Rare or orphan diseases. A review study by Ener Mantilla Horna, Jóhel Osorio Fernández

“…Rare or orphan diseases represent a significant challenge to modern medicine due to their low prevalence and lack of effective treatments. …”
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Application of machine learning and genomics for orphan crop improvement by Tessa R. MacNish, Monica F. Danilevicz, Philipp E. Bayer, Mitchell S. Bestry, David Edwards

“…Abstract Orphan crops are important sources of nutrition in developing regions and many are tolerant to biotic and abiotic stressors; however, modern crop improvement technologies have not been widely applied to orphan crops due to the lack of resources available. …”
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Stress and Traditional Support: The Role of Orphans’ and Vulnerable Children’s Primary Caregivers in Rural Ethiopia by Aweke Tadesse, Kenan Li, Jesse Helton

“…Background/Objectives: Orphans’ and Vulnerable Children’s (OVC) primary caregivers (PCGs) in Ethiopia live with multiple social and emotional problems stemming from extreme poverty, war, environmental disasters, and the HIV pandemic. …”
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Rehabilitation and release of orphaned Eurasian lynx (Lynx lynx) in Europe: Implications for management and conservation. by Anja Molinari-Jobin, Fridolin Zimmermann, Stéphanie Borel, Luc Le Grand, Elena Iannino, Ole Anders, Elisa Belotti, Ludek Bufka, Duško Ćirović, Nolwenn Drouet-Hoguet, Thomas Engleder, Michał Figura, Christian Fuxjäger, Eva Gregorova, Marco Heurich, Sylvia Idelberger, Jakub Kubala, Josip Kusak, Dime Melovski, Tomma Lilli Middelhoff, Tereza Mináriková, Paolo Molinari, Lorane Mouzon-Moyne, Gilles Moyne, Robert W Mysłajek, Sabina Nowak, Janis Ozolins, Andreas Ryser, Bardh Sanaja, Maryna Shkvyria, Teodora Sin, Magda Sindičić, Vedran Slijepčević, Christian Stauffer, Branislav Tám, Aleksander Trajce, Josefa Volfová, Sybille Wölfl, Diana Zlatanova, Kristina Vogt

“…A total of 66 orphans were released back to nature. The portion of rehabilitated lynx who survived at least one year after release was 0.66. …”
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Inverse Agonist of Retinoid-Related Orphan Receptor-Alpha Prevents Apoptosis and Degeneration in Nucleus Pulposus Cells via Upregulation of YAP by Tongzhou Liang, Jincheng Qiu, Shaoguang Li, Zhihuai Deng, Xianjian Qiu, Wenjun Hu, Pengfei Li, Taiqiu Chen, Zhancheng Liang, Hang Zhou, Bo Gao, Dongsheng Huang, Anjing Liang, Wenjie Gao

“…Intervertebral disc degenerative disease (IDD) is the most common degenerative spine disease, which leads to chronic low back pain and symptoms in the lower extremities. …”
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Prevalence and pattern of skin disorders among children living in orphanages in Fayoum and Giza governorates, Egypt by Noha Ezzat Mohamed, Wafaa Yousif Abdel-Wahed, Shimaa Mohammed Gomaa, Mai Ashraf Hosny

“…Abstract Background Childhood is a crucial period that shapes a person’s growth and development. For orphans, a lack of familial support affects their upbringing, making orphanages crucial for care. …”
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A qualitative study examining psychosocial distress and coping mechanisms among orphan and vulnerable children living in institutional care in New Delhi, India by Abhishek Saraswat, Sayeed Unisa

“…Introduction: India is home to the largest population of orphaned children in the South Asia, who are at increased risk of poor psychosocial well-being. …”
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Relasi Ibu-Anak dan Kematangan Emosi Remaja Yatim Duafa by Rizky Hasanah, Efi Fitriana, Marisa Fransiska Moeliono

“…The target population of the study was poor orphans aged between 15 and 18 years who live in Cileunyi Bandung. …”
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Ukončení poručenské správy nezletilých osob v raně novověkém městském prostředí by Pavla Slavíčková

“…In practice, however, the process of getting the money back to the full-aged child, whether it had been placed on deposit at the townhall or at the tutors', usually protracted for many years. …”
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Barbora Markéta Eliášová: Nippon druhým domovem. První česká samostatná cestovatelka, její život a literární dílo by Bohumila Rázková

“…After that she decided to concentrate to go and search for the luck far away in Japan. She found a second home there and she came back really very glad. …”
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La déviance sociale à Londres vue par une enquêtrice socialiste française : Flora Tristan et les Promenades dans Londres (1840) by Stéphane Michaud

“…Do her lack of culture and the difficulty she felt in dealing with her topic objectively impair the quality of the opinions she expressed in her book ? …”
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Natural products as anticancer agents and enhancing their efficacy by a mechanism-based precision approach by Stephen Safe

“…Among these compounds cytotoxic agents such as bleomycin, paclitaxel and vincristine block essential pathways and genes required for cancer cell growth and these agents have diverse clinical applications. …”
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Evaluation of Lyso-Gb1 as a biomarker for Gaucher disease treatment outcomes using data from the Gaucher Outcome Survey by Ari Zimran, Shoshana Revel-Vilk, Tama Dinur, Majdolen Istaiti, Jaco Botha, Elena Lukina, Pilar Giraldo, Patrick Deegan, Stephan vom Dahl

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Diverse Molecular Genotypes of Mycobacterium tuberculosis Complex Isolates Circulating in the Free State, South Africa by Anneke Van der Spoel van Dijk, Pakiso M. Makhoahle, Leen Rigouts, Kamaldeen Baba

“…Studies describing strain diversity are lacking in the Free State region of South Africa. …”
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Notch Signaling Pathway Promotes Th17 Cell Differentiation and Participates in Thyroid Autoimmune Injury in Experimental Autoimmune Thyroiditis Mice by Hao Liu, Yiwen Li, Yujiao Zhu, Lei Ma, Haibo Xue

“…The degrees of thyroiditis, the proportions of Th17 cells, and the expression of RORγt and IL-17A were significantly decreased in the EAT-B group after blocking the Notch signaling pathway by DAPT, and these parameters were significantly increased in the EAT-A group compared to the control group (all P<0.05). …”
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Development and characterization of orthotopic patient-derived xenograft models of peritoneal metastatic mucinous appendiceal adenocarcinoma by I. Ito, V.K. Pattalachinti, A.M.G. Yousef, S. Chowdhury, M.M. Fanaeian, E. Haque, B.B. Gunes, M. Yousef, E.R. Salle, M.A. Zeineddine, S. Ji, R. Li, W. Wang, B.A. Helmink, M.W. Taggart, M.G. White, K.F. Fournier, N.W. Fowlkes, J.P. Shen

“…Background: Appendiceal adenocarcinomas (AAs) are a rare and heterogeneous group of tumors for which few preclinical models exist. The lack of preclinical models of AA has hindered drug development and is a major factor in why AA remains without a single Food and Drug Administration-approved systemic treatment. …”
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Value contribution of leniolisib in the Treatment of Activated PI3Kδ syndrome (APDS) in Spain using Multi-Criteria Decision Analysis (MCDA) by María Reyes Abad, Carmen Alerany, Luis Ignacio Gonzalez, Olaf Neth, Concepción Payares-Herrera, Carlos Rodríguez-Gallego, Jose Luis Trillo, Kirsten H. Herrmann, Raquel Figueiredo, Alicia Gil

“…An MCDA framework tailored for Orphan Drugs (ODs), consisting of 5 comparative and 2 quantitative non-comparative criteria, was used. …”
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Working in partnership with parents: the triangular connection by Maayan Burstein

“…Modern residential care in Israel can trace its history back to the end of the Second World War. At that time, orphaned Jewish children were sent to Palestine for refuge, and as part of the building of a Jewish society in the future. …”