SUMO modified ETV1 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by facilitating CCL2 transcription in esophageal squamous cell carcinoma ce... by Tianci Han, Xiaoqi Guo, Junwei Xie, Wei Tong, Liang Zhang

“…Immunofluorescence double staining was used to detect the tumor-associated macrophage (TAM) infiltration. …”
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Glucocorticoids and mineralocorticoids in hair: facilitating accurate diagnosis of adrenal-related endocrine disorders by Bianca Heyns, Rialet Pieters, Marietjie Aletta Stander, Stephen Lawrence Atkin, Amanda Cecilia Swart, Amanda Cecilia Swart

“…Cortisol was 1.5-fold higher than cortisone in accordance with the circulatory cortisol/cortisone relationship.ConclusionsThe novel extraction method optimized steroid measurement, showing the consistency of measurement for glucocorticoids, cortisol and cortisone, and mineralocorticoids, corticosterone, 18-hydroxycorticosterone, and aldosterone. …”
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Enhanced intestinal epithelial co-culture model with orbital mechanical stimulation: a proof-of-concept application in food nanotoxicology by Mattia Santoni, Giovanni Piccinini, Giovanni Piccinini, Giovanni Liguori, Maria Roberta Randi, Massimo Baroncini, Liliana Milani, Francesca Danesi

“…Mechanical stimulation selectively promoted goblet cell differentiation without affecting general epithelial markers. The optimized model successfully detected concentration-dependent oxidative stress responses to TiO₂ exposure, revealing cellular dysfunction preceding membrane damage.DiscussionThis improved co-culture system provides a better physiological platform for nanotoxicology studies. …”
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HistoDX: Revolutionizing Breast Cancer Diagnosis Through Advanced Imaging Techniques by Wishal Arshad, Tehreem Masood, H. M. Shahzad, Hassan A. Ahmed, Syed Hamza Ahmed, Hafiz Muhammad Tayyab Khushi

“…Validation on BreakHis (97% accuracy) and BACH (90% accuracy) datasets confirm generalizability, though detecting under sampled IDC(+) cases remains challenging. …”
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Estimation of Ukraine’s foreign trade structure in order to determine the areas of export potential by Nadiya Dekhtyar, Oksana Mazorenko, Maksym Serpukhov

“…Nevertheless, new potential exporting destinations may be found, precisely because of the detected imbalances.…”
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Deep Learning Architectures for Single-Label and Multi-Label Surgical Tool Classification in Minimally Invasive Surgeries by Hisham ElMoaqet, Hamzeh Qaddoura, Mutaz Ryalat, Natheer Almtireen, Tamer Abdulbaki Alshirbaji, Nour Aldeen Jalal, Thomas Neumuth, Knut Moeller

“…Nonetheless, our results demonstrated that the proposed CNN-SE-FFM-BiLSTM multi-label model achieved competitive performance to state-of-the-art methods with excellent performance in detecting tools with complex usage patterns and in minority classes. …”
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Evaluation des perturbations biologiques chez les brûlés admis aux urgences [Evaluation of biological disorders in burn patients admitted on emergency unit ] by Ibtissem Kihel, Mourad Nachi, Fouzia Berrahal, Yousra Meguenni, Zineb Tahiri

“…Conclusion- Biological assessment upon admission to the emergency room is necessary to detect damages and guide treatment. The study of predictive biomarkers is also important to be able to predict the prognosis of the burn in order to optimize the management of burn patients. …”
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Evaluation of Left Main Coronary Artery Using Optical Frequency Domain Imaging and Its Pitfalls by Vincent Roule, Idir Rebouh, Adrien Lemaitre, Mathieu Bignon, Pierre Ardouin, Rémi Sabatier, Fabien Labombarda, Katrien Blanchart, Farzin Beygui

“…Methods. We included 42 consecutive patients who underwent OFDI, including LM imaging. …”
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Virtual reality and mixed reality in the assessment of spatial memory by Sara Garcia-Navarra, Lucia Solares, Marta Mendez

“…Traditional assessment methods, such as paper-based tests and laboratory paradigms, often lack ecological validity and fail to capture the complexities of real-world navigation. …”
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Long-term outcomes of congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a retrospective study from a tertiary care center in Saudi Arabia by Haneen Aldalaan, Afaf Alsagheir, Nujud Alghamdi, Raghad Alhuthil, Maha Almslam, Mohamed H. Al-Hamed

“…Continuous monitoring and improved treatment strategies are essential for optimizing the quality of life of patients with CAH.…”
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Growth Assessment and Nutritional Status in Children with Congenital Adrenal Hyperplasia—A Cross-Sectional Study from a Vietnamese Tertiary Pediatric Center by Thi Thuy Hong Nguyen, Khanh Minh Le, Thi Anh Thuong Tran, Khanh Ngoc Nguyen, Thi Bich Ngoc Can, Phuong Thao Bui, Dat Tien Tran, Chi Dung Vu

“…Vitamin D insufficiency or deficiency was detected in 85.6% of patients, and hypocalcemia was present in 85.1%. …”
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Etiology and differential diagnosis of binocular diplopia in comitant and incomitant strabismus by O. V. Proskurina, E. P. Tarutta, T. Z. Khvedelidze, S. G. Harutyunyan, N. A. Aklaeva, A. V. Apaev

“…In 44.6% of cases, mobility restrictions could not be visually detected. The deflection angle conformed to the strength of the compensating prism. …”
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Integrating vision transformer-based deep learning model with kernel extreme learning machine for non-invasive diagnosis of neonatal jaundice using biomedical images by M. Eliazer, Sibi Amaran, K. Sreekumar, A. Vikram, Gyanendra Prasad Joshi, Woong Cho

“…Finally, the enhanced coati optimization algorithm (ECOA) method is implemented for the hyperparameter tuning of the KELM method, which results in a higher classification process. …”
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Is fibromyalgia secondary to rheumatic diseases? by E. G. Filatova, N. A. Melikova, E. S. Filatova, A. M. Lila

“…The diagnosis of FM in patients with RD will optimize treatment: patients suffering from RD and FM require complex therapy.…”
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Effective Dose Estimation in Computed Tomography by Machine Learning by Matteo Ferrante, Paolo De Marco, Osvaldo Rampado, Laura Gianusso, Daniela Origgi

“…Different machine learning algorithms were selected, optimizing parameters to achieve the best performance for each algorithm. …”
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Abnormal activity in the brainstem affects gait in a neuromusculoskeletal model by Daisuke Ichimura, Makoto Sawada, Kenji Wada, Ritsuko Hanajima

“…Results The normal models walked successfully following internal parameter optimization using standard genetic algorithms. In an abnormal model, 156 freezing of gait events were detected among 40,000 parameter sets using a freezing of gait-identifying algorithm. …”
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Neonicotinoid Residues in Tea Products from China: Contamination Patterns and Implications for Human Exposure by Yulong Fan, Hongwei Jin, Jinru Chen, Kai Lin, Lihua Zhu, Yijia Guo, Jiajia Ji, Xiaming Chen

“…The distribution of NEO residues was significantly influenced by tea processing techniques, such as full fermentation in black tea. Optimizing processing methods (e.g., using infrared enzyme deactivation) and implementing targeted pesticide application strategies may help mitigate risk. …”
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Incidence and Risk Factors of Morbidity and Mortality in Emergency Laparotomy by Hanaa Taha, Sardar Arif, Ayad Mohammed

“… Objectives: We aimed to detect the different predicting factors for morbidity and mortality after emergency laparotomies.Materials and methods: This prospective cohort study was conducted on 100 patients who were subjected to an emergency laparotomy. …”
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Features of the High Blood Pressure Daily Monitoring Indices in Patients with Different Degree of Systemic Lupus Erythematosus Activity by Abrahamovych U.

“…In the patients with SLE of the 3rd activity degree were recorded the significantly elevated levels of mean HR during the day, the active and passive periods; average daily levels of SysBP, DiaBP and MBP throughout the day, the active and passive periods; SysBP DI, DiaBP DI and MBP DI; SysBP TI, DiaBP TI, MBP TI throughout the day and active and passive periods. Conclusions. The detected regularities of BPDM help to optimize the treatment of arterial hypertension in patients with SLE.…”
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Epidemiological Characteristics and Carbapenemase Analysis of Carbapenem-Resistant Enterobacterales Isolates in a Teaching Hospital in Guangzhou, China by Li Y, Mai Y, Liu Y, Jiang Y

“…This comprehensive analysis serves as an invaluable insight for optimizing CRE treatment strategies for clinical practitioners and implementing robust measures to prevent and control nosocomial infections within healthcare settings.Methods: The antimicrobial susceptibility testing aimed to ascertain carbapenem resistance in Enterobacterales, while the production of carbapenemase was assessed through rapid phenotypic identification by immunochromatographic assay (KPC, NDM, VIM, IMP, and OXA-48-like) and confirmed by PCR.Results: Among the 300 CRE strains collected from January 2020 to March 2023, Klebsiella pneumoniae (CR-Kpn) accounted for 72.7%, Escherichia coli (CR-Eco) 12.3%, Enterobacter cloacae (CR-Ecl) 8.3%, Klebsiella aerogenes (CR-Eae) 2.3%, Citrobacter freundii (CR-Cfr) 2.0%, and others 2.3%. …”
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