequency of unacceptably low glucose levels.Conclusions These findings imply that HCL offers important psychological benefits. …”
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Analysis of some error-causing factors in two-dimensional geoelectrical studies and providing a solution to minimize them by Hosein Moghaddasi, Mohsen Moghaddasi, Ahmad Neyamadpour

“…Dipole-dipole array This array has been, and is still, widely used in I.P. surveys because of the low EM coupling between the current and potential circuits. …”
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Challenges to overcome in a randomised trial for Proper Understanding of Recurrent Stress Urinary Incontinence Treatment in women: the PURSUIT RCT by Caroline Pope, Madeleine Cochrane, Clare Clement, Yumeng Liu, Sangeetha Paramasivan, Sian Noble, Stephanie J MacNeill, Amanda L Lewis, Jodi Taylor, Bethanie Fitzgerald, Nikki Cotterill, Tamsin Greenwell, Hashim Hashim, Swati Jha, Nikesh Thiruchelvam, Philip Toozs-Hobson, Alison White, Wael Agur, J Athene Lane, Marcus Drake

“…Design A multicentre, unblinded, parallel-group randomised controlled trial. Setting Fifteen centres across the United Kingdom. …”
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On signal encryption at MapReduce and collaborative attribute-based access with ECAs for a preprocessed data set with ML in a privacy-preserving health 4.0 by Arnab Mitra, Anabik Pal

“…In contrast, ECAs were proposed to offer an integral parallelism and very-large-scale-integration (VLSI) capability at a low cost for its physical implementation and low power consumption towards data security and privacy of such big data in PPH 4.0. …”
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Optimizing the performance of a server-based classification for a large business document flow by O. A. Slavin

“…Low-level optimization was carried out via compiler tools allowing for an extended set of SIMD instructions. …”
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Design and Implementation of Environmental Monitoring System Using Flask-Based Web Application by Rong-Tai Hong

“…Since the sensor data need to be consecutively and continuous in real-time, multiple tasks are executed simultaneously to complete the process; therefore, thread-based parallelism is used. The proposed system enables real-time environmental monitoring with low maintenance costs by leveraging the micro-framework web application and ad hoc network. …”
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Effect of intensive treatment for schistosomiasis on immune responses to vaccines among rural Ugandan island adolescents: randomised controlled trial protocol A for the ‘POPulation... by Pontiano Kaleebu, Emily Webb, Moses Muwanga, Gyaviira Nkurunungi, Ludoviko Zirimenya, Agnes Natukunda, Jacent Nassuuna, Gloria Oduru, Caroline Ninsiima, Christopher Zziwa, Florence Akello, Robert Kizindo, Mirriam Akello, Anne Wajja, Henry Luzze, Stephen Cose, Alison M Elliott, Alison Elliott, Rebecca Amongin, Beatrice Nassanga, Irene Nambuya, Prossy Kabuubi, Emmanuel Niwagaba, Grace Kabami, Helen Akurut, Alex Mutebe, Milly Namutebi, Caroline Onen, Esther Nakazibwe, Josephine Tumusiime, Susan Amongi, Moses Sewankambo, Denis Nsubuga, Samuel Kiwanuka, Fred Kiwudhu, David Abiriga, Moses Kizza, Samsi Nansukusa, Hermelijn Smits, Maria Yazdanbakhsh, Govert van Dam, Paul Corstjens, Sarah Staedke, James Kaweesa, Edridah Tukahebwa, Elly Tumushabe, Prossy N Kabuubi, Joel Serubanja

“…Introduction Several licensed and investigational vaccines have lower efficacy, and induce impaired immune responses, in low-income versus high-income countries and in rural, versus urban, settings. …”
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Effects of Density Stress on Growth and Physiology of Epinephelus fuscoguttatus ♀×Epinephelus lanceolatus ♂ by Xianhong ZHANG, Wenyang LI, Baoliang LIU, Fan FEI, Xiaoqiang GAO, Ran GUO, Shuquan CAO, Zhiwen ZHU

“…Three density gradient groups were set: low-density (LD), medium-density (MD), and high-density (HD). …”
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Research On Calculation of Longitudinal Deformation of The Underlying Shield Tunnel Caused By Excavation of The Foundation Pit Considering Consolidation Effects by LYU Linhai, DONG Cheng, ZHAO Zhe, JIANG Mingjie, JI Yongkai, QIU Shizheng, ZHANG Zhendong, MEI Guoxiong

“…The soil permeability coefficient significantly affects the stabilization time of tunnel displacement without altering the ultimate displacement values - high permeability (<italic>k</italic> = 0.1 m/day) leads to rapid stabilization (10 days), while low permeability(<italic>k</italic>=0.000 1 m/day) requires approximately 10 000 days. …”
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Inflectional Changes of Double Marked Form: Evidence from a Corpus Study of English Verbal System by Basima Othman Mahmood

“…On language and connectionism: Analysis of a parallel distributed processing model of language acquisition. …”
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Le sanctuaire romain du Vigneau à Pussigny (Indre-et-Loire) : un lieu de mémoire, de vie et d’accueil by Arnaud Coutelas, Sébastien Lepetz

“…These are likely remainders or samples from the sacrifice and/or banquet, whose burial represented an act of devotion.This temple is bordered to the north and south by two roads, indicated by the presence of parallel furrows. The southern portion is oriented towards a group of stone or wooden buildings densely distributed 70 m to the west, and which are organised along a NNW-SSE axis. …”
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