Measuring the rate of NADPH consumption by glutathione reductase in the cytosol and mitochondria. by Kenneth K Y Ting, Eric Floro, Riley Dow, Jenny Jongstra-Bilen, Myron I Cybulsky, Jonathan V Rocheleau

“…Although individual NADPH-dependent pathways are well characterized, how these opposing pathways are co-regulated to orchestrate an optimized inflammatory response is not well understood. …”
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Results of a Prospective Study Concerning the Clinical Efficiency of Recent Russian-Made Specialized Foods without Phenylalanine by T. V. Bushueva, T. E. Borovik, K. S. Ladodo, L. M. Kuzenkova

“…The chemical composition of the ration was controlled using dietology methods.Results: 57 children at the age of 14 days to 15 years with phenylketonuria (which was detected in neonatal screening) were picked for this study. …”
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CLSTM-MT (a Combination of 2-Conv CNN and BiLSTM Under the Mean Teacher Collaborative Learning Framework): Encryption Traffic Classification Based on CLSTM (a Combination of 2-Conv... by Xiaozong Qiu, Guohua Yan, Lihua Yin

“…The identification and classification of network traffic are crucial for maintaining network security, optimizing network management, and ensuring reliable service quality. …”
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Smart indoor monitoring for disabled individuals using an ensemble of deep learning models in an IoT environment by Faisal S. Alsubaei, Abdulrahman A. Alshdadi, Mohammed Rizwanullah

“…Abstract Indoor activity monitoring methods assurance the well-being and security of disabled and aging individuals living in their homes. …”
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NuclampFISH enables cell sorting based on nuclear RNA expression for chromatin analysis by Yifang Liu, Yuchen Qiu, Keqing Nian, Sara H. Rouhanifard

“…This method combines the specificity of a single-cell assay for detecting transcription sites with the throughput of flow cytometry to enable bulk assays such as chromatin conformation or other biochemical assays. …”
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Characterizing modifications to the mental health gap action programme (mhGAP) intervention guide during implementation in low- and middle-income countries using the framework for... by Harikeerthan Raghuram, Akanksha Jayant Rajguru, Mythili Menon Pathiyil, Aakrushi Brahmbhatt, Anant Bhan, Jessica Spagnolo, John A. Naslund

“…Strengthening frameworks like FRAME can improve reporting, optimize resources, and enhance implementation and scale-up in similar contexts.…”
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BRAF in Melanoma: Pathogenesis, Diagnosis, Inhibition, and Resistance by Ryan J. Sullivan, Keith T. Flaherty

“…This paper provides an overview on the pathogenic ramifications of mutant BRAF signaling, the latest molecular testing methods to detect BRAF mutations, and the most recent clinical data of BRAF pathway inhibitors in patients with melanoma and BRAF mutations. …”
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Occurrence and Ecological Risks of Neonicotinoids in Wheat, Corn and Rice Field Soils in China by Junxue Wu, Pingzhong Yu, Ziyu Zou, Ercheng Zhao, Junjie Jing, Jinwei Zhang, Yan Tao, Lirui Ren, Min He, Li Chen, Ping Han

“…., rice, wheat and corn) in China were investigated in the present study. Employing an optimized UPLC-MS/MS method (LOQ = 0.01–1.7 ng/g, RSD < 12.21%), ten NEOs across 69 representative field soils (rice: 23, corn: 18, wheat: 28) were quantified. …”
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Defining the sensitivity of cosmic ray muons to groundwater storage changes by Tramontini, Matías, Rosas-Carbajal, Marina, Zyserman, Fabio Iván,  Longuevergne, Laurent, Nussbaum, Christophe, Marteau, Jacques

“…We find that the geometrical relationship between the trajectories of detected muons and the topography has a significant effect in the amplitude of the detected variations. …”
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Economic assessment of energy consumption and greenhouse gas emissions from wheat production in Ardabil provience by Jabraeil Taghinazhad, َAdel Vahedi, Fayaz Ranjbar

“…The being Independent on agricultural productions lead to take more attention to modern methods and the objective of all these methods is increasing the performance with the efficient use of inputs or optimizing energy consumptions in agricultural systems. …”
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Development of a culture-independent whole-genome sequencing of Nipah virus using the MinION Oxford Nanopore platform by Md. Mahfuzur Rahman, Mojnu Miah, Mohammad Enayet Hossain, Samiur Rahim, Sharmin Sultana, Syed Moinuddin Satter, Ariful Islam, Shannon L. M. Whitmer, Jonathan H. Epstein, Christina F. Spiropoulou, John D. Klena, Tahmina Shirin, Joel M. Montgomery, Maria E. Kaczmarek, Mohammed Ziaur Rahman, Iqbal Kabir Jahid

“…It is a cost-effective, rapid, and efficient approach to the WGS of NiV, making it suitable for resource-limited settings like Bangladesh. The method enhances the capacity for outbreak investigations, epidemiological analyses, and monitoring virus, aiding in detecting emerging strains. …”
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Harmonization trial on ESR1 testing strategies in ER+/HER2- breast cancer patients: an Italian experience by Francesco Pepe, Gianluca Russo, Konstantinos Venetis, Claudia Scimone, Lucia Palumbo, Mariantonia Nacchio, Domenica di Giovanni, Claudia Sarracino, Ilaria Tomaiuolo, Elisabetta Zulato, Matteo Fassan, Daniela Righi, Giuseppe Perrone, Dario de Biase, Gabriele Casati, Fabio Pagni, Lucia Gullotti, Antonio Rizzo, Alessandro Perez, Antonio Russo, Katia Zavaglia, Gianluca Gragnano, Domenico Cozzolino, Sabrina Alfano, Cristian Scatena, Sara D’andrea, Monica Schiappacassi, Giuseppina Roscigno, Alessia Paganotti, Renzo Boldorini, Francesco Esposito, Pierlorenzo Pallante, Daniela Furlan, Marta Sbaraglia, Angelo Paolo Dei Tos, Giancarlo Troncone, Nicola Fusco, Umberto Malapelle

“…Here, we sought to harmonize technical procedures comparing technical performance of diagnostically available testing strategies on a series of three reference specimens (sample A, B, C) harboring ESR1 p.D538G mutation at different mutant allele fraction (MAF) (5.0 %, 1.0 %, 0.5 %) shared with n = 10 Italian referral institutions. Methods: A total of 10 μl of gDNA from each reference sample built to mimic clinically detectable ESR1 molecular alteration (5.0 %, 1.0 %, 0.5 % VAF) was shipped by coordinator institution to each participating group to test p.D538G ESR1 alteration leveraging own routinely available testing strategy. …”
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Heart rate variability dynamics in obese men following the results of the health improvement programme by T. A. Mityukova, A. A. Basalai, S. B. Kokhan, O. Y. Poluliakh, M. S. Kastsiuchenka, M. A. Darenskaya, L. V. Rychkova, S. I. Kolesnikov, N. V. Semenova, L. I. Kolesnikova

“…Obesity is known to be very detrimental to health, so wellness programs are needed to optimize dietary habits and physical activity in people of different ages. …”
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Experimental usage of a multicomponent film in treatment of wounds by A. Yu. Grigoryan, A. I. Bezhin, T. A. Pankrusheva, B. S. Sukovatykh, M. S. Chekmareva, L. V. Zhilyaeva

“…Purulent wound was modeled in the animals according to the method of P.I. Tolstykh. To evaluate the effectiveness of the treatment, the following methods were used: microbiological method (determination of areas of growth retardation and bacterial contamination in the wounds), Renier’s method (determination of local anesthetic activity), visual assessment of wounds, planimetric method (measurement of the wound area, percentage of area reduction and healing speed) and measurement of pH in the wounds. …”
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The role of high-resolution manometry in the diagnosis of esophageal disorders (literature review and personal clinical observations) by Yu.M. Stepanov, N.V. Prolom, S.O. Tarabarov, O.M. Babii, I.M. Adamska

“…HRM has established itself as an exceptionally effective method for detecting motor disorders such as achalasia, gastroesophageal reflux disease, diffuse esopha­geal spasm, as well as other functional abnormalities that may cause dysphagia or impair bolus transit. …”
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Vehicle Motion Sickness Profiling Through Interpretable Gradient Boosting: A Framework for Advanced Driver Assistance Systems by Jon Ander Ruiz Colmenares, Estibaliz Asua

“…The proposed approach leverages both classical and modern algorithms, with CatBoost emerging as the top-performing model after optimization. To address the interpretability of these models, SHAP methods are employed to extract actionable insights, revealing key factors contributing to motion sickness. …”
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Solvothermal synthesis of polyvinyl pyrrolidone encapsulated, amine-functionalized copper ferrite and its use as a magnetic resonance imaging contrast agent. by Fatemeh Heydari, Ágnes M Ilosvai, Noémi Kovács, Domokos Máthé, Ferenc Kristály, Lajos Daróczi, Zoltán Kaleta, Béla Viskolcz, Miklós Nagy, László Vanyorek, László Forgách, Krisztián Szigeti

“…The study provides valuable insights into the synthesis, properties, and potential applications of these materials, emphasizing the importance of eco-friendly methods and the optimization of ferrite-based MRI contrast agents.…”
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Predicting the subclinical carotid atherosclerosis in overweight and obese patients using a machine learning model by D. V. Gavrilov, T. Yu. Kuznetsova, M. A. Druzhilov, I. N. Korsakov, A. V. Gusev

“…To develop a model for predicting the subclinical carotid atherosclerosis (SCA) in order to refine cardiovascular risk (CVR) using machine learning methods in overweight and obese patients without hypertension, diabetes and/or cardiovascular disease (CVD).Material and methods. …”
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Development of an automated, high-throughput SARS-CoV-2 neutralization assay based on a pseudotyped virus using a vesicular stomatitis virus (VSV) vector by Ziteng Liang, Xi Wu, Jiajing Wu, Shuo Liu, Jincheng Tong, Tao Li, Yuanling Yu, Li Zhang, Chenyan Zhao, Qiong Lu, Haiyang Qin, Jianhui Nie, Weijin Huang, Youchun Wang

“…In this study, a high-titre SARS-CoV-2 pseudovirus was successfully packaged by truncating the C-terminus of the SARS-CoV-2 spike protein by 21 amino acids and infecting 293 T cells that had been stably transfected with the angiotensin-converting enzyme 2 (ACE2) receptor and furin (named AF cells), to establish a simple, high-throughput, and automated 384-well plate neutralization assay. The method was optimized for cell amount, virus inoculation, incubation time, and detection time. …”
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Product Development of High-Dose Ambroxol HCl Capsules for an n-of-1 Clinical Trial Involving Dutch Patients with Gaucher Disease Type 3 by Hoang Lan Le, Natalja Bouwhuis, Carla E. M. Hollak, Abraham J. Wilhelm, Anne-Loes E. Gerards, Yuma A. Bijleveld, Eleonora L. Swart

“…No degradation products or microbiological impurities were detected after production. <b>Conclusions</b>: The optimized formulation of 75 mg AMB capsules formulated within the hospital pharmacy setting resulted in qualitative and uniform capsules which can be used in clinical trials.…”
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