Evaluation of a very brief pedometer-based physical activity intervention delivered in NHS Health Checks in England: The VBI randomised controlled trial. by Wendy Hardeman, Joanna Mitchell, Sally Pears, Miranda Van Emmenis, Florence Theil, Vijay S Gc, Joana C Vasconcelos, Kate Westgate, Søren Brage, Marc Suhrcke, Simon J Griffin, Ann Louise Kinmonth, Edward C F Wilson, A Toby Prevost, Stephen Sutton, VBI Research Team

“…The study's limitations include a participation rate of 16% and low return of audiotapes by practices for fidelity assessment.…”
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Ductular reaction or hepatic reparative complex: immunohistochemical features in liver cirrhosis in patients with chronic hepatitis by V. A. Tumanskiy, S. V. Fen’

“…When the severity of micronodular liver cirrhosis increases, when the area of hepatic lobules and pseudotypes becomes equal to or less than the area of the surrounding fibrosis, there is a parallel increase in the number of Ki-67+ cells in portal-lobular ductules and chains, as well as the number of Ki-67+ hepatocytes in hepatic lobules and pseudolobes. …”
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Costs and cost-effectiveness of management of possible serious bacterial infections in young infants in outpatient settings when referral to a hospital was not possible: Results fr... by Charu C Garg, Antoinette Tshefu, Adrien Lokangaka Longombe, Jean-Serge Ngaima Kila, Fabian Esamai, Peter Gisore, Adejumoke Idowu Ayede, Adegoke Gbadegesin Falade, Ebunoluwa A Adejuyigbe, Chineme Henry Anyabolu, Robinson D Wammanda, Joshua Daba Hyellashelni, Sachiyo Yoshida, Lu Gram, Yasir Bin Nisar, Shamim Ahmad Qazi, Rajiv Bahl

“…While hospitalized treatment is recommended, families cannot access inpatient treatment in low resource settings. Two parallel randomized control trials were conducted at five sites in three countries (Democratic Republic of Congo, Kenya, and Nigeria) to compare the effectiveness of treatment with experimental regimens requiring fewer injections with a reference regimen A (injection gentamicin plus injection procaine penicillin both once daily for 7 days) on the outpatient basis provided to young infants (0-59 days) with signs of possible serious bacterial infection (PSBI) when the referral was not feasible. …”
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Effects of coal seam dip angle on asymmetric load transfer paths in the overburden of inclined stopes by Kaipeng ZHU, Shenghu LUO, Panshi XIE, Zhilin LI, Juan FAN, Chengyang TIAN, Leilei YI, Hui XU

“…Meanwhile, in the direction parallel to coal seams, these components were transferred in the shape of double Vs. …”
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Multimodality local consolidative treatment versus conventional care of advanced lung cancer after first-line systemic anti-cancer treatment: study protocol for the RAMON multicent... by Matthew Evison, Tim Batchelor, Chris A Rogers, Sarah Baos, Elizabeth A Stokes, Rosie Harris, Eric Lim, Chloe Beard, Janette Rawlinson, Nicola Mills, John Conibear, Paulo De Sousa, Thomas Newsom-Davis, Tara Barwick, Leah Fleming

“…One-year survival is improving but remains low (37%) despite novel systemic anti-cancer treatments forming the current standard of care. …”
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A Representation-Learning-Based Graph and Generative Network for Hyperspectral Small Target Detection by Yunsong Li, Jiaping Zhong, Weiying Xie, Paolo Gamba

“…Hyperspectral small target detection (HSTD) is a promising pixel-level detection task. However, due to the low contrast and imbalanced number between the target and the background spatially and the high dimensions spectrally, it is a challenging one. …”
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Collaborating With Schools for Public Health Research in England: Lessons Learned for Successful Partnerships by Ivelina Tsocheva, Jasmine Chavda, James Scales, Rosamund Dove, Harpal Kalsi, Helen E Wood, Grainne Colligan, Louise Cross, Luke Sartori, Jessica Moon, Aisling Murray, Sarah Van Den Berg, Alice Hirst, Jessica Mitchell, Jason Le, Frances Balkwill, Kristian Petrovic, Esther Lie, Mia Keating, Britzer Vincent Paul Raj, Pavani Kotala, Gurch Randhawa, Ian S Mudway, Chris Griffiths

“…Our study involved annual health assessment visits to schools to test over 3000 participants and parental self-report questionnaires, to assess the potential benefits of air quality improvements arising from London Ultra Low Emission Zone (introduced in April 2019) on children’s lung development and health. …”
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Evaluating the impact, implementation experience and political economy of primary care networks in Kenya: protocol for a mixed methods study by Beatrice Amboko, Jacinta Nzinga, Benjamin Tsofa, Peter Mugo, Anita Musiega, Beryl Maritim, Ethan Wong, Caitlin Mazzilli, Wangari Ng’ang’a, Brittany Hagedorn, Gillian Turner, Anne Musuva, Felix Murira, Nirmala Ravishankar, Salim Hussein, Edwine Barasa

“…Abstract Background Primary care networks (PCNs) are increasingly being adopted in low- and middle-income countries (LMICs) to improve the delivery of primary health care (PHC). …”
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Changes in cardiovascular disease risk, lung function and other clinical health outcomes when people who smoke use e-cigarettes to reduce cigarette smoking: an exploratory analysis... by Susan Veldheer, Jonathan Foulds, Caroline O Cobb, Xi Wang, Sarah Maloney, Matthew Halquist, Le Kang, Shari Hrabovsky, Alexa A Lopez, Sitasnu Dahal, Jessica Yingst, Matthew Carrillo, Rebecca Bascom

“…However, participants randomised to the 36 mg/mL e-cigarette condition had significantly higher levels of high-density lipoprotein (HDL) (p=0.003 unadjusted, p=0.002 adjusted) and lower levels of low-density lipoprotein (LDL) (p=0.044 adjusted) and cholesterol/HDL ratio (p=0.034 unadjusted, p=0.026 adjusted) compared with the cigarette substitute condition. …”
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Targeted detection of endogenous LINE-1 proteins and ORF2p interactions by Mathias I. Nielsen, Justina C. Wolters, Omar G. Rosas Bringas, Hua Jiang, Luciano H. Di Stefano, Mehrnoosh Oghbaie, Samira Hozeifi, Mats J. Nitert, Alienke van Pijkeren, Marieke Smit, Lars ter Morsche, Apostolos Mourtzinos, Vikram Deshpande, Martin S. Taylor, Brian T. Chait, John LaCava

“…Results Here we present targeted mass spectrometry assays, selected and parallel reaction monitoring (SRM and PRM, respectively) to detect and quantify L1 ORF1p and ORF2p at their endogenous abundances. …”
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New models for MPNST: establishment and comprehensive characterization of two tumor cell lines by Sara Ortega-Bertran, Edgar Creus-Bachiller, Miriam Magallón-Lorenz, Meritxell Carrió, Bernat Gel, Alberto Villanueva, Juan Carlos Lopez-Gutierrez, Anna Estival, Eduard Serra, Juana Fernández-Rodríguez, Conxi Lázaro

“…In contrast, the NF1-18B < 3n showed a low migration rate and did not form colonies or aggregates in vitro. …”
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Comparison of the STANDARD M10 C. difficile, Xpert C. difficile, and BD MAX Cdiff assays as confirmatory tests in a two-step algorithm for diagnosing Clostridioides difficile infec... by Hyunseul Choi, Minhee Kang, Sun Ae Yun, Hui-Jin Yu, Eunsang Suh, Tae Yeul Kim, Hee Jae Huh, Nam Yong Lee

“…Two hundred archived stool specimens, previously tested GDH-positive but toxin-negative by EIA, were analyzed in parallel with these NAATs and toxigenic culture, which served as the reference standard. …”
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Ca2+ sonotransfer into breast cancer cells in a suspension, 3-D spheroid and subcutaneous tumor models by Martynas Maciulevičius, Reda Rulinskaitė, Lukas Giedrimas, Rūta Palepšienė, Paulius Ruzgys, Rytis Jurkonis, Mindaugas Tamošiūnas, Renaldas Raišutis, Kristine Saleniece, Saulius Šatkauskas

“…Murine breast cancer is an established analogue of stage IV human breast cancer. For comparison, parallel experiments, using classical anticancer drug bleomycin were performed.Ca2+ sonoporation efficiently enhanced 4 T1 cell death in a suspension in the absence of microbubbles, under relatively low acoustic pressure (100–200 kPa). …”
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Machine learning-driven multi-omics analysis identifies a prognostic gene signature associated with programmed cell death and metabolism in hepatocellular carcinoma by Xiang Li, Donghao Yin, Jiahao Geng, Yanyu Xu, Zijing Xu, Xuemeng Yang, Quanwei Li, Zimeng Shang, Zhiyun Yang, Zhong Xu, Jiabo Wang, Enxiang Zhang, Xinhua Song

“…Based on prognosis-related DEGs, patients and cells were stratified into high- and low-expression groups using corresponding computational algorithms. …”
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High-Efficiency Multi-Standard Polynomial Multiplication Accelerator on RISC-V SoC for Post-Quantum Cryptography by Duc-Thuan Dam, Trong-Hung Nguyen, Thai-Ha Tran, Duc-Hung Le, Trong-Thuc Hoang, Cong-Kha Pham

“…This paper proposes a high-speed, low-complexity, and run-time configurable accelerator that supports all three standards. …”
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Salivary lactoferrin levels in Down Syndrome: a case-control study by Desireé Antequera, Lucía Sande, Eliane García Mato, Deborah Romualdi, Laura Carrero, Cristina Municio, Pedro Diz, Eva Carro

“…In addition to genetic causes, this high risk involves dysregulated immune-inflammatory system. Low lactoferrin levels, one of the main antimicrobial proteins present in saliva, has been associated with AD. …”
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FRET Visualization of High Mechanosensation of von Willebrand Factor to Hydrodynamic Force by Mingxing Ouyang, Yao Gao, Binqian Zhou, Jia Guo, Lei Lei, Yingxiao Wang, Linhong Deng

“…The FRET increases indicate closer positioning of A2’s two terminals in vWF or the addition of a more parallel orientation of the FRET pair, supported with the high FRET of the A2-only-based biosensor, which probably resulted from flow-induced A2 dissociation from vWF intramolecular binding such as that in A1/A3 domains. …”
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Geology of the boundary between the Sierra Madre Occidental and the Trans-Mexican Volcanic Belt in the Guadalajara region, western Mexico by Andrea Rossotti, Luca Ferrari, Margarita López-Martínez, José Rosas-Elguera

“…This agrees with models suggesting that mafic volcanism preferentially erupt along arc-parallel, high strain rate faults, whereas arc-normal, low strain rate faults control the location of more differentiated lavas. …”
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'Which treatment do you believe you received?' A randomised blinding feasibility trial of spinal manual therapy by Javier Muñoz Laguna, Astrid Kurmann, Léonie Hofstetter, Emanuela Nyantakyi, Julia Braun, Lauren Clack, Heejung Bang, Mazda Farshad, Nadine E. Foster, Milo A. Puhan, Cesar A. Hincapié, the SALuBRITY Blinding Clinician Group

“…Abstract Background Blinding is essential for mitigating biases in trials of low back pain (LBP). Our main objectives were to assess the feasibility of blinding: (1) participants randomly allocated to active or placebo spinal manual therapy (SMT), and (2) outcome assessors. …”
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Oxygenation targets for endovascular therapy in acute ischemic stroke patients (Oxy-TARGET): protocol for a single-centre, open-label randomised controlled trial by Anxin Wang, Zhengfang Hu, Ruquan Han, Fa Liang, Youxuan Wu, Minyu Jian, Xinyan Wang, Yunzhen Wang, Haiyang Liu, Xuan Hou, Kangda Zhang, Zihui Zhang

“…Therefore, we are conducting a randomised controlled trial (RCT) to evaluate the impact of high-concentration oxygen vs low-concentration normobaric oxygen on early neurological function after EVT.Methods and analysis The Oxy-TARGET trial is an ongoing prospective, open-label, parallel-design RCT being conducted at Beijing Tiantan Hospital, Capital Medical University. …”
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