Clinical safety and pharmacokinetics of a novel oral niclosamide formulation compared with marketed niclosamide chewing tablets in healthy volunteers: A three-part randomized, doub... by Niklas Walther, Robert Schultz-Heienbrok, Heino Staß, Victor M Corman, Nils C Gassen, Marcel A Müller, Christian Drosten, Martin Witzenrath, Hweeling Lee, Maximilian G Posch

“…There was also no apparent dependence between drug exposure levels (AUC, Cmax) and the severity and incidence of adverse events detectable. A relevant food effect was observed with a mean AUClast about 2-fold higher in fed condition compared to fasted condition. …”
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Study protocol for COVID-19 breakthrough infections and vaccine-induced immune response among a cohort of healthcare workers, Bangladesh. by Md Zakiul Hassan, Ahamed Khairul Basher, Mohammed Ziaur Rahman, Taufiqur Rahman Bhuiyan, Fahmida Chowdhury, Md Kamal Hossain, Aninda Rahman, Md Nazmul Islam, Lindsey M Duca, Susan Cornelia Kaydos-Daniels, Benjamin A Dahl, Firdausi Qadri, Nancy Ortiz

“…<h4>Background</h4>To optimize vaccination strategies, it is useful to detect breakthrough infections and assess vaccine effectiveness in programmatic use. …”
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Non-invasive MRI measurements of age-dependent in vivo human glymphatic exchange using magnetization transfer spin labeling by Dahan Kim, Yujia Huang, Jiaen Liu

“…These findings survived when the exchange metrics were compensated for potential atrophy-related dilution effect caused by variations in intra-voxel CSF volume. Conclusion: Optimized MT-based parenchyma spin labeling followed by CSF partial saturation measurement demonstrated feasibility of a noninvasive MRI approach to detect glymphatic water exchange between human brain parenchyma and CSF in vivo, with statistically significant findings of age-related differences in the exchange measures.…”
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Investigation of heavy metals adsorbed on microplastics in drinking water and water resources of Zabol by Mohammad Reza Rezaei Kahkha, Jamshid Piri, Ali Faghihi-Zarandi, Massoud Kaykhaii

“…Future studies should explore the health effects of MPs and HMs, optimize sampling methods, and focus on long-term monitoring under diverse environmental conditions to address this emerging issue comprehensively.…”
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Developing a Smart Sensing Sock to Prevent Diabetic Foot Ulcers: Qualitative Focus Group and Interview Study by Jenny Corser, Irantzu Yoldi, Neil D Reeves, Pete Culmer, Prabhuraj D Venkatraman, Giorgio Orlando, Rory Peter Turnbull, Paul Boakes, Eric Woodin, Roger Lightup, Graham Ponton, Katherine Bradbury

“…MethodsThis qualitative study combined semistructured interviews and a focus group alongside a participant advisory group that was consulted throughout the study. …”
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Single- vs double-layer uterine closure of the cesarean scar in niche development: the Nicest StudyAJOG Global Reports at a Glance by Ha Thi Thu Nguyen, PhD, Giang Thi Tra Duong, MD, Dat Tuan Do, PhD, Thuong Thi Huyen Phan, PhD, Duc Anh Tran, MD, Toan Khac Nguyen, MD, Anh Duy Nguyen, PhD

“…Transvaginal ultrasound was used to evaluate uterine ultrasound characteristics. If the niche was detected, 3-dimensional transvaginal ultrasound was applied to measure the niche volume via the Virtual Organ Computer-aided AnaLysis method. …”
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Cervical ripening at home or in hospital during induction of labour: the CHOICE prospective cohort study, process evaluation and economic analysis by Mairead Black, Cassandra Yuill, Mairi Harkness, Sayem Ahmed, Linda Williams, Kathleen A Boyd, Maggie Reid, Amar Bhide, Neelam Heera, Jane Huddleston, Neena Modi, John Norrie, Dharmintra Pasupathy, Julia Sanders, Gordon C S Smith, Rosemary Townsend, Helen Cheyne, Christine McCourt, Sarah Stock

“…Low numbers of women having at-home cervical ripening limited the power to detect differences in safety, effectiveness, cost and acceptability between study groups. …”
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Comparison of the Blood–Brain Barrier Penetration Ability and Anti-Neuroinflammatory Activity of Chromones in Two Types of Agarwood by Mengyuan Yang, Yanan Yuan, Jingfan Wei, Yifei Pei, Yuanfei Niu, Yifan Zhao, Xiangying Kong, Zhijie Zhang

“…Correspondingly, only FTPECs were detected using DESI-MS imaging; no THPECs were detected in rat brain tissue, and DESI-MS imaging localized FTPECs to neuroanatomic regions (cerebral cortex, thalamus, and hippocampus). …”
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Radiomic study on preoperative multi‐modal magnetic resonance images identifies IDH‐mutant TERT promoter‐mutant gliomas by Haoyu Wang, Shuxin Zhang, Xiang Xing, Qiang Yue, Wentao Feng, Siliang Chen, Jun Zhang, Dan Xie, Ni Chen, Yanhui Liu

“…A diagnostic model (multilayer perceptron classifier) for detecting the IDHmut pTERTmut gliomas was trained using an automatic machine‐learning algorithm named tree‐based pipeline optimization tool (TPOT). …”
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Presence of toxin-producing bacterial pathogens and associated risk factors in neonatal diarrhea of piglets on commercial sow farms in Vietnam by Duy Tien Do, Tram Thi Ngoc Ngo, Huong Dieu Vu, Nhat Minh Duong, Sittikorn Traiyarach, Danh Cong Lai, Joaquin Miguel Escuder

“…Key virulence genes detected included LT (35.96%), alpha toxin (95.61%), and toxin A (20.17%). …”
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Predicting the potential distribution areas of Leptotrombidium rubellum under current and future climate change by Qunzheng Mu, Qunzheng Mu, Fengfeng Li, Wenyu Li, Wenyu Li, Xiaoxia Wang, Mingyuan Tang, Kehan Chen, Yihao Jiang, Jingqi Liu, Shirong Zhang, Qiyong Liu, Chuan Wang

“…The results may facilitate a transition from passive to proactive vector monitoring.MethodsFifty-seven potential influencing factors were evaluated. …”
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The role of diffuse correlation spectroscopy and frequency-domain near-infrared spectroscopy in monitoring cerebral hemodynamics during hypothermic circulatory arrestsCentral Messa... by Alexander I. Zavriyev, BS, Kutlu Kaya, MS, Parisa Farzam, PhD, Parya Y. Farzam, BS, John Sunwoo, PhD, Arminder S. Jassar, MBBS, Thoralf M. Sundt, MD, Stefan A. Carp, PhD, Maria Angela Franceschini, PhD, Jason Z. Qu, MD

“…Conclusions: FDNIRS-DCS is able to detect changes in CBFi, SO2, and CMRO2i with intervention and can become a valuable tool for optimizing cerebral protection during HCA.…”
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Exploring the neuromagnetic signatures of cognitive decline from mild cognitive impairment to Alzheimer's disease dementiaResearch in context by Sinead Gaubert, Pilar Garces, Jörg Hipp, Ricardo Bruña, Maria Eugenia Lopéz, Fernando Maestu, Delshad Vaghari, Richard Henson, Claire Paquet, Denis-Alexander Engemann

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Impact of Nasal Anatomical Variation Subtype on Surgical Outcomes for Rhinogenic Contact Point Headache by Salvatore Lavalle, Annalisa Pace, Giuseppe Magliulo, Mario Lentini, Jerome Rene Lechien, Christian Calvo-Henriquez, Federica Maria Parisi, Giannicola Iannella, Antonino Maniaci, Daniela Messineo

“…This study aimed to clarify the correlation with nasal anatomical variation detected by CT and RCPH treatment outcomes. <b>Methods:</b> A prospective cohort study was conducted on 90 RCPH patients undergoing surgery or medical therapy. …”
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Prediction of Therapeutic Response and Prognosis in Ovarian Cancer Patients With Plasma Circulating Biomarkers by Haixia Cheng, Guangwen Yuan, Leilei Liang, Tiantian Wang, Jiarun Zhu, Hongying Yang, Zhendiao Zhou, Pei Wang, Qianqian Song, Yuchen Jiao, Mei Liu, Lingying Wu

“…The TUCA algorithm was optimized based on TICA results. Fourteen patients without matched tumor tissues were used just for TUCA analysis. …”
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Comparison of prognostic factors that affect the survival of patients with metachronous and synchronous metastases of renal cell carcinoma by D. V. Semenov, R. V. Orlova, V. I. Shirokorad, S. V. Kostritsky, S. G. Grigoriev, Yu. S. Korneva

“…Synchronous metastases (Smts) and metachronous metastases (Mmts) were detected in 380 (40.7%) and 554 (59.3%) patients, respectively. …”
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Associations Between the Polymorphisms in the Coding Sequence of SLCO1B1 and Blood Lipid Levels Before and After Treatment by Atorvastatin in the Chinese Han Adults with Dyslipidem... by Chen C, Tian Y, Jia F, Feng M, Zhang G, Li Q, Zhang Y, Sun N, Hu S, Ji Z

“…It is thus advisable to consider genetic testing for SLCO1B1 variants to optimize atorvastatin therapy.Keywords: pharmacogenomics, SLCO1B1 polymorphisms, atorvastatin, dyslipidemia, Chinese Han…”
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Recombinant Hydrophobic Polypeptide MBAY Loaded Into SPION-Exosome Realizes Sustained-Release to Improve Type 2 Diabetes Mellitus by Zong X, Xiao S, Xia H, Guo D, Wu J, Zhuang M, Rao L

“…The in vitro release profile and in vivo pharmacokinetic profile of MBAY-Exosome-SPION were detected using high-performance liquid chromatography (HPLC). …”
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PD-L1 and p53 expression in squamous cell carcinoma of the oropharynx depending on human papilloma virus status by D. Sh. Polatova, A. Yu. Madaminov, A. V. Savkin, A. I. Nurzhabov, N. K. Asamedinov, D. A. Ibragimova, R. R. Davletov, S. K. Nasirov

“…High-risk human papilloma virus (Hpv), especially genotype 16, causes oropharyngeal squamous cell carcinoma (OSCC). It is detected in about 70 % of tumors developing from lymphoid tissue of the tonsils or the base of the tongue. …”
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Prevalence and molecular characterisation of multi-drug resistant ST11 hypervirulent Klebsiella pneumoniae in a teaching hospital by Xue Li, Kai Ma, Xin Liu, Ping Cheng, Lailai Li, Yihui Chai, Mingle Cao, Yuqi Yang

“…Methods We conducted a retrospective analysis of 102 carbapenem-resistant CRKP strains. …”
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